Explanipedia

Building an Adverse Outcome Pathway network for COVID-19 Open

Penny Nymark, Laure‐Alix Clerbaux, Maria João Amorim, Christos Andronis, F Bernardi , et al. · 2024

The COVID-19 pandemic generated large amounts of data on the disease pathogenesis leading to a need for organizing the vast knowledge in a succinct manner. Between April 2020 and February 2023, the CIAO consortium exploited the Adverse Out…

Exploring the Role of Platelets in Virus-Induced Inflammatory Demyelinating Disease and Myocarditis Open

Ijaz Ahmad, Seiichi Omura, Fumitaka Sato, Ah-Mee Park, Sundar Khadka , et al. · 2024

Theiler’s murine encephalomyelitis virus (TMEV) infection has been used as a mouse model for two virus-induced organ-specific immune-mediated diseases. TMEV-induced demyelinating disease (TMEV-IDD) in the central nervous system (CNS) is a …

Annexins—a family of proteins with distinctive tastes for cell signaling and membrane dynamics Open

Volker Gerke, Felicity N. E. Gavins, Michael J. Geisow, Thomas Grewal, Jyoti K. Jaiswal , et al. · 2024

Regulating Neutrophil PAD4/NOX-Dependent Cerebrovasular Thromboinflammation Open

Junaid Ansari, Shantel Vital, Shreya Yadav, Felicity N. E. Gavins · 2023

Background: Neutrophil extracellular trap (NET) production has been implicated in the pathogenesis of thromboinflammatory conditions such as Sickle Cell Disease (SCD), contributing to heightened risk for ischemic stroke. NETs are ca…

Skeletal muscle angiogenic, regulatory, and heat shock protein responses to prolonged passive hyperthermia of the human lower limb Open

Oliver R. Gibson, Rónan Astin, Zudin Puthucheary, Shreya Yadav, Sophie Preston , et al. · 2022

Passive hyperthermia induces a range of physiological responses including augmenting skeletal muscle mRNA expression. This experiment aimed to examine gene and protein responses to prolonged passive leg hyperthermia. Seven young participan…

Bryostatin-1 Attenuates Ischemia-Elicited Neutrophil Transmigration and Ameliorates Graft Injury after Kidney Transplantation Open

Felix Becker, Linus Kebschull, Constantin Rieger, Annika Mohr, Barbara Heitplatz , et al. · 2022

Ischemia reperfusion injury (IRI) is a form of sterile inflammation whose severity determines short- and long-term graft fates in kidney transplantation. Neutrophils are now recognized as a key cell type mediating early graft injury, which…

The Spectrum of Acute Cerebrovascular Disease in Patients with COVID-19 Open

Rachel Triay, Prabandh Buchhanolla, Alexas Gaudet, Victoria Winter, Alexandra Gaudet , et al. · 2022

(1) Background: COVID-19 infection is responsible for the ongoing pandemic and acute cerebrovascular disease (CVD) has been observed in COVID-19 patients. (2) Methods: We conducted a retrospective, observational study of hospitalized adult…

A Biomicrofluidic Screening Platform for Dysfunctional Endothelium‐Targeted Nanoparticles and Therapeutics Open

Salime Bazban‐Shotorbani, Felicity N. E. Gavins, Krishna Kant, Martin Dufva, Nazila Kamaly · 2022

Copyright © 2022 The Author(s) and Wiley-VCH GmbH. Biomicrofluidic Models Biomicrofluidic models allow nanoparticle-cellular interactions to be studied under physiological flow conditions. Investigating nanoparticle biophysicochemical prop…

Neutrophils and Platelets: Immune Soldiers Fighting Together in Stroke Pathophysiology Open

Junaid Ansari, Felicity N. E. Gavins · 2021

Neutrophils and platelets exhibit a diverse repertoire of functions in thromboinflammatory conditions such as stroke. Most cerebral ischemic events result from longstanding chronic inflammation secondary to underlying pathogenic conditions…

