Felix Girrbach
YOU?
Author Swipe
View article: Prediction of Postoperative ICU Requirements: Closing the Translational Gap with a Real-World Clinical Benchmark for Artificial Intelligence Approaches
Prediction of Postoperative ICU Requirements: Closing the Translational Gap with a Real-World Clinical Benchmark for Artificial Intelligence Approaches Open
Background: Accurate prediction of postoperative care requirements is critical for patient safety and resource allocation. Although numerous approaches involving artificial intelligence (AI) and machine learning (ML) have been proposed to …
View article: Impact of Obesity on Serum Concentrations of Vancomycin Administered as Continuous Infusion and on Clinical Outcomes in Critically Ill Patients—A Retrospective Observational Study
Impact of Obesity on Serum Concentrations of Vancomycin Administered as Continuous Infusion and on Clinical Outcomes in Critically Ill Patients—A Retrospective Observational Study Open
Background/Objectives: Vancomycin is a commonly used antibiotic in critically ill patients with severe methicillin-resistant Staphylococcus aureus infections. Due to its narrow therapeutic window, under- or overdosing is likely to result i…
View article: Can Machine Learning Methods Improve the Prediction of Postoperative ICU Requirements? Real-World Evidence and Practical Implications
Can Machine Learning Methods Improve the Prediction of Postoperative ICU Requirements? Real-World Evidence and Practical Implications Open
Accurate prediction of postoperative care requirements following elective surgical procedures is of central importance from both medical and organizational perspectives. Although machine learning (ML) methods have been developed to support…
View article: Die neue britische Leitlinie zur Rettung von Personen nach Verkehrsunfällen – Vorstellung und Diskussion
Die neue britische Leitlinie zur Rettung von Personen nach Verkehrsunfällen – Vorstellung und Diskussion Open
Zusammenfassung Verkehrsunfälle mit Kraftfahrzeugen stellen weltweit eine der häufigsten Todesursachen dar. Trotz notfallmedizinischer und feuerwehrtechnischer Fortschritte blieb der Prozess der Rettung von Traumapatient:innen aus verunfal…
View article: Local Anesthetic Infiltration, Awake Veno-Venous Extracorporeal Membrane Oxygenation, and Airway Management for Resection of a Giant Mediastinal Cyst: A Narrative Review and Case Report
Local Anesthetic Infiltration, Awake Veno-Venous Extracorporeal Membrane Oxygenation, and Airway Management for Resection of a Giant Mediastinal Cyst: A Narrative Review and Case Report Open
Background: Mediastinal mass syndrome represents a major threat to respiratory and cardiovascular integrity, with difficult evidence-based risk stratification for interdisciplinary management. Methods: We conducted a narrative review conce…
View article: Electrical Impedance Tomography-Based Evaluation of Anesthesia-Induced Development of Atelectasis in Obese Patients
Electrical Impedance Tomography-Based Evaluation of Anesthesia-Induced Development of Atelectasis in Obese Patients Open
Background/Objectives: The induction of general anesthesia leads to the development of atelectasis and redistribution of ventilation to non-dependent lung regions with subsequent impairment of gas exchange. However, it remains unclear how …
View article: Correction: Percutaneous hepatic melphalan perfusion: Single center experience of procedural characteristics, hemodynamic response, complications, and postoperative recovery
Correction: Percutaneous hepatic melphalan perfusion: Single center experience of procedural characteristics, hemodynamic response, complications, and postoperative recovery Open
[This corrects the article DOI: 10.1371/journal.pone.0254817.].
View article: Innovative Regional Services and Heterogeneous Communication Channels: Results from the Nationwide German egePan Project for Pandemic Management
Innovative Regional Services and Heterogeneous Communication Channels: Results from the Nationwide German egePan Project for Pandemic Management Open
Background: In the COVID-19 pandemic, novel regional services and communication channels emerged across all sectors of the German healthcare system. To contribute to pandemic preparedness, this study aims to describe newly established serv…
View article: When too much closeness harms: circumflex artery injury during mitral valve surgery
When too much closeness harms: circumflex artery injury during mitral valve surgery Open
Occlusion of the left coronary circumflex artery (LCX) during surgical procedures of the mitral valve is an infrequent but potentially life-threatening complication ( 1 – 3 ). Due to its close anatomical relationship to the posterior mitra…
View article: High positive end-expiratory pressure ventilation mitigates the progression from unilateral pulmonary contusion to ARDS: An animal study
High positive end-expiratory pressure ventilation mitigates the progression from unilateral pulmonary contusion to ARDS: An animal study Open
BACKGROUND Pulmonary contusion (PC) is common in severely traumatized patients and can lead to respiratory failure requiring mechanical ventilation (MV). Ventilator-induced lung injury (VILI) might aggravate lung damage. Despite underrepre…
View article: Radioaktivität im Rettungsdienst
Radioaktivität im Rettungsdienst Open
View article: Anästhesiologisches und postinterventionelles Management bei perkutaner hepatischer Melphalanperfusion (Chemosaturation)
Anästhesiologisches und postinterventionelles Management bei perkutaner hepatischer Melphalanperfusion (Chemosaturation) Open
View article: Chest Tube Placement in Mechanically Ventilated Trauma Patients: Differences between Computed Tomography-Based Indication and Clinical Decision
Chest Tube Placement in Mechanically Ventilated Trauma Patients: Differences between Computed Tomography-Based Indication and Clinical Decision Open
The rate of occult pneumothorax in intubated and mechanically ventilated trauma patients until initial computed tomography (CT) remains undetermined. The primary aims of this study were to analyze initial chest CTs with respect to the thor…
