Felix Kaspar
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View article: High-Throughput Profiling of Prenylelongases Enables the Assembly of Modified Prenoids
High-Throughput Profiling of Prenylelongases Enables the Assembly of Modified Prenoids Open
Modified (non-natural) prenoids are useful as chemical biology tools, designer fragrances and building blocks of bioactive compounds. However, their laborious synthesis generally limits their widespread application. Although prenylelongase…
View article: Engineering of Conserved Sequence Motif 1 Residues in Halohydrin Dehalogenase HheC Simultaneously Enhances Activity, Stability, and Enantioselectivity
Engineering of Conserved Sequence Motif 1 Residues in Halohydrin Dehalogenase HheC Simultaneously Enhances Activity, Stability, and Enantioselectivity Open
Halohydrin dehalogenases (HHDHs) are powerful enzymes for the asymmetric diversification of oxyfunctionalized synthons. They feature two characteristic sequence motifs that distinguish them from homologous short-chain dehydrogenases and re…
View article: Biocatalytic Ether Lipid Synthesis by an Archaeal Glycerolprenylase
Biocatalytic Ether Lipid Synthesis by an Archaeal Glycerolprenylase Open
Although ethers are common in secondary natural products, they are an underrepresented functional group in primary metabolism. As such, there are comparably few enzymes capable of constructing ether bonds in a general fashion. However, suc…
View article: Biocatalytic Ether Lipid Synthesis by an Archaeal Glycerolprenylase
Biocatalytic Ether Lipid Synthesis by an Archaeal Glycerolprenylase Open
Although ethers are common in secondary natural products, they are an underrepresented functional group in primary metabolism. As such, there are comparably few enzymes capable of constructing ether bonds in a general fashion. However, suc…
View article: A deamination-driven biocatalytic cascade for the synthesis of ribose-1-phosphate
A deamination-driven biocatalytic cascade for the synthesis of ribose-1-phosphate Open
Ribose-1-phosphate (Rib1P) is a key substrate for the synthesis of difficult-to-access nucleoside analogues by nucleoside phosphorylases. However, its use in preparative synthesis is hampered by low yields and low selectivity during its pr…
View article: Nucleoside Phosphorylases make N7-xanthosine
Nucleoside Phosphorylases make N7-xanthosine Open
Modern, highly evolved nucleoside-processing enzymes are known to exhibit perfect regioselectivity over the glycosylation of purine nucleobases at N 9. We herein report an exception to this paradigm. Wild-type nucleoside phosphorylases als…
View article: Engineering of conserved sequence motif 1 residues in halohydrin dehalogenase HheC simultaneously enhances activity, stability and enantioselectivity
Engineering of conserved sequence motif 1 residues in halohydrin dehalogenase HheC simultaneously enhances activity, stability and enantioselectivity Open
Halohydrin dehalogenases (HHDHs) are powerful enzymes for the asymmetric diversification of oxyfunctionalized synthons. They feature two characteristic sequence motifs that distinguish them from homologous short-chain dehydrogenases and re…
View article: Biocatalytic Ether Lipid Synthesis by an Archaeal Glycerolprenylase
Biocatalytic Ether Lipid Synthesis by an Archaeal Glycerolprenylase Open
Although ethers are common in secondary natural products, they are an underrepresented functional group in primary metabolism. As such, there are comparably few enzymes capable of constructing ether bonds in a general fashion. However, suc…
View article: Biocatalytic Ether Lipid Synthesis by an Archaeal Glycerolprenylase
Biocatalytic Ether Lipid Synthesis by an Archaeal Glycerolprenylase Open
Although ethers are common in secondary natural products, they are an underrepresented functional group in primary metabolism. As such, there are comparably few enzymes capable of constructing ether bonds in a general fashion. However, suc…
View article: Supplementary Information for "Nucleoside Phosphorylases Make N7-Xanthosine, a "Non native" Regioisomer of Xanthosine"
Supplementary Information for "Nucleoside Phosphorylases Make N7-Xanthosine, a "Non native" Regioisomer of Xanthosine" Open
This is the external Supplementary Information for our publication "Nucleoside Phosphorylases Make N7-Xanthosine, a "Non native" Regioisomer of Xanthosine". The .pdf file contains the Supplementary Information: author contributions, access…
View article: Supplementary Information for "Biocatalytic Ether Lipid Synthesis by an Archaeal Glycerolprenylase" - Experimental Data
Supplementary Information for "Biocatalytic Ether Lipid Synthesis by an Archaeal Glycerolprenylase" - Experimental Data Open
This is the external Supplementary Information for our publication "Biocatalytic Ether Lipid Synthesis by an Archaeal Glycerolprenylase", freely available as a preprint from ChemRxiv (https://doi.org/10.26434/chemrxiv-2024-2lmv8-v2) and as…
View article: Supplementary Information for "Biocatalytic Ether Lipid Synthesis by an Archaeal Glycerolprenylase"
Supplementary Information for "Biocatalytic Ether Lipid Synthesis by an Archaeal Glycerolprenylase" Open
This is the external Supplementary Information for our publication "Biocatalytic Ether Lipid Synthesis by an Archaeal Glycerolprenylase", freely available as a preprint from ChemRxiv ( ). The .zip files contain the raw data and metadata fo…
View article: A deamination-driven biocatalytic cascade for the synthesis of ribose-1-phosphate
A deamination-driven biocatalytic cascade for the synthesis of ribose-1-phosphate Open
We present a sustainable biocatalytic process for the one-pot synthesis of Rib1P. By coupling a guanine deaminase to the nucleoside phosphorylase-catalysed Guo cleavage, the reaction was shifted towards almost complete Guo cleavage.
