Felix Bormann
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View article: Long-term prediction of mortality by heart rate turbulence in hemodialysis patients and the impact of diabetes mellitus–a longitudinal observational study
Long-term prediction of mortality by heart rate turbulence in hemodialysis patients and the impact of diabetes mellitus–a longitudinal observational study Open
View article: The significance of <scp>PAX5</scp> in Merkel cell carcinoma
The significance of <span>PAX5</span> in Merkel cell carcinoma Open
Merkel cell carcinoma (MCC) is a highly malignant skin cancer that expresses epithelial‐, neuroendocrine‐, and lymphoid‐associated genes. Here, we focused on B‐cell differentiation, which is characterised by the coexpression of PAX5 and Td…
View article: Overlapping Stromal Alterations in Myeloid and Lymphoid Neoplasms
Overlapping Stromal Alterations in Myeloid and Lymphoid Neoplasms Open
Myeloid and lymphoid neoplasms share the characteristics of potential bone marrow infiltration as a primary or secondary effect, which readily leads to hematopoietic insufficiency. The mechanisms by which clonal malignant cells inhibit nor…
View article: Stromal alterations in patients with monoclonal gammopathy of undetermined significance, smoldering myeloma, and multiple myeloma
Stromal alterations in patients with monoclonal gammopathy of undetermined significance, smoldering myeloma, and multiple myeloma Open
The hallmark of multiple myeloma (MM) is a clonal plasma cell infiltration in the bone marrow accompanied by myelosuppression and osteolysis. Premalignant stages such as monoclonal gammopathy of undetermined significance (MGUS) and asympto…
View article: An m6A-Driven Prognostic Marker Panel for Renal Cell Carcinoma Based on the First Transcriptome-Wide m6A-seq
An m6A-Driven Prognostic Marker Panel for Renal Cell Carcinoma Based on the First Transcriptome-Wide m6A-seq Open
To date, only a single transcriptome-wide m6A sequencing study of clear cell renal cell carcinoma (ccRCC) has been reported, with no validation so far. Herein, by TCGA analysis of the KIRC cohort (n = 530 ccRCC; n = 72 normal), an external…
View article: Differentiation‐related epigenomic changes define clinically distinct keratinocyte cancer subclasses
Differentiation‐related epigenomic changes define clinically distinct keratinocyte cancer subclasses Open
Keratinocyte cancers (KC) are the most prevalent malignancies in fair-skinned populations, posing a significant medical and economic burden to health systems. KC originate in the epidermis and mainly comprise basal cell carcinoma (BCC) and…
View article: DNA methylation reveals distinct cells of origin for pancreatic neuroendocrine carcinomas and pancreatic neuroendocrine tumors
DNA methylation reveals distinct cells of origin for pancreatic neuroendocrine carcinomas and pancreatic neuroendocrine tumors Open
View article: Additional file 1 of DNA methylation reveals distinct cells of origin for pancreatic neuroendocrine carcinomas and pancreatic neuroendocrine tumors
Additional file 1 of DNA methylation reveals distinct cells of origin for pancreatic neuroendocrine carcinomas and pancreatic neuroendocrine tumors Open
Additional file 1. Supplementary tables S1-S19.
View article: Acute myeloid leukemia-induced functional inhibition of healthy CD34+ hematopoietic stem and progenitor cells
Acute myeloid leukemia-induced functional inhibition of healthy CD34+ hematopoietic stem and progenitor cells Open
Acute myeloid leukemia (AML) is characterized by an expansion of leukemic cells and a simultaneous reduction of normal hematopoietic precursors in the bone marrow (BM) resulting in hematopoietic insufficiency, but the underlying mechanisms…
View article: Format chain exchange (FORCE) for high-throughput generation of bispecific antibodies in combinatorial binder-format matrices
Format chain exchange (FORCE) for high-throughput generation of bispecific antibodies in combinatorial binder-format matrices Open
Generation of bispecific antibodies (bsAbs) requires a combination of compatible binders in formats that support desired functionalities. Here, we report that bsAb-matrices can be generated by Format Chain Exchange (FORCE), enabling screen…
View article: DNA methylation reveals distinct cells of origin for pancreatic neuroendocrine carcinomas (PanNECs) and pancreatic neuroendocrine tumors (PanNETs)
DNA methylation reveals distinct cells of origin for pancreatic neuroendocrine carcinomas (PanNECs) and pancreatic neuroendocrine tumors (PanNETs) Open
Pancreatic Neuroendocrine Carcinomas (PanNECs) are high-grade, poorly-differentiated tumors grouped together with Pancreatic Neuroendocrine Tumors (PanNETs) and placed within the Pancreatic Neuroendocrine Neoplasms (PanNENs) WHO tumor clas…
View article: The curious case of Merkel cell carcinoma: epigenetic youth and lack of pluripotency
