Feifei She
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View article: Copper enhances tetracycline resistance via the efflux transporter CrdAB-CzcBA in Helicobacter pylori
Copper enhances tetracycline resistance via the efflux transporter CrdAB-CzcBA in Helicobacter pylori Open
Helicobacter pylori infection is a significant risk factor for various gastrointestinal diseases, while the standard triple therapy for its eradication is increasingly compromised by antibiotic resistance. This study investigates the role …
View article: High salt condition alters LPS synthesis and induces the emergence of drug resistance mutations in <i>Helicobacter pylori</i>
High salt condition alters LPS synthesis and induces the emergence of drug resistance mutations in <i>Helicobacter pylori</i> Open
The burgeoning emergence of drug-resistant Helicobacter pylori strains poses a significant challenge to the clinical success of eradication therapies and is primarily attributed to mutations within drug-targeting genes that lead to antibio…
View article: TGF-β1 facilitates gallbladder carcinoma metastasis by regulating FOXA1 translation efficiency through m6A modification
TGF-β1 facilitates gallbladder carcinoma metastasis by regulating FOXA1 translation efficiency through m6A modification Open
TGF-β1 plays a pivotal role in the metastatic cascade of malignant neoplasms. N6-methyladenosine (m 6 A) stands as one of the most abundant modifications on the mRNA transcriptome. However, in the metastasis of gallbladder carcinoma (GBC),…
View article: IL-8 is a novel prometastatic chemokine in intrahepatic cholangiocarcinoma that induces CXCR2-PI3K/AKT signaling upon CD97 activation
IL-8 is a novel prometastatic chemokine in intrahepatic cholangiocarcinoma that induces CXCR2-PI3K/AKT signaling upon CD97 activation Open
Intrahepatic cholangiocarcinoma (ICC) is a rare but highly aggressive malignant tumor arising within the liver, with a 5-year survival rate of only 20–40% after surgery. The role of interleukin-8 (IL-8) in ICC progression remains elusive. …
View article: CEP55 as a promising biomarker and therapeutic target on gallbladder cancer
CEP55 as a promising biomarker and therapeutic target on gallbladder cancer Open
Introduction Gallbladder cancer (GBC) is a highly malignant biliary tumor with a poor prognosis. As existing therapies for advanced metastatic GBC are rarely effective, there is an urgent need to identify more effective targets for treatme…
View article: Role of AlgC and GalU in the Intrinsic Antibiotic Resistance of Helicobacter pylori
Role of AlgC and GalU in the Intrinsic Antibiotic Resistance of Helicobacter pylori Open
UDP-glucose may play an important role in increasing drug resistance to AMO, MNZ, CLA, LEV, TET, and RIF by maintaining the lipid A-core structure and decreasing membrane permeability. AlgC and GalU may serve as potential drug targets for …
View article: AI-2 Induces Urease Expression Through Downregulation of Orphan Response Regulator HP1021 in Helicobacter pylori
AI-2 Induces Urease Expression Through Downregulation of Orphan Response Regulator HP1021 in Helicobacter pylori Open
Helicobacter pylori causes gastric infections in more than half of the world's population. The bacterium's survival in the stomach is mediated by the abundant production of urease to enable acid acclimation. In this study, our transcriptom…
View article: The Role of a Dipeptide Transporter in the Virulence of Human Pathogen, Helicobacter pylori
The Role of a Dipeptide Transporter in the Virulence of Human Pathogen, Helicobacter pylori Open
Helicobacter pylori harbors a dipeptide (Dpp) transporter consisting of a substrate-binding protein (DppA), two permeases (DppB and C), and two ATPases (DppD and F). The Dpp transporter is responsible for the transportation of dipeptides a…
View article: CagA orchestrates eEF1A1 and PKCδ to induce interleukin-6 expression in Helicobacter pylori-infected gastric epithelial cells
CagA orchestrates eEF1A1 and PKCδ to induce interleukin-6 expression in Helicobacter pylori-infected gastric epithelial cells Open
Background Helicobacter pylori colonises the stomach of approximately 50% of the global population. Cytotoxin-associated gene A protein (CagA) is one of the important virulent factors responsible for the increased inflammation and increase…
View article: <p>A Newly Discovered Drug Resistance Gene <em>rfaF</em> In <em>Helicobacter pylori</em></p>
A Newly Discovered Drug Resistance Gene <em>rfaF</em> In <em>Helicobacter pylori</em> Open
We found a new drug resistance gene, rfaF, in H. pylori, which changes the permeability of cell membrane to confer cross-resistance to AMO, TET, CLA, and CHL and is involved in clinical strain drug resistance. It can be used as a drug targ…
View article: Receptor‑interacting serine/threonine‑protein kinase 1 promotes the progress and lymph metastasis of gallbladder cancer
Receptor‑interacting serine/threonine‑protein kinase 1 promotes the progress and lymph metastasis of gallbladder cancer Open
Receptor‑interacting serine/threonine‑protein kinase 1 (RIP‑1) is highly expressed in gallbladder cancer, and is very important in promoting tumor proliferation and invasion. The underlying mechanism in this promotion is the RIP‑1‑nuclear …
View article: cIAP1 promotes proliferation and migration and prevents apoptosis in gallbladder cancer <i>in vitro</i>
cIAP1 promotes proliferation and migration and prevents apoptosis in gallbladder cancer <i>in vitro</i> Open
Gallbladder cancer (GBC) is a demanding fatal disease with no ideal treatment for inoperable patients. Recent reports have determined TNF-α associated lymphatic metastasis in GBC, while its resistance to TNF-α-killing remains largely unexp…
View article: Serum vascular endothelial growth factor‑C levels predict lymph node metastasis and prognosis of patients with gallbladder cancer
Serum vascular endothelial growth factor‑C levels predict lymph node metastasis and prognosis of patients with gallbladder cancer Open
Lymph node metastasis is the primary site of metastasis for patients with gallbladder cancer (GBC). Vascular endothelial growth factor-C (VEGF-C) has been implicated in the control of lymphangiogenesis and lymph node metastasis in various …
View article: RIP1 regulates TNF-&alpha;-mediated lymphangiogenesis and lymphatic metastasis in gallbladder cancer by modulating the NF-&kappa;B-VEGF-C pathway
RIP1 regulates TNF-α-mediated lymphangiogenesis and lymphatic metastasis in gallbladder cancer by modulating the NF-κB-VEGF-C pathway Open
We conclude that RIP1 regulates TNF-α-mediated lymphangiogenesis and lymph node metastasis in GBC by modulating the NF-κB-VEGF-C pathway.
