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View article: Evaluation of enterochromaffin-like cell hyperplasia can help categorize patients with <i>Helicobacter</i>-negative atrophic gastritis
Evaluation of enterochromaffin-like cell hyperplasia can help categorize patients with <i>Helicobacter</i>-negative atrophic gastritis Open
Objectives Atrophic gastritis (AG) is characterized by atrophy of gastric glands—in particular, oxyntic glands—in the setting of chronic inflammation; it is often autoimmune. The diagnosis is confirmed by immunohistochemistry (IHC) for gas…
View article: Correction: RORγt Represses IL-10 Production in Th17 Cells To Maintain Their Pathogenicity in Inducing Intestinal Inflammation
Correction: RORγt Represses IL-10 Production in Th17 Cells To Maintain Their Pathogenicity in Inducing Intestinal Inflammation Open
Sun, M., C. He, L. Chen, W. Yang, W. Wu, F. Chen, A. T. Cao, S. Yao, S. M. Dann, T. G. M. Dhar, L. Salter-Cid, Q. Zhao, Z. Liu, and Y. Cong. 2019. RORγt represses IL-10 production in Th17 cells to maintain their pathogenicity in inducing i…
View article: Microbiota Metabolite Short-Chain Fatty Acids Facilitate Mucosal Adjuvant Activity of Cholera Toxin through GPR43
Microbiota Metabolite Short-Chain Fatty Acids Facilitate Mucosal Adjuvant Activity of Cholera Toxin through GPR43 Open
The gut microbiota has been shown critical for mucosal adjuvant activity of cholera toxin (CT), a potent mucosal adjuvant. However, the mechanisms involved remain largely unknown. In this study, we report that depletion of gut bacteria sig…
View article: RORγt Represses IL-10 Production in Th17 Cells To Maintain Their Pathogenicity in Inducing Intestinal Inflammation
RORγt Represses IL-10 Production in Th17 Cells To Maintain Their Pathogenicity in Inducing Intestinal Inflammation Open
The role of retinoid-related orphan receptor γ t (RORγt) in Th17 cell differentiation has been well established; however, how it regulates other T cell lineages is still not clearly understood. In this study, we report that in mice, while …
View article: Neutrophils Promote Amphiregulin Production in Intestinal Epithelial Cells through TGF-β and Contribute to Intestinal Homeostasis
Neutrophils Promote Amphiregulin Production in Intestinal Epithelial Cells through TGF-β and Contribute to Intestinal Homeostasis Open
Neutrophils are the first responders to sites of inflammation when the intestinal epithelial barrier is breached and the gut microbiota invade. Despite current efforts in understanding the role of neutrophils in intestinal homeostasis, the…
View article: Microbiota-specific Th17 Cells
Microbiota-specific Th17 Cells Open
Multiple mechanisms are involved in regulation of host response to microbiota to maintain the intestinal homeostasis. Th17 cells are enriched in the intestinal lamina propria under steady conditions. Many studies have demonstrated that mic…
View article: mTOR Mediates IL-23 Induction of Neutrophil IL-17 and IL-22 Production
mTOR Mediates IL-23 Induction of Neutrophil IL-17 and IL-22 Production Open
It has been shown recently that neutrophils are able to produce IL-22 and IL-17, which differentially regulate the pathogenesis of inflammatory bowel disease. However, it is still largely unknown how the neutrophil production of IL-22 and …
View article: Commensal A4 bacteria inhibit intestinal Th2‐cell responses through induction of dendritic cell TGF‐β production
Commensal A4 bacteria inhibit intestinal Th2‐cell responses through induction of dendritic cell TGF‐β production Open
It has been shown that while commensal bacteria promote Th1, Th17 and Treg cells in lamina propria (LP) in steady‐state conditions, they suppress mucosal Th2 cells. However, it is still unclear whether there are specific commensal organism…