Feiya Wang
YOU?
Author Swipe
View article: Filovirus infection disrupts epithelial barrier function and ion transport in human iPSC-derived gut organoids
Filovirus infection disrupts epithelial barrier function and ion transport in human iPSC-derived gut organoids Open
Gastrointestinal (GI) dysfunction, characterized by severe diarrhea and dehydration, is a central contributor to morbidity and mortality in filovirus disease in patients, yet the role of the epithelium in this clinical outcome remains poor…
View article: Aberrant intermediate alveolar epithelial cells promote pathogenic activation of lung fibroblasts in preclinical fibrosis models
Aberrant intermediate alveolar epithelial cells promote pathogenic activation of lung fibroblasts in preclinical fibrosis models Open
Pulmonary fibrosis (PF) is a progressive disease histologically defined by pathological fibroblasts and epithelial cells. PF lungs contain alveolar type 2 epithelial cells (AT2s) that acquire an aberrant intermediate state phenotype. Howev…
View article: Generation of effector CD4+ T cells from human iPSC
Generation of effector CD4+ T cells from human iPSC Open
Off the shelf CD4+ T cell therapies, particularly those with immunoregulatory or cell repair functions, could be transformative in CAR therapies for cancers and treatment of chronic inflammatory diseases. However, progress is stunted in th…
View article: Author Correction: Life-long functional regeneration of in vivo airway epithelium by the engraftment of airway basal stem cells
Author Correction: Life-long functional regeneration of in vivo airway epithelium by the engraftment of airway basal stem cells Open
View article: Human-induced Pluripotent Stem Cell-derived Gut Organoids Recapitulate Regional Specific Genetic Programs and a Role for cAMP in Lineage Specification
Human-induced Pluripotent Stem Cell-derived Gut Organoids Recapitulate Regional Specific Genetic Programs and a Role for cAMP in Lineage Specification Open
View article: Derivation of transplantable human thyroid follicular epithelial cells from induced pluripotent stem cells
Derivation of transplantable human thyroid follicular epithelial cells from induced pluripotent stem cells Open
The production of mature functioning thyroid follicular cells (TFCs) from human induced pluripotent stem cells (iPSCs) is critical for potential novel therapeutic approaches to post-surgical and congenital hypothyroidism. To accomplish thi…
View article: A specialized population of monocyte-derived tracheal macrophages promote airway epithelial regeneration through a CCR2-dependent mechanism
A specialized population of monocyte-derived tracheal macrophages promote airway epithelial regeneration through a CCR2-dependent mechanism Open
Macrophages are critical for maintenance and repair of mucosal tissues. While functionally distinct subtypes of macrophage are known to have important roles in injury response and repair in the lungs, little is known about macrophages in t…
View article: Generation of human alveolar epithelial type I cells from pluripotent stem cells
Generation of human alveolar epithelial type I cells from pluripotent stem cells Open
Alveolar epithelial type I cells (AT1s) line the gas exchange barrier of the distal lung and have been historically challenging to isolate or maintain in cell culture. Here, we engineer a human in vitro AT1 model system via directed differ…
View article: Abnormal global longitudinal strain and reduced serum inflammatory markers in cardiac AL amyloidosis patients without significant amyloid fibril deposition
Abnormal global longitudinal strain and reduced serum inflammatory markers in cardiac AL amyloidosis patients without significant amyloid fibril deposition Open
Background Cardiac dysfunction in AL amyloidosis is thought to be partly related to the direct impact of AL LCs on cardiomyocyte function, with the degree of dysfunction at diagnosis as a major determinant of clinical outcomes. Nonetheless…
View article: Investigation on Mechanical Properties and Temperature Control Efficiency of Novel Load-Bearing and Heat-Storing Metastructure Walls in Hot Summer-Cold Winter Regions
Investigation on Mechanical Properties and Temperature Control Efficiency of Novel Load-Bearing and Heat-Storing Metastructure Walls in Hot Summer-Cold Winter Regions Open
View article: VEGFA mRNA-LNP promotes biliary epithelial cell-to-hepatocyte conversion in acute and chronic liver diseases and reverses steatosis and fibrosis
VEGFA mRNA-LNP promotes biliary epithelial cell-to-hepatocyte conversion in acute and chronic liver diseases and reverses steatosis and fibrosis Open
View article: The COPD GWAS gene ADGRG6 instructs function and injury response in human iPSC-derived type II alveolar epithelial cells
The COPD GWAS gene ADGRG6 instructs function and injury response in human iPSC-derived type II alveolar epithelial cells Open
View article: De novo hematopoiesis from the fetal lung
De novo hematopoiesis from the fetal lung Open
Hemogenic endothelial cells (HECs) are specialized cells that undergo endothelial-to-hematopoietic transition (EHT) to give rise to the earliest precursors of hematopoietic progenitors that will eventually sustain hematopoiesis throughout …
View article: Airway stem cell reconstitution by the transplantation of primary or pluripotent stem cell-derived basal cells
