Félix Elortza
YOU?
Author Swipe
View article: Proteomics Reveals Differential Diagnosis Biomarkers Between Sepsis and Hemophagocytic Syndrome
Proteomics Reveals Differential Diagnosis Biomarkers Between Sepsis and Hemophagocytic Syndrome Open
Background/Objectives: Hemophagocytic Lymphohistiocytosis (HLH) shares many clinical features with sepsis. To improve HLH diagnosis and its differential diagnosis with sepsis, serum proteomic analyses of healthy donors, HLH and septic pati…
View article: Generation and Characterization of Novel Contilisant+Tubastatin a Multitarget Small Molecules Against Glioblastoma
Generation and Characterization of Novel Contilisant+Tubastatin a Multitarget Small Molecules Against Glioblastoma Open
Background/Objectives: Glioblastoma is the most common and aggressive primary brain tumor in adults, with patient prognosis remaining poor. Treatment resistance and tumor recurrence are frequent, primarily due to the high intra- and inter-…
View article: Metabolic dysfunction–associated steatotic liver disease alters brain function and behavior: Insights from liver-targeted siRNA therapy
Metabolic dysfunction–associated steatotic liver disease alters brain function and behavior: Insights from liver-targeted siRNA therapy Open
Metabolic dysfunction–associated steatotic liver disease (MASLD), a liver-centric condition, is associated with cognitive impairment and sensorimotor alterations. However, it remains unclear whether MASLD is sufficient to drive central ner…
View article: The role of PEGylation in the pulmonary delivery of antifibrotic liposomal therapies
The role of PEGylation in the pulmonary delivery of antifibrotic liposomal therapies Open
PEGylation is commonly used to improve the pharmacokinetics and efficacy of intravenously administered drug nanocarriers; however its impact on pulmonary drug delivery remains unclear. While previous studies have focused on its role in cro…
View article: Proteogenomic approach to immunopeptidomics of ovarian tumors identifies shared peptide vaccine candidates
Proteogenomic approach to immunopeptidomics of ovarian tumors identifies shared peptide vaccine candidates Open
View article: An astrocytic AMPK clock drives circadian behaviour
An astrocytic AMPK clock drives circadian behaviour Open
Summary Circadian clocks coordinate behaviour and physiology with daily cycles of light and nutrient availability, yet how metabolic signals tune brain timing remains unclear. Astrocytes integrate metabolic and hormonal cues and sustain ce…
View article: Phenotypic and omics analyses of the Sordariomycetes <i>Marquandomyces marquandii</i> and <i>Albophoma yamanashiensis</i> isolated from estuarine sediments
Phenotypic and omics analyses of the Sordariomycetes <i>Marquandomyces marquandii</i> and <i>Albophoma yamanashiensis</i> isolated from estuarine sediments Open
Marine environments harbor a vast diversity of microorganisms, which have developed multiple strategies to adapt to challenging conditions and represent a valuable source for new products such as pigments, enzymes, and bioactive compounds.…
View article: Correction: The PP2A regulator IER5L supports prostate cancer progression
Correction: The PP2A regulator IER5L supports prostate cancer progression Open
View article: Supplementary Table S3 from NEDDylation Regulates CD8<sup>+</sup> T-cell Metabolism and Antitumor Immunity
Supplementary Table S3 from NEDDylation Regulates CD8<sup>+</sup> T-cell Metabolism and Antitumor Immunity Open
IPA analysis of proteomic data.
