Felix J. Frey
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View article: Author response: Balancing stability and flexibility when reshaping archaeal membranes
Author response: Balancing stability and flexibility when reshaping archaeal membranes Open
View article: Balancing stability and flexibility when reshaping archaeal membranes
Balancing stability and flexibility when reshaping archaeal membranes Open
Cellular membranes differ across the tree of life. In most bacteria and eukaryotes, single-headed lipids self-assemble into flexible bilayer membranes. By contrast, thermophilic archaea tend to possess bilayer lipids together with double-h…
View article: Stability vs flexibility: reshaping archaeal membranes in silico
Stability vs flexibility: reshaping archaeal membranes in silico Open
Cellular membranes differ across the tree of life. In most bacteria and eukaryotes, single-headed lipids self-assemble into flexible bilayer membranes. By contrast, thermophilic archaea tend to possess bilayer lipids together with double-h…
View article: Author response: Stability vs flexibility: reshaping archaeal membranes in silico
Author response: Stability vs flexibility: reshaping archaeal membranes in silico Open
View article: Stability vs flexibility: reshaping archaeal membranes in silico
Stability vs flexibility: reshaping archaeal membranes in silico Open
Across the tree of life, distinct designs of cellular membranes have evolved. In bacteria and eukaryotes single-headed lipids self-assemble into flexible bilayer membranes. By contrast, archaea often possess double-headed, monolayer spanni…
View article: Balancing stability and flexibility when reshaping archaeal membranes
Balancing stability and flexibility when reshaping archaeal membranes Open
Cellular membranes differ across the tree of life. In most bacteria and eukaryotes, single-headed lipids self-assemble into flexible bilayer membranes. By contrast, thermophilic archaea tend to possess bilayer lipids together with double-h…
View article: A tutorial for mesoscale computer simulations of lipid membranes: tether pulling, tubulation and fluctuation
A tutorial for mesoscale computer simulations of lipid membranes: tether pulling, tubulation and fluctuation Open
Lipid membranes and membrane deformations are a long-standing area of research in soft matter and biophysics. Computer simulations have complemented analytical and experimental approaches as one of the pillars in the field. However, settin…
View article: A tutorial for mesoscale computer simulations of lipid membranes: tether pulling, tubulation and fluctuations
A tutorial for mesoscale computer simulations of lipid membranes: tether pulling, tubulation and fluctuations Open
A tutorial review on mesoscale computer simulations of fluid lipid membranes presenting three tutorials with repositories of ready-to-run codes for tether pulling, membrane tubulation and membrane fluctuation analysis.
View article: Whole-Exome Sequencing, Mutational Signature Analysis, and Outcome in Multiple Myeloma—A Pilot Study
Whole-Exome Sequencing, Mutational Signature Analysis, and Outcome in Multiple Myeloma—A Pilot Study Open
The complex and heterogeneous genomic landscape of multiple myeloma (MM) and many of its clinical and prognostic implications remains to be understood. In other cancers, such as breast cancer, using whole-exome sequencing (WES) and molecul…
View article: Endosomal membrane budding patterns in plants
Endosomal membrane budding patterns in plants Open
Multivesicular endosomes (MVEs) sequester membrane proteins destined for degradation within intralumenal vesicles (ILVs), a process mediated by the membrane-remodeling action of Endosomal Sorting Complex Required for Transport (ESCRT) prot…
View article: Electron tomograms of high-pressure frozen-freeze substituted multivesicular endosomes
Electron tomograms of high-pressure frozen-freeze substituted multivesicular endosomes Open
View article: Coat stiffening can explain invagination of clathrin-coated membranes
Coat stiffening can explain invagination of clathrin-coated membranes Open
Clathrin-mediated endocytosis is the main pathway used by eukaryotic cells to take up extracellular material, but the dominant physical mechanisms driving this process are still elusive. Recently several high-resolution imaging techniques …
View article: Branched actin cortices reconstituted in vesicles sense membrane curvature
Branched actin cortices reconstituted in vesicles sense membrane curvature Open
View article: Biomimetic actin cortices shape cell-sized lipid vesicles
Biomimetic actin cortices shape cell-sized lipid vesicles Open
Animal cells are shaped by a thin layer of actin filaments underneath the plasma membrane known as the actin cortex. This cortex stiffens the cell surface and thus opposes cellular deformation, yet also actively generates membrane protrusi…
View article: Clathrin coats partially preassemble and subsequently bend during endocytosis
Clathrin coats partially preassemble and subsequently bend during endocytosis Open
Eukaryotic cells use clathrin-mediated endocytosis to take up a large range of extracellular cargo. During endocytosis, a clathrin coat forms on the plasma membrane, but it remains controversial when and how it is remodeled into a spherica…
View article: A systematic review and comparison of automated tools for quantification of fibrous networks