A Biomicrofluidic Screening Platform for Dysfunctional Endothelium‐Targeted Nanoparticles and Therapeutics Open

Salime Bazban‐Shotorbani, Felicity N. E. Gavins, Krishna Kant, Martin Dufva, Nazila Kamaly · 2021

The internal surfaces of all blood and lymphatic vessels are lined with an endothelium, which tightly controls and regulates the permeability of biological molecules. A dysfunctional endothelium (Dys‐En) is a hallmark of many diseases, inc…

Thromboinflammation in coronavirus disease 2019: The clot thickens Open

Raayma Iffah, Felicity N. E. Gavins · 2021

Since the start of the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) pandemic, a disease that has become one of the world's greatest global health challenges, the role of the immune system has been at the forefront of scient…

Thromboinflammation in COVID-19: The Clot Thickens Open

Raayma Iffah, Felicity N. E. Gavins · 2021

Since the start of the novel coronavirus SARS-Cov-2 pandemic, a disease that has become one of the world’s greatest global health challenges, the role of the immune system has been at the forefront of scientific studies. The pathophysiolog…

Neurological Manifestations of Patients Hospitalized with COVID-19 Diagnosis at OLSU-S (1892) Open

Junaid Ansari, Alexas Gaudet, Jessica Hicks, Alena Stevens, Eduardo Gonzalez‐Toledo , et al. · 2021

Meeting Abstract presented to the 2021 AAN 73rd Annual Meeting, 17-22 April 2021 (Virtual).

The impact of thrombo‐inflammation on the cerebral microcirculation Open

Junaid Ansari, Felicity N. E. Gavins · 2021

The intertwined processes of thrombosis and inflammation (termed “thrombo‐inflammation”) are significant drivers of cerebrovascular diseases, and as such, they represent prime targets for drug discovery programs focusing on treatment and m…

Targeting the AnxA1/Fpr2/ALX pathway regulates neutrophil function, promoting thromboinflammation resolution in sickle cell disease Open

Junaid Ansari, Elena Y. Senchenkova, Shantel Vital, Zaki Al‐Yafeai, Gaganpreet Kaur , et al. · 2021

Neutrophils play a crucial role in the intertwined processes of thrombosis and inflammation. An altered neutrophil phenotype may contribute to inadequate resolution, which is known to be a major pathophysiological contributor of thromboinf…

Long-lived lanthanide emissionviaa pH-sensitive and switchable LRET complex Open

Tamara Boltersdorf, Felicity N. E. Gavins, Nicholas J. Long · 2021

A pH-sensitive luminescence resonance energy transfer (LRET) was explored as a method to increase photon flux in a terbium-rhodamine-receptor targeting group construct. At low pH, long-lived dye emission and shorter terbium lifetimes were …

Targeting AnxA1/Formyl Peptide Receptor 2 Pathway Affords Protection against Pathological Thrombo-Inflammation Open

Shantel Vital, Elena Y. Senchenkova, Junaid Ansari, Felicity N. E. Gavins · 2020

Stroke is a leading cause of death and disability globally and is associated with a number of co-morbidities including sepsis and sickle cell disease (SCD). Despite thrombo-inflammation underlying these co-morbidities, its pathogenesis rem…

Bioinformatics Analysis of Gut Microbiota and CNS Transcriptome in Virus-Induced Acute Myelitis and Chronic Inflammatory Demyelination; Potential Association of Distinct Bacteria With CNS IgA Upregulation Open

Seiichi Omura, Fumitaka Sato, Ah-Mee Park, Mitsugu Fujita, Sundar Khadka , et al. · 2020

Virus infections have been associated with acute and chronic inflammatory central nervous system (CNS) diseases, e.g., acute flaccid myelitis (AFM) and multiple sclerosis (MS), where animal models support the pathogenic roles of viruses. I…

Targeting of Formyl Peptide Receptor 2 for in vivo imaging of acute vascular inflammation Open

Tamara Boltersdorf, Junaid Ansari, Elena Y. Senchenkova, Jieny Groeper, Denise Pajonczyk , et al. · 2020

