Explanipedia

Hemostatic properties of a venomic protein in rat organ trauma Open

Roscoe L. Warner, Shannon D. McClintock, Adam Barron, Felix A. de la Iglesia · 2009

Co‐administration of oxycodone and morphine and analgesic synergy re‐examined Open

Maree T. Smith, Felix A. de la Iglesia · 2005

The paper by Grach et al.[1] in the Journal addresses the little explored potential benefit of combination opioids in analgesia. Compared with a published study documenting oxycodone-morphine synergy in rats [2], the antinociception study …

Rodent Carcinogenicity with the Thiazolidinedione Antidiabetic Agent Troglitazone Open

James R. Herman, Lloyd A. Dethloff, Edward J. McGuire, R. F. Parker, Kathleen M. Walsh , et al. · 2002

Carcinogenic potential of the thiazolidinedione antidiabetic troglitazone was assessed in 104-week studies in mice and rats. Mice were given 50, 400, or 800 mg/kg, male rats 100, 400, or 800 mg/kg, and female rats 25, 50, or 200 mg/kg. Veh…

Chronic toxicity in monkeys with the thiazolidinedione antidiabetic agent troglitazone. Open

Charles E. Rothwell, Edward J. McGuire, Douglas M. Altrogge, Hiroshi Masuda, Felix A. de la Iglesia · 2002

The antidiabetic agent troglitazone was given to groups of 4 cynomolgus monkeys per sex at 300, 600, or 1200 mg/kg daily by gavage for 52 weeks. A group of 4 monkeys per sex received vehicle alone and served as controls. Emesis and soft st…

Rna Expression in the Early Characterization of Hepatotoxicants in Wistar Rats by High–Density Dna Microarrays Open

Steven J. Bulera, Susan Eddy, Erika Ferguson, T. Jatkoe, James F. Reindel , et al. · 2001

High–density microarrays are useful tools to study gene expression for the purpose of characterizing functional tissue changes in response to the action of drugs and chemicals. To test whether high–density expression data can identify mech…

High throughput genotyping for the detection of a single nucleotide polymorphism in NAD(P)H quinone oxidoreductase (DT diaphorase) using TaqMan probes Open

Michael Shi, Scott P. Myrand, M. R. Bleavins, Felix A. de la Iglesia · 1999

This genotyping method is highly accurate and could be applied to automated large scale genotyping studies.

a2u-Globulin Nephropathy and Ravens: Do Ravens of a Different Feather Flock Together? Open

Felix A. de la Iglesia, Alexander W. Gough, Robert E. Sigler · 1997

differentiate significant and trivial chemical hazards and to assess likely risks to humans.This latter justification can be illustrated by the following statement: if all chemicals that are mutagenic in vitro were mutagenic and

alpha2u-Globulin nephropathy and ravens: do ravens of a different feather flock together? Open

Felix A. de la Iglesia, Alec W. Gough, Robert E. Sigler · 1997

differentiate significant and trivial chemical hazards and to assess likely risks to humans.This latter justification can be illustrated by the following statement: if all chemicals that are mutagenic in vitro were mutagenic and

Increased Nuclear Ploidy, Not Cell Proliferation, Is Sustained in the Peroxisome Proliferator-Treated Rat Liver Open

Narendra D. Lalwani, Lloyd A. Dethloff, Jeffrey R. Haskins, Donald G. Robertson, Felix A. de la Iglesia · 1997

Peroxisome proliferators are believed to induce liver tumors in rodents due to sustained increase in cell proliferation and oxidative stress resulting from the induction of peroxisomal enzymes. The objective of this study was to conduct a …

Book Review Open

Felix A. de la Iglesia · 1996

Preclinical toxicology studies with the angiotensin-converting enzyme inhibitor quinapril hydrochloride (accupril). Open

Edward J. McGuire, John A. Anderson, Alexander W. Gough, James R. Herman, David G. Pegg , et al. · 1996

Acute, subacute, and chronic toxicity studies, carcinogenicity bioassays, and reproductive and genetic toxicology studies were performed with quinapril, an ACE inhibitor used in the treatment of hypertension. Acute toxicity is minimal in r…