A systematic review and comparison of automated tools for quantification of fibrous networks Open
Fibrous networks are essential structural components of biological and engineered materials. Accordingly, many approaches have been developed to quantify their structural properties, which define their material properties. However, a compr…
View article: A systematic review and comparison of automated tools for quantification of fibrous networks
A systematic review and comparison of automated tools for quantification of fibrous networks Open
Fibrous networks are essential structural components of biological and engineered materials. Accordingly, many approaches have been developed to quantify their structural properties, which define their material properties. However, a compr…
View article: Reconstituted branched actin networks sense and generate micron-scale membrane curvature
Reconstituted branched actin networks sense and generate micron-scale membrane curvature Open
The actin cortex is a complex cytoskeletal machinery which drives and responds to changes in cell shape. It must generate or adapt to plasma membrane curvature to facilitate diverse functions such as cell division, migration and phagocytos…
View article: Membrane area gain and loss during cytokinesis
Membrane area gain and loss during cytokinesis Open
In cytokinesis of animal cells, the cell is symmetrically divided into two. Since the cell's volume is conserved, the projected area has to increase to allow for the change of shape. Here we aim to predict how membrane gain and loss adapt …
View article: Superresolution microscopy reveals partial preassembly and subsequent bending of the clathrin coat during endocytosis
Superresolution microscopy reveals partial preassembly and subsequent bending of the clathrin coat during endocytosis Open
Eukaryotic cells use clathrin-mediated endocytosis to take up a large range of extracellular cargos. During endocytosis, a clathrin coat forms on the plasma membrane, but it remains controversial when and how it is remodeled into a spheric…
View article: Global strategy for the conservation and use of Vanilla genetic resources
Global strategy for the conservation and use of Vanilla genetic resources Open
This report aims to provide a framework for the efficient and effective ex situ conservation and use of Vanilla genetic resources at global level.
View article: More than just a barrier: using physical models to couple membrane shape to cell function
More than just a barrier: using physical models to couple membrane shape to cell function Open
Physical models can help us to infer, from the shape of the outer membrane, which biological processes happen inside the living cell.
View article: Eden growth models for flat clathrin lattices with vacancies
Eden growth models for flat clathrin lattices with vacancies Open
Clathrin-mediated endocytosis is one of the major pathways by which cells internalise cargo molecules. Recently it has been shown that clathrin triskelia can first assemble as flat lattices before the membrane starts to bend. However, for …
View article: Forces during cellular uptake of viruses and nanoparticles at the ventral side
Forces during cellular uptake of viruses and nanoparticles at the ventral side Open
View article: Dynamics of particle uptake at cell membranes
Dynamics of particle uptake at cell membranes Open
Receptor-mediated endocytosis requires that the energy of adhesion overcomes the deformation energy of the plasma membrane. The resulting driving force is balanced by dissipative forces, leading to deterministic dynamical equations. While …
View article: Stochastic Dynamics of Nanoparticle and Virus Uptake
Stochastic Dynamics of Nanoparticle and Virus Uptake Open
The cellular uptake of nanoparticles or viruses requires that the gain of adhesion energy overcomes the cost of plasma membrane bending. It is well known that this leads to a minimal particle size for uptake. Using a simple deterministic t…
View article: Clathrin-adaptor ratio and membrane tension regulate the flat-to-curved transition of the clathrin coat during endocytosis
Clathrin-adaptor ratio and membrane tension regulate the flat-to-curved transition of the clathrin coat during endocytosis Open
Although essential for many cellular processes, the sequence of structural and molecular events during clathrin-mediated endocytosis remains elusive. While it was long believed that clathrin-coated pits grow with a constant curvature, it w…
View article: Modeling the Flat to Curved Transition during Clathrin Mediated Endocytosis
Modeling the Flat to Curved Transition during Clathrin Mediated Endocytosis Open
View article: Clathrin-adaptor ratio and membrane tension regulate the flat-to-curved transition of the clathrin coat during endocytosis
Clathrin-adaptor ratio and membrane tension regulate the flat-to-curved transition of the clathrin coat during endocytosis Open
Dataset used in 'Clathrin-adaptor ratio and membrane tension regulate the flat-to-curved transition of the clathrin coat during endocytosis'
View article: Ein Fall für eine Public-Private-Partnership-Strategie
Ein Fall für eine Public-Private-Partnership-Strategie Open
Der Übergang von Erkenntnissen der Grundlagenforschung und der industriellen Entwicklung in klinisch nützliche Produkte harzt weltweit. Gründe sind die Komplexität des Translationsprozesses, die unabdingbare Interaktion von Playern verschi…