Feifei Qiu
YOU?
Author Swipe
View article: Metagenomic insights reveal the differences in the community composition and functional characteristics of the sea turtle microbiomes based on host species and tissue region
Metagenomic insights reveal the differences in the community composition and functional characteristics of the sea turtle microbiomes based on host species and tissue region Open
Introduction and methods Sea turtles have been proposed as health indicators of marine ecosystems for their characteristic of longevity and migratory, but they are facing serious threats due to various factors. The microbial communities wi…
View article: Tissue resident memory T cells triggered recurrent psoriasiform dermatitis dependent on RELA/p52 signaling in mice
Tissue resident memory T cells triggered recurrent psoriasiform dermatitis dependent on RELA/p52 signaling in mice Open
Immunological memory triggered recurrence is the critical challenge in treating psoriasis. Tissue resident memory T (Trm) cells is the primary pacemaker in recurrent psoriasiform dermatitis, but the mechanism of activating Trm cells is sti…
View article: Anti-inflammatory and anti-rejection effects of herbal medicine ingredients in organ transplantation: a systematic review and meta-analysis
Anti-inflammatory and anti-rejection effects of herbal medicine ingredients in organ transplantation: a systematic review and meta-analysis Open
Background Although postoperative rejection in transplant patients can be managed with immunosuppressants, their use is associated with some complications due to excessive immunosuppression. Recent animal studies in allotransplantation hav…
View article: The immunoregulatory effects of scoparone on immune-mediated inflammatory diseases
The immunoregulatory effects of scoparone on immune-mediated inflammatory diseases Open
Scoparone (SCO), also known as 6,7-Dimethoxycoumarin, is a naturally occurring bioactive ingredient originally derived from Chinese herb Artemisiae Scopariae Herba (Yin-Chen-Hao). Previous studies have shown that it is effective in treatin…
View article: ESAT-6 protein suppresses allograft rejection by inducing CD4+Foxp3+ regulatory T cells through IκBα/cRel pathway
ESAT-6 protein suppresses allograft rejection by inducing CD4+Foxp3+ regulatory T cells through IκBα/cRel pathway Open
Background Maintenance immunosuppression is required for suppression of alloimmunity or allograft rejection. However, continuous use of immunosuppressants may lead to various side effects, necessitating the use of alternative immunosuppres…
View article: Depiction of Drought Over Africa in the Light of Changing Climate from CMIP6 Models
Depiction of Drought Over Africa in the Light of Changing Climate from CMIP6 Models Open
Drought stands as a prevalent weather-related natural climatic disaster on a global scale. This study employs twenty GCMs from CMIP6 to investigate hydrological drought characteristics (frequency, duration, and intensity) across Africa und…
View article: Zhen-Wu-Tang ameliorates lupus nephritis by diminishing renal tissue-resident memory CD8+ T cells via suppressing IL-15/STAT3 pathway
Zhen-Wu-Tang ameliorates lupus nephritis by diminishing renal tissue-resident memory CD8+ T cells via suppressing IL-15/STAT3 pathway Open
Zhen-Wu-Tang (ZWT), a conventional herbal mixture, has been recommended for treating lupus nephritis (LN) in clinic. However, its mechanisms of action remain unknown. Here we aimed to define the immunological mechanisms underlying the effe…
View article: Zhen-Wu-Tang decoction ameliorates lupus nephritis by diminishing renal tissue-resident memory CD8+ T cells via suppressing IL15/STAT3 pathway
Zhen-Wu-Tang decoction ameliorates lupus nephritis by diminishing renal tissue-resident memory CD8+ T cells via suppressing IL15/STAT3 pathway Open
Background Zhen-Wu-Tang (ZWT), a traditional herbal formula, has been recommended for treating lupus nephritis (LN) in clinic, but the mechanisms underlying its effects remain unclear. Here we aimed to define the immunological mechanisms u…
View article: RETRACTED: Effectiveness of nursing intervention in the operating room to prevent pressure ulcer and wound infection in patients undergoing intertrochanteric fracture: A meta‐analysis
RETRACTED: Effectiveness of nursing intervention in the operating room to prevent pressure ulcer and wound infection in patients undergoing intertrochanteric fracture: A meta‐analysis Open
In this study, a meta‐analysis was conducted to comprehensively assess the effectiveness of nursing intervention in the operating room to prevent pressure ulcers and wound infections in patients with intertrochanteric fractures. A computer…
View article: Corrigendum: Polyphyllin I suppresses the gastric cancer growth by promoting cancer cell ferroptosis
Corrigendum: Polyphyllin I suppresses the gastric cancer growth by promoting cancer cell ferroptosis Open
[This corrects the article DOI: 10.3389/fphar.2023.1145407.].
