Explanipedia

Hepatobiliary long-term consequences of COVID-19: dramatically increased rate of secondary sclerosing cholangitis in critically ill COVID-19 patients Open

Silke Leonhardt, Christian Jürgensen, Josephine Frohme, Donata Grajecki, Andreas Adler , et al. · 2023

A proteomic survival predictor for COVID-19 patients in intensive care Open

Vadim Demichev, Pinkus Tober‐Lau, Tatiana Nazarenko, Oliver Lemke, Simran Kaur Aulakh , et al. · 2022

Global healthcare systems are challenged by the COVID-19 pandemic. There is a need to optimize allocation of treatment and resources in intensive care, as clinically established risk assessments such as SOFA and APACHE II scores show only …

SARS-CoV-2 infection triggers profibrotic macrophage responses and lung fibrosis Open

Daniel Wendisch, Oliver Dietrich, Tommaso Mari, Saskia von Stillfried, Ignacio L. Ibarra , et al. · 2021

COVID-19-induced "acute respiratory distress syndrome" (ARDS) is associated with prolonged respiratory failure and high mortality, but the mechanistic basis of lung injury remains incompletely understood. Here, we analyze pulmonary immune …

A proteomic survival predictor for COVID-19 patients in intensive care Open

Vadim Demichev, Pinkus Tober‐Lau, Tatiana Nazarenko, Simran Kaur Aulakh, Harry J. Whitwell , et al. · 2021

Global healthcare systems are challenged by the COVID-19 pandemic. There is a need to optimize allocation of treatment and resources in intensive care, as clinically established risk assessments such as SOFA and APACHE II scores show only …

Impact of dexamethasone on SARS-CoV-2 concentration kinetics and antibody response in hospitalized COVID-19 patients: results from a prospective observational study Open

Barbara Mühlemann, Charlotte Thibeault, David Hillus, Elisa T. Helbig, Lena J. Lippert , et al. · 2021

A time-resolved proteomic and prognostic map of COVID-19 Open

Vadim Demichev, Pinkus Tober‐Lau, Oliver Lemke, Tatiana Nazarenko, Charlotte Thibeault , et al. · 2021

Clinical and virological characteristics of hospitalised COVID-19 patients in a German tertiary care centre during the first wave of the SARS-CoV-2 pandemic: a prospective observational study Open

Charlotte Thibeault, Barbara Mühlemann, Elisa T. Helbig, Mirja Mittermaier, Tilman Lingscheid , et al. · 2021

Purpose Adequate patient allocation is pivotal for optimal resource management in strained healthcare systems, and requires detailed knowledge of clinical and virological disease trajectories. The purpose of this work was to identify risk …

A time-resolved proteomic and diagnostic map characterizes COVID-19 disease progression and predicts outcome Open

Vadim Demichev, Pinkus Tober‐Lau, Tatiana Nazarenko, Charlotte Thibeault, Harry J. Whitwell , et al. · 2020

COVID-19 is highly variable in its clinical presentation, ranging from asymptomatic infection to severe organ damage and death. There is an urgent need for predictive markers that can guide clinical decision-making, inform about the effect…

Evaluation of PEEP and prone positioning in early COVID-19 ARDS Open

Mirja Mittermaier, Philipp A. Pickerodt, Florian Kurth, Laure Bosquillon de Jarcy, Alexander Uhrig , et al. · 2020

German Research Foundation, German Federal Ministry of Education and Research.

Severe COVID-19 Is Marked by a Dysregulated Myeloid Cell Compartment Open

Jonas Schulte-Schrepping, Nico Reusch, Daniela Paclik, Kevin Baßler, Stephan Schlickeiser , et al. · 2020

COVID-19 severity correlates with airway epithelium–immune cell interactions identified by single-cell analysis Open

Robert Lorenz Chua, Soeren Lukassen, Saskia Trump, Bianca P. Hennig, Daniel Wendisch , et al. · 2020

Suppressive myeloid cells are a hallmark of severe COVID-19 Open

Jonas Schulte-Schrepping, Nico Reusch, Daniela Paclik, Kevin Baßler, Stephan Schlickeiser , et al. · 2020

‘Severe Acute Respiratory Syndrome - Coronavirus-2’ (SARS-CoV-2) infection causes Coronavirus Disease 2019 (COVID-19), a mild to moderate respiratory tract infection in the majority of patients. A subset of patients, however, progresses to…

Cross-talk between the airway epithelium and activated immune cells defines severity in COVID-19 Open

Robert Lorenz Chua, Soeren Lukassen, Saskia Trump, Bianca P. Hennig, Daniel Wendisch , et al. · 2020

The clinical course of COVID-19 is highly variable, however, underlying host factors and determinants of severe disease are still unknown. Based on single-cell transcriptomes of nasopharyngeal and bronchial samples from clinically well-cha…

COVID-19 severity correlates with airway epithelium-immune cell interactions identified by single-cell analysis Open

Robert Lorenz Chua, Soeren Lukassen, Saskia Trump, Bianca P. Hennig, Daniel Wendisch , et al. · 2020

Single-cell RNA-Seq of airway samples of COVID-19 patients and healthy controlsThis dataset comprises single-cell RNA-Seq data of nasopharyngeal, protected specimen brush, and bronchial lavage samples of 19 COVID-19 patients (eight …

COVID-19 severity correlates with airway epithelium-immune cell interactions identified by single-cell analysis Open

Robert Lorenz Chua, Soeren Lukassen, Saskia Trump, Bianca P. Hennig, Daniel Wendisch , et al. · 2020

Single-cell RNA-Seq of airway samples of COVID-19 patients and healthy controlsThis dataset comprises single-cell RNA-Seq data of nasopharyngeal, protected specimen brush, and bronchial lavage samples of 19 COVID-19 patients (eight …

Evaluation of PEEP and Prone Positioning in COVID-19 ARDS Open

Mirja Mittermaier, Philipp A. Pickerodt, Florian Kurth, Laure Bosquillon de Jarcy, Leif Erik Sander , et al. · 2020

GHRH-mediated GH release is associated with sympathoactivation and baroreflex resetting: a microneurographic study in healthy humans Open

Moritz Meusel, Magdalena Herrmann, Felix Machleidt, Klaas Franzen, Alexander F. Krapalis , et al. · 2019

Previous research suggested substantial interactions of growth hormone (GH) and sympathetic nervous activity. This cross talk can be presumed both during physiological (e.g., slow-wave sleep) and pathological conditions of GH release. Howe…

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