The curious case of Merkel cell carcinoma: epigenetic youth and lack of pluripotency Open
Merkel cell carcinoma (MCC) is a very rare, but highly aggressive skin cancer which occurs mainly in elderly patients. MCC cells show an expression pattern of three cell lineages: epithelial, neuroendocrine, and B-cell progenitor. This tri…
View article: Epigenetic deregulation of lamina-associated domains in Hutchinson-Gilford progeria syndrome
Epigenetic deregulation of lamina-associated domains in Hutchinson-Gilford progeria syndrome Open
Background Hutchinson-Gilford progeria syndrome (HGPS) is a progeroid disease characterized by the early onset of age-related phenotypes including arthritis, loss of body fat and hair, and atherosclerosis. Cells from affected individuals e…
View article: Epigenetic deregulation of lamina-associated domains in Hutchinson-Gilford Progeria Syndrome
Epigenetic deregulation of lamina-associated domains in Hutchinson-Gilford Progeria Syndrome Open
Hutchinson-Gilford Progeria Syndrome (HGPS) is a progeroid disease characterized by the early onset of some classically age-related phenotypes including arthritis, loss of body fat and hair and atherosclerosis. Cells from affected individu…
View article: Differential induction of interferon stimulated genes between type I and type III interferons is independent of interferon receptor abundance
Differential induction of interferon stimulated genes between type I and type III interferons is independent of interferon receptor abundance Open
It is currently believed that type I and III interferons (IFNs) have redundant functions. However, the preferential distribution of type III IFN receptor on epithelial cells suggests functional differences at epithelial surfaces. Here, usi…
View article: Differential induction of interferon stimulated genes between type I andtype III interferons is independent of interferon receptor abundance
Differential induction of interferon stimulated genes between type I andtype III interferons is independent of interferon receptor abundance Open
It is currently believed that type I and III interferons (IFNs) have redundant functions. However, the preferential distribution of type III IFN receptor on epithelial cells suggests functional differences at epithelial surfaces. Here, usi…
View article: Epigenetic regulation of Amphiregulin and Epiregulin in colorectal cancer
Epigenetic regulation of Amphiregulin and Epiregulin in colorectal cancer Open
Expression of the epidermal growth factor ligands amphiregulin (AREG) and epiregulin (EREG) is positively correlated with a response to EGFR‐targeted therapies in colorectal cancer. Gene‐body methylation sites, which show a strong inverse …
View article: Cell-of-Origin DNA Methylation Signatures Are Maintained during Colorectal Carcinogenesis
Cell-of-Origin DNA Methylation Signatures Are Maintained during Colorectal Carcinogenesis Open
Colorectal adenomas are precursor lesions of colorectal cancers and represent clonal amplifications of single cells from colonic crypts. DNA methylation patterns specify cell-type identity during cellular differentiation and, therefore, pr…
View article: Transforming growth factor β1-mediated functional inhibition of mesenchymal stromal cells in myelodysplastic syndromes and acute myeloid leukemia
Transforming growth factor β1-mediated functional inhibition of mesenchymal stromal cells in myelodysplastic syndromes and acute myeloid leukemia Open
Mesenchymal stromal cells are involved in the pathogenesis of myelodysplastic syndromes and acute myeloid leukemia, but the underlying mechanisms are incompletely understood. To further characterize the pathological phenotype we performed …
View article: Methylation profiling identifies two subclasses of squamous cell carcinoma related to distinct cells of origin
Methylation profiling identifies two subclasses of squamous cell carcinoma related to distinct cells of origin Open
View article: Genetic and epigenetic profiling of a solitary Peutz–Jeghers colon polyp
Genetic and epigenetic profiling of a solitary Peutz–Jeghers colon polyp Open
Colon polyps represent precursor lesions of colon cancers and their malignant potential varies according to histological subtype. A rare subtype of colon polyps is the Peutz–Jeghers (PJ) polyp. PJ polyps mostly occur in the context of Peut…
View article: Reduced <scp>DNA</scp> methylation patterning and transcriptional connectivity define human skin aging
Reduced <span>DNA</span> methylation patterning and transcriptional connectivity define human skin aging Open
Epigenetic changes represent an attractive mechanism for understanding the phenotypic changes associated with human aging. Age-related changes in DNA methylation at the genome scale have been termed 'epigenetic drift', but the defining fea…