View article: Methods for Determination of Individual PEEP for Intraoperative Mechanical Ventilation Using a Decremental PEEP Trial
Methods for Determination of Individual PEEP for Intraoperative Mechanical Ventilation Using a Decremental PEEP Trial Open
(1) Background: Individual PEEP settings (PEEPIND) may improve intraoperative oxygenation and optimize lung mechanics. However, there is uncertainty concerning the optimal procedure to determine PEEPIND. In this secondary analysis of a ran…
View article: Central COVID-19 Coordination Centers in Germany: Description, Economic Evaluation, and Systematic Review
Central COVID-19 Coordination Centers in Germany: Description, Economic Evaluation, and Systematic Review Open
Background During the COVID-19 pandemic, Central COVID-19 Coordination Centers (CCCCs) have been established at several hospitals across Germany with the intention to assist local health care professionals in efficiently referring patients…
View article: Central COVID-19 Coordination Centers in Germany: Description, Economic Evaluation, and Systematic Review (Preprint)
Central COVID-19 Coordination Centers in Germany: Description, Economic Evaluation, and Systematic Review (Preprint) Open
BACKGROUND During the COVID-19 pandemic, Central COVID-19 Coordination Centers (CCCCs) have been established at several hospitals across Germany with the intention to assist local health care professionals in efficiently referring patient…
View article: Percutaneous hepatic melphalan perfusion: Single center experience of procedural characteristics, hemodynamic response, complications, and postoperative recovery
Percutaneous hepatic melphalan perfusion: Single center experience of procedural characteristics, hemodynamic response, complications, and postoperative recovery Open
Background Percutaneous hepatic melphalan perfusion (PHMP) for the selective treatment of hepatic metastases is known to be associated with procedural hypotension and coagulation disorders. Studies on anesthetic management, perioperative c…
View article: Individualized versus Fixed Positive End-expiratory Pressure for Intraoperative Mechanical Ventilation in Obese Patients: A Secondary Analysis
Individualized versus Fixed Positive End-expiratory Pressure for Intraoperative Mechanical Ventilation in Obese Patients: A Secondary Analysis Open
Background General anesthesia may cause atelectasis and deterioration in oxygenation in obese patients. The authors hypothesized that individualized positive end-expiratory pressure (PEEP) improves intraoperative oxygenation and ventilatio…
View article: Meropenem Plasma and Interstitial Soft Tissue Concentrations in Obese and Nonobese Patients—A Controlled Clinical Trial
Meropenem Plasma and Interstitial Soft Tissue Concentrations in Obese and Nonobese Patients—A Controlled Clinical Trial Open
Background: This controlled clinical study aimed to investigate the impact of obesity on plasma and tissue pharmacokinetics of meropenem. Methods: Obese (body mass index (BMI) ≥ 35 kg/m2) and age-/sex-matched nonobese (18.5 kg/m2 ≥ BMI ≤ 3…
View article: Individualized versus Standard Positive End-Expiratory Pressure for Intraoperative Mechanical Ventilation in Morbidly Obese Patients - A Prospective Secondary Sub-Analysis of Two Randomized Controlled Trials
Individualized versus Standard Positive End-Expiratory Pressure for Intraoperative Mechanical Ventilation in Morbidly Obese Patients - A Prospective Secondary Sub-Analysis of Two Randomized Controlled Trials Open
View article: Linezolid Concentrations in Plasma and Subcutaneous Tissue are Reduced in Obese Patients, Resulting in a Higher Risk of Underdosing in Critically Ill Patients: A Controlled Clinical Pharmacokinetic Study
Linezolid Concentrations in Plasma and Subcutaneous Tissue are Reduced in Obese Patients, Resulting in a Higher Risk of Underdosing in Critically Ill Patients: A Controlled Clinical Pharmacokinetic Study Open
Background: Linezolid is used for the treatment of soft tissue infections in critically ill patients. However, data for characterizing the pharmacokinetics (PK) and assessing whether effective concentrations are reached at the target site …
View article: Detection of posttraumatic pneumothorax using electrical impedance tomography—An observer-blinded study in pigs with blunt chest trauma
Detection of posttraumatic pneumothorax using electrical impedance tomography—An observer-blinded study in pigs with blunt chest trauma Open
In our analysis, visual interpretation of EIT without specific image processing or comparison with baseline data did not allow clinically useful diagnosis of posttraumatic PTX. Multimodal imaging approaches, technical improvements and imag…
View article: A Modified Method to Assess Tidal Recruitment by Electrical Impedance Tomography
A Modified Method to Assess Tidal Recruitment by Electrical Impedance Tomography Open
Avoiding tidal recruitment and collapse during mechanical ventilation should reduce the risk of lung injury. Electrical impedance tomography (EIT) enables detection of tidal recruitment by measuring regional ventilation delay inhomogeneity…
View article: Optimizing intraoperative ventilation during one-lung ventilation—is individualization the road to success?
Optimizing intraoperative ventilation during one-lung ventilation—is individualization the road to success? Open
Avoiding ventilator associated lung injury in surgical patients requiring general anesthesia is a primary focus of anesthetic research—mechanical ventilation should not induce further harm. With the knowledge gained from important clinical…
View article: Detection of patient-ventilator asynchrony should be improved: and then what?
Detection of patient-ventilator asynchrony should be improved: and then what? Open
Invasive mechanical ventilation often saves the lives of patients suffering from acute respiratory distress. Placement and maintenance of an endotracheal airway usually requires sedation and analgesia, which generally results in cessation …