Fu Shang
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View article: Rosthornin B alleviates inflammatory diseases via directly targeting <scp>NLRP3</scp>
Rosthornin B alleviates inflammatory diseases via directly targeting <span>NLRP3</span> Open
Aberrant activation of the NLRP3 inflammasome contributes to the evolution of diverse inflammatory diseases. Inhibition of the NLRP3 inflammasome has been proven to be an effective treatment strategy for NLRP3‐driven diseases. This study r…
View article: Celastrol inhibits laser-induced choroidal neovascularization by decreasing VEGF induced proliferation and migration
Celastrol inhibits laser-induced choroidal neovascularization by decreasing VEGF induced proliferation and migration Open
AIM: To evaluate celastrol’s effect on choroidal neovascularization (CNV). METHODS: In this study, neovascular formation in vitro (tube formation and aortic ring culture) and in vivo (laser induced neovascular in mice) was treated with cel…
View article: Anti-viral activity of Staphylococcus aureus lysates against herpes simplex virus type-I infection: an in vitro and in vivo study
Anti-viral activity of Staphylococcus aureus lysates against herpes simplex virus type-I infection: an in vitro and in vivo study Open
AIM: To investigate the effect of Staphylococcus aureus (S. aures) lysates (SALs) on herpes simplex virus type-I (HSV1) infection in human corneal epithelial (HCE) cells and in a mouse model of HSV1 keratitis. METHODS: HCE, Vero, HeLa, and…
View article: Table of Contents: ChemBioEng Reviews 3/2021
Table of Contents: ChemBioEng Reviews 3/2021 Open
The electrochemical reduction of atmospheric carbon dioxide can provide a sustainable source of ethylene.This review explores the many interacting parameters in the electrochemical reduction of carbon dioxide to ethylene using a copper cat…
View article: The triage of damaged proteins: degradation by the ubiquitin-proteasome pathway or repair by molecular chaperones
The triage of damaged proteins: degradation by the ubiquitin-proteasome pathway or repair by molecular chaperones Open
Accumulation of damaged proteins is causally related to many age-related diseases. The ubiquitin-proteasome pathway (UPP) plays a role in selective degradation of damaged proteins, whereas molecular chaperones, such as heat shock proteins,…
View article: Proteotoxic Stress Desensitizes TGF-beta Signaling Through Receptor Downregulation in Retinal Pigment Epithelial Cells
Proteotoxic Stress Desensitizes TGF-beta Signaling Through Receptor Downregulation in Retinal Pigment Epithelial Cells Open
Proteotoxic stress suppressed TGFβ-induced EMT through downregulation of TGFβR-II and subsequent blockade of Smad2, ERK1/2, and FAK activation.
View article: Fasudil inhibits LPS-induced migration of retinal microglial cells via regulating p38-MAPK signaling pathway.
Fasudil inhibits LPS-induced migration of retinal microglial cells via regulating p38-MAPK signaling pathway. Open
Our studies indicated that fasudil inhibited LPS-stimulated RMG cell migration via suppression of the p38-MAPK signaling pathway.
View article: Methylglyoxal modified HIF-1α and induced its polyubiquitination.
Methylglyoxal modified HIF-1α and induced its polyubiquitination. Open
(A) ARPE-19 cells were subjected to hypoxia (2% O2) for 6 hours and then incubated with MGO (3 mM) for 40 and 70 minutes. HIF-1α was immunoprecipitated and the immunoprecipitates were probed against CML and MG-H1. (B and C) ARPE-19 cells w…
View article: Methylglyoxal decreased the transcriptional activity of HIF-1 and the release of VEGF<sub>121/165</sub> into the medium.
Methylglyoxal decreased the transcriptional activity of HIF-1 and the release of VEGF<sub>121/165</sub> into the medium. Open
(A) ARPE-19 cells were transiently transfected with the pT81 HRE-luciferase vector and were subjected to hypoxia (2% O2) for 6 hours in the absence or presence of MGO (1 mM for 4 hours). Subsequently, the luciferase activity was determined…
View article: Unfolded‐protein response‐associated stabilization of p27(Cdkn1b) interferes with lens fiber cell denucleation, leading to cataract
Unfolded‐protein response‐associated stabilization of p27(Cdkn1b) interferes with lens fiber cell denucleation, leading to cataract Open
Failure of lens fiber cell denucleation (LFCD) is associated with congenital cataracts, but the pathobiology awaits elucidation. Recent work has suggested that mechanisms that direct the unidirectional process of LFCD are analogous to the …
View article: Altered ubiquitin causes perturbed calcium homeostasis, hyperactivation of calpain, dysregulated differentiation, and cataract
Altered ubiquitin causes perturbed calcium homeostasis, hyperactivation of calpain, dysregulated differentiation, and cataract Open
Significance Eye lens opacification or cataract is the most prevalent age-related disease, blinding 18 million people. Cataractogenesis involves accumulation and precipitation of damaged proteins from the normally clear lens. The ubiquitin…