Xiang Zhang
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View article: Sestrin2 Exerts a Novel Protective Effect Against <scp>LPS</scp> ‐Induced Ferroptosis via the Nrf2– <scp>SLC7A11</scp> – <scp>GPX4</scp> Signaling Axis
Sestrin2 Exerts a Novel Protective Effect Against <span>LPS</span> ‐Induced Ferroptosis via the Nrf2– <span>SLC7A11</span> – <span>GPX4</span> Signaling Axis Open
Uveitis is a leading cause of visual impairment linked to systemic inflammatory diseases. Current corticosteroid treatments are limited by significant long‐term side effects. Sestrin 2 (SESN2), a stress‐responsive antioxidant protein, is i…
View article: Randomized controlled trial of Shikani optical stylet’s one-person technique in nasotracheal intubation for children undergoing dental treatment
Randomized controlled trial of Shikani optical stylet’s one-person technique in nasotracheal intubation for children undergoing dental treatment Open
View article: Molecular Mechanisms of Cold Stress Response in Strawberry and Breeding Strategies
Molecular Mechanisms of Cold Stress Response in Strawberry and Breeding Strategies Open
As a globally popular crop, strawberry is highly susceptible to cold stress, which significantly limits its cultivation and yield. This review synthesizes current knowledge on the morphological, physiological, and molecular responses of st…
View article: Mutant p53 Regulates Pyruvate Dehydrogenase Kinase 1 ( <scp>PDK1</scp> ) to Promote Proliferation and Migration in Breast Cancer
Mutant p53 Regulates Pyruvate Dehydrogenase Kinase 1 ( <span>PDK1</span> ) to Promote Proliferation and Migration in Breast Cancer Open
Tumor suppressor p53 is the most frequently mutated gene in cancers. Mutations in p53 not only result in the loss of its classical tumor‐suppressive functions but also confer new oncogenic properties. The protein stabilization of mutant p5…
View article: Association of blood biomarkers with cardiovascular and kidney adverse outcomes in people with heart failure with preserved ejection fraction
Association of blood biomarkers with cardiovascular and kidney adverse outcomes in people with heart failure with preserved ejection fraction Open
Background Greater than 50% of people with chronic kidney disease have left ventricular hypertrophy and are at risk for developing heart failure with preserved ejection fraction (HFpEF). Up to 56% of those with HF suffer from kidney functi…
View article: Prediction of Refracture After Surgery for Osteoporotic Vertebral Compression Fractures Using the Vertebral B one Quality Index on T1- and T2-Weighted MRI
Prediction of Refracture After Surgery for Osteoporotic Vertebral Compression Fractures Using the Vertebral B one Quality Index on T1- and T2-Weighted MRI Open
Objective : To evaluate the value of the vertebral bone quality (VBQ) index on MRI in predicting refracture after percutaneous vertebral augmentation (PVA) for osteoporotic vertebral compression fractures (OVCF), and to compare its perform…
View article: Multi-omics analysis reveals the protective role of transcriptional enhancer factor and the pathogenic mechanism of monocytes in Parkinson's disease
Multi-omics analysis reveals the protective role of transcriptional enhancer factor and the pathogenic mechanism of monocytes in Parkinson's disease Open
Parkinson's disease (PD) is a multifactorial neurodegenerative disorder whose pathogenic mechanisms remain incompletely elucidated. This study aimed to systematically identify key regulatory factors involved in PD at the genetic, cellular,…
View article: Comprehensive genomic landscape of metastatic hormone-sensitive prostate cancer in the Chinese population
Comprehensive genomic landscape of metastatic hormone-sensitive prostate cancer in the Chinese population Open
Not applicable. This study is a retrospective observational analysis.
