Explanipedia

Pulsed Field Ablation Using a Novel Biphasic Catheter vs Thermal Ablation for Paroxysmal Atrial Fibrillation Open

Yuegang Wang, Qiwei Liao, Wenqing Zhu, Songnan Li, Zhuli Guo , et al. · 2025

Disposable electrochemical aptasensor based on surface group-engineered NH2-MXene/CNT nanocomposite for sensitive determination of immunoglobulin E in human serum Open

Congkai Xie, Jiangfeng Huang, Xiaofei Gao, J.N. Heo, Travis Shihao Hu , et al. · 2025

Real-World Predictor Factors and Clinical Outcomes in Patients With Major Depressive Disorder Undergoing Percutaneous Coronary Intervention: Rationale and Study Protocol for the PCI CODE Study Open

Jiang Xiao, Jun Wang, Tian Xu, Junjie Zhang, Xiaodong Mu , et al. · 2025

The predictors and clinical outcomes of Percutaneous Coronary Intervention in patients with suspected coronary heart disease with COmorbid major DEpressive disorder (PCI CODE) study employs a prospective, multidisciplinary, observational d…

A mammalian coacervate-based platform for high-efficiency gene editing in hematopoietic stem cells Open

Xiaofei Gao · 2025

Gene editing in hematopoietic stem cells (HSCs) holds tremendous promise for treating inherited blood disorders such as sickle cell disease and β-thalassemia. However, commonly used delivery systems like viral vectors, electroporation, and…

Iron Deficiency Drives Th2-Mediated Immunity in Pediatric Atopic Dermatitis Through DNA Hypermethylation and TIGIT Suppression in IL-10-Producing Breg Cells Open

Xiaofei Gao, Z. L. Hou, Xidie Li, Tao Ouyang, Shuting Yu , et al. · 2025

Iron deficiency contributes to Th2 cell expansion in pediatric AD via DNA methylation and TIGIT suppression in IL-10-producing Breg cells.

Efficacy and Safety of Tenecteplase in the Treatment of Acute Branch Atheromatous Disease: A Retrospective Multicenter Case–Control Study Open

Li-Li Zhu, Songling Fu, Ying Zhang, Baoyang Shi, Haoran Li , et al. · 2025

Mechanism of Action of Resveratrol Affecting the Biological Function of Breast Cancer Through the Glycolytic Pathway Open

Yu Gao, Yao Yao Wang, Baohua Wang, Qun Ying Hu, Jun Jiang , et al. · 2025

Our findings suggest that targeting the PGK1 glycolytic pathway could be a promising approach for resveratrol-based treatment of breast cancer.

Reduction of neuronal activity mediated by blood-vessel regression in the adult brain Open

Xiaofei Gao, Xing-jun Chen, Meng Ye, Jun-Liszt Li, Nannan Lu , et al. · 2025

The brain vasculature supplies neurons with glucose and oxygen, but little is known about how vascular plasticity contributes to brain function. Using longitudinal in vivo imaging, we report that a substantial proportion of blood vessels i…

Effect of rapa on proliferation and migration of human umbilical vein endothelial cells and differential expression of microRNA Open

Wenxing Mao, Xiaoping Jin, Xiaofei Gao, Fei Ye · 2025

Pediatric Pustular Psoriasis in Southern China: A 12-Year Retrospective Analysis of 41 Cases Focusing on Clinical Characteristics and Treatment Outcomes Open

Jin-Ling Tang, Z. L. Hou, Wei Liao, Yuwei Wang, Ge Zhang , et al. · 2025

Pediatric PP is a disease that often occurs in the pre-school period and predominantly affects males. It is characterized by typical skin lesions and systemic inflammatory reactions. Common comorbidities include nutritional disorders such …

Extensive Nail Changes Are a Possible Clue Indicating Multisystem Involvement in Childhood Langerhans Cell Histiocytosis: A Case Report and Literature Review Open

Xiaofei Gao, Bin Yu, Jennifer T. Huang, Haixia Yang, Wei Zhu · 2025

Introduction: Langerhans cell histiocytosis (LCH) is a rare myeloid neoplasm that can involve nearly any organ, leading to multisystem damage. Nail involvement in LCH is particularly uncommon. Here we report a case of a young boy with mult…

Tumor‐Associated Macrophages: Key Players in the Non‐Small Cell Lung Cancer Tumor Microenvironment Open

Tongtong Lv, Rui Fan, Jiaqi Wu, Hui Gong, Xiaofei Gao , et al. · 2025

Background Lung cancer is among the most common and deadliest malignant tumors worldwide. It is often detected at late stages, resulting in unfavorable outcomes, with tumor cell heterogeneity and medication resistance. Tumor‐associated mac…

Experimental Study and Numerical Analysis of the Mechanical Properties of Lifting Anchors Subjected to Combined Tensile and Shear Forces in Precast Concrete Components Open

Jun Tan, Chuanming Zhai, Chao Zhang, Xiaofei Gao, Guojun Sun · 2025

To study the mechanical properties of the lifting anchor under combined tension and shear, the failure mode and bearing capacity of lifting anchor under different load angles are systematically analyze through the comparison of test and fi…

Anterior and Posterior Default Mode Network May Be the Trait and Residual Signatures of Major Depressive Disorder Open

Zhi‐Peng Guo, Xiaofei Gao, Kexin Wang, Li-Rong Tang, Yue Gao , et al. · 2025

BRAF inhibitors enhance erythropoiesis and treat anemia through paradoxical activation of MAPK signaling Open

Shuai Wu, Yuelin Deng, Haobo Sun, Xuewen Liu, Shuo Zhou , et al. · 2024

Erythropoiesis is a crucial process in hematopoiesis, yet it remains highly susceptible to disruption by various diseases, which significantly contribute to the global challenges of anemia and blood shortages. Current treatments like eryth…

