Felix Ehret
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View article: The interdisciplinary management of craniopharyngioma – practice patterns, outcomes, and insights
The interdisciplinary management of craniopharyngioma – practice patterns, outcomes, and insights Open
Background Craniopharyngiomas are rare, mostly benign brain tumors, and their management remains challenging due to the limited data from large cohorts. This study evaluates the practice patterns and outcomes for craniopharyngioma patients…
View article: Patterns of care in primary brain tumour Reirradiation: A survey by the ESTRO CNS focus Group
Patterns of care in primary brain tumour Reirradiation: A survey by the ESTRO CNS focus Group Open
This survey reveals high heterogeneity in brain tumour reirradiation practices across Europe, especially regarding dose, technique, and target definition. Despite shared principles, consensus is lacking for rarer tumour types. These findin…
View article: Impact of target volume and dose concepts on the outcomes of prostate cancer patients treated with stereotactic body radiotherapy for spinal metastases − a European multicenter cohort study
Impact of target volume and dose concepts on the outcomes of prostate cancer patients treated with stereotactic body radiotherapy for spinal metastases − a European multicenter cohort study Open
This multicenter cohort analysis showed that SBRT of spine BoM from prostate cancer is an effective and well-tolerated treatment. Both BED and usage of a SIB concept were associated with improved PFS and BRFS. Prospective studies are neede…
View article: RADT-28. THE ROLE OF RADIOTHERAPY IN LEPTOMENINGEAL DISEASE FROM BREAST CANCER – A MULTICENTER ANALYSIS OF OUTCOMES AND INTERDISCIPLINARY MANAGEMENT
RADT-28. THE ROLE OF RADIOTHERAPY IN LEPTOMENINGEAL DISEASE FROM BREAST CANCER – A MULTICENTER ANALYSIS OF OUTCOMES AND INTERDISCIPLINARY MANAGEMENT Open
BACKGROUND Many breast cancer patients will eventually develop leptomeningeal disease (LMD). However, there is a lack of large, in-depth analyses of the pattern of care and outcomes, with a particular focus on radiotherapy. We report our e…
View article: NCMP-17. Clinical Presentation, Management and Outcome of Tumor inflammation-associated neurotoxicity (TIAN) in CNS lymphoma treated with CD19-CAR T-cell therapy
NCMP-17. Clinical Presentation, Management and Outcome of Tumor inflammation-associated neurotoxicity (TIAN) in CNS lymphoma treated with CD19-CAR T-cell therapy Open
Tumor inflammation-associated neurotoxicity (TIAN) was recently proposed as a unique complication of immunotherapy in brain tumor patients. Here, we report a first comprehensive characterization of TIAN in CNS lymphoma (CNSL) patients trea…
View article: BIOM-08. CHROMOSOME 1P LOSS AND 1Q GAIN ARE HIGHLY PROGNOSTIC AND CAN INFORM WHO GRADING OF MENINGIOMA
BIOM-08. CHROMOSOME 1P LOSS AND 1Q GAIN ARE HIGHLY PROGNOSTIC AND CAN INFORM WHO GRADING OF MENINGIOMA Open
The CNS WHO grade of meningioma was updated in 2021 to include rare molecular features, namely homozygous deletions of CDKN2A or CDKN2B and TERT promotor mutations. Previous work including the cIMPACT-NOW update 8 have discussed the potent…
View article: IMG-82. Positron emission tomography (PET) use among European Organisation for Research and Treatment of Cancer – Brain Tumour Group (EORTC-BTG) sites – a cross-sectional survey
IMG-82. Positron emission tomography (PET) use among European Organisation for Research and Treatment of Cancer – Brain Tumour Group (EORTC-BTG) sites – a cross-sectional survey Open
BACKGROUND Positron emission tomography (PET) is increasingly used in patients with brain tumors, yet its adoption varies across institutions. METHODS To assess the current landscape, a cross-sectional survey was conducted among European O…
View article: Quality of life following total neoadjuvant therapy for rectal cancer
Quality of life following total neoadjuvant therapy for rectal cancer Open
Purpose This study aimed to assess the health-related quality of life (HRQoL) in patients with locally advanced rectal cancer (LARC) undergoing total neoadjuvant therapy (TNT), comparing outcomes with the German general population and colo…
View article: Short-course radiotherapy versus long-course chemoradiotherapy in total neoadjuvant therapy of rectal cancer – A multicenter analysis of early outcomes and toxicity
Short-course radiotherapy versus long-course chemoradiotherapy in total neoadjuvant therapy of rectal cancer – A multicenter analysis of early outcomes and toxicity Open
LCRT was associated with higher CR and NOM rates. Whether it might be preferred over SCRT for intended NOM remains a relevant question to be answered by ongoing randomized trials.
