Felix Reichel
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View article: Rheological and physicochemical optimization of hydrogels as potential vitreous body substitutes for in vitro release testing
Rheological and physicochemical optimization of hydrogels as potential vitreous body substitutes for in vitro release testing Open
Due to an aging society and the associated increase in age-related eye diseases of the posterior segment of the eye, an optimized in vitro vitreous model would be beneficial to assess drug release and distribution in preclinical dosage for…
View article: Viscoelastic characterization of cells in microfluidic channels with 3D hydrodynamic focusing
Viscoelastic characterization of cells in microfluidic channels with 3D hydrodynamic focusing Open
The viscoelastic nature of biological cells has emerged as an increasingly important research subject due to its relevance for cellular functions under physiological and pathological conditions. Advancements in microfluidics have made this…
View article: Author Correction: Cytoskeleton-functionalized synthetic cells with life-like mechanical features and regulated membrane dynamicity
Author Correction: Cytoskeleton-functionalized synthetic cells with life-like mechanical features and regulated membrane dynamicity Open
View article: Cytoskeleton-functionalized synthetic cells with life-like mechanical features and regulated membrane dynamicity
Cytoskeleton-functionalized synthetic cells with life-like mechanical features and regulated membrane dynamicity Open
The cytoskeleton is a crucial determinant of mammalian cell structure and function, providing mechanical resilience, supporting the cell membrane and orchestrating essential processes such as cell division and motility. Because of its fund…
View article: High-throughput viscoelastic characterization of cells in hyperbolic microchannels
High-throughput viscoelastic characterization of cells in hyperbolic microchannels Open
We use hyperbolic microchannels to create a flow field with linearly increasing velocity, leading to a constant tensile stress to probe the viscoelastic properties of cells. We verify our approach on oil droplets and polyacrylamide beads.
View article: High-throughput viscoelastic characterization of cells in hyperbolic microchannels
High-throughput viscoelastic characterization of cells in hyperbolic microchannels Open
Extensive research has demonstrated the potential of cell viscoelastic properties as intrinsic indicators of cell state, functionality, and disease. For this, several microfluidic techniques have been developed to measure cell viscoelastic…
View article: Effective viscosity of methyl cellulose solutions in phosphate buffered saline in real-time deformability cytometry
Effective viscosity of methyl cellulose solutions in phosphate buffered saline in real-time deformability cytometry Open
Here, we derive the equations to calculate the effective viscosity of solutions of methyl cellulose (MC) dissolved in phosphate buffered saline (PBS) in real-time deformability cytometry (RT-DC) experiments. The calculations are based on t…
View article: HyperDC Figure 5: Viscoelasticity of HL60 cells with Latrunculin B treatment
HyperDC Figure 5: Viscoelasticity of HL60 cells with Latrunculin B treatment Open
This dataset contains the raw measurement data for the measurements on HL60 cells with Latrunculin B treatmet in Reichel et al. "High-throughput viscoelastic characterization of cells in hyperbolic microchannels" (Fig. 5A-D), https://www.b…
View article: HyperDC Figure 5: Viscoelasticity of HL60 cells with Latrunculin B and Nocodazole treatment
HyperDC Figure 5: Viscoelasticity of HL60 cells with Latrunculin B and Nocodazole treatment Open
This dataset contains the raw measurement data for the measurements on HL60 cells with Latrunculin B and Nocodazole treatment in Reichel et al. "High-throughput viscoelastic characterization of cells in hyperbolic microchannels" (Fig. 5E-G…
View article: HyperDC Figure 4: PAAm beads viscoelasticity
HyperDC Figure 4: PAAm beads viscoelasticity Open
This dataset contains the raw measurement data for the viscoelasticity of PAAm beads described in Reichel et al. "High-throughput viscoelastic characterization of cells in hyperbolic microchannels" (Fig. 4), https://www.biorxiv.org/content…
View article: HyperDC Figure 5: Viscoelasticity of HL60 cells with Latrunculin B treatment
HyperDC Figure 5: Viscoelasticity of HL60 cells with Latrunculin B treatment Open
This dataset contains the raw measurement data for the measurements on HL60 cells with Latrunculin B treatmet in Reichel et al. "High-throughput viscoelastic characterization of cells in hyperbolic microchannels" (Fig. 5A-D), https://www.b…
View article: A new hyperelastic lookup table for RT-DC
A new hyperelastic lookup table for RT-DC Open
An improved lookup table is introduced based on three-dimensional finite element simulations with a hyperelastic neo-Hookean solid and non-Newtonian fluid to extract the cell stiffness in real-time deformability cytometry (RT-DC).
