Felix C. Kohler
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View article: Fixing geriatric ankle fractures: fibular nail versus locking plate in a prospective multicenter study
Fixing geriatric ankle fractures: fibular nail versus locking plate in a prospective multicenter study Open
Background: Elderly patients with unstable ankle fractures face a high risk of wound and implant-related complications after open reduction and internal fixation (ORIF). Less invasive intramedullary fibular nail (FN) fixation may reduce so…
View article: Comparison of Spectral CT and MRI in Pelvic Ring Fragility Fractures: A Prospective Diagnostic Accuracy Study
Comparison of Spectral CT and MRI in Pelvic Ring Fragility Fractures: A Prospective Diagnostic Accuracy Study Open
Background/Objectives: Fragility fractures of the pelvis (FFP) are characterized by inadequate trauma to a structurally compromised bone, primarily in osteoporosis. Conventional CT studies can be inadequate in identifying FFPs. An MRI of t…
View article: Biomechanical comparison of radiopalmar double plating with conventional palmar plating in comminuted distal radius fractures
Biomechanical comparison of radiopalmar double plating with conventional palmar plating in comminuted distal radius fractures Open
Purpose The aim of this study is to analyse the effect of an additional radial buttress plate for palmar plate osteosynthesis in an AO/OTA 2R3 C2.1 fracture model.Methods Nine pairs of fresh-frozen radii were examined for pathology and bon…
View article: Importance of IL-6 trans-signaling and high autocrine IL-6 production in human osteoarthritic chondrocyte metabolism
Importance of IL-6 trans-signaling and high autocrine IL-6 production in human osteoarthritic chondrocyte metabolism Open
Although IL-6 trans-signaling induced by IL-6/sIL-6R complex negatively affects OA chondrocytes, antibodies against IL-6 or IL-6R did not affect chondrocyte metabolism. Since inhibition of gp130-signaling reduced the enhanced basal release…
View article: Standardized analysis of syndesmosis stability in ankle trauma with an innovative syndesmosis-test-tool: a biomechanical study
Standardized analysis of syndesmosis stability in ankle trauma with an innovative syndesmosis-test-tool: a biomechanical study Open
When treating ankle fractures, the question of syndesmosis complex involvement often arises. So far, there is no standardized method to reliably detect syndesmosis injuries in the surgical treatment of ankle fractures. For this reason, an …
View article: Clinical outcome of inpatient treatment of osteoporotic sacral and pelvic ring fractures
Clinical outcome of inpatient treatment of osteoporotic sacral and pelvic ring fractures Open
View article: Prospective recording of complications of conservatively and surgically treated fragility fractures of the pelvis as part of the multicenter of-pelvis study
Prospective recording of complications of conservatively and surgically treated fragility fractures of the pelvis as part of the multicenter of-pelvis study Open
View article: Objective assessment of syndesmosis stability with an innovative Syndesmosis-Test-Tool - a biomechanical study
Objective assessment of syndesmosis stability with an innovative Syndesmosis-Test-Tool - a biomechanical study Open
When treating ankle fractures, the question of syndesmosis complex involvement often arises. So far there is no standardized method to reliably detect syndesmosis injuries in the surgical treatment of ankle fractures. For this reason, an i…
View article: Objective Assessment of Syndesmosis Stability Using the Hook Test
Objective Assessment of Syndesmosis Stability Using the Hook Test Open
The hook test is a widely used intraoperative method for assessing syndesmosis stability. However, there are no recommendations regarding the force required to perform this test. Furthermore, the reliability of the test is unclear. Ten exp…
View article: Biomechanical Comparison of Medio-Plantar and Plantar Plate Fixation for First Tarsometatarsal Joint Arthrodesis
