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View article: GPC5 expression highlights astrocytic heterogeneity and divergent hippocampal responses in Alzheimer’s and Parkinson’s Dementia
GPC5 expression highlights astrocytic heterogeneity and divergent hippocampal responses in Alzheimer’s and Parkinson’s Dementia Open
Astrocytes are central to central nervous system (CNS) homeostasis and memory consolidation. They also display remarkably heterogeneous morphological phenotypes, functions and molecular profiles between and within distinct regions of the h…
View article: Microglia aggregates define distinct immune and neurodegenerative niches in Alzheimer's disease hippocampus
Microglia aggregates define distinct immune and neurodegenerative niches in Alzheimer's disease hippocampus Open
View article: Microglia aggregates define distinct immune and neurodegenerative niches in Alzheimer's disease hippocampus.
Microglia aggregates define distinct immune and neurodegenerative niches in Alzheimer's disease hippocampus. Open
In Alzheimer's disease (AD), microglia show strong associations with amyloid-β (Aβ) and tau pathology, forming cellular aggregates such as Aβ plaque-associated microglia (PaM). Using high-content neuropathology, we found another type of mi…
View article: DJ-1 mediates regulation of metabolism and immune response in Parkinson’s disease astrocytes and Glioblastoma cells
DJ-1 mediates regulation of metabolism and immune response in Parkinson’s disease astrocytes and Glioblastoma cells Open
An inverse correlation for the expression of Parkinson’s disease (PD)- and cancer-associated genes has been previously reported. Genes that are upregulated in cancer are frequently downregulated in PD and vice versa . PARK7, encoding DJ-1,…
View article: The Multifaceted Neurotoxicity of Astrocytes in Ageing and Age-Related Neurodegenerative Diseases: A Translational Perspective
The Multifaceted Neurotoxicity of Astrocytes in Ageing and Age-Related Neurodegenerative Diseases: A Translational Perspective Open
In a healthy physiological context, astrocytes are multitasking cells contributing to central nervous system (CNS) homeostasis, defense, and immunity. In cell culture or rodent models of age-related neurodegenerative diseases (NDDs), such …