View article: Data from NEDDylation Regulates CD8<sup>+</sup> T-cell Metabolism and Antitumor Immunity
Data from NEDDylation Regulates CD8<sup>+</sup> T-cell Metabolism and Antitumor Immunity Open
NEDDylation is a posttranslational modification whereby the ubiquitin-like molecule NEDD8 is attached to protein substrates in a process dependent on NEDD8-activating enzyme regulatory subunit (NAE1). NEDDylation is emerging as a regulator…
View article: Supplementary Figure S7 from NEDDylation Regulates CD8<sup>+</sup> T-cell Metabolism and Antitumor Immunity
Supplementary Figure S7 from NEDDylation Regulates CD8<sup>+</sup> T-cell Metabolism and Antitumor Immunity Open
T cell receptor signaling, migration, MYC activity, metabolic pathways and HIF-1α signaling are impaired in NAE1-KO CD8+ T cells.
View article: Supplementary Table S2 from NEDDylation Regulates CD8<sup>+</sup> T-cell Metabolism and Antitumor Immunity
Supplementary Table S2 from NEDDylation Regulates CD8<sup>+</sup> T-cell Metabolism and Antitumor Immunity Open
Raw proteomics data.
View article: Supplementary Figure S2 from NEDDylation Regulates CD8<sup>+</sup> T-cell Metabolism and Antitumor Immunity
Supplementary Figure S2 from NEDDylation Regulates CD8<sup>+</sup> T-cell Metabolism and Antitumor Immunity Open
Analysis of thymus, spleen and lymph node populations in NAE1-KO mice.
View article: Supplementary Table S1 from NEDDylation Regulates CD8<sup>+</sup> T-cell Metabolism and Antitumor Immunity
Supplementary Table S1 from NEDDylation Regulates CD8<sup>+</sup> T-cell Metabolism and Antitumor Immunity Open
List of Western Blot antibodies, Flow Cytometry antibodies, and primers used in the study.
View article: Supplementary Figure S4 from NEDDylation Regulates CD8<sup>+</sup> T-cell Metabolism and Antitumor Immunity
Supplementary Figure S4 from NEDDylation Regulates CD8<sup>+</sup> T-cell Metabolism and Antitumor Immunity Open
In vivo tumor-challenge assays show a defect in the anti-tumor function of NAE1-KO CD8+ T cells.
View article: Supplementary Figure S1 from NEDDylation Regulates CD8<sup>+</sup> T-cell Metabolism and Antitumor Immunity
Supplementary Figure S1 from NEDDylation Regulates CD8<sup>+</sup> T-cell Metabolism and Antitumor Immunity Open
T cell activation triggers the upregulation of NAE1 expression and NEDDylation activity.
View article: Supplementary Figure S8 from NEDDylation Regulates CD8<sup>+</sup> T-cell Metabolism and Antitumor Immunity
Supplementary Figure S8 from NEDDylation Regulates CD8<sup>+</sup> T-cell Metabolism and Antitumor Immunity Open
Densitometric analysis of bands corresponding to LDHA, ENO1 and HK-1 in the indicated conditions.
View article: Supplementary Figure S6 from NEDDylation Regulates CD8<sup>+</sup> T-cell Metabolism and Antitumor Immunity
Supplementary Figure S6 from NEDDylation Regulates CD8<sup>+</sup> T-cell Metabolism and Antitumor Immunity Open
The reduced anti-tumor function of NAE1-KO CD8+ T cells is confirmed by additional tumor-challenge experiments and antigen-specific assays.
View article: Supplementary Table S4 from NEDDylation Regulates CD8<sup>+</sup> T-cell Metabolism and Antitumor Immunity
Supplementary Table S4 from NEDDylation Regulates CD8<sup>+</sup> T-cell Metabolism and Antitumor Immunity Open
NEDD8 targets in CD8+ T cells: proteomic analysis.
View article: Supplementary Figure S3 from NEDDylation Regulates CD8<sup>+</sup> T-cell Metabolism and Antitumor Immunity
Supplementary Figure S3 from NEDDylation Regulates CD8<sup>+</sup> T-cell Metabolism and Antitumor Immunity Open
Inhibition of NEDDylation induces a viability impairment in mouse and human CD8+ T cells, as well as an accumulation of cell cycle regulators WEE-1, P21 and P27.
