Feiquan Ying
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View article: Combined CHK1 and PD-L1 blockade as a novel therapeutic strategy against stemness and immunosuppression in ovarian cancer
Combined CHK1 and PD-L1 blockade as a novel therapeutic strategy against stemness and immunosuppression in ovarian cancer Open
View article: LEF1 confers resistance to DNA-damaging chemotherapies through upregulation of PARP1 and NUMA1 in ovarian cancer
LEF1 confers resistance to DNA-damaging chemotherapies through upregulation of PARP1 and NUMA1 in ovarian cancer Open
View article: hnRNPA2B1 facilitates ovarian carcinoma metastasis by sorting cargoes into small extracellular vesicles driving myofibroblasts activation
hnRNPA2B1 facilitates ovarian carcinoma metastasis by sorting cargoes into small extracellular vesicles driving myofibroblasts activation Open
These findings highlight the miRNA sorting to sEVs mediated by hnRNPA2B1 as an important mechanism involved in OvCa metastasis, which may illuminate new therapeutic strategies.
View article: Preclinical study of inetetamab combined with atezolizumab to synergistically inhibit HER2 and PD-L1 in the treatment of ovarian cancer
Preclinical study of inetetamab combined with atezolizumab to synergistically inhibit HER2 and PD-L1 in the treatment of ovarian cancer Open
View article: Glutamine metabolism prognostic index predicts tumour microenvironment characteristics and therapeutic efficacy in ovarian cancer
Glutamine metabolism prognostic index predicts tumour microenvironment characteristics and therapeutic efficacy in ovarian cancer Open
Mounting evidence has highlighted the multifunctional characteristics of glutamine metabolism (GM) in cancer initiation, progression and therapeutic regimens. However, the overall role of GM in the tumour microenvironment (TME), clinical s…
View article: Tumor-derived small extracellular vesicles facilitate omental metastasis of ovarian cancer by triggering activation of mesenchymal stem cells
Tumor-derived small extracellular vesicles facilitate omental metastasis of ovarian cancer by triggering activation of mesenchymal stem cells Open
Background Omental metastasis is the major cause of ovarian cancer recurrence and shortens patient survival, which can be largely attributed to the dynamic evolution of the fertile metastatic microenvironment driven by cancer cells. Previo…
View article: A protocol for selection in mice of highly metastatic ovarian cancer cell with omental tropism
A protocol for selection in mice of highly metastatic ovarian cancer cell with omental tropism Open
Preclinical models mimicking spontaneous omental metastasis from ovarian cancer (OC) can benefit the study of anti-metastatic therapies for OC patients. Here, we present a protocol to establish a highly metastatic (HM) mouse model with ome…
View article: Establishment of highly metastatic ovarian cancer model with omental tropism via in vivo selection
Establishment of highly metastatic ovarian cancer model with omental tropism via in vivo selection Open
Epithelial ovarian cancer (OC) is often diagnosed at an advanced stage with peritoneal metastasis, and preclinical models mimicking the natural course of OC peritoneal metastasis are essential to improve treatment. We implanted ES2 and ID8…
View article: Identification and validation of pyroptosis-related gene landscape in prognosis and immunotherapy of ovarian cancer
Identification and validation of pyroptosis-related gene landscape in prognosis and immunotherapy of ovarian cancer Open
Background Emerging evidence has highlighted the biological significance of pyroptosis in tumor tumorigenesis and progression. Nonetheless, the potential roles of pyroptosis in tumor immune microenvironment and target therapy of ovarian ca…
View article: Additional file 9 of Identification and validation of pyroptosis-related gene landscape in prognosis and immunotherapy of ovarian cancer
Additional file 9 of Identification and validation of pyroptosis-related gene landscape in prognosis and immunotherapy of ovarian cancer Open
Additional file 9: Table S1. Basic characteristics of datasets enrolled in this study for identifying pyroptosis-associated genes (PYAGs) signatures. Table S2. Demographic and clinical characteristics of 1334 ovarian cancer patients from T…
View article: <p>Circulating Tie2-Expressing Monocytes: A Potential Biomarker for Cervical Cancer</p>
Circulating Tie2-Expressing Monocytes: A Potential Biomarker for Cervical Cancer Open
The cTEM proportion might be a promising biomarker for the malignant transformation of cervical lesions and the progression of cervical cancer.
View article: BNIP3 contributes to cisplatin‐induced apoptosis in ovarian cancer cells
BNIP3 contributes to cisplatin‐induced apoptosis in ovarian cancer cells Open
BNIP3 is a proapoptotic protein that mediates apoptosis, necrosis and autophagy. However, the involvement of BNIP3 in cisplatin‐induced apoptosis in ovarian cancer is not clear. In this study, we examined the role of BNIP3 in ovarian cance…
View article: EZH2/H3K27Me3 and phosphorylated EZH2 predict chemotherapy response and prognosis in ovarian cancer
EZH2/H3K27Me3 and phosphorylated EZH2 predict chemotherapy response and prognosis in ovarian cancer Open
Background EZH2 acts as an oncogene through canonical pathway EZH2/H3K27Me3 and uncanonical pathway pAkt1/pS21EZH2 in many solid tumors including ovarian cancer. However, the clinical value of EZH2/H3K27Me3 and pAkt1/pS21EZH2 remain unclea…