View article: P08.06.B THE EGFL7-INTEGRIN Β2 AXIS: A NOVEL REGULATOR OF IMMUNE EVASION IN GLIOBLASTOMA
P08.06.B THE EGFL7-INTEGRIN Β2 AXIS: A NOVEL REGULATOR OF IMMUNE EVASION IN GLIOBLASTOMA Open
BACKGROUND Glioblastoma is the most aggressive form of malignant brain cancer, characterized by an immunosuppressive environment that leads to immune evasion. Multiple strategies have been undertaken to shift the immune landscape within th…
View article: P03.22.A USE OF POSITRON EMISSION TOMOGRAPHY (PET) IN PATIENTS WITH BRAIN TUMOURS AMONG EUROPEAN ORGANISATION FOR RESEARCH AND TREATMENT OF CANCER - BRAIN TUMOUR GROUP (EORTC-BTG) SITES
P03.22.A USE OF POSITRON EMISSION TOMOGRAPHY (PET) IN PATIENTS WITH BRAIN TUMOURS AMONG EUROPEAN ORGANISATION FOR RESEARCH AND TREATMENT OF CANCER - BRAIN TUMOUR GROUP (EORTC-BTG) SITES Open
BACKGROUND Data on the use of positron emission tomography (PET) among neuro-oncology centers in Europe are scarce. MATERIAL AND METHODS From 06/2024 to 08/2024, a cross-sectional survey among European Organization for Research and Treatme…
View article: OS08.6.A A PROGNOSTIC CLASSIFICATION SYSTEM FOR EXTENT OF RESECTION IN IDH-MUTANT GRADE 2 GLIOMA: A REPORT BY THE RANO RESECT GROUP
OS08.6.A A PROGNOSTIC CLASSIFICATION SYSTEM FOR EXTENT OF RESECTION IN IDH-MUTANT GRADE 2 GLIOMA: A REPORT BY THE RANO RESECT GROUP Open
BACKGROUND The effects of resection in IDH-mutant grade 2 gliomas remain controversial since terminology for extent of resection was inconsistent across trials. We aimed to (I) establish a standardized classification system for extent of r…
View article: Abscopal effects in patients with malignant melanoma treated with radiotherapy and immune checkpoint inhibition: analysis of a large observational multicenter study
Abscopal effects in patients with malignant melanoma treated with radiotherapy and immune checkpoint inhibition: analysis of a large observational multicenter study Open
Background Abscopal effect (AbE), the regression of non-irradiated metastatic lesions (NILs) following radiotherapy (RT), is relevant in patients with malignant melanoma (MM) with progressive disease (PD) under immune checkpoint inhibition…
View article: RMTD-05 PERI-OPERATIVE DEXAMETHASONE USE IN BRAIN METASTASIS SURGERY: ANALYSIS OF PRACTICE VARIATION ACROSS EIGHT NEUROSURGICAL CENTERS
RMTD-05 PERI-OPERATIVE DEXAMETHASONE USE IN BRAIN METASTASIS SURGERY: ANALYSIS OF PRACTICE VARIATION ACROSS EIGHT NEUROSURGICAL CENTERS Open
BACKGROUND Peri-operative corticosteroids are routinely administered in brain metastasis surgery to manage edema, yet standardized dosing protocols are lacking. Practice variation between neurosurgical centers has not been systematically q…
View article: 17 CHROMOSOME 1P LOSS AND 1Q GAIN ARE HIGHLY PROGNOSTIC AND CAN INFORM WHO GRADING OF MENINGIOMA
17 CHROMOSOME 1P LOSS AND 1Q GAIN ARE HIGHLY PROGNOSTIC AND CAN INFORM WHO GRADING OF MENINGIOMA Open
BACKGROUND The CNS WHO grade of meningioma was updated in 2021 to include rare molecular features, namely homozygous deletions of CDKN2A or CDKN2B and TERT promotor mutations. Previous work including the recent cIMPACT-NOW statement have d…
View article: 17 CHROMOSOME 1P LOSS AND 1Q GAIN ARE HIGHLY PROGNOSTIC AND CAN INFORM WHO GRADING OF MENINGIOMA
17 CHROMOSOME 1P LOSS AND 1Q GAIN ARE HIGHLY PROGNOSTIC AND CAN INFORM WHO GRADING OF MENINGIOMA Open
Brain Tumour Foundation of Canada Travel Award Recipient The CNS WHO grade of meningioma was updated in 2021 to include rare molecular features, namely homozygous deletions of CDKN2A or CDKN2B and TERT promotor mutations. Previous work inc…
View article: Stereotactic Body Radiation Therapy for the Treatment of Adrenal Metastases — A Case-Based Radiosurgery Society Practice Guide and Review
Stereotactic Body Radiation Therapy for the Treatment of Adrenal Metastases — A Case-Based Radiosurgery Society Practice Guide and Review Open
View article: Tenth anniversary of the Young DEGRO Team Trial—reflecting on the past, shaping the future
Tenth anniversary of the Young DEGRO Team Trial—reflecting on the past, shaping the future Open
View article: Impact of Extent of Resection on Survival in Brain Metastasis: An Analysis of 867 Patients
Impact of Extent of Resection on Survival in Brain Metastasis: An Analysis of 867 Patients Open
BACKGROUND AND OBJECTIVES: The association between extent of resection (EOR) and outcomes after brain metastasis (BM) surgery remains unclear. The aim of this study was to examine the relation between EOR and overall survival (OS)/intracra…