Peroxisome induction potential and lipid-regulating activity in rats. Quantitative microscopy and chemical structure-activity relationships. Open

Edward J. McGuire, J. Lucas, Robert H. Gray, Felix A. de la Iglesia · 1991

Structurally diverse lipid-regulating agents induce hepatomegaly, hepatic peroxisome proliferation, and hepatocarcinoma in rats by mechanisms not fully understood. Nevertheless the initial hepatic response is a prompt, florid proliferation…

The pathogenesis of trimethyltin chloride-induced nephrotoxicity Open

Donald G. Robertson, Sang-Nam Kim, Robert H. Gray, Felix A. de la Iglesia · 1987

Structure-activity relationships in the induction of mammary gland neoplasia in male rats with substituted aminopyrazoles. Open

James E. Fitzgerald, Edward J. McGuire, Lori Andrews, Felix A. de la Iglesia · 1986

In toxicity studies with a potential antipsychotic agent, N-(4-[2-fluorobenzoyl]-1,3-dimethyl-1H-pyrazol-5-yl)-2-([3- (2-methyl-1-piperidinyl)propyl]amino)-acetamide(Z)-2-butenedioate (1:2) (FP-1), mammary gland neoplasia in male rats was …

Evaluation of chronic toxicity and carcinogenesis in rodents with the synthetic analgesic, tilidine fumarate Open

Edward J. McGuire, C.J. DiFonzo, Ronald E. Martin, Felix A. de la Iglesia · 1986

Emmanuel Farber, M.D., Ph.D.—Honorary Member of the Society of Toxicologic Pathologists Open

Felix A. de la Iglesia · 1985

Bacterial Mutagenesis and Cell Transformation Assays of Pyrvinium Pamoate (Povan), An Antiparasitic Agent Open

Felix A. de la Iglesia, Robert S. Lake, James E. Fitzgerald, Ernest Bueding, David Brusick · 1984

Mutagenicity of pyrvinium pamoate formulations was determined in various Salmonella typhimurium strains in a well test and plate incorporation assays in the presence and absence of liver homogenate (S9) from Aroclor-1254-induced rats or fr…

Carcinogenesis Testing Updated Open

Ronald E. Martin, Felix A. de la Iglesia · 1984

Morphologic Features and Incidence of Spontaneous Hyperplastic and Neoplastic Mammary Gland Lesions in Wistar Rats Open

N. J. Barsoum, Alexander W. Gough, Jennifer M. Sturgess, Felix A. de la Iglesia · 1984

A morphologic study of spontaneous proliferative lesions of the mammary gland was based on histologic examination of mammary glands from 1020 male and 1145 female albino Wistar rats aged 6 to 110 weeks. Three hundred and seventy-five mamma…

Hypolipidemics Carcinogenicity and Extrapolation of Experimental Results for Human Safety Assessments Open

Felix A. de la Iglesia, Emmanuel Farber · 1982

Dyslipoproteinemias represent a group of disorders closely related to alterations of cholesterol and triglycerides. The alterations of these lipids are considered important risk factors in coronary heart disease and indicate the need for c…

Peroxisome population parameters in rats fed a high-fat diet Open

Edward J. McGuire, Robert H. Gray, John A. Lucas, Felix A. de la Iglesia · 1982

Quantitative Stereology: Toxicologic Pathology Applications Open

Felix A. de la Iglesia, Edward J. McGuire · 1981

1 NTRODUCTION Quantitative stereology concerns a specialized area of microscopic image analysis in which measurements of objects can be accurately obtained by means of rationalized steps of sampling combined with mathematical reconstructio…

MORPHOMETRY OF THE GOLGI APPARATUS IN DEVELOPING LIVER Open

J. M. Sturgess, Felix A. de la Iglesia · 1972

HISTOCHEMICAL URATE OXIDASE ACTIVITY AND MICROBODIES IN NONHUMAN PRIMATE LIVER Open

Felix A. de la Iglesia, Eduardo A. Porta, W. Stanley Hartroft · 1966

Felix A. de la Iglesia YOU? Author Swipe