View article: HyperDC Figure 2: PAAm bead stress measurements
HyperDC Figure 2: PAAm bead stress measurements Open
This dataset contains the raw measurement data for the stress measurements using PAAm beads described in Reichel et al. "High-throughput viscoelastic characterization of cells in hyperbolic microchannels" (Fig. 2), https://www.biorxiv.org/…
View article: HyperDC Figure 2: PAAm bead stress measurements - 1
HyperDC Figure 2: PAAm bead stress measurements - 1 Open
This dataset contains the raw measurement data for the stress measurements using PAAm beads described in Reichel et al. "High-throughput viscoelastic characterization of cells in hyperbolic microchannels" (Fig. 2), https://www.biorxiv.org/…
View article: HyperDC Figure 3: Mechanics of silicone oil droplets
HyperDC Figure 3: Mechanics of silicone oil droplets Open
This dataset contains the raw measurement data for the silicone oil droplet measurements in Reichel et al. "High-throughput viscoelastic characterization of cells in hyperbolic microchannels" (Fig. 3), https://www.biorxiv.org/content/10.11…
View article: HyperDC Figure 5: Viscoelasticity of HL60 cells with Latrunculin B treatment
HyperDC Figure 5: Viscoelasticity of HL60 cells with Latrunculin B treatment Open
This dataset contains the raw measurement data for the measurements on HL60 cells with Latrunculin B treatmet in Reichel et al. "High-throughput viscoelastic characterization of cells in hyperbolic microchannels" (Fig. 5A-D), https://www.b…
View article: Shear rheology of methyl cellulose based solutions for cell mechanical measurements at high shear rates
Shear rheology of methyl cellulose based solutions for cell mechanical measurements at high shear rates Open
Methyl cellulose solutions that are commonly used for cell mechanical measurements were characterized in three rheometers. We found shear thinning behavior but also normal stress differences indicating the viscoelasticity of the solutions.
View article: HyperDC Figure 5: Viscoelasticity of HL60 cells with Latrunculin B treatment
HyperDC Figure 5: Viscoelasticity of HL60 cells with Latrunculin B treatment Open
This dataset contains the raw measurement data for the measurements on HL60 cells with Latrunculin B treatmet in Reichel et al. "High-throughput viscoelastic characterization of cells in hyperbolic microchannels" (Fig. 5A-D), https://www.b…
View article: HyperDC Figure 2: PAAm bead stress measurements
HyperDC Figure 2: PAAm bead stress measurements Open
This dataset contains the raw measurement data for the stress measurements using PAAm beads described in Reichel et al. "High-throughput viscoelastic characterization of cells in hyperbolic microchannels" (Fig. 2), https://www.biorxiv.org/…
View article: HyperDC Figure 5: Viscoelasticity of HL60 cells with Latrunculin B and Nocodazole treatment
HyperDC Figure 5: Viscoelasticity of HL60 cells with Latrunculin B and Nocodazole treatment Open
This dataset contains the raw measurement data for the measurements on HL60 cells with Latrunculin B and Nocodazole treatment in Reichel et al. "High-throughput viscoelastic characterization of cells in hyperbolic microchannels" (Fig. 5E-G…
View article: HyperDC Figure 5: Viscoelasticity of HL60 cells with Latrunculin B treatment
HyperDC Figure 5: Viscoelasticity of HL60 cells with Latrunculin B treatment Open
This dataset contains the raw measurement data for the measurements on HL60 cells with Latrunculin B treatmet in Reichel et al. "High-throughput viscoelastic characterization of cells in hyperbolic microchannels" (Fig. 5A-D), https://www.b…
View article: HyperDC Figure 5: Viscoelasticity of HL60 cells with Latrunculin B treatment