Biomechanical Comparison of Medio-Plantar and Plantar Plate Fixation for First Tarsometatarsal Joint Arthrodesis Open
Plantar plate positioning has been demonstrated as biomechanically superior. However, some operators remain resentful about the morbidity of the surgical approach. To provide improved plate fixation for first tarsometatarsal joint arthrode…
View article: Fibula Nail versus Locking Plate Fixation—A Biomechanical Study
Fibula Nail versus Locking Plate Fixation—A Biomechanical Study Open
In the treatment of ankle fractures, complications such as wound healing problems following open reduction and internal fixation are a major problem. An innovative alternative to this procedure offers a more minimally invasive nail stabili…
View article: Biomechanical Comparison of Cannulated Screw Osteosynthesis With Tension-Band Wiring for Proximal Fractures of the Fifth Metatarsal (Jones Fracture)
Biomechanical Comparison of Cannulated Screw Osteosynthesis With Tension-Band Wiring for Proximal Fractures of the Fifth Metatarsal (Jones Fracture) Open
Jones fractures, which lie at the junction of the diaphysis to the metaphysis of the fifth metatarsal, are a well-described clinical issue. There are various surgical approaches, including the commonly performed cannulated screw osteosynth…
View article: Osteoarthritis-Induced Metabolic Alterations of Human Hip Chondrocytes
Osteoarthritis-Induced Metabolic Alterations of Human Hip Chondrocytes Open
Osteoarthritis (OA) alters chondrocyte metabolism and mitochondrial biology. We explored whether OA and non-OA chondrocytes show persistent differences in metabolism and mitochondrial function and different responsiveness to cytokines and …
View article: How the Direction of Screws Affects the Primary Stability of a Posterior Malleolus Osteosynthesis under Torsional Loading: A Biomechanical Study
How the Direction of Screws Affects the Primary Stability of a Posterior Malleolus Osteosynthesis under Torsional Loading: A Biomechanical Study Open
Insufficient fixation of a posterior malleolus fracture (PM) can lead to posttraumatic complications such as osteoarthritis and chronic pain. The purpose of this biomechanical study was to test the hypothesis of whether the direction of PM…
View article: The role of the posterior malleolus in the treatment of unstable upper ankle joint injuries - A biomechanical study
The role of the posterior malleolus in the treatment of unstable upper ankle joint injuries - A biomechanical study Open
The Fixation of the PM alone without an additional syndesmotic screw cannot achieve intact upper ankle stability. Fixation of a PM fracture with an SS helps in nearly achieving the natural condition.
View article: Open versus minimally invasive fixation of thoracic and lumbar spine fractures in patients with ankylosing spinal diseases
Open versus minimally invasive fixation of thoracic and lumbar spine fractures in patients with ankylosing spinal diseases Open
Purpose Posterior multilevel fixation of traumatic instability in ankylosing spinal disease (ASD) can be performed by open surgery (OS) or minimally invasive surgery (MIS). We investigated whether both methods differ based on the reduction…
View article: Initial Characterization of Transgenic Mice Overexpressing Human Histamine H2 Receptors
Initial Characterization of Transgenic Mice Overexpressing Human Histamine H2 Receptors Open
View article: Monocytic angiotensin-converting enzyme 2 relates to atherosclerosis in patients with chronic kidney disease
Monocytic angiotensin-converting enzyme 2 relates to atherosclerosis in patients with chronic kidney disease Open
Background: Increased levels of monocytic angiotensin-converting enzyme (ACE) found in haemodialysis (HD) patients may directly participate in the pathogenesis of atherosclerosis. We demonstrated recently that uremia triggers the developme…
View article: SP340POSTTRANSLATIONAL REGULATION OF IL-1ß IN CKD-5D PATIENTS COMPARED TO INDIVIDUALS WITHIN FLAMMATION AND NORMAL RENAL FUNCTION
SP340POSTTRANSLATIONAL REGULATION OF IL-1ß IN CKD-5D PATIENTS COMPARED TO INDIVIDUALS WITHIN FLAMMATION AND NORMAL RENAL FUNCTION Open