Fei‐Long Meng
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View article: Explore antibody repertoire in the era of AI
Explore antibody repertoire in the era of AI Open
The diverse antibodies of adaptive immunity comprise an antibody repertoire that combats various pathogens. This repertoire is shaped by both intrinsic antibody gene diversification and extrinsic cellular selection. Conversely, an antibody…
View article: Cross-species comparison of single-cell landscapes reveals conservation and innovation in chicken immune systems
Cross-species comparison of single-cell landscapes reveals conservation and innovation in chicken immune systems Open
Molecular characterization of chicken cells is essential for understanding avian physiology and vertebrate evolution, yet an organism-wide single-cell atlas in chicken is still lacking. Here we describe a comprehensive reference atlas of t…
View article: A dual role of Cohesin in DNA DSB repair
A dual role of Cohesin in DNA DSB repair Open
Cells undergo tens of thousands of DNA-damaging events each day. Defects in repairing double-stranded breaks (DSBs) can lead to genomic instability, contributing to cancer, genetic disorders, immunological diseases, and developmental defec…
View article: Comparison of single-cell landscapes among three amniotes reveals conservation and innovation in avian immune systems
Comparison of single-cell landscapes among three amniotes reveals conservation and innovation in avian immune systems Open
Molecular characterization of chicken cells is essential for understanding avian physiology and vertebrate evolution, yet an organism-wide single-cell atlas in chicken is still lacking. Here we describe a comprehensive reference atlas of t…
View article: Comparison of NOD-like and Toll-like receptors gene expression levels in blood monocytes of colon cancer patients
Comparison of NOD-like and Toll-like receptors gene expression levels in blood monocytes of colon cancer patients Open
Colon cancer is one of the most common cancers affecting many people worldwide. This disease can be treated if diagnosed in the early stages. Therefore, with the hypothesis that the level of expression of inflammatory genes in peripheral b…
View article: A facile Tn5-HTGTS protocol to clone chromosomal structural variants
A facile Tn5-HTGTS protocol to clone chromosomal structural variants Open
Here we describe the protocol for Tn5-mediated high-throughput genome-wide translocation sequencing (Tn5-HTGTS). Tn5-HTGTS combines Tn5-tagmentation and translocation-cloning to capture genome-wide translocations from the intended bait sit…
View article: Lymph node metastasis related gene BICC1 promotes tumor progression by promoting EMT and immune infiltration in pancreatic cancer
Lymph node metastasis related gene BICC1 promotes tumor progression by promoting EMT and immune infiltration in pancreatic cancer Open
Background Pancreatic cancer (PC) is one of the most aggressive abdominal malignancies with a poor prognosis and it is urgent to find effective biomarkers for prediction. Although BICC1 expression is related to the survival, no evidence fo…
View article: Data from A Rapid Embryonic Stem Cell–Based Mouse Model for B-cell Lymphomas Driven by Epstein–Barr Virus Protein LMP1
Data from A Rapid Embryonic Stem Cell–Based Mouse Model for B-cell Lymphomas Driven by Epstein–Barr Virus Protein LMP1 Open
The Epstein–Barr virus (EBV) latent membrane protein 1 (LMP1) contributes to oncogenic human B-cell transformation. Mouse B cells conditionally expressing LMP1 are not predisposed to B-cell malignancies, as LMP1-expressing B cells are elim…
View article: Supplmentary Figures 1-5 and Tables 1-2 from A Rapid Embryonic Stem Cell–Based Mouse Model for B-cell Lymphomas Driven by Epstein–Barr Virus Protein LMP1
Supplmentary Figures 1-5 and Tables 1-2 from A Rapid Embryonic Stem Cell–Based Mouse Model for B-cell Lymphomas Driven by Epstein–Barr Virus Protein LMP1 Open
Figure S1. Flow cytometry measurement of peripheral blood B and T cells in indicated CLT RDBC chimeras and control mice. Figure S2. Comparative measurement of splenic and peripheral blood B-cell populations in the indicated CLT RDBC chimer…
View article: Supplmentary Figures 1-5 and Tables 1-2 from A Rapid Embryonic Stem Cell–Based Mouse Model for B-cell Lymphomas Driven by Epstein–Barr Virus Protein LMP1
Supplmentary Figures 1-5 and Tables 1-2 from A Rapid Embryonic Stem Cell–Based Mouse Model for B-cell Lymphomas Driven by Epstein–Barr Virus Protein LMP1 Open
Figure S1. Flow cytometry measurement of peripheral blood B and T cells in indicated CLT RDBC chimeras and control mice. Figure S2. Comparative measurement of splenic and peripheral blood B-cell populations in the indicated CLT RDBC chimer…
View article: Data from A Rapid Embryonic Stem Cell–Based Mouse Model for B-cell Lymphomas Driven by Epstein–Barr Virus Protein LMP1
