Felix W. Leung
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View article: Unveiling the genetic overlap and causal links between gastroesophageal reflux disease and asthma
Unveiling the genetic overlap and causal links between gastroesophageal reflux disease and asthma Open
Background: Gastroesophageal reflux disease (GERD) and asthma are commonly co-occurring conditions, with shared genetic factors identified. However, the specific loci and the influence of common genetic architecture remain undefined. Metho…
View article: Multi-Omics Analysis Reveals Potential Therapeutic Targets and Genetic Mechanisms in Primary Biliary Cholangitis
Multi-Omics Analysis Reveals Potential Therapeutic Targets and Genetic Mechanisms in Primary Biliary Cholangitis Open
Background Primary biliary cholangitis (PBC) is a chronic autoimmune liver disease with limited treatment options. This study employs multi-omics approaches to investigate its genetic mechanisms and identify potential therapeutic targets. …
View article: Atmospheric Pollutants, Cardiometabolic Disorders, and Dementia in Trajectory Analysis: A 13‐Year Longitudinal Cohort Study
Atmospheric Pollutants, Cardiometabolic Disorders, and Dementia in Trajectory Analysis: A 13‐Year Longitudinal Cohort Study Open
Background First cardiometabolic disorders (FCMDs) and dementia pose a significant burden on aging populations. Investigating the association between atmospheric pollutants and the progression of FCMDs and dementia is crucial. Methods A pr…
View article: Peripheral Designed Indigo Bola‐Amphiphiles for Supramolecular Assembled Nanoarchitectonics in Aqueous Media
Peripheral Designed Indigo Bola‐Amphiphiles for Supramolecular Assembled Nanoarchitectonics in Aqueous Media Open
Indigo, an ancient natural dye, featured excellent biodegradability to advance in sustainable polymer. Indigo amphiphiles can pave a way for sustainable supramolecular polymers in aqueous media for potential biomedical functional materials…
View article: Plasma proteomic profiles in diverse populations identify biomarkers predicting metabolic dysfunction-associated steatotic liver disease up to 16 years before onset
Plasma proteomic profiles in diverse populations identify biomarkers predicting metabolic dysfunction-associated steatotic liver disease up to 16 years before onset Open
Early identification of metabolic dysfunction-associated steatotic liver disease (MASLD) is crucial for preventing disease progression, yet reliable predictive tools remain lacking. We analyzed proteomics data of 37,966 participants withou…
View article: The risks of autoimmune inflammatory outcomes in patients infected with SARS-CoV-2: a longitudinal, population-based cohort study
The risks of autoimmune inflammatory outcomes in patients infected with SARS-CoV-2: a longitudinal, population-based cohort study Open
View article: Retraction Note: Pre-activation of mesenchymal stem cells with TNF-α, IL-1β and nitric oxide enhances its paracrine effects on radiation-induced intestinal injury
Retraction Note: Pre-activation of mesenchymal stem cells with TNF-α, IL-1β and nitric oxide enhances its paracrine effects on radiation-induced intestinal injury Open
View article: Accelerated biological aging, inflammatory bowel disease, genetic susceptibility and life expectancy: Evidence from UK Biobank and All of Us Cohorts
Accelerated biological aging, inflammatory bowel disease, genetic susceptibility and life expectancy: Evidence from UK Biobank and All of Us Cohorts Open
Background: Inflammatory bowel disease (IBD) is a chronic condition affecting individuals across all age groups. However, the association between IBD and biological aging remains unclear. Methods: We utilized data from the UK Biobank and t…
View article: Observational, causal relationship and shared genetic basis between cholelithiasis and gastroesophageal reflux disease: evidence from a cohort study and comprehensive genetic analysis.
