Fu Shang
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View article: Rosthornin B alleviates inflammatory diseases via directly targeting <scp>NLRP3</scp>
Rosthornin B alleviates inflammatory diseases via directly targeting <span>NLRP3</span> Open
Aberrant activation of the NLRP3 inflammasome contributes to the evolution of diverse inflammatory diseases. Inhibition of the NLRP3 inflammasome has been proven to be an effective treatment strategy for NLRP3‐driven diseases. This study r…
View article: Celastrol inhibits laser-induced choroidal neovascularization by decreasing VEGF induced proliferation and migration
Celastrol inhibits laser-induced choroidal neovascularization by decreasing VEGF induced proliferation and migration Open
AIM: To evaluate celastrol’s effect on choroidal neovascularization (CNV). METHODS: In this study, neovascular formation in vitro (tube formation and aortic ring culture) and in vivo (laser induced neovascular in mice) was treated with cel…
View article: Anti-viral activity of Staphylococcus aureus lysates against herpes simplex virus type-I infection: an in vitro and in vivo study
Anti-viral activity of Staphylococcus aureus lysates against herpes simplex virus type-I infection: an in vitro and in vivo study Open
AIM: To investigate the effect of Staphylococcus aureus (S. aures) lysates (SALs) on herpes simplex virus type-I (HSV1) infection in human corneal epithelial (HCE) cells and in a mouse model of HSV1 keratitis. METHODS: HCE, Vero, HeLa, and…
View article: The triage of damaged proteins: degradation by the ubiquitin-proteasome pathway or repair by molecular chaperones
The triage of damaged proteins: degradation by the ubiquitin-proteasome pathway or repair by molecular chaperones Open
Accumulation of damaged proteins is causally related to many age-related diseases. The ubiquitin-proteasome pathway (UPP) plays a role in selective degradation of damaged proteins, whereas molecular chaperones, such as heat shock proteins,…
View article: Proteotoxic Stress Desensitizes TGF-beta Signaling Through Receptor Downregulation in Retinal Pigment Epithelial Cells
Proteotoxic Stress Desensitizes TGF-beta Signaling Through Receptor Downregulation in Retinal Pigment Epithelial Cells Open
Proteotoxic stress suppressed TGFβ-induced EMT through downregulation of TGFβR-II and subsequent blockade of Smad2, ERK1/2, and FAK activation.
View article: Fasudil inhibits LPS-induced migration of retinal microglial cells via regulating p38-MAPK signaling pathway.
Fasudil inhibits LPS-induced migration of retinal microglial cells via regulating p38-MAPK signaling pathway. Open
Our studies indicated that fasudil inhibited LPS-stimulated RMG cell migration via suppression of the p38-MAPK signaling pathway.