View article: Radiosurgery for pediatric central nervous system lesions – initial report and insights from a multicenter registry
Radiosurgery for pediatric central nervous system lesions – initial report and insights from a multicenter registry Open
View article: Comparison of survival and progression after focal- or whole brain radiotherapy in patients with primary CNS lymphoma – Results from a large multicenter analysis of the German Society of Radiation Oncology’s Neuro-Radio-Oncology Working Group (DEGRO AG-NRO)
Comparison of survival and progression after focal- or whole brain radiotherapy in patients with primary CNS lymphoma – Results from a large multicenter analysis of the German Society of Radiation Oncology’s Neuro-Radio-Oncology Working Group (DEGRO AG-NRO) Open
fRT may be a beneficial treatment option for patients with PCNSL and needs to be studied further in prospective clinical trials.
View article: Reirradiation with stereotactic radiosurgery for vestibular schwannomas – a systematic review and meta-analysis
Reirradiation with stereotactic radiosurgery for vestibular schwannomas – a systematic review and meta-analysis Open
View article: Availability and use of PET in patients with brain tumours – a European Organisation for Research and Treatment of Cancer - Brain Tumour Group (EORTC-BTG) survey
Availability and use of PET in patients with brain tumours – a European Organisation for Research and Treatment of Cancer - Brain Tumour Group (EORTC-BTG) survey Open
View article: Re-resection of brain metastases – outcomes of an institutional cohort study and literature review
Re-resection of brain metastases – outcomes of an institutional cohort study and literature review Open
View article: F.7 Chromosome 1p loss and 1q gain are highly prognostic and can inform WHO grading of meningioma
F.7 Chromosome 1p loss and 1q gain are highly prognostic and can inform WHO grading of meningioma Open
Background: The WHO grade of meningioma was updated in 2021 to include homozygous deletions of CDKN2A/B and TERT promotor mutations. Previous work including the recent cIMPACT-NOW statement have discussed the potential value of including c…
View article: F.1 Validation and next-generation update of a DNA methylation-based recurrence predictor for meningioma: a multicenter prospective study
F.1 Validation and next-generation update of a DNA methylation-based recurrence predictor for meningioma: a multicenter prospective study Open
Background: We previously developed a DNA methylation-based risk predictor for meningioma, which has been used locally in a prospective fashion. As a follow-up, we validate this model using a large prospective cohort and introduce a stream…
View article: Balancing barriers: Family, career, and gender equality in radiation oncology and radiation research—An interdisciplinary prospective survey among the young workforce
Balancing barriers: Family, career, and gender equality in radiation oncology and radiation research—An interdisciplinary prospective survey among the young workforce Open
Purpose There is an urgent need to recruit and retain young professionals in radiation oncology and radiation research as the healthcare system faces major challenges. Our study investigated the experiences and needs of young professionals…
View article: Treatment Plan Comparison Between Self-Shielding Gyroscopic Radiosurgery and Robotic Radiosurgery
Treatment Plan Comparison Between Self-Shielding Gyroscopic Radiosurgery and Robotic Radiosurgery Open
Stereotactic radiosurgery with established systems like the Gamma Knife and CyberKnife (Accuray Inc., Madison, WI, USA) is a well-characterized treatment concept. The novel ZAP-X® platform (ZAP Surgical Systems Inc., San Carlos,…
View article: Early experience with proton craniospinal irradiation in adult patients with leptomeningeal disease
Early experience with proton craniospinal irradiation in adult patients with leptomeningeal disease Open
View article: Potential Benefits of Green Tea on Cancer-Related Outcomes: The Impact of Dosage and BMI as Effect Modifiers
Potential Benefits of Green Tea on Cancer-Related Outcomes: The Impact of Dosage and BMI as Effect Modifiers Open
Introduction: Green tea, GT, catechins, epigallocatechin-3-gallate (EGCG) and its polyphenol extract called Polyphenon E have been studied as potential anticancer agents. This systematic review evaluates the effect of GT exposure on cancer…