View article: Polyphyllin I suppresses the gastric cancer growth by promoting cancer cell ferroptosis
Polyphyllin I suppresses the gastric cancer growth by promoting cancer cell ferroptosis Open
Background: Ferroptosis is a new form of regulated cell death characterized by the accumulation of iron-dependent lipid peroxides and membrane damages. Recent studies have identified an important role for cancer cell ferroptosis in antitum…
View article: Nursing of Vulvar Cancer Radical Operation Combined with Laparoscopic Inguinal Lymph Node Dissection
Nursing of Vulvar Cancer Radical Operation Combined with Laparoscopic Inguinal Lymph Node Dissection Open
Purpose. The application, development, and care of radical surgery combined with laparoscopic inguinal lymph node dissection for vulvar cancer. Methods. We searched the PubMed, Web of Science, the Cochrane Library, and EMBASE databases for…
View article: Immunoregulation by Artemisinin and Its Derivatives: A New Role for Old Antimalarial Drugs
Immunoregulation by Artemisinin and Its Derivatives: A New Role for Old Antimalarial Drugs Open
Artemisinin and its derivatives (ARTs) are known as conventional antimalarial drugs with clinical safety and efficacy. Youyou Tu was awarded a Nobel Prize in Physiology and Medicine due to her discovery of artemisinin and its therapeutic e…
View article: Berberine Promotes Induction of Immunological Tolerance to an Allograft via Downregulating Memory CD8+ T-Cells Through Altering the Gut Microbiota
Berberine Promotes Induction of Immunological Tolerance to an Allograft via Downregulating Memory CD8+ T-Cells Through Altering the Gut Microbiota Open
Emerging evidence has linked the gut microbiota dysbiosis to transplant rejection while memory T-cells pose a threat to long-term transplant survival. However, it's unclear if the gut microbiome alters the formation and function of allorea…
View article: Corrigendum: A New Immunosuppressive Molecule Emodin Induces both CD4+FoxP3+ and CD8+CD122+ Regulatory T Cells and Suppresses Murine Allograft Rejection
Corrigendum: A New Immunosuppressive Molecule Emodin Induces both CD4+FoxP3+ and CD8+CD122+ Regulatory T Cells and Suppresses Murine Allograft Rejection Open
[This corrects the article DOI: 10.3389/fimmu.2017.01519.].
View article: Shegan-Mahuang Decoction ameliorates asthmatic airway hyperresponsiveness by downregulating Th2/Th17 cells but upregulating CD4+FoxP3+ Tregs
Shegan-Mahuang Decoction ameliorates asthmatic airway hyperresponsiveness by downregulating Th2/Th17 cells but upregulating CD4+FoxP3+ Tregs Open
Our findings demonstrate that SMD attenuates asthmatic airway hyperresponsiveness by hindering Th2/Th17 differentiation, promoting CD4+FoxP3+ Treg generation and suppressing mTOR and NF-kB activities.
View article: Resveratrol exerts antitumor effects by downregulating CD8 <sup>+</sup> CD122 <sup>+</sup> Tregs in murine hepatocellular carcinoma
Resveratrol exerts antitumor effects by downregulating CD8 <sup>+</sup> CD122 <sup>+</sup> Tregs in murine hepatocellular carcinoma Open
CD4+Foxp3+ regulatory T cells (Tregs) in the tumor microenvironment restrain antitumor immunity, resulting in tumor aggression and poor survival in hepatocellular carcinoma (HCC). CD8+CD122+ Tregs have been previously shown to be more pote…
View article: Dihydroartemisinin ameliorates psoriatic skin inflammation and its relapse by diminishing CD8<sup>+</sup> T-cell memory in wild-type and humanized mice
Dihydroartemisinin ameliorates psoriatic skin inflammation and its relapse by diminishing CD8<sup>+</sup> T-cell memory in wild-type and humanized mice Open
Conventional immunosuppressants cause side effects and do not prevent the recurrence of autoimmune diseases. Moreover, they may not inhibit autoimmunity mediated by pathogenic memory T-cells. Dihydroartemisinin (DHA) has been shown to regu…
View article: Shikonin Prolongs Allograft Survival via Induction of CD4+FoxP3+ Regulatory T Cells
Shikonin Prolongs Allograft Survival via Induction of CD4+FoxP3+ Regulatory T Cells Open
A transplanted organ is usually rejected without any major immunosuppressive treatment because of vigorous alloimmune responsiveness. However, continuous global immunosuppression may cause severe side effects, including nephrotoxicity, tum…