Airway stem cell reconstitution by the transplantation of primary or pluripotent stem cell-derived basal cells Open
View article: Durable alveolar engraftment of PSC-derived lung epithelial cells into immunocompetent mice
Durable alveolar engraftment of PSC-derived lung epithelial cells into immunocompetent mice Open
View article: Directed differentiation of mouse pluripotent stem cells into functional lung-specific mesenchyme
Directed differentiation of mouse pluripotent stem cells into functional lung-specific mesenchyme Open
While the generation of many lineages from pluripotent stem cells has resulted in basic discoveries and clinical trials, the derivation of tissue-specific mesenchyme via directed differentiation has markedly lagged. The derivation of lung-…
View article: <i>De Novo</i> Generation of Pulmonary Ionocytes from Normal and Cystic Fibrosis Human Induced Pluripotent Stem Cells
<i>De Novo</i> Generation of Pulmonary Ionocytes from Normal and Cystic Fibrosis Human Induced Pluripotent Stem Cells Open
"De Novo Generation of Pulmonary Ionocytes from Normal and Cystic Fibrosis Human Induced Pluripotent Stem Cells." American Journal of Respiratory and Critical Care Medicine, 0(ja), pp. –
View article: Generation of human alveolar epithelial type I cells from pluripotent stem cells
Generation of human alveolar epithelial type I cells from pluripotent stem cells Open
In the distal lung, alveolar epithelial type I cells (AT1s) comprise the vast majority of alveolar surface area and are uniquely flattened to allow the diffusion of oxygen into the capillaries. This structure along with a quiescent, termin…
View article: Human iPSC-hepatocyte modeling of alpha-1 antitrypsin heterozygosity reveals metabolic dysregulation and cellular heterogeneity
Human iPSC-hepatocyte modeling of alpha-1 antitrypsin heterozygosity reveals metabolic dysregulation and cellular heterogeneity Open
Individuals homozygous for the "Z" mutation in alpha-1 antitrypsin deficiency are known to be at increased risk for liver disease. It has also become clear that some degree of risk is similarly conferred by the heterozygous state. A lack o…
View article: Notch activation during early mesoderm induction modulates emergence of the T/NK cell lineage from human iPSCs
Notch activation during early mesoderm induction modulates emergence of the T/NK cell lineage from human iPSCs Open
View article: Ebola virus infection induces a delayed type I IFN response in bystander cells and the shutdown of key liver genes in human iPSC-derived hepatocytes
Ebola virus infection induces a delayed type I IFN response in bystander cells and the shutdown of key liver genes in human iPSC-derived hepatocytes Open
View article: Durable alveolar engraftment of PSC-derived lung epithelial cells into immunocompetent mice
Durable alveolar engraftment of PSC-derived lung epithelial cells into immunocompetent mice Open
Durable reconstitution of the injured distal lung epithelium with pluripotent stem cell (PSC) derivatives, if realized, would represent a promising potential therapy for diseases that result from alveolar damage. Here we differentiate muri…
View article: Multi-modal profiling of human fetal liver hematopoietic stem cells reveals the molecular signature of engraftment
Multi-modal profiling of human fetal liver hematopoietic stem cells reveals the molecular signature of engraftment Open
View article: Xq26.3-q27.1 duplication including SOX3 gene in a Chinese boy with hypopituitarism: case report and two years treatment follow up
Xq26.3-q27.1 duplication including SOX3 gene in a Chinese boy with hypopituitarism: case report and two years treatment follow up Open
View article: Modeling of Alpha-1 Antitrypsin Deficiency with Syngeneic Human iPSC-Hepatocytes Reveals Metabolic Dysregulation and Cellular Heterogeneity in PiMZ and PiZZ Hepatocytes
Modeling of Alpha-1 Antitrypsin Deficiency with Syngeneic Human iPSC-Hepatocytes Reveals Metabolic Dysregulation and Cellular Heterogeneity in PiMZ and PiZZ Hepatocytes Open
Individuals homozygous for the pathogenic “Z” mutation in alpha-1 antitrypsin deficiency (AATD) are known to be at increased risk for chronic liver disease. That some degree of risk is similarly conferred by the heterozygous state, estimat…
View article: Influence of Processing Parameters on Laser Direct Joining of CFRTP and Stainless Steel
Influence of Processing Parameters on Laser Direct Joining of CFRTP and Stainless Steel Open
The CFRTP and the stainless steel were joined by the fiber laser, and the effect of processing parameters on the joint quality was investigated in detail. The heat‐affected zone on the stainless steel and the microstructure of the joint in…
View article: Female PAPP-A knockout mice are resistant to metabolic dysfunction induced by high-fat/high-sucrose feeding at middle age
Female PAPP-A knockout mice are resistant to metabolic dysfunction induced by high-fat/high-sucrose feeding at middle age Open
View article: Inflammatory and Glutamatergic Homeostasis Are Involved in Successful Aging
Inflammatory and Glutamatergic Homeostasis Are Involved in Successful Aging Open
Whole body studies using long-lived growth hormone receptor gene disrupted or knock out (GHR-KO) mice report global GH resistance, increased insulin sensitivity, reduced insulin-like growth factor 1 (IGF-1), and cognitive retention in old-…