Felipe Andrés Cordero da Luz
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View article: Circulating chemokines and leukocytes and their impact on breast cancer prognosis
Circulating chemokines and leukocytes and their impact on breast cancer prognosis Open
Risk stratification in BC patients is grounded in tumor staging and immunohistochemistry. However, systemic inflammatory responses, including cytokine- and chemokine-mediated signaling of neutrophils and lymphocytes, play a critical role i…
View article: Survival differences between women and men in the non-reproductive cancers: Results from a matched analysis of the surveillance, epidemiology, and end-results program
Survival differences between women and men in the non-reproductive cancers: Results from a matched analysis of the surveillance, epidemiology, and end-results program Open
Background Men with non-reproductive cancers have a discrepant outcome compared to women. However, they differ significantly in the incidence of cancer type and characteristics. Methods Patients with single primary cancer who were 18 years…
View article: Epidermal growth factor receptor (EGFR) expression in the serum of patients with triple-negative breast carcinoma: prognostic value of this biomarker
Epidermal growth factor receptor (EGFR) expression in the serum of patients with triple-negative breast carcinoma: prognostic value of this biomarker Open
Increased sEGFR expression in patients with TN tumours is a significant predictor of lower OS and its quantification is inexpensive and straightforward.
View article: A hierarchical approach to combine histological grade and immunohistochemical factors to identify high-risk luminal breast cancers
A hierarchical approach to combine histological grade and immunohistochemical factors to identify high-risk luminal breast cancers Open
The semi-quantitative expression of both cHR, Ki-67 proliferation index and histological grade can identify luminal breast cancer patients at greater risk of developing metastasis and death when combined in a hierarchical fashion, and coul…
View article: Prognosis value of lymphovascular invasion in patients with invasive ductal breast carcinoma according to lymph node metastasis status
Prognosis value of lymphovascular invasion in patients with invasive ductal breast carcinoma according to lymph node metastasis status Open
The presence of lymphovascular invasion is a predictor of worse prognosis in patients with invasive ductal carcinoma of the breast, even with metastatic lymph node disease (N1-N3).
View article: The benefits of trastuzumab in the treatment of HER2+ breast cancer as a function of exposure time
The benefits of trastuzumab in the treatment of HER2+ breast cancer as a function of exposure time Open
Despite showing some benefits, the protective effect derived from a suboptimal time of trastuzumab exposure is inferior to the standard course of 1 year.
View article: Association of the time of trastuzumab exposition with outcome in breast cancer patients
Association of the time of trastuzumab exposition with outcome in breast cancer patients Open
Shorter times of trastuzumab exposition (<1 year) could protect from disease progression in breast cancer patients. Survival analysis of continuous predictor was used to obtain optimal cut-offs regarding DMFS, DFS, and OS.
View article: Corrigendum: Decreased Survival of Invasive Ductal Breast Cancer Patients With Two Macrometastatic Lymph Nodes Among Few Resected Ones: Should Current Sentinel-Lymph-Node Guidelines Be Revised?
Corrigendum: Decreased Survival of Invasive Ductal Breast Cancer Patients With Two Macrometastatic Lymph Nodes Among Few Resected Ones: Should Current Sentinel-Lymph-Node Guidelines Be Revised? Open
[This corrects the article DOI: 10.3389/fonc.2021.669890.].
View article: Decreased Survival of Invasive Ductal Breast Cancer Patients With Two Macrometastatic Lymph Nodes Among Few Resected Ones: Should Current Sentinel-Lymph-Node Guidelines Be Revised?
Decreased Survival of Invasive Ductal Breast Cancer Patients With Two Macrometastatic Lymph Nodes Among Few Resected Ones: Should Current Sentinel-Lymph-Node Guidelines Be Revised? Open
Purpose Sentinel-lymph-node (SLN) biopsy (SLB) is an efficient and safe axillary surgical approach with decreased morbidity than total axillary lymph node dissection (ALND) in initial patients (T1–T2). Current guidelines strongly suggest a…
View article: The Recombinant Protein Based on Trypanosoma cruzi P21 Interacts With CXCR4 Receptor and Abrogates the Invasive Phenotype of Human Breast Cancer Cells
The Recombinant Protein Based on Trypanosoma cruzi P21 Interacts With CXCR4 Receptor and Abrogates the Invasive Phenotype of Human Breast Cancer Cells Open
Trypanosoma cruzi P21 is a protein secreted by the parasite that plays biological roles directly involved in the progression of Chagas disease. The recombinant protein (rP21) demonstrates biological properties, such as binding to CXCR4 rec…
View article: EGF (epidermal growth factor) receptor expression in blood: Prognostic biomarker in overall survival (OS) of patients with non-metastatic triple negative (TN) breast carcinoma.
EGF (epidermal growth factor) receptor expression in blood: Prognostic biomarker in overall survival (OS) of patients with non-metastatic triple negative (TN) breast carcinoma. Open
e14518 Background: EGF acts on tumor progression and its receptor can be measured by immunohistochemistry, or in the blood by immunoenzymatic method. This study quantified the expression of blood EGF receptors (bEGFR) in the molecular subt…
View article: Cell-adhesion molecules and their soluble forms: Promising predictors of “tumor progression” and relapse in leukemia
Cell-adhesion molecules and their soluble forms: Promising predictors of “tumor progression” and relapse in leukemia Open
Some surface markers are used to discriminate certain leukemic subpopulations that retain a greater oncogenic potential than others, and, for this reason, they were termed as leukemic stem cells, similar to the concept of cancer stem cells…
View article: Splicing Factors in Breast Cancer: Drivers of the Breast Tumor Fate
Splicing Factors in Breast Cancer: Drivers of the Breast Tumor Fate Open
Splicing is a critical step in gene expression, responsible for the excision of introns, producing the mature form of mRNA. Also, the possible arrangements of exons enlarge the proteome in 80%, enabling one gene to encode more than one pro…
View article: The multifaceted role of extracellular vesicles in metastasis: Priming the soil for seeding
The multifaceted role of extracellular vesicles in metastasis: Priming the soil for seeding Open
Extracellular vesicles (EVs), including exosomes, play a key role in inter and intracellular communication, promoting the proliferation and invasion of recipient cells to support tumor growth and metastasis. Metastasis comprises multiple s…