View article: Nucleoside Phosphorylases Make N7-Xanthosine, the “Non-native” Regioisomer of Xanthosine
Nucleoside Phosphorylases Make N7-Xanthosine, the “Non-native” Regioisomer of Xanthosine Open
Modern, highly evolved, nucleoside-processing enzymes are known to exhibit perfect regioselectivity over the glycosylation of purine nucleobases at N9. We herein report an exception to this paradigm. Wild-type nucleoside phosphorylases als…
View article: Supplementary Information for "Nucleoside Phosphorylases Make N7-Xanthosine, the "Non native" Regioisomer of Xanthosine"
Supplementary Information for "Nucleoside Phosphorylases Make N7-Xanthosine, the "Non native" Regioisomer of Xanthosine" Open
This is the external Supplementary Information for our publication "Nucleoside Phosphorylases Make N7-Xanthosine, the "Non native" Regioisomer of Xanthosine". The .pdf file contains the Supplementary Information: author contributions, acce…
View article: Supplementary Information for "Nucleoside Phosphorylases Make N7-Xanthosine, the "Non native" Regioisomer of Xanthosine"
Supplementary Information for "Nucleoside Phosphorylases Make N7-Xanthosine, the "Non native" Regioisomer of Xanthosine" Open
This is the external Supplementary Information for our publication "Nucleoside Phosphorylases Make N7-Xanthosine, the "Non native" Regioisomer of Xanthosine". IMPORTANT: This is only the zero version. To access the dataset, see the most re…
View article: Biased Borate Esterification during Nucleoside Phosphorylase‐Catalyzed Reactions: Apparent Equilibrium Shifts and Kinetic Implications**
Biased Borate Esterification during Nucleoside Phosphorylase‐Catalyzed Reactions: Apparent Equilibrium Shifts and Kinetic Implications** Open
Biocatalytic nucleoside (trans‐)glycosylations catalyzed by nucleoside phosphorylases have evolved into a practical and convenient approach to the preparation of modified nucleosides, which are important pharmaceuticals for the treatment o…
View article: Einseitige Borat‐Veresterung während enzymatischer Nukleosid‐phosphorolyse: Scheinbare Gleichgewichtsverschiebungen und kinetische Auswirkungen**
Einseitige Borat‐Veresterung während enzymatischer Nukleosid‐phosphorolyse: Scheinbare Gleichgewichtsverschiebungen und kinetische Auswirkungen** Open
Biokatalytische Nukleosid(trans‐)glykosylierungen mithilfe von Nukleosidphosphorylasen haben sich zu einem praktischen und bequemen Ansatz zur Herstellung von modifizierten Nukleosiden entwickelt, die wichtige Pharmazeutika für die Behandl…
View article: Quality Data from Messy Spectra: How Isometric Points Increase Information Content in Highly Overlapping Spectra
Quality Data from Messy Spectra: How Isometric Points Increase Information Content in Highly Overlapping Spectra Open
Spectroscopic techniques are immensely useful for obtaining information about chemical transformations while they are happening. However, such data are often messy, and it is challenging to extract reliable information from them without ca…
View article: Supplementary Information for "Biased Borate Esterification during Nucleoside Phosphorylase-Catalyzed Reactions: Apparent Equilibrium Shifts and Kinetic Implications"
Supplementary Information for "Biased Borate Esterification during Nucleoside Phosphorylase-Catalyzed Reactions: Apparent Equilibrium Shifts and Kinetic Implications" Open
This is the external Supplementary Information for our publication "Biased Borate Esterification during Nucleoside Phosphorylase-Catalyzed Reactions: Apparent Equilibrium Shifts and Kinetic Implications". The .zip files contains the raw da…
View article: Supplementary Information for "Biased Borate Esterification during Nucleoside Phosphorylase-Catalyzed Reactions: Apparent Equilibrium Shifts and Kinetic Implications"
Supplementary Information for "Biased Borate Esterification during Nucleoside Phosphorylase-Catalyzed Reactions: Apparent Equilibrium Shifts and Kinetic Implications" Open
This is the external Supplementary Information for our publication "Biased Borate Esterification during Nucleoside Phosphorylase-Catalyzed Reactions: Apparent Equilibrium Shifts and Kinetic Implications". The .zip files contains the raw da…
View article: G‐type Halohydrin Dehalogenases Catalyze Ring Opening Reactions of Cyclic Epoxides with Diverse Anionic Nucleophiles**
G‐type Halohydrin Dehalogenases Catalyze Ring Opening Reactions of Cyclic Epoxides with Diverse Anionic Nucleophiles** Open
