Felix Merboth
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View article: Intratumoral regulatory T cells are associated with treatment response to neoadjuvant chemotherapy and prognosis in gastroesophageal adenocarcinoma
Intratumoral regulatory T cells are associated with treatment response to neoadjuvant chemotherapy and prognosis in gastroesophageal adenocarcinoma Open
Gastroesophageal junction (GEJ) adenocarcinoma is an increasingly common cancer with complex biology and poor prognosis. The treatment strategy for locally advanced tumors involves multimodal treatment with perioperative chemotherapy. Howe…
View article: Indirect calorimetry identifies hypermetabolism associated with muscle wasting and increased risk of energy deficit in ICU patients
Indirect calorimetry identifies hypermetabolism associated with muscle wasting and increased risk of energy deficit in ICU patients Open
View article: Soluble TIM-3 and galectin-9 predict survival in gastric and gastroesophageal junction cancer
Soluble TIM-3 and galectin-9 predict survival in gastric and gastroesophageal junction cancer Open
Current biomarkers for diagnosis and prognosis prediction in gastric cancer (GC) and gastroesophageal junction (GEJ) cancer have limited accuracy, and the role of soluble immune checkpoints is unknown. In this study, T cell immunoglobulin …
View article: Predicting resectability after neoadjuvant chemotherapy for patients with borderline resectable pancreatic cancer: a single center, retrospective trial
Predicting resectability after neoadjuvant chemotherapy for patients with borderline resectable pancreatic cancer: a single center, retrospective trial Open
Background/Objectives Pancreatic ductal adeno carcinoma (PDAC) in its borderline resectable (BR) stage often limits the possibility of complete resection, currently the only potential path to a cure. Neoadjuvant chemotherapy seeks to downs…
View article: Sarcopenia in Colorectal Cancer Surgery—Minimally Invasive vs. Open
Sarcopenia in Colorectal Cancer Surgery—Minimally Invasive vs. Open Open
Background Sarcopenia, characterized by loss of skeletal muscle mass and strength, is prevalent in patients undergoing treatment for colorectal cancer. Sarcopenia's prevalence in patients with cancer can reach up to 50% and is known to exa…
View article: Impact of an enhanced anti-infection prophylaxis strategy for pancreatoduodenectomy: a single centre analysis
Impact of an enhanced anti-infection prophylaxis strategy for pancreatoduodenectomy: a single centre analysis Open
Introduction Surgical site infection (SSI) after pancreatoduodenectomy (PD) is a significant concern. Targeted antibiotic prophylaxis (pAP) has been tested to mitigate antibiotic resistance patterns, especially after preoperative bile duct…
View article: Bacterial shift and resistance pattern in pancreatic head resections after selective decontamination of the digestive tract – a propensity score-matched analysis
Bacterial shift and resistance pattern in pancreatic head resections after selective decontamination of the digestive tract – a propensity score-matched analysis Open
SDD in pancreatic head resection reduces bacterial load in the biliary tract, but it is associated with a shift toward more gram-negative species and higher rates of severe postoperative complications. Our findings suggest that SDD may neg…
View article: Customizing GPT-4 for clinical information retrieval from standard operating procedures
Customizing GPT-4 for clinical information retrieval from standard operating procedures Open
Background The increasing complexity of medical knowledge necessitates efficient and reliable information access systems in clinical settings. For quality purposes, most hospitals use standard operating procedures (SOPs) for information ma…
View article: Early detection of anastomotic leakage in upper gastrointestinal surgery
Early detection of anastomotic leakage in upper gastrointestinal surgery Open
Background Although surgical methods for upper gastrointestinal tract cancer continue to advance with the aim of reducing the incidence of anastomotic leakage (AL), it remains a prevalent and serious complication. Therefore, early identifi…
View article: Stratifying esophago-gastric cancer treatment using a patient-derived organoid-based threshold
Stratifying esophago-gastric cancer treatment using a patient-derived organoid-based threshold Open
View article: Single chest drain is not inferior to double chest drain after robotic esophagectomy: a propensity score-matched analysis
Single chest drain is not inferior to double chest drain after robotic esophagectomy: a propensity score-matched analysis Open
Background Chest drain management has a significant influence on postoperative recovery after robot-assisted minimally invasive esophagectomy (RAMIE). The use of chest drains increases postoperative pain by irritating intercostal nerves an…
View article: Robotic Esophagectomy Compared With Open Esophagectomy Reduces Sarcopenia within the First Postoperative Year: A Propensity Score-Matched Analysis
Robotic Esophagectomy Compared With Open Esophagectomy Reduces Sarcopenia within the First Postoperative Year: A Propensity Score-Matched Analysis Open
View article: Robotic-assisted minimally invasive Ivor Lewis esophagectomy within the prospective multicenter German da Vinci Xi registry trial
Robotic-assisted minimally invasive Ivor Lewis esophagectomy within the prospective multicenter German da Vinci Xi registry trial Open
Purpose Robotic-assisted minimally invasive esophagectomy (RAMIE) has become one standard approach for the operative treatment of esophageal tumors at specialized centers. Here, we report the results of a prospective multicenter registry f…
View article: Strategiewechsel zur minimal-invasiven Ösophagektomie – Ergebnisse an einem zertifizierten Zentrum
Strategiewechsel zur minimal-invasiven Ösophagektomie – Ergebnisse an einem zertifizierten Zentrum Open
View article: Comparative Analysis of Postoperative Complications after Cytoreductive Surgery and HIPEC in Gastric Cancer
Comparative Analysis of Postoperative Complications after Cytoreductive Surgery and HIPEC in Gastric Cancer Open
Introduction: Patients with advanced gastric cancer (AGC) frequently show peritoneal carcinomatosis (PC). PC reduces life expectancy and quality of life. Cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemother…
View article: Supplementary Material for: Comparative Analysis of Postoperative Complications after Cytoreductive Surgery and HIPEC in Gastric Cancer
Supplementary Material for: Comparative Analysis of Postoperative Complications after Cytoreductive Surgery and HIPEC in Gastric Cancer Open
Introduction: Patients with advanced gastric cancer (AGC) frequently show peritoneal carcinomatosis (PC). PC reduces life expectancy and quality of life. Cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemother…
View article: An Optimized Approach to Perform Bone Histomorphometry
An Optimized Approach to Perform Bone Histomorphometry Open
Bone histomorphometry allows quantitative evaluation of bone micro-architecture, bone formation, and