View article: Seeing Through the Brain: New Insights from Decoding Visual Stimuli with fMRI
Seeing Through the Brain: New Insights from Decoding Visual Stimuli with fMRI Open
Understanding how the brain encodes visual information is a central challenge in neuroscience and machine learning. A promising approach is to reconstruct visual stimuli, essentially images, from functional Magnetic Resonance Imaging (fMRI…
View article: A novel miRNA-TF-mRNA regulatory network associated with cellular senescence in osteoporosis
A novel miRNA-TF-mRNA regulatory network associated with cellular senescence in osteoporosis Open
This study investigated the role of miR-22-3p/ESR1 axis in osteoporosis (OP) pathogenesis. Bioinformatics analysis of OP datasets and patient bone marrow samples revealed significant upregulation of miR-22-3p accompanied by downregulation …
View article: Maternal cadmium exposure promotes amyloid-beta pathology by interrupting the interaction of AQP1 and HCN1 in male offspring
Maternal cadmium exposure promotes amyloid-beta pathology by interrupting the interaction of AQP1 and HCN1 in male offspring Open
Maternal cadmium (Cd) exposure induces Alzheimer's disease (AD)-like cognitive decline in male offspring, yet the precise mechanisms remain poorly understood. Proteomic analysis identified AQP1 as a key protein in the hippocampus of male o…
View article: Neutrophil degranulation is increased at seven days after human intracerebral hemorrhage, but not at 72 h, and correlates with decreased miR-3613 and miR-3690
Neutrophil degranulation is increased at seven days after human intracerebral hemorrhage, but not at 72 h, and correlates with decreased miR-3613 and miR-3690 Open
Background The molecular mechanisms of inflammatory pathophysiology after intracerebral hemorrhage (ICH) are not well established. We report mRNA-seq and miRNA-seq in the peripheral blood of ICH patients with three serial samples during th…
View article: Chromosome-level genome assembly of <i>Cornus officinalis</i> reveals the evolution of loganin biosynthesis
Chromosome-level genome assembly of <i>Cornus officinalis</i> reveals the evolution of loganin biosynthesis Open
Cornus officinalis is a traditional medicinal plant known for producing loganin, a bioactive iridoid glycoside with potential anticancer properties. However, the absence of a high-quality reference genome has limited insights into its bios…
View article: Exploring Organ‐Specific Extracellular Vesicles in Metabolic Improvements Following Bariatric Surgery in Youth With Obesity
Exploring Organ‐Specific Extracellular Vesicles in Metabolic Improvements Following Bariatric Surgery in Youth With Obesity Open
Objective Vertical sleeve gastrectomy (VSG) promotes significant metabolic improvements, though the underlying molecular mechanisms are not fully understood. Emerging evidence suggests that small extracellular vesicles (sEVs) contribute to…
View article: A concept reflecting relative visual acuity insufficiency among low and moderate myopia students in east of China: Yicheng Myopia Study
A concept reflecting relative visual acuity insufficiency among low and moderate myopia students in east of China: Yicheng Myopia Study Open
View article: Provenance Analysis of the Silurian Kepingtag Formation in the Northwest Margin of Tarim Basin-Evidence from Petrology and Geochemistry
Provenance Analysis of the Silurian Kepingtag Formation in the Northwest Margin of Tarim Basin-Evidence from Petrology and Geochemistry Open
The integration of petrological and geochemical analyses serves as an effective methodology for reconstructing depositional environments and constraining sediment provenance within distinct tectonic frameworks. This study investigates the …
View article: AEBP1 drives fibroblast-mediated T cell dysfunction in tumors
AEBP1 drives fibroblast-mediated T cell dysfunction in tumors Open
View article: Association of Erythrocyte Distribution Width with the Albumin-to- Ratio (RAR) and Osteoporosis: Mediation by Obesity Indicators (BRI/ABSI)
Association of Erythrocyte Distribution Width with the Albumin-to- Ratio (RAR) and Osteoporosis: Mediation by Obesity Indicators (BRI/ABSI) Open
Background: The Albumin-to-Ratio (RAR) value represents an innovative composite indicator defined as the ratio of red blood cell distribution width (RDW) to serum albumin（SA）. Recent research has highlighted its potential as a biomarker in…
View article: Mannose‐binding lectin insufficiency is associated with airway <i>Haemophilus</i> colonization and a higher risk of post‐RSV bronchiolitis recurrent wheezing
Mannose‐binding lectin insufficiency is associated with airway <i>Haemophilus</i> colonization and a higher risk of post‐RSV bronchiolitis recurrent wheezing Open
Objective To investigate whether mannose‐binding lectin (MBL) insufficiency influences the airway microbiota composition and development of subsequent recurrent wheezing in infants with severe respiratory syncytial virus (RSV) bronchioliti…
View article: Larger nail-shaft gap as a potential risk factor of femoral head varus in patients treated with proximal femoral nail antirotation fixation: a retrospective, observational, single-center study with corresponding numerical simulation