Observational, causal relationship and shared genetic basis between cholelithiasis and gastroesophageal reflux disease: evidence from a cohort study and comprehensive genetic analysis. Open
The elucidation of the shared genetic basis underlying the phenotypic relationship of these 2 complex phenotypes offers new insights into the intrinsic linkage between cholelithiasis and GERD, providing a novel research direction for futur…
View article: Causal association and genetic correlation of frailty with metabolic dysfunction-associated steatotic liver disease: Epidemiological and genetic analyses
Causal association and genetic correlation of frailty with metabolic dysfunction-associated steatotic liver disease: Epidemiological and genetic analyses Open
Frailty has become a major public health issue, but its association with Metabolic dysfunction-associated steatotic liver disease (MASLD) remains controversial. We conducted an observational study of frailty and MASLD using the frailty ind…
View article: Extended flexible sigmoidoscopy using water exchange facilitates a complete colon examination without sedation in participants undergoing average risk colorectal cancer screening: results from a randomized trial
Extended flexible sigmoidoscopy using water exchange facilitates a complete colon examination without sedation in participants undergoing average risk colorectal cancer screening: results from a randomized trial Open
Lay Summary Colon cancer is a leading cause of cancer deaths. Leading guidelines recommend flexible sigmoidoscopy (FS) every 10 years as a screening option for average-risk people. One area of progress involves a method called water exchan…
View article: Associations of proton pump inhibitors with susceptibility to influenza, pneumonia, and COVID-19: Evidence from a large population-based cohort study
Associations of proton pump inhibitors with susceptibility to influenza, pneumonia, and COVID-19: Evidence from a large population-based cohort study Open
Background: Adverse effects of proton pump inhibitors (PPIs) have raised wide concerns. The association of PPIs with influenza is unexplored, while that with pneumonia or COVID-19 remains controversial. Our study aims to evaluate whether P…
View article: Author response: Associations of proton pump inhibitors with susceptibility to influenza, pneumonia, and COVID-19: Evidence from a large population-based cohort study
Author response: Associations of proton pump inhibitors with susceptibility to influenza, pneumonia, and COVID-19: Evidence from a large population-based cohort study Open
View article: Associations of proton pump inhibitors with susceptibility to influenza, pneumonia, and COVID-19: Evidence from a large population based cohort study
Associations of proton pump inhibitors with susceptibility to influenza, pneumonia, and COVID-19: Evidence from a large population based cohort study Open
Adverse effects of proton pump inhibitors (PPIs) have raised wide concerns. The association of PPIs with influenza is unexplored, while that with pneumonia or COVID-19 remains controversial. Our study aims to evaluate whether PPI use incre…
View article: Author response: Associations of proton pump inhibitors with susceptibility to influenza, pneumonia, and COVID-19: Evidence from a large population based cohort study
Author response: Associations of proton pump inhibitors with susceptibility to influenza, pneumonia, and COVID-19: Evidence from a large population based cohort study Open
Adverse effects of proton pump inhibitors (PPIs) have raised wide concerns. The association of PPIs with influenza is unexplored, while that with pneumonia or COVID-19 remains controversial. Our study aims to evaluate whether PPI use incre…
View article: The mediating effect of blood biomarkers in the associations between inflammatory bowel disease and incident psychiatric disorders: a prospective cohort study
The mediating effect of blood biomarkers in the associations between inflammatory bowel disease and incident psychiatric disorders: a prospective cohort study Open
Background: Despite the growing evidence of an association between inflammatory bowel disease (IBD) and psychiatric disorders, there has been limited research exploring the underlying mediating role of blood biomarkers on the gut-brain axi…
View article: Sleep patterns, genetic susceptibility, and digestive diseases: a large-scale longitudinal cohort study
Sleep patterns, genetic susceptibility, and digestive diseases: a large-scale longitudinal cohort study Open
Background: Sleep problems are prevalent. However, the impact of sleep patterns on digestive diseases remains uncertain. Moreover, the interaction between sleep patterns and genetic predisposition with digestive diseases has not been compr…
View article: Unveiling promising drug targets for autism spectrum disorder: insights from genetics, transcriptomics, and proteomics
Unveiling promising drug targets for autism spectrum disorder: insights from genetics, transcriptomics, and proteomics Open
Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder for which current treatments are limited and drug development costs are prohibitive. Identifying drug targets for ASD is crucial for the development of targeted therap…