Data from A Rapid Embryonic Stem Cell–Based Mouse Model for B-cell Lymphomas Driven by Epstein–Barr Virus Protein LMP1 Open
The Epstein–Barr virus (EBV) latent membrane protein 1 (LMP1) contributes to oncogenic human B-cell transformation. Mouse B cells conditionally expressing LMP1 are not predisposed to B-cell malignancies, as LMP1-expressing B cells are elim…
View article: Supplementary Figure Legends from A Rapid Embryonic Stem Cell–Based Mouse Model for B-cell Lymphomas Driven by Epstein–Barr Virus Protein LMP1
Supplementary Figure Legends from A Rapid Embryonic Stem Cell–Based Mouse Model for B-cell Lymphomas Driven by Epstein–Barr Virus Protein LMP1 Open
Supplementary Figure Legends
View article: Supplementary Figure Legends from A Rapid Embryonic Stem Cell–Based Mouse Model for B-cell Lymphomas Driven by Epstein–Barr Virus Protein LMP1
Supplementary Figure Legends from A Rapid Embryonic Stem Cell–Based Mouse Model for B-cell Lymphomas Driven by Epstein–Barr Virus Protein LMP1 Open
Supplementary Figure Legends
View article: DNA repair mechanisms that promote insertion-deletion events during immunoglobulin gene diversification
DNA repair mechanisms that promote insertion-deletion events during immunoglobulin gene diversification Open
Insertions and deletions (indels) are low-frequency deleterious genomic DNA alterations. Despite their rarity, indels are common, and insertions leading to long complementarity-determining region 3 (CDR3) are vital for antigen-binding func…
View article: Small-molecule activators specific to adenine base editors through blocking the canonical TGF-β pathway
Small-molecule activators specific to adenine base editors through blocking the canonical TGF-β pathway Open
Adenine base editors (ABEs) catalyze A-to-G conversions, offering therapeutic options to treat the major class of human pathogenic single nucleotide polymorphisms (SNPs). However, robust and precise editing at diverse genome loci remains c…
View article: B cell receptor signatures associated with strong and poor SARS-CoV-2 vaccine responses
B cell receptor signatures associated with strong and poor SARS-CoV-2 vaccine responses Open
Breakthrough infection of SARS-CoV-2 is a serious challenge, as increased infections were documented in fully-vaccinated individuals. Recipients with poor antibody response are highly vulnerable to reinfection, whereas those with strong an…
View article: UdgX-Mediated Uracil Sequencing at Single-Nucleotide Resolution
UdgX-Mediated Uracil Sequencing at Single-Nucleotide Resolution Open
As an aberrant base in DNA, uracil is generated by either deoxyuridine (dU) misincorporation or cytosine deamination, and involved in multiple physiological and pathological processes. Genome-wide profiles of uracil are important for study…
View article: B cell receptor signatures associated with strong and poor SARS-CoV-2 vaccine responses
B cell receptor signatures associated with strong and poor SARS-CoV-2 vaccine responses Open
Breakthrough infection of SARS-CoV-2 is a serious challenge, as increased infections were documented in fully-vaccinated individuals. Recipients with poor antibody response are highly vulnerable to reinfection, whereas those with strong an…
View article: Ig Enhancers Increase RNA Polymerase II Stalling at Somatic Hypermutation Target Sequences
Ig Enhancers Increase RNA Polymerase II Stalling at Somatic Hypermutation Target Sequences Open
Somatic hypermutation (SHM) drives the genetic diversity of Ig genes in activated B cells and supports the generation of Abs with increased affinity for Ag. SHM is targeted to Ig genes by their enhancers (diversification activators [DIVACs…
View article: Immunoglobulin enhancers increase RNA polymerase 2 stalling at somatic hypermutation target sequences
Immunoglobulin enhancers increase RNA polymerase 2 stalling at somatic hypermutation target sequences Open
Somatic hypermutation (SHM) drives the genetic diversity of immunoglobulin (Ig) genes in activated B cells and supports the generation of antibodies with increased affinity for antigen. SHM is targeted to Ig genes by their enhancers (DIVAC…
View article: The 3′-flap endonuclease XPF-ERCC1 promotes alternative end joining and chromosomal translocation during B cell class switching
The 3′-flap endonuclease XPF-ERCC1 promotes alternative end joining and chromosomal translocation during B cell class switching Open
Robust alternative end joining (A-EJ) in classical non-homologous end joining (c-NHEJ)-deficient murine cells features double-strand break (DSB) end resection and microhomology (MH) usage and promotes chromosomal translocation. The activit…
View article: Global detection of DNA repair outcomes induced by CRISPR–Cas9
Global detection of DNA repair outcomes induced by CRISPR–Cas9 Open
CRISPR–Cas9 generates double-stranded DNA breaks (DSBs) to activate cellular DNA repair pathways for genome editing. The repair of DSBs leads to small insertions or deletions (indels) and other complex byproducts, including large deletions…