View article: CD8+CD122+PD-1+ Tregs Synergize With Costimulatory Blockade of CD40/CD154, but Not B7/CD28, to Prolong Murine Allograft Survival
CD8+CD122+PD-1+ Tregs Synergize With Costimulatory Blockade of CD40/CD154, but Not B7/CD28, to Prolong Murine Allograft Survival Open
A transplanted organ is always rejected in the absence of any immunosuppressive treatment due to vigorous alloimmunity. However, continuously global immunosuppression with a conventional immunosuppressant may result in severe side effects,…
View article: Chimeric Antigen Receptor (CAR) Treg: A Promising Approach to Inducing Immunological Tolerance
Chimeric Antigen Receptor (CAR) Treg: A Promising Approach to Inducing Immunological Tolerance Open
Cellular therapies with polyclonal regulatory T-cells (Tregs) in transplantation and autoimmune diseases have been carried out in both animal models and clinical trials. However, The use of large numbers of polyclonal Tregs with unknown an…
View article: Esculetin Ameliorates Psoriasis-Like Skin Disease in Mice by Inducing CD4+Foxp3+ Regulatory T Cells
Esculetin Ameliorates Psoriasis-Like Skin Disease in Mice by Inducing CD4+Foxp3+ Regulatory T Cells Open
Psoriasis is an autoimmune and inflammatory skin disease affecting around 2-3% of the world's population. Patients with psoriasis need extensive treatments with global immunosuppressive agents that may cause severe side effects. Esculetin,…
View article: Herbal Components of a Novel Formula PSORI-CM02 Interdependently Suppress Allograft Rejection and Induce CD8+CD122+PD-1+ Regulatory T Cells
Herbal Components of a Novel Formula PSORI-CM02 Interdependently Suppress Allograft Rejection and Induce CD8+CD122+PD-1+ Regulatory T Cells Open
A recipient usually rejects a transplanted organ and thus needs immunosuppressive treatments to prevent rejection. Achieving long-term allograft survival without continuous global immunosuppression is highly desirable in transplantation as…
View article: Mangiferin Attenuates Murine Lupus Nephritis by Inducing CD4+Foxp3+ Regulatory T Cells via Suppression of mTOR Signaling
Mangiferin Attenuates Murine Lupus Nephritis by Inducing CD4+Foxp3+ Regulatory T Cells via Suppression of mTOR Signaling Open
Background/Aims: Lupus nephritis (LN) is an autoimmune glomerulonephritis that frequently develops secondary to systemic lupus erythematosus. Patients with LN require extensive treatments with global immunosuppressive agents. However, long…
View article: A New Immunosuppressive Molecule Emodin Induces both CD4+FoxP3+ and CD8+CD122+ Regulatory T Cells and Suppresses Murine Allograft Rejection
A New Immunosuppressive Molecule Emodin Induces both CD4+FoxP3+ and CD8+CD122+ Regulatory T Cells and Suppresses Murine Allograft Rejection Open
[This corrects the article DOI: 10.3389/fimmu.2017.01519.].
View article: The role of alternative polyadenylation in the antiviral innate immune response
The role of alternative polyadenylation in the antiviral innate immune response Open
Alternative polyadenylation (APA) is an important regulatory mechanism of gene functions in many biological processes. However, the extent of 3′ UTR variation and the function of APA during the innate antiviral immune response are unclear.…
View article: Suppression of allograft rejection by CD8+CD122+PD-1+ Tregs is dictated by their Fas ligand-initiated killing of effector T cells<i>versus</i>Fas-mediated own apoptosis
Suppression of allograft rejection by CD8+CD122+PD-1+ Tregs is dictated by their Fas ligand-initiated killing of effector T cells<i>versus</i>Fas-mediated own apoptosis Open
Mounting evidence has shown that naturally occurring CD8+CD122+ T cells are regulatory T cells (Tregs) that suppress both autoimmunity and alloimmunity. We have previously shown that CD8+CD122+PD-1+ Tregs not only suppress allograft reject…
View article: Effects of Cigarette Smoking on Transplant Survival: Extending or Shortening It?
Effects of Cigarette Smoking on Transplant Survival: Extending or Shortening It? Open
Cigarette smoking (CS) regulates both innate and adaptive immunity and causes numerous diseases, including cardiovascular, respiratory, and autoimmune diseases, allergies, cancers, and transplant rejection. Therefore, smoking poses a serio…