Félix M. Goñi
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View article: Lipidome Plasticity Preserves Membrane Function in Sphingolipid‐Depleted <scp>HAP1</scp> Cells
Lipidome Plasticity Preserves Membrane Function in Sphingolipid‐Depleted <span>HAP1</span> Cells Open
Sphingolipids (SL) are minor but essential component of mammalian membranes, known for their distinctive biophysical properties and their involvement in disease. In this study, we challenged human cells to grow under extreme SL depletion a…
View article: A nile red fluorescence assay for LC3 autophagy protein binding to lipid bilayers
A nile red fluorescence assay for LC3 autophagy protein binding to lipid bilayers Open
Autophagy consists of the degradation and recycling of defective or aging cellular components. This process occurs in all eukaryotes, and starts by the formation of a double-bilayer structure known as the autophagosome. In humans, autophag…
View article: Ceramide and the membrane-fusion activity of LC3/GABARAP autophagy proteins
Ceramide and the membrane-fusion activity of LC3/GABARAP autophagy proteins Open
View article: The puzzle of sphingolipids and cholesterol under the atomic force microscope: bilayer thicknesses and breakthrough forces
The puzzle of sphingolipids and cholesterol under the atomic force microscope: bilayer thicknesses and breakthrough forces Open
A variety of studies published in the last decades in the field of lipid biophysics deal with the puzzle regarding the relationship between the signaling power of bioactive lipids (sphingolipids) and their capacity to induce lipid membrane…
View article: Long-term memory in lipid assemblies: Rate-independent hysteresis in the ripple-to-liquid-disordered transition of sphingomyelin bilayers
Long-term memory in lipid assemblies: Rate-independent hysteresis in the ripple-to-liquid-disordered transition of sphingomyelin bilayers Open
Sphingomyelin (SM) is the most abundant sphingolipid in mammalian cells. It contains a phosphorylcholine headgroup, which makes SM an analog of the (glycerol-containing) phosphatidylcholines. Palmitoyl (C16:0) SM bilayers in excess water e…
View article: Corrigendum to “(1-Deoxy)ceramides in bilayers containing sphingomyelin and cholesterol” [Colloids Surf. B: Biointerfaces 243 (2024) 114155]
Corrigendum to “(1-Deoxy)ceramides in bilayers containing sphingomyelin and cholesterol” [Colloids Surf. B: Biointerfaces 243 (2024) 114155] Open
View article: (1-Deoxy)ceramides in bilayers containing sphingomyelin and cholesterol
(1-Deoxy)ceramides in bilayers containing sphingomyelin and cholesterol Open
The discovery of a novel sphingolipid subclass, the (1-deoxy)sphingolipids, which lack the 1-hydroxy group, attracted considerable attention in the last decade, mainly due to their involvement in disease. They differed in their physico-che…
View article: Ceramide and the membrane-fusion activity of LC3/GABARAP autophagy proteins
Ceramide and the membrane-fusion activity of LC3/GABARAP autophagy proteins Open
Macroautophagy is a cellular degradation process characterized by the formation of the double-membrane structure termed autophagosome (AP). The process of AP formation is not fully understood, but it is thought to happen through the combin…
View article: Understanding Aβ Peptide Binding to Lipid Membranes: A Biophysical Perspective
Understanding Aβ Peptide Binding to Lipid Membranes: A Biophysical Perspective Open
Aβ peptides are known to bind neural plasma membranes in a process leading to the deposit of Aβ-enriched plaques. These extracellular structures are characteristic of Alzheimer’s disease, the major cause of late-age dementia. The mechanism…
View article: Understanding Aβ Peptide Binding to Lipid Membranes. A Biophysical Perspective
Understanding Aβ Peptide Binding to Lipid Membranes. A Biophysical Perspective Open
Aβ peptides are known to bind neural plasma membranes in a process leading to the deposit of Aβ-enriched plaques. These extracellular structures are characteristic of Alzheimer’s disease, the major cause of late-age dementia. The mechanism…
View article: The Influence of Lipid Electric Charge on the Binding of Aβ(1–42) Amyloid Peptide to Bilayers in the Liquid-Ordered State
The Influence of Lipid Electric Charge on the Binding of Aβ(1–42) Amyloid Peptide to Bilayers in the Liquid-Ordered State Open
The amyloidogenic Aβ peptides are widely considered as a pathogenic agent in Alzheimer’s disease. Aβ(1-42) would form aggregates of amyloid fibrils on the neuron plasma membranes, thus perturbing neuronal functionality. Conflicting data ar…
View article: A progesterone derivative linked to a stable phospholipid activates breast cancer cell response without leaving the cell membrane
A progesterone derivative linked to a stable phospholipid activates breast cancer cell response without leaving the cell membrane Open
View article: (1-Deoxy)Ceramides in Bilayers Containing Sphingomyelin and Cholesterol
(1-Deoxy)Ceramides in Bilayers Containing Sphingomyelin and Cholesterol Open
View article: Ceramide regulation of autophagy: A biophysical approach
Ceramide regulation of autophagy: A biophysical approach Open
Specific membrane lipids play unique roles in (macro)autophagy. Those include phosphatidylethanolamine, to which LC3/GABARAP autophagy proteins become covalently bound in the process, or cardiolipin, an important effector in mitochondrial …
View article: Effects of a N-Maleimide-derivatized Phosphatidylethanolamine on the Architecture and Properties of Lipid Bilayers
Effects of a N-Maleimide-derivatized Phosphatidylethanolamine on the Architecture and Properties of Lipid Bilayers Open
N-maleimide-derivatized phospholipids are often used to facilitate protein anchoring to membranes. In autophagy studies, this is applied to the covalent binding of Atg8, an autophagy protein, to a phosphatidylethanolamine (PE) in the nasce…