Halohydrin dehalogenases are promiscuous biocatalysts, which enable asymmetric ring opening reactions of epoxides with various anionic nucleophiles. However, despite the increasing interest in such asymmetric transformations, the substrate…
View article: G-type Halohydrin Dehalogenases Catalyze Ring Opening Reactions of Cyclic Epoxides with Diverse Anionic Nucleophiles
G-type Halohydrin Dehalogenases Catalyze Ring Opening Reactions of Cyclic Epoxides with Diverse Anionic Nucleophiles Open
Halohydrin dehalogenases are promiscuous biocatalysts, which enable asymmetric ring opening reactions of epoxides with various anionic nucleophiles. However, despite the increasing interest in such asymmetric transformations, the substrate…
View article: Industrial potential of the enzymatic synthesis of nucleoside analogs: Existing challenges and perspectives
Industrial potential of the enzymatic synthesis of nucleoside analogs: Existing challenges and perspectives Open
Nucleoside phosphorylases have progressed from an enzymatic curiosity to a viable synthetic tool. However, despite the recent advances in nucleoside phosphorylase-catalyzed nucleoside synthesis, the widespread application of these enzymes …
View article: Industrial potential of the enzymatic synthesis of nucleoside analogs: Existing challenges and perspectives
Industrial potential of the enzymatic synthesis of nucleoside analogs: Existing challenges and perspectives Open
Nucleoside phosphorylases have progressed from an enzymatic curiosity to a viable synthetic tool. However, despite the recent advances in nucleoside phosphorylase-catalyzed nucleoside synthesis, the widespread application of these enzymes …
View article: Supplementary Information for "G-type Halohydrin Dehalogenases Catalyze Ring Opening Reactions of Cyclic Epoxides with Diverse Anionic Nucleophiles"
Supplementary Information for "G-type Halohydrin Dehalogenases Catalyze Ring Opening Reactions of Cyclic Epoxides with Diverse Anionic Nucleophiles" Open
This is the external Supplementary Information for our publication "G-type Halohydrin Dehalogenases Catalyze Ring Opening Reactions of Cyclic Epoxides with Diverse Anionic Nucleophiles". The .zip files contain the raw NMR data for all comp…
View article: Supplementary Information for "G-type Halohydrin Dehalogenases Catalyze Ring Opening Reactions of Cyclic Epoxides with Diverse Anionic Nucleophiles"
Supplementary Information for "G-type Halohydrin Dehalogenases Catalyze Ring Opening Reactions of Cyclic Epoxides with Diverse Anionic Nucleophiles" Open
This is the external Supplementary Information for our publication "G-type Halohydrin Dehalogenases Catalyze Ring Opening Reactions of Cyclic Epoxides with Diverse Anionic Nucleophiles". IMPORTANT: This is only the zero version. To…
View article: Supplementary Information for "G-type Halohydrin Dehalogenases Catalyze Ring Opening Reactions of Cyclic Epoxides with Diverse Anionic Nucleophiles"
Supplementary Information for "G-type Halohydrin Dehalogenases Catalyze Ring Opening Reactions of Cyclic Epoxides with Diverse Anionic Nucleophiles" Open
This is the external Supplementary Information for our publication "G-type Halohydrin Dehalogenases Catalyze Ring Opening Reactions of Cyclic Epoxides with Diverse Anionic Nucleophiles". The .zip files contain the raw NMR data for all comp…
View article: Strategic Enzymatic Transformations in Modern Natural Product Synthesis
Strategic Enzymatic Transformations in Modern Natural Product Synthesis Open
Enzymes continue to gain recognition as valuable tools in synthetic chemistry as they enable transformations, which elude conventional organochemical approaches. As such, the progressing expansion of the biocatalytic arsenal has introduced…
View article: Supplementary Information for "Biased Borate Esterification during Nucleoside Phosphorylase-Catalyzed Reactions: Apparent Equilibrium Shifts and Kinetic Implications"
Supplementary Information for "Biased Borate Esterification during Nucleoside Phosphorylase-Catalyzed Reactions: Apparent Equilibrium Shifts and Kinetic Implications" Open
This is the external Supplementary Information for our publication "Biased Borate Esterification during Nucleoside Phosphorylase-Catalyzed Reactions: Apparent Equilibrium Shifts and Kinetic Implications". The .pdf file contains the Supplem…