Inflammatory conditions are associated with a variety of diseases and can significantly contribute to their pathophysiology. Neutrophils are recognised as key players in driving vascular inflammation and promoting inflammation resolution. …

In vivo delivery of a fluorescent FPR2/ALX-targeted probe using focused ultrasound and microbubbles to image activated microglia Open

Sophie V. Morse, Tamara Boltersdorf, Tiffany G. Chan, Felicity N. E. Gavins, James J. Choi , et al. · 2020

Targeted imaging agent labels activated microglia when delivered into the brain with focused ultrasound and microbubbles – a tool to investigate inflammation in neurological disorders.

Endogenous Specialized Proresolving Mediator Profiles in a Novel Experimental Model of Lymphatic Obstruction and Intestinal Inflammation in African Green Monkeys Open

Felix Becker, Emily Romero, Jason Goetzmann, Dana L. Hasselschwert, Beth K. Dray , et al. · 2019

Table of Contents Open

L. Black, Jody Fromm Longo, Steven L. Carroll, Stephan Brouwer, Mark Walker , et al. · 2019

Dynamic gut microbiome changes following regional intestinal lymphatic obstruction in primates Open

Felix Becker, Felicity N. E. Gavins, Jane Fontenot, Paul Jordan, J.Y. Yun , et al. · 2019

The pathogenesis of inflammatory bowel disease (IBD) has been linked with lymphostasis, but whether and how lymphatic obstruction might disturb the intestinal microbiome in the setting of Crohn's Disease (CD) is currently unknown. We emplo…

Novel Role for the AnxA1-Fpr2/ALX Signaling Axis as a Key Regulator of Platelet Function to Promote Resolution of Inflammation Open

Elena Y. Senchenkova, Junaid Ansari, Felix Becker, Shantel Vital, Zaki Al‐Yafeai , et al. · 2019

Background: Ischemia reperfusion injury (I/RI) is a common complication of cardiovascular diseases. Resolution of detrimental I/RI-generated prothrombotic and proinflammatory responses is essential to restore homeostasis. Platelets play a …

Table of Contents Open

Junaid Ansari, Felicity N. E. Gavins, Bharat Bhushan, Udayan Apte, Aline Cristina , et al. · 2019

Ischemia-Reperfusion Injury in Sickle Cell Disease Open

Junaid Ansari, Felicity N. E. Gavins · 2019

Potential therapeutic roles of stem cells in ischemia-reperfusion injury Open

Mansoureh Barzegar, Gaganpreet Kaur, Felicity N. E. Gavins, Y. Wang, Christen J. Boyer , et al. · 2019

Novel Role of T Cells and IL-6 (Interleukin-6) in Angiotensin II–Induced Microvascular Dysfunction Open

Elena Y. Senchenkova, Janice Russell, Alper Yıldırım, D. Neil Granger, Felicity N. E. Gavins · 2019

Hypertension is an established risk factor for subsequent cardiovascular diseases, with Ang II (angiotensin II) playing a major role in mediating thrombotic and inflammatory abnormalities. Although T cells and IL-6 (interleukin-6) play an …

The isothiocyanate sulforaphane modulates platelet function and protects against cerebral thrombotic dysfunction Open

Scarlett Gillespie, Paul M. Holloway, Felix Becker, Francesca Rauzi, Shantel Vital , et al. · 2018

Background and Purpose Platelet activation provides a critical link between inflammation and thrombosis. Sulforaphane (SFN), a naturally occurring isothiocyanate, has been shown to display both anti‐inflammatory and anti‐thrombotic actions…

Therapeutic Potential of Annexin A1 in Ischemia Reperfusion Injury Open

Junaid Ansari, Gaganpreet Kaur, Felicity N. E. Gavins · 2018

Cardiovascular disease (CVD) continues to be the leading cause of death in the world. Increased inflammation and an enhanced thrombotic milieu represent two major complications of CVD, which can culminate into an ischemic event. Treatment …

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