Félix Balazard
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View article: FedECA: federated external control arms for causal inference with time-to-event data in distributed settings
FedECA: federated external control arms for causal inference with time-to-event data in distributed settings Open
External control arms can inform early clinical development of experimental drugs and provide efficacy evidence for regulatory approval. However, accessing sufficient real-world or historical clinical trials data is challenging. Indeed, re…
View article: FedECA: A Federated External Control Arm Method for Causal Inference with Time-To-Event Data in Distributed Settings
FedECA: A Federated External Control Arm Method for Causal Inference with Time-To-Event Data in Distributed Settings Open
External control arms (ECA) can inform the early clinical development of experimental drugs and provide efficacy evidence for regulatory approval. However, the main challenge in implementing ECA lies in accessing real-world or historical c…
View article: FedECA: Federated External Control Arms for Causal Inference with Time-To-Event Data in Distributed Settings
FedECA: Federated External Control Arms for Causal Inference with Time-To-Event Data in Distributed Settings Open
External control arms can inform early clinical development of experimental drugs and provide efficacy evidence for regulatory approval. However, accessing sufficient real-world or historical clinical trials data is challenging. Indeed, re…
View article: The use of deep learning models to predict progression-free survival in patients with neuroendocrine tumors
The use of deep learning models to predict progression-free survival in patients with neuroendocrine tumors Open
Aim: The RAISE project assessed whether deep learning could improve early progression-free survival (PFS) prediction in patients with neuroendocrine tumors. Patients & methods: Deep learning models extracted features from CT scans from pat…
View article: Response heterogeneity as a new biomarker of treatment response in patients with neuroendocrine tumors
Response heterogeneity as a new biomarker of treatment response in patients with neuroendocrine tumors Open
Aim: The RAISE project aimed to find a surrogate end point to predict treatment response early in patients with enteropancreatic neuroendocrine tumors (NET). Response heterogeneity, defined as the coexistence of responding and non-respondi…
View article: Adjuvant endocrine therapy uptake, toxicity, quality of life, and prediction of early discontinuation
Adjuvant endocrine therapy uptake, toxicity, quality of life, and prediction of early discontinuation Open
Background Many patients receiving adjuvant endocrine therapy (ET) for breast cancer experience side effects and reduced quality of life (QoL) and discontinue ET. We sought to describe these issues and develop a prediction model of early d…
View article: More efficient and inclusive time-to-event trials with covariate adjustment: a simulation study
More efficient and inclusive time-to-event trials with covariate adjustment: a simulation study Open
Adjustment for prognostic covariates increases the statistical power of randomized trials. The factors influencing the increase of power are well-known for trials with continuous outcomes. Here, we study which factors influence power and s…
View article: Strategy-aware evaluation of treatment personalization
Strategy-aware evaluation of treatment personalization Open
Personalizing treatment according to patient's characteristics is at the core of stratified or precision medicine. There has been a recent surge of statistical methods aiming at identifying so-called optimal treatment strategies, i.e., str…
View article: More efficient and inclusive time-to-event trials with covariate adjustment: a simulation study
More efficient and inclusive time-to-event trials with covariate adjustment: a simulation study Open
Adjustment for prognostic covariates increases the statistical power of randomized trials. The factors influencing increase of power are well-known for trials with continuous outcomes. Here, we study which factors influence power and sampl…
View article: Interactions and collider bias in case-only gene-environment data
Interactions and collider bias in case-only gene-environment data Open
Background: Case-only design for gene-environment interaction (CODGEI) relies on the rare disease assumption. A negative association due to collider bias appears between gene and environment when this assumption is not respected. Genetic r…
View article: Asymptotic equivalence of paired Hotelling test and conditional logistic regression
Asymptotic equivalence of paired Hotelling test and conditional logistic regression Open
Matching, the stratification of observations, is of primary importance for the analysis of observational studies. We show that the score test of conditional logistic regression and the paired Student/Hotelling test, two tests for paired da…
View article: Asymptotic equivalence of paired Hotelling test and conditional logistic\n regression
Asymptotic equivalence of paired Hotelling test and conditional logistic\n regression Open
Matching, the stratification of observations, is of primary importance for\nthe analysis of observational studies. We show that the score test of\nconditional logistic regression and the paired Student/Hotelling test, two\ntests for paired…
View article: Association of environmental markers with childhood type 1 diabetes mellitus revealed by a long questionnaire on early life exposures and lifestyle in a case-control study
Association of environmental markers with childhood type 1 diabetes mellitus revealed by a long questionnaire on early life exposures and lifestyle in a case-control study Open
Background The incidence of childhood type 1 diabetes (T1D) incidence is rising in many countries, supposedly because of changing environmental factors, which are yet largely unknown. Purpose To unravel environmental markers associated wit…
View article: Haplotype based genetic risk estimation for complex diseases
Haplotype based genetic risk estimation for complex diseases Open
Genome-wide association studies (GWAS) have uncovered thousands of associations between genetic variants and diseases. Using the same datasets, prediction of disease risk can be attempted. Phase information is an important biological struc…
View article: Haplotype based genetic risk estimation for complex diseases
Haplotype based genetic risk estimation for complex diseases Open
Genome-wide association studies (GWAS) have uncovered thousands of associations between genetic variants and diseases. Using the same datasets, prediction of disease risk can be attempted. Phase information is an important biological struc…
View article: Additional file 2: of Association of environmental markers with childhood type 1 diabetes mellitus revealed by a long questionnaire on early life exposures and lifestyle in a case–control study
Additional file 2: of Association of environmental markers with childhood type 1 diabetes mellitus revealed by a long questionnaire on early life exposures and lifestyle in a case–control study Open
The results of matched analysis and propensity analysis including questionnaire section, question description, labels used in figures, missing data separately for cases and controls, p-values, effect size ad confidence interval. (XLS 355 k…
View article: Additional file 4: of Association of environmental markers with childhood type 1 diabetes mellitus revealed by a long questionnaire on early life exposures and lifestyle in a case–control study
Additional file 4: of Association of environmental markers with childhood type 1 diabetes mellitus revealed by a long questionnaire on early life exposures and lifestyle in a case–control study Open
Results of the analysis described in Additional file 3. (XLS 12 kb)