Lenalidomide-induced pure red cell aplasia is associated with elevated expression of MHC-I molecules on erythrocytes Open

Qi Hu, Yang Liu, Qiuyu Yue, Shuo Zhou, Xianghong Jin , et al. · 2024

The RVd therapy, combining lenalidomide, bortezomib, and dexamethasone, is a mainstay treatment for multiple myeloma. A multiple myeloma patient developed pure red cell aplasia (PRCA) following RVd treatment, despite the absence of common …

MED26-enriched condensates drive erythropoiesis through modulating transcription pausing Open

Shicong Zhu, Xiaoting Zhang, Na Li, Xinying Zhao, Man Li , et al. · 2024

The Mediator complex regulates various aspects of hematopoietic development, but whether composition of the Mediator complex undergoes dynamic changes for diversifying transcription and functional outputs is unknown. Here, we found that ME…

Author response: MED26-enriched condensates drive erythropoiesis through modulating transcription pausing Open

Shicong Zhu, Xiaoting Zhang, Na Li, Xinying Zhao, Man Li , et al. · 2024

MED26-enriched condensates drive erythropoiesis through modulating transcription pausing Open

Shicong Zhu, Xiaoting Zhang, Na Li, Xinying Zhao, Man Li , et al. · 2024

The Mediator complex regulates various aspects of hematopoietic development, but whether composition of the Mediator complex undergoes dynamic changes for diversifying transcription and functional outputs is unknown. Here, we found that ME…

Effects of Toxic and Non-Toxic Microcystis aeruginosa on the Defense System of Ceratophyllum demersum–Scenedesmus obliquus Open

Yuanpu Sha, Shuwen Zhang, Jing Dong, Xiaofei Gao, Huatao Yuan , et al. · 2024

The effects of toxic and non-toxic Microcystis aeruginosa on the Ceratophyllum demersum–Scenedesmus obliquus system were simulated in the laboratory, and some parameters in relation to these organisms were measured. In this experiment, C. …

354 Erythrocyte-αPD-1 conjugates suppress cancers with resistance to checkpoint blockade immunotherapy Open

Xiaoqian Nie, Xiaofei Gao, Yuehua Liu, Yang Liu, Zheling Chen · 2024

Developing an erythrocyte‒MHC-I conjugate for cancer treatment Open

Yuehua Liu, Xiaoqian Nie, Xingyun Yao, Huafeng Shou, Yang Yuan , et al. · 2024

The Distribution and Succession of Filamentous Algae in the Southern Taihang Catchment under Different Nutrient Regimes Open

Bo Yang, Yiguang Zhang, Man Zhang, Xu‐Cong Lv, Yuhua Li , et al. · 2024

Human activities have resulted in the eutrophication of rivers, leading to heightened concerns regarding the occurrence of filamentous algal blooms. With the increasing utilization of rivers by humans, the occurrence of these nuisance fila…

MED26-enriched condensates drive erythropoiesis through modulating transcription pausing Open

Shicong Zhu, Xiaoting Zhang, Na Li, Xinying Zhao, Man Li , et al. · 2024

The Mediator complex regulates various aspects of hematopoietic development, but whether composition of the Mediator complex undergoes dynamic changes for diversifying transcription and functional outputs is unknown. Here, we found that ME…

Circ‐PITX1 promotes non‐small‐cell lung cancer progression through regulating ETS1 expression via miR‐615‐5p Open

Yang Guo, Jianfang Pan, Xiaofei Gao, Yan Zheng · 2024

Background Circular RNAs (circRNAs), produced by reverse splicing, act as important players in human cancers. We aimed to assess the biological functions of circRNA pituitary homeobox 1 (circ‐PITX1) in non‐small‐cell lung cancer (NSCLC). M…

Research Progress on Extraction and Detection Technologies of Flavonoid Compounds in Foods Open

Wen Li, Xiaoping Zhang, Shuanglong Wang, Xiaofei Gao, Xinglei Zhang · 2024

Flavonoid compounds have a variety of biological activities and play an essential role in preventing the occurrence of metabolic diseases. However, many structurally similar flavonoids are present in foods and are usually in low concentrat…

Live Mapping of the Brain Extracellular Matrix and Remodeling in Neurological Disorders Open

Xiaoqian Ge, Xueqi Xu, Qi Cai, Hejian Xiong, Chen Xie , et al. · 2023

Live imaging of the brain extracellular matrix (ECM) provides vital insights into changes that occur in neurological disorders. Current techniques such as second or third‐harmonic generation offer limited contrast for live imaging of the b…

Alterations in gut microbiota and host transcriptome of patients with coronary artery disease Open

Liuying Chen, Xuanting Mou, Jingjing Li, Miaofu Li, C. Ye , et al. · 2023

Glioblastoma Margin as a Diffusion Barrier Revealed by Photoactivation of Plasmonic Nanovesicles Open

Hejian Xiong, Blake A. Wilson, Xiaoqian Ge, Xiaofei Gao, Qi Cai , et al. · 2023

Glioblastoma (GBM) is the most complex and lethal adult primary brain cancer. Adequate drug diffusion and penetration are essential for treating GBM, but how the spatial heterogeneity in GBM impacts drug diffusion and transport is poorly u…

Regulatory factor X1 induces macrophage M1 polarization by promoting DNA demethylation in autoimmune inflammation Open

Shuang Yang, Du, Haobo Cui, Meiling Zheng, Wei He , et al. · 2023

Abnormal macrophage polarization is generally present in autoimmune diseases. Overwhelming M1 macrophage activation promotes the continuous progression of inflammation, which is one of the reasons for the development of autoimmune diseases…

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