Feihu Zhou
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View article: Lutein attenuates rhabdomyolysis-induced acute kidney injury by inhibiting ACSL4-mediated ferroptosis
Lutein attenuates rhabdomyolysis-induced acute kidney injury by inhibiting ACSL4-mediated ferroptosis Open
Tubule-specific knockout of ACSL4 confers protection against RM-induced AKI by inhibiting ferroptosis. Lutein has been shown to prevent ferroptosis in renal tubules by suppressing the expression of ACSL4, suggesting its potential as a phar…
View article: Analysis of mechanical structure operating deflection shape based on modal weighted interpolation
Analysis of mechanical structure operating deflection shape based on modal weighted interpolation Open
Operating deflection shape (ODS) analysis is widely used in mechanical fault diagnosis, vibration source identification, modal analysis, and structural damage identification. However, obtaining an accurate ODS requires a large number of me…
View article: The study of the association between exercise motivation and cardiorespiratory fitness in young students: a systematic review and meta-analysis
The study of the association between exercise motivation and cardiorespiratory fitness in young students: a systematic review and meta-analysis Open
Background In recent years, many studies have shown that exercise motivation is essential for encouraging students to engage in physical activities. Cardiorespiratory function, which is closely related to cardiorespiratory fitness, plays a…
View article: The efficacy and safety of thymosin α1 for sepsis (TESTS): multicentre, double blinded, randomised, placebo controlled, phase 3 trial
The efficacy and safety of thymosin α1 for sepsis (TESTS): multicentre, double blinded, randomised, placebo controlled, phase 3 trial Open
Objective To evaluate whether the immunomodulatory drug thymosin α1 reduces mortality in adults with sepsis. Design Multicentre, double blinded, placebo controlled phase 3 trial. Setting 22 centres in China, September 2016 to December 2020…
View article: Targeting P21‐Activated Kinase 2 as a Novel Therapeutic Approach to Mitigate Endoplasmic Reticulum Stress in Heart Failure With Preserved Ejection Fraction
Targeting P21‐Activated Kinase 2 as a Novel Therapeutic Approach to Mitigate Endoplasmic Reticulum Stress in Heart Failure With Preserved Ejection Fraction Open
Background Heart failure with preserved ejection fraction (HFpEF) is linked to prolonged endoplasmic reticulum (ER) stress. P21‐activated kinase 2 (Pak2) facilitates a protective ER stress response. This study explores the mechanism and ro…
View article: Acute kidney injury in different time windows: a retrospective study of hospitalized elderly patients
Acute kidney injury in different time windows: a retrospective study of hospitalized elderly patients Open
Background To compare the differences between the Kidney Disease Improving Global Outcomes (KDIGO) criteria of the 48-hour window (early acute kidney injury [AKI], 3–5 day window [middle AKI], and 6–7 day window [late AKI]) in the diagnosi…
View article: Ameliorative effects of mesenchymal stromal cells on senescence associated phenotypes in naturally aged rats
Ameliorative effects of mesenchymal stromal cells on senescence associated phenotypes in naturally aged rats Open
Background Aging is a multifaceted process that affects all organ systems. With the increasing trend of population aging, aging-related diseases have resulted in significant medical challenges and socioeconomic burdens. Mesenchymal stromal…
View article: Advances in the Application of AI Robots in Critical Care: Scoping Review
Advances in the Application of AI Robots in Critical Care: Scoping Review Open
Background In recent epochs, the field of critical medicine has experienced significant advancements due to the integration of artificial intelligence (AI). Specifically, AI robots have evolved from theoretical concepts to being actively i…
View article: Uplift modeling to predict individual treatment effects of renal replacement therapy in sepsis-associated acute kidney injury patients
Uplift modeling to predict individual treatment effects of renal replacement therapy in sepsis-associated acute kidney injury patients Open
Renal replacement therapy (RRT) is a crucial treatment for sepsis-associated acute kidney injury (S-AKI), but it is uncertain which S-AKI patients should receive immediate RRT. Identifying the characteristics of patients who may benefit th…
View article: Chinese experts’ consensus on the application of intensive care big data
Chinese experts’ consensus on the application of intensive care big data Open
The development of intensive care medicine is inseparable from the diversified monitoring data. Intensive care medicine has been closely integrated with data since its birth. Critical care research requires an integrative approach that emb…
View article: Early and minimal changes in serum creatinine can predict prognosis in elderly patients receiving invasive mechanical ventilation: A retrospective observational study
Early and minimal changes in serum creatinine can predict prognosis in elderly patients receiving invasive mechanical ventilation: A retrospective observational study Open
Our study suggests that a ≥ 10% SCr rise from baseline within 48 h after MV was independently associated with short-term all-cause mortality in mechanically ventilated elderly patients.