Larger nail-shaft gap as a potential risk factor of femoral head varus in patients treated with proximal femoral nail antirotation fixation: a retrospective, observational, single-center study with corresponding numerical simulation Open
A larger nail-shaft gap does not lead to more severe varus deformity of the femoral head from a biomechanical perspective. This phenomenon may be attributed to the optimal anchorage capability of the cortical shaft, even in elderly patient…
View article: Propofol-assisted deep extubation in the dental treatment of pediatrics: a randomized controlled triple-blind trial
Propofol-assisted deep extubation in the dental treatment of pediatrics: a randomized controlled triple-blind trial Open
For pediatric patients undergoing dental treatment, propofol-assisted deep extubation is superior, allowing for less extubation time without increasing airway complications. This technique provides a smoother extubation with fewer hemodyna…
View article: Development and validation of a clinical prediction model for osteoporosis diagnosis by lumbosacral X-ray and radiomics
Development and validation of a clinical prediction model for osteoporosis diagnosis by lumbosacral X-ray and radiomics Open
Purpose To develop a clinical prediction model for the diagnosis of osteoporosis using lumbosacral X-ray images through radiomics analysis. Methods A total of 272 patients who underwent dual-energy X-ray absorptiometry (DXA) and lumbosacra…
View article: Experimental Study of Thermal Conductivity of Multilayer Cylindrical Walls
Experimental Study of Thermal Conductivity of Multilayer Cylindrical Walls Open
Thermal conductivity is an important physical parameter in thermal equipment, in the blast furnace, rotary kiln and other equipment, multi-layer cylindrical wall is extremely important in industrial production of a thermal conductivity mod…
View article: Resistance or power training to enhance lower limb muscle morphology in ambulatory children with cerebral palsy? A focused systematic review with meta-analysis
Resistance or power training to enhance lower limb muscle morphology in ambulatory children with cerebral palsy? A focused systematic review with meta-analysis Open
Background Early exercise interventions targeting lower limb muscles are critical for enhancing motor development in children with cerebral palsy (CP). While both resistance training, which enhances muscular strength and endurance, and pow…
View article: TNS4 promotes lymph node metastasis of gastric cancer by interacting with integrin Β1 and inducing the activation of fibroblastic reticular cell
TNS4 promotes lymph node metastasis of gastric cancer by interacting with integrin Β1 and inducing the activation of fibroblastic reticular cell Open
Lymph node (LN) metastasis of gastric cancer (GC) is one of the important pathways of GC metastasis, indicating the clinical staging and prognosis of patients. To investigate the underlying mechanism during the process of GC-induced LN met…
View article: Whole Brain Monosynaptic Input of Distinct Neurons in the Globus Pallidus Externa
Whole Brain Monosynaptic Input of Distinct Neurons in the Globus Pallidus Externa Open
Objective The globus pallidus externa (GPe) is involved in mediating physiological functions and contains two types of neurons: Forkhead box protein P2‐expressing (GPe FoxP2 ) neurons which inhibit motor, and parvalbumin‐expressing (GPe PV…
View article: The prognostic and predictive value of homologous recombination deficiency in gastrointestinal cancer
The prognostic and predictive value of homologous recombination deficiency in gastrointestinal cancer Open
The homologous recombination (HR) system repairs DNA double-strand breaks produced by the DNA damage response, which is a complex signaling pathway consisting of the key proteins BRCA1/2 and other DNA repair proteins, such as the ATM, PALB…
View article: The Advance and Clinical Practice on Lung Disease Caused by Mycobacterium abscessus
The Advance and Clinical Practice on Lung Disease Caused by Mycobacterium abscessus Open
Mycobacterium abscessus (M. abscessus) lung disease has gradually become a common clinical condition, with its incidence rate continuously rising, especially among patients with weakened immune function or those with chronic lung di…
View article: Lateral Cortical Fixation as the Optimal Strategy for Achieving Stability in Rib Fractures: A Patient-Specific Finite Element Analysis
Lateral Cortical Fixation as the Optimal Strategy for Achieving Stability in Rib Fractures: A Patient-Specific Finite Element Analysis Open
The surgical stabilization of rib fractures helps maintain chest wall stability and reduces respiratory complications. This study aimed to identify the key biomechanical parameters for evaluating the stability of rib fracture fixation usin…
View article: Genomic insights into deleterious mutations and their impact on agronomic traits during pear domestication
Genomic insights into deleterious mutations and their impact on agronomic traits during pear domestication Open
The pear (Pyrus spp.), a perennial fruit tree, is subjected to genetic alterations over decades or even centuries to adapt to complex climatic and cultivation conditions. Genome-wide studies of deleterious mutations remain limited in peren…