HyperDC Figure 5: Viscoelasticity of HL60 cells with Latrunculin B treatment Open
This dataset contains the raw measurement data for the measurements on HL60 cells with Latrunculin B treatmet in Reichel et al. "High-throughput viscoelastic characterization of cells in hyperbolic microchannels" (Fig. 5A-D), https://www.b…
View article: HyperDC Figure 5: Viscoelasticity of HL60 cells with Latrunculin B and Nocodazole treatment
HyperDC Figure 5: Viscoelasticity of HL60 cells with Latrunculin B and Nocodazole treatment Open
This dataset contains the raw measurement data for the measurements on HL60 cells with Latrunculin B and Nocodazole treatment in Reichel et al. "High-throughput viscoelastic characterization of cells in hyperbolic microchannels" (Fig. 5E-G…
View article: HyperDC Figure 4: PAAm beads viscoelasticity
HyperDC Figure 4: PAAm beads viscoelasticity Open
This dataset contains the raw measurement data for the viscoelasticity of PAAm beads described in Reichel et al. "High-throughput viscoelastic characterization of cells in hyperbolic microchannels" (Fig. 4), https://www.biorxiv.org/content…
View article: HyperDC Figure 5: Viscoelasticity of HL60 cells with Latrunculin B treatment
HyperDC Figure 5: Viscoelasticity of HL60 cells with Latrunculin B treatment Open
This dataset contains the raw measurement data for the measurements on HL60 cells with Latrunculin B treatmet in Reichel et al. "High-throughput viscoelastic characterization of cells in hyperbolic microchannels" (Fig. 5A-D), https://www.b…
View article: Shear rheology of methyl cellulose based solutions for cell mechanical measurements at high shear rates
Shear rheology of methyl cellulose based solutions for cell mechanical measurements at high shear rates Open
Methyl cellulose (MC) is a widely used material in various microfluidic applications in biology. Due to its biocompatibility, it has become a popular crowding agent for microfluidic cell deformability measurements, which usually operate at…
View article: A New Hyperelastic Lookup Table for RT-DC
A New Hyperelastic Lookup Table for RT-DC Open
Real-time deformability cytometry (RT-DC) is an established method that quantifies features like size, shape, and stiffness for whole cell populations on a single-cell level in real time. To extract the cell stiffness, a lookup table (LUT)…
View article: Extreme compression of sentence-transformer ranker models: faster inference, longer battery life, and less storage on edge devices
Extreme compression of sentence-transformer ranker models: faster inference, longer battery life, and less storage on edge devices Open
Modern search systems use several large ranker models with transformer architectures. These models require large computational resources and are not suitable for usage on devices with limited computational resources. Knowledge distillation…
View article: Changes in Blood Cell Deformability in Chorea-Acanthocytosis and Effects of Treatment With Dasatinib or Lithium
Changes in Blood Cell Deformability in Chorea-Acanthocytosis and Effects of Treatment With Dasatinib or Lithium Open
Misshaped red blood cells (RBCs), characterized by thorn-like protrusions known as acanthocytes, are a key diagnostic feature in Chorea-Acanthocytosis (ChAc), a rare neurodegenerative disorder. The altered RBC morphology likely influences …
View article: Hyperelastic Lookup Table for Real-Time Deformability Cytometry (RT-DC)
Hyperelastic Lookup Table for Real-Time Deformability Cytometry (RT-DC) Open
Hyperelastic Lookup Table for Real-Time Deformability Cytometry (RT-DC) Background In real-time deformability cytometry (RT-DC), the area and the deformation of a sphere in a microfluidic channel at high flow rates can be translated into …