View article: Sobre la necesidad de una reforma universitaria
Sobre la necesidad de una reforma universitaria Open
Se presentan en el artículo algunos aspectos del informe Propuestas para la reforma ymejora de la calidad y eficiencia del sistema universitario español (12 de febrero de 2013), elaborado a propuesta del Ministro de Educación, Cultura y De…
View article: Effects of a N-Maleimide-Derivatized Phosphatidylethanolamine on the Architecture and Properties of Lipid Bilayers
Effects of a N-Maleimide-Derivatized Phosphatidylethanolamine on the Architecture and Properties of Lipid Bilayers Open
N-maleimide-derivatized phospholipids are often used to facilitate protein anchoring to membranes. In autophagy studies, this is applied to the covalent binding of Atg8, an autophagy protein, to a phosphatidylethanolamine (PE) in the nasce…
View article: 2016-2020: Números rojos, futuro rosa (y si lo sé no vengo)
2016-2020: Números rojos, futuro rosa (y si lo sé no vengo) Open
Me piden unas líneas recordando las principales dificultades de mi etapa de presidente de la SEBBM, y mi visión sobre su futuro.Bueno, en realidad, no me han preguntado por las dificultades, sino por los "retos", que es más moderno.Tan mod…
View article: A progesterone derivative linked to a stable phospholipid activates breast cancer cell response without leaving the cell membrane
A progesterone derivative linked to a stable phospholipid activates breast cancer cell response without leaving the cell membrane Open
In hormone-responsive breast cancer cells, progesterone (P4) has been shown to act via its nuclear receptor (PR), a ligand-activated transcription factor. A small fraction of PR is palmitoylated and anchored to the cell membrane (mbPR) for…
View article: Lipids in Mitochondrial Macroautophagy: Phase Behavior of Bilayers Containing Cardiolipin and Ceramide
Lipids in Mitochondrial Macroautophagy: Phase Behavior of Bilayers Containing Cardiolipin and Ceramide Open
Cardiolipin (CL) is a key lipid for damaged mitochondrial recognition by the LC3/GABARAP human autophagy proteins. The role of ceramide (Cer) in this process is unclear, but CL and Cer have been proposed to coexist in mitochondria under ce…
View article: Effect of ATG12–ATG5-ATG16L1 autophagy E3-like complex on the ability of LC3/GABARAP proteins to induce vesicle tethering and fusion
Effect of ATG12–ATG5-ATG16L1 autophagy E3-like complex on the ability of LC3/GABARAP proteins to induce vesicle tethering and fusion Open
View article: Birth and Early Steps of the Organization of Biophysics in Spain
Birth and Early Steps of the Organization of Biophysics in Spain Open
In the 1960s, Biophysics was an unheard of scientific field in Spain, and even outside Spain, the distinction between Biophysics and Molecular Biology was not clear at the time. This paper describes briefly the developments that led to the…
View article: Sphingomyelin: What is it good for?
Sphingomyelin: What is it good for? Open
View article: The Myth of The Annular Lipids
The Myth of The Annular Lipids Open
In the early 1970s, the existence of a “lipid annulus” stably surrounding the individual intrinsic protein molecules was proposed by several authors. They referred to a number of lipid molecules in slow exchange with the bulk lipid in the …
View article: Phase behaviour of C18-N-acyl sphingolipids, the prevalent species in human brain
Phase behaviour of C18-N-acyl sphingolipids, the prevalent species in human brain Open
Lipidomic analysis of the N-acyl components of sphingolipids in different mammalian tissues had revealed that brain tissue differed from all the other samples in that SM contained mainly C18:0 and C24:1N-acyl chains, and that the most abun…
View article: Effect of ATG12–ATG5-ATG16L1 autophagy E3 complex on the ability of LC3/GABARAP proteins to induce vesicle tethering and fusion
Effect of ATG12–ATG5-ATG16L1 autophagy E3 complex on the ability of LC3/GABARAP proteins to induce vesicle tethering and fusion Open
In macroautophagy, the autophagosome (AP) engulfs portions of cytoplasm to allow their lysosomal degradation. AP formation in humans requires the concerted action of the ATG12 and LC3/GABARAP conjugation systems. The ATG12–ATG5-ATG16L1 (E3…
View article: Phase behaviour of C18-N-acyl sphingolipids, the prevalent species in human brain
Phase behaviour of C18-N-acyl sphingolipids, the prevalent species in human brain Open
Lipidomic analysis of the N-acyl components of sphingolipids in different mammalian tissues had revealed that brain tissue differed from all the other samples in that SM contained mainly C18:0 and C24:1 N-acyl chains, and that the most abu…
View article: Liquid-crystalline, liquid-ordered, rippled and gel lipid bilayer phases as observed with nile red fluorescence
Liquid-crystalline, liquid-ordered, rippled and gel lipid bilayer phases as observed with nile red fluorescence Open
View article: Autophagy protein LC3C binding to phospholipid and interaction with lipid membranes
Autophagy protein LC3C binding to phospholipid and interaction with lipid membranes Open
Autophagy is a process in which parts of the eukaryotic cell are selectively degraded in the lysosome. The materials to be catabolized are first surrounded by a double-membrane structure, the autophagosome. Autophagosome generation is a co…
View article: LC3 subfamily in cardiolipin-mediated mitophagy: a comparison of the LC3A, LC3B and LC3C homologs
LC3 subfamily in cardiolipin-mediated mitophagy: a comparison of the LC3A, LC3B and LC3C homologs Open
Externalization of the phospholipid cardiolipin (CL) to the outer mitochondrial membrane has been proposed to act as a mitophagy trigger. CL would act as a signal for binding the LC3 macroautophagy/autophagy proteins. As yet, the behavior …