Felix Freuler
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View article: Dual BACH1 regulation by complementary SCF-type E3 ligases
Dual BACH1 regulation by complementary SCF-type E3 ligases Open
Broad-complex, tramtrack, and bric-à-brac domain (BTB) and CNC homolog 1 (BACH1) is a key regulator of the cellular oxidative stress response and an oncogene that undergoes tight post-translational control by two distinct F-box ubiquitin l…
View article: Development of a p62 biodegrader for autophagy targeted degradation
Development of a p62 biodegrader for autophagy targeted degradation Open
Harnessing autophagy for targeted degradation is a promising extension to proteasome-based targeted protein degradation because of the capacity and versatility of lysosomes to degrade large and complex cargo, thus broadening the scope of t…
View article: Structural basis of dual BACH1 regulation by SCF<sup>FBXO22</sup>and SCF<sup>FBXL17</sup>
Structural basis of dual BACH1 regulation by SCF<sup>FBXO22</sup>and SCF<sup>FBXL17</sup> Open
Summary BTB and CNC homolog 1 (BACH1) is a master transcriptional regulator of the cellular oxidative stress response and pro-metastatic oncogene. Post-translational stability of BACH1 is tightly regulated by distinct F-box ubiquitin ligas…
View article: Small molecule induced STING degradation facilitated by the HECT ligase HERC4
Small molecule induced STING degradation facilitated by the HECT ligase HERC4 Open
Stimulator of interferon genes (STING) is a central component of the cytosolic nucleic acids sensing pathway and as such master regulator of the type I interferon response. Due to its critical role in physiology and its’ involvement in a v…
View article: A novel HERC4-dependent glue degrader targeting STING
A novel HERC4-dependent glue degrader targeting STING Open
Stimulator of interferon genes (STING) is a central component of the pathway sensing the presence of cytosolic nucleic acids, having a key role in type I interferon innate immune response. Localized at the endoplasmic reticulum (ER), STING…
View article: PAX8 and MECOM are interaction partners driving Ovarian Carcinogenesis
PAX8 and MECOM are interaction partners driving Ovarian Carcinogenesis Open
The transcription factor PAX8 is critical for the development of the thyroid and urogenital system. Comprehensive genomic screens furthermore indicate an additional oncogenic role for PAX8 in renal and ovarian carcinogenesis. While a pleth…
View article: Two Antagonistic MALT1 Auto-Cleavage Mechanisms Reveal a Role for TRAF6 to Unleash MALT1 Activation
Two Antagonistic MALT1 Auto-Cleavage Mechanisms Reveal a Role for TRAF6 to Unleash MALT1 Activation Open
The paracaspase MALT1 has arginine-directed proteolytic activity triggered by engagement of immune receptors. Recruitment of MALT1 into activation complexes is required for MALT1 proteolytic function. Here, co-expression of MALT1 in HEK293…
View article: High Throughput Random Mutagenesis and Single Molecule Real Time Sequencing of the Muscle Nicotinic Acetylcholine Receptor
High Throughput Random Mutagenesis and Single Molecule Real Time Sequencing of the Muscle Nicotinic Acetylcholine Receptor Open
High throughput random mutagenesis is a powerful tool to identify which residues are important for the function of a protein, and gain insight into its structure-function relation. The human muscle nicotinic acetylcholine receptor was used…