View article: Determination of the ideal plate for medial femoral condyle fracture fixation: an anatomical fit and biomechanical study
Determination of the ideal plate for medial femoral condyle fracture fixation: an anatomical fit and biomechanical study Open
Background The aim of this study is to determine the best plate to use as a substitute to fix a medial femoral condyle fracture. Materials and methods The first part is to measure the best fit between several anatomical plates including th…
View article: Associations of proton pump inhibitors with susceptibility to influenza, pneumonia, and COVID-19: Evidence from a large population based cohort study
Associations of proton pump inhibitors with susceptibility to influenza, pneumonia, and COVID-19: Evidence from a large population based cohort study Open
Adverse effects of proton pump inhibitors (PPIs) have raised wide concerns. The association of PPIs with influenza is unexplored, while that with pneumonia or COVID-19 remains controversial. Our study aims to evaluate whether PPI use incre…
View article: Reviewer #2 (Public Review): Associations of proton pump inhibitors with susceptibility to influenza, pneumonia, and COVID-19: Evidence from a large population based cohort study
Reviewer #2 (Public Review): Associations of proton pump inhibitors with susceptibility to influenza, pneumonia, and COVID-19: Evidence from a large population based cohort study Open
Adverse effects of proton pump inhibitors (PPIs) have raised wide concerns. The association of PPIs with influenza is unexplored, while that with pneumonia or COVID-19 remains controversial. Our study aims to evaluate whether PPI use incre…
View article: Author Response: Associations of proton pump inhibitors with susceptibility to influenza, pneumonia, and COVID-19: Evidence from a large population based cohort study
Author Response: Associations of proton pump inhibitors with susceptibility to influenza, pneumonia, and COVID-19: Evidence from a large population based cohort study Open
Adverse effects of proton pump inhibitors (PPIs) have raised wide concerns. The association of PPIs with influenza is unexplored, while that with pneumonia or COVID-19 remains controversial. Our study aims to evaluate whether PPI use incre…
View article: Associations of proton pump inhibitors with susceptibility to influenza, pneumonia, and COVID-19: Evidence from a large population-based cohort study
Associations of proton pump inhibitors with susceptibility to influenza, pneumonia, and COVID-19: Evidence from a large population-based cohort study Open
Background: Adverse effects of proton pump inhibitors (PPIs) have raised wide concerns. The association of PPIs with influenza is unexplored, while that with pneumonia or COVID-19 remains controversial. Our study aims to evaluate whether P…
View article: Reviewer #1 (Public Review): Associations of proton pump inhibitors with susceptibility to influenza, pneumonia, and COVID-19: Evidence from a large population based cohort study
Reviewer #1 (Public Review): Associations of proton pump inhibitors with susceptibility to influenza, pneumonia, and COVID-19: Evidence from a large population based cohort study Open
Adverse effects of proton pump inhibitors (PPIs) have raised wide concerns. The association of PPIs with influenza is unexplored, while that with pneumonia or COVID-19 remains controversial. Our study aims to evaluate whether PPI use incre…
View article: Long-term risks of respiratory diseases in patients infected with SARS-CoV-2: a longitudinal, population-based cohort study
Long-term risks of respiratory diseases in patients infected with SARS-CoV-2: a longitudinal, population-based cohort study Open
View article: Investigating shared genetic architecture between inflammatory bowel diseases and primary biliary cholangitis
Investigating shared genetic architecture between inflammatory bowel diseases and primary biliary cholangitis Open
View article: Risks of digestive diseases in long COVID: evidence from a population-based cohort study
Risks of digestive diseases in long COVID: evidence from a population-based cohort study Open
Background In the post-pandemic era, a wide range of COVID-19 sequelae is of growing health concern. However, the risks of digestive diseases in long COVID have not been comprehensively understood. To investigate the long-term risk of dige…
View article: The Mediating Effect of Blood Biomarkers in the Associations between Inflammatory Bowel Disease and Incident Psychiatric Disorders: A Prospective Cohort Study
The Mediating Effect of Blood Biomarkers in the Associations between Inflammatory Bowel Disease and Incident Psychiatric Disorders: A Prospective Cohort Study Open
View article: Percutaneous coronary intervention and GI hemorrhage: need for accurate predictors of the link to rebleeding
Percutaneous coronary intervention and GI hemorrhage: need for accurate predictors of the link to rebleeding Open
View article: Genetically predicted causal associations between periodontitis and psychiatric disorders
Genetically predicted causal associations between periodontitis and psychiatric disorders Open
Background Psychiatric disorders have serious harm to individuals’ lives with high disease burden. Observational studies reported inconsistent associations between periodontitis and some psychiatric disorders, and the causal correlations b…