View article: Advances in the Application of AI Robots in Critical Care: Scoping Review (Preprint)
Advances in the Application of AI Robots in Critical Care: Scoping Review (Preprint) Open
BACKGROUND In recent epochs, the field of critical medicine has experienced significant advancements due to the integration of artificial intelligence (AI). Specifically, AI robots have evolved from theoretical concepts to being actively …
View article: Ameliorative Effects of Mesenchymal Stem Cells on Senescence Associated Phenotypes in Naturally Aged Rats
Ameliorative Effects of Mesenchymal Stem Cells on Senescence Associated Phenotypes in Naturally Aged Rats Open
Background Aging is a multifaceted process that affects all organ systems. With the increasing trend of population aging, age-related diseases have resulted in significant medical challenges and socioeconomic burdens. Mesenchymal stem cell…
View article: Uplift modeling to predict individual treatment effects of renal replacement therapy in sepsis-associated acute kidney injury patients
Uplift modeling to predict individual treatment effects of renal replacement therapy in sepsis-associated acute kidney injury patients Open
Background: Renal replacement therapy (RRT) is a crucial treatment for sepsis-associated acute kidney injury (S-AKI), but it is uncertain which S-AKI patients should receive immediate RRT. Identifying the characteristics of patients who ma…
View article: Intelligent Intensive Care Unit: Current and Future Trends
Intelligent Intensive Care Unit: Current and Future Trends Open
There is a growing demand for intensive care units, but there is a relative shortage of medical staff. Intensive care work is heavy and stressful. Optimizing the working conditions and processes of the intensive care unit is of great signi…
View article: Effect of an Herbal-Based Injection on 28-Day Mortality in Patients With Sepsis
Effect of an Herbal-Based Injection on 28-Day Mortality in Patients With Sepsis Open
Importance Previous research has suggested that Xuebijing injection (XBJ), an herbal-based intravenous preparation, may reduce mortality among patients with sepsis. Objective To determine the effect of XBJ vs placebo on 28-day mortality am…
View article: Conservative versus liberal oxygen therapy in relation to all-cause mortality among patients in the intensive care unit: a systematic review of randomized controlled trials with meta-analysis and trial sequential analysis
Conservative versus liberal oxygen therapy in relation to all-cause mortality among patients in the intensive care unit: a systematic review of randomized controlled trials with meta-analysis and trial sequential analysis Open
No beneficial or harmful effects of conservative oxygen therapy were found compared to liberal oxygen therapy in relation to all-cause mortality among adult patients in the ICU. Conservative oxygen therapy did not reduce all-cause mortalit…
View article: Association Between the Severity of Early Acute Kidney Injury and Subsequent in-Hospital Complications and 90-Day Mortality in Geriatric Patients Receiving Invasive Mechanical Ventilation
Association Between the Severity of Early Acute Kidney Injury and Subsequent in-Hospital Complications and 90-Day Mortality in Geriatric Patients Receiving Invasive Mechanical Ventilation Open
Our study suggests that the presence of AKI within the first 48 hours of MV in geriatric patients is associated with a higher risk for postintubation complications and 90-day mortality. Moreover, the risk of complications was greater for p…
View article: A mouse model of exertional heatstroke-related acute kidney injury
A mouse model of exertional heatstroke-related acute kidney injury Open
We established a stable mouse model of EHS-AKI by conducting a heat exercise after the intramuscular injection of glycerol. Our findings lay the foundation for follow-up clinical and basic research.
View article: Comparison of Two Predictive Models of Sepsis in Critically Ill Patients Based on the Combined Use of Inflammatory Markers
Comparison of Two Predictive Models of Sepsis in Critically Ill Patients Based on the Combined Use of Inflammatory Markers Open
This study combining five commonly available inflammatory markers (WBC, CRP, IL-6, PCT and NLR) developed a nomogram model and a simple risk scoring model to predict sepsis in critically ill patients. Although the prediction performance of…
View article: Duration of acute kidney injury predicts 90-day mortality and chronic kidney disease progression in elderly patients
Duration of acute kidney injury predicts 90-day mortality and chronic kidney disease progression in elderly patients Open
AKI duration is useful for predicting poorer clinical outcomes in elderly patients, emphasizing the importance of identifying an appropriate treatment window for early intervention.