Feilong Deng
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View article: Preparation, Physicochemical Characterization, and In Vitro and In Vivo Osteogenic Evaluation of Reinforced <scp>PLLA</scp>‐<scp>PLCL</scp>/<scp>HA</scp> Resorbable Membranes
Preparation, Physicochemical Characterization, and In Vitro and In Vivo Osteogenic Evaluation of Reinforced <span>PLLA</span>‐<span>PLCL</span>/<span>HA</span> Resorbable Membranes Open
This study aimed to develop reinforced poly(L‐lactide)‐poly(L‐lactide‐co‐ε‐caprolactone)/hydroxyapatite (PLLA‐PLCL/HA) resorbable membranes for guided bone regeneration (GBR), focusing on optimizing the degradation rate by adjusting PLLA m…
View article: CircAars‐Engineered ADSCs Facilitate Maxillofacial Bone Defects Repair Via Synergistic Capability of Osteogenic Differentiation, Macrophage Polarization and Angiogenesis
CircAars‐Engineered ADSCs Facilitate Maxillofacial Bone Defects Repair Via Synergistic Capability of Osteogenic Differentiation, Macrophage Polarization and Angiogenesis Open
Adipose‐derived stem cells (ADSCs) hold significant promise in bone tissue engineering due to their self‐renewal capacity and easy accessibility. However, their limited osteogenic potential remains a critical challenge for clinical applica…
View article: Nature Knows Best: Extracellular Matrix‐Gelatin Hydrogel Masking Bioauthentic Bone Scaffold Locking Blood Clot to Induce M2 Macrophage‐Mediated Bone Regeneration via Activating an Endocytosis‐Macroautophagy‐Inflammation Axis
Nature Knows Best: Extracellular Matrix‐Gelatin Hydrogel Masking Bioauthentic Bone Scaffold Locking Blood Clot to Induce M2 Macrophage‐Mediated Bone Regeneration via Activating an Endocytosis‐Macroautophagy‐Inflammation Axis Open
Individualized biological hydroxyapatite (BHA) scaffolds are essential for repairing critical craniomaxillofacial bone defects. Additive manufacturing relies on synthetic hydroxyapatite and biomimetic structures, making the resulting scaff…
View article: Black phosphorus quantum dot-modified ADSCs as a novel therapeutic for periodontitis bone loss coupling of osteogenesis and osteoimmunomodulation
Black phosphorus quantum dot-modified ADSCs as a novel therapeutic for periodontitis bone loss coupling of osteogenesis and osteoimmunomodulation Open
Alveolar bone defect repair remains a persistent clinical challenge for periodontitis treatment. The use of peripheral functional seed cells is a hot topic in periodontitis. Herein, we explored the cellular behaviors and osteogenic ability…
View article: Magnetic Graphene Oxide Nanocomposites Boosts Craniomaxillofacial Bone Regeneration by Modulating circAars/miR-128-3p/SMAD5 Signaling Axis
Magnetic Graphene Oxide Nanocomposites Boosts Craniomaxillofacial Bone Regeneration by Modulating circAars/miR-128-3p/SMAD5 Signaling Axis Open
We found that MGO nanocomposites regulated osteogenic differentiation of BMSCs via the circAars/miR-128-3p/SMAD5 pathway, which provided a feasible and effective strategy for the treatment of craniomaxillofacial bone defects.
View article: Calcitonin gene-related peptide-modulated macrophage phenotypic alteration regulates angiogenesis in early bone healing
Calcitonin gene-related peptide-modulated macrophage phenotypic alteration regulates angiogenesis in early bone healing Open
Collectively, our results reveal the effect of CGRP on M1 to M2 macrophage phenotypic alteration possibly via upregulating IL-6 in M1 macrophages, and demonstrate the macrophage-regulated pro-angiogenic potential of CGRP in early bone heal…
View article: Mettl3‑mediated m<sup>6</sup>A RNA methylation regulates osteolysis induced by titanium particles
Mettl3‑mediated m<sup>6</sup>A RNA methylation regulates osteolysis induced by titanium particles Open
Peri‑prosthetic osteolysis (PPO) induced by wear particles is considered the primary cause of titanium prosthesis failure and revision surgery. The specific molecular mechanisms involve titanium particles inducing multiple intracellular pa…
View article: Single missing molar with wide mesiodistal length restored using a single or double implant-supported crown: A self-controlled case report and 3D finite element analysis
Single missing molar with wide mesiodistal length restored using a single or double implant-supported crown: A self-controlled case report and 3D finite element analysis Open
Compared with the single implant-supported crown, the double implant-supported crown reduced peri-implant bone stress and produced a more appropriate stress transfer model at the implant-bone interface when the MDL of the single missing mo…
View article: Magnetic graphene oxide nanocomposites induce cytotoxicity in ADSCs via GPX4 regulating ferroptosis
Magnetic graphene oxide nanocomposites induce cytotoxicity in ADSCs via GPX4 regulating ferroptosis Open
Magnetic graphene oxide nanocomposites (MGO NPs) have been widely studied in biomedical applications. However, their cytotoxicity and underlying mechanisms remain unclear. In this study, the biosafety of MGO NPs was investigated, and the m…
View article: Size-dependent Effect of Titania Nanotubes on ERS to Re-establish Diabetic Macrophages Homeostasis
Size-dependent Effect of Titania Nanotubes on ERS to Re-establish Diabetic Macrophages Homeostasis Open
Background: As the diabetics age and the high incidence of severe periodontitis, they have inevitably enormous demands for oral implantation. However, impaired osseointegration remains an obstacle to implant success, in which the disturbed…
View article: Evaluation of Different Reverse Osmosis Membranes for Textile Dyeing and Finishing Wastewater Reuse