View article: c‑Jun suppresses the expression of WNT inhibitory factor 1 through transcriptional regulation and interaction with DNA methyltransferase 1 in gallbladder cancer
c‑Jun suppresses the expression of WNT inhibitory factor 1 through transcriptional regulation and interaction with DNA methyltransferase 1 in gallbladder cancer Open
WNT inhibitory factor 1 (WIF‑1) is involved in the tumorigenicity and progression of several types of tumor, which has been attributed to aberrant hypermethylation of its promoter. However, the role of WIF‑1 in the pathogenesis of gallblad…
View article: YWHAE is a novel interaction partner of Helicobacter pylori CagA
YWHAE is a novel interaction partner of Helicobacter pylori CagA Open
CagA, an important virulence factor of Helicobacter pylori, targets and interacts with a series of host proteins to activate signaling factors involved in many functions, such as development, cytoskeleton rearrangement and inflammatory mol…
View article: cIAP2 promotes gallbladder cancer invasion and lymphangiogenesis by activating the NF‐κB pathway
cIAP2 promotes gallbladder cancer invasion and lymphangiogenesis by activating the NF‐κB pathway Open
Several studies have produced contradictory findings about the prognostic implications for inhibitor of apoptosis proteins ( IAP ) in different types of cancer. Cellular inhibitor of apoptosis 2 ( cIAP 2/ BIRC ) is one of the most extensiv…
View article: Rescued expression of WIF-1 in gallbladder cancer inhibits tumor growth and induces tumor cell apoptosis with altered expression of proteins
Rescued expression of WIF-1 in gallbladder cancer inhibits tumor growth and induces tumor cell apoptosis with altered expression of proteins Open
As a highly conserved metabolic pathway, the Wnt signaling pathway is involved in cell differentiation, proliferation and several other processes. In normal cells, this pathway is suppressed, and abnormal activation is often associated wit…
View article: CCR7 mediates the TNF-α-induced lymphatic metastasis of gallbladder cancer through the “ERK1/2 - AP-1” and “JNK - AP-1” pathways
CCR7 mediates the TNF-α-induced lymphatic metastasis of gallbladder cancer through the “ERK1/2 - AP-1” and “JNK - AP-1” pathways Open
Our study suggests that CCR7 is highly expressed in GBC, and mediates the TNF-α-induced lymphatic metastasis of GBC through the "TNF-α - ERK1/2 - AP-1 - CCR7" and "TNF-α - JNK - AP-1 - CCR7" pathways.
View article: TNF-alpha promotes lymphangiogenesis and lymphatic metastasis of gallbladder cancer through the ERK1/2/AP-1/VEGF-D pathway
TNF-alpha promotes lymphangiogenesis and lymphatic metastasis of gallbladder cancer through the ERK1/2/AP-1/VEGF-D pathway Open
Taken together, our data suggest that TNF-α can promote lymphangiogenesis and lymphatic metastasis of GBC through the ERK1/2/AP-1/VEGF-D pathway.
View article: Identification of residues involved in nucleotidyltransferase activity of JHP933 from helicobacter pyloriby site-directed mutagenesis
Identification of residues involved in nucleotidyltransferase activity of JHP933 from helicobacter pyloriby site-directed mutagenesis Open
Helicobacter pylori is a well-known bacterial pathogen involved in the development of peptic ulcer, gastric adenocarcinoma and other forms of gastric cancer. Evidence has suggested that certain strain-specific genes in the plasticity regio…
View article: Impact of Helicobacter pylori on the growth of hepatic orthotopic graft tumors in mice
Impact of Helicobacter pylori on the growth of hepatic orthotopic graft tumors in mice Open
Helicobacter pylori is a well-known causative organism of chronic gastric diseases and has been found in many hepatic carcinoma samples. To explore the expression of apoptosis-related proteins and carcinoma development in H. pylori-infecte…
View article: Serum vascular endothelial growth factors C and D as forecast tools for patients with gallbladder carcinoma
Serum vascular endothelial growth factors C and D as forecast tools for patients with gallbladder carcinoma Open
Gallbladder carcinoma (GBC) is the most common cancer of the biliary tract. Lymph node metastasis (LNM) is the major diffusion route of GBC and is a prognosis factor. The aim of study was to assess the potential of the serum VEGF-C and VEG…
View article: Tea consumption and risk of gallbladder cancer: A meta-analysis of epidemiological studies
Tea consumption and risk of gallbladder cancer: A meta-analysis of epidemiological studies Open
Previous epidemiological studies investigating the association between tea consumption and the risk of gallbladder cancer have yielded inconsistent results. Therefore, we aimed to assess this association by conducting a meta-analysis of al…