View article: Supplementary Figure S5 from NEDDylation Regulates CD8<sup>+</sup> T-cell Metabolism and Antitumor Immunity
Supplementary Figure S5 from NEDDylation Regulates CD8<sup>+</sup> T-cell Metabolism and Antitumor Immunity Open
NEDDylation is a relevant agent in exhausted CD8+ T cells.
View article: Effects of Different Titanium Anodized Surfaces on Peri-Implant Soft Tissue Healing Around Dental Abutments: In Vitro and Proteomic Study
Effects of Different Titanium Anodized Surfaces on Peri-Implant Soft Tissue Healing Around Dental Abutments: In Vitro and Proteomic Study Open
Objectives: This study aimed to evaluate the effects of different titanium (Ti) anodized surfaces on soft tissue healing around dental implant abutments. Methods: Discs of machined (MC), pink anodized (PA) and yellow anodized (YA) surfaces…
View article: Differences in the proteomic profiles of the eutopic endometrium in patients with internal and external adenomyosis
Differences in the proteomic profiles of the eutopic endometrium in patients with internal and external adenomyosis Open
Two separate phenotypes of adenomyosis have been recognized, determined by the anatomical position of the adenomyotic lesions within the myometrium. This suggests that adenomyosis impacting the inner myometrium and that affecting the outer…
View article: Loss of UFMylation supports prostate cancer metastasis and rewires cell metabolism towards hexosamine biosynthesis
Loss of UFMylation supports prostate cancer metastasis and rewires cell metabolism towards hexosamine biosynthesis Open
The acquisition of metastatic features in tumor cells encompasses genetic and non-genetic adaptation, including reprogramming of cellular metabolism. Here we show that loss of UFMylation reroutes glucose metabolism, promotes invasive capac…
View article: Vesicular Rps6 released by astrocytes regulate local translation and enhance synaptic markers in neurons
Vesicular Rps6 released by astrocytes regulate local translation and enhance synaptic markers in neurons Open
In neurons, like in any other cell, their function often relies on the fine tuning of their protein levels, which is achieved by the balance between protein synthesis and turnover. Defects in protein homeostasis frequently leads to neurona…
View article: Structural and functional significance of <i>Aedes aegypti</i> AgBR1 flavivirus immunomodulator
Structural and functional significance of <i>Aedes aegypti</i> AgBR1 flavivirus immunomodulator Open
Zika virus (ZIKV), an arbovirus, relies on mosquitoes as vectors for its transmission. During blood feeding, mosquitoes inoculate saliva containing various proteins. Recently, AgBR1, an Aedes aegypti salivary gland protein, has gained atte…
View article: NEDDylation Regulates CD8+ T-cell Metabolism and Antitumor Immunity
NEDDylation Regulates CD8+ T-cell Metabolism and Antitumor Immunity Open
NEDDylation is a posttranslational modification whereby the ubiquitin-like molecule NEDD8 is attached to protein substrates in a process dependent on NEDD8-activating enzyme regulatory subunit (NAE1). NEDDylation is emerging as a regulator…
View article: Generation and validation of a novel multitarget small molecule in glioblastoma
Generation and validation of a novel multitarget small molecule in glioblastoma Open
View article: Cullin-RING ligase BioE3 reveals molecular-glue-induced neosubstrates and rewiring of the endogenous Cereblon ubiquitome
Cullin-RING ligase BioE3 reveals molecular-glue-induced neosubstrates and rewiring of the endogenous Cereblon ubiquitome Open
View article: The influence of amniotic membrane proteins on corneal regeneration when delivered directly or using hydrogel platforms
The influence of amniotic membrane proteins on corneal regeneration when delivered directly or using hydrogel platforms Open
Background/aims Chemical burns to the eye cause extensive ocular surface damage, often resulting in permanent visual impairment. The amniotic membrane (AM), with its regenerative properties, has shown great potential in treating such injur…