Evaluation of Different Reverse Osmosis Membranes for Textile Dyeing and Finishing Wastewater Reuse Open
Different commercial reverse osmosis (RO) membranes from Vontron and DuPont Filmtec were evaluated for textile dyeing and finishing wastewater (TDFW) reuse in China. All six tested RO membranes produced qualified permeate meeting TDFW reus…
View article: <scp>Hollow mesoporous organosilica nanoparticles reduced graphene oxide based</scp> nanosystem for multimodal image‐guided photothermal/photodynamic/chemo combinational therapy triggered by near‐infrared
<span>Hollow mesoporous organosilica nanoparticles reduced graphene oxide based</span> nanosystem for multimodal image‐guided photothermal/photodynamic/chemo combinational therapy triggered by near‐infrared Open
Developing a nanosystem that can perform multimodal imaging‐guided combination therapy is highly desirable but challenging. In this study, we introduced multifunctional nanoparticles (NPs) consisting of graphene oxide‐grafted hollow mesopo…
View article: Osseointegration of functionally-graded Ti6Al4V porous implants: Histology of the pore network
Osseointegration of functionally-graded Ti6Al4V porous implants: Histology of the pore network Open
The additive manufacturing of titanium into porous geometries offers a means to generate low-stiffness endosseous implants with a greater surface area to improve osseointegration. In order to optimize pore size in the scaffolds, it is impo…
View article: Nanostructured Graphdiyne: Synthesis and Biomedical Applications
Nanostructured Graphdiyne: Synthesis and Biomedical Applications Open
Graphdiyne (GDY) is a 2D carbon allotrope that features a one-atom-thick network of sp- and sp2-hybridized carbon atoms with high degrees of π conjugation. Due to its distinct electronic, chemical, mechanical, and magnetic properties, GDY …
View article: Micro/Nanostructured Topography on Titanium Orchestrates Dendritic Cell Adhesion and Activation via β2 Integrin-FAK Signals
Micro/Nanostructured Topography on Titanium Orchestrates Dendritic Cell Adhesion and Activation via β2 Integrin-FAK Signals Open
Compared to the SA surface with solely micro-scale topography, titanium surfaces with hybrid micro/nano-topographies reduced DC inflammatory response by influencing their adhesion states. This regulatory effect was accompanied by the modul…
View article: Marginal bone level change during sequential loading periods of partial edentulous rehabilitation using immediately loaded self-tapping implants: a 6.5-year retrospective study
Marginal bone level change during sequential loading periods of partial edentulous rehabilitation using immediately loaded self-tapping implants: a 6.5-year retrospective study Open
Slight bone loss occurred continuously, and more radical changes of marginal bone can be observed during the period of 4-7.5 years. Thus, long-term effective follow-up of immediately loaded implants is needed.
View article: Multi-Omics Analysis of Oral Bacterial Biofilm on Titanium Oxide Nanostructure Modified Implant Surface: in Vivo Sequencing-Based Pilot Study in Beagle Dogs
Multi-Omics Analysis of Oral Bacterial Biofilm on Titanium Oxide Nanostructure Modified Implant Surface: in Vivo Sequencing-Based Pilot Study in Beagle Dogs Open
Background and aimsSurface modifications of titanium implants play essential role in facilitating osteointegration and enhancing their antimicrobial properties, while the latter is critical for preventing infectious diseases caused by the …
View article: Transfer Learning via Artificial Intelligence for Guiding Implant Placement in the Posterior Mandible: an in vitro Study
Transfer Learning via Artificial Intelligence for Guiding Implant Placement in the Posterior Mandible: an in vitro Study Open
Background: To explore the capacity of a single shot multibox detector (SSD) and Voxel-to-voxel prediction network for pose estimation (V2V-PoseNet) based artificial intelligence (AI) system in automatically designing implant plan. Methods…
View article: Different Cell and Tissue Behavior of Micro-/Nano-Tubes and Micro-/Nano-Nets Topographies on Selective Laser Melting Titanium to Enhance Osseointegration
Different Cell and Tissue Behavior of Micro-/Nano-Tubes and Micro-/Nano-Nets Topographies on Selective Laser Melting Titanium to Enhance Osseointegration Open
TNNs and TNTs have dual advantages in promotion of osteogenesis and inhibition of osteoclastogenesis. Furthermore, TNNs showed better capability in inhibiting osteoclast activity while TNTs facilitated stronger osteogenesis. Our results im…
View article: Antibacterial Evaluation of Lithium-Loaded Nanofibrous Poly(L-Lactic Acid) Membranes Fabricated via an Electrospinning Strategy
Antibacterial Evaluation of Lithium-Loaded Nanofibrous Poly(L-Lactic Acid) Membranes Fabricated via an Electrospinning Strategy Open
Lithium (Li) reportedly has anti-bacterial properties. Thus, it is an ideal option to modify barrier membranes used for guided bone regeneration to inhibit the bacterial adhesion. The aims of this study were to fabricate and characterize n…
View article: Influence of implant protrusion length on non-grafting osteotome sinus floor elevation with simultaneous implant: a 3- to 9-year retrospective study
Influence of implant protrusion length on non-grafting osteotome sinus floor elevation with simultaneous implant: a 3- to 9-year retrospective study Open
Background This study analyzed the influence of implant protrusion length (IPL) on the possible factors that affect the long-term outcomes utilizing non-grafting osteotome sinus floor elevation (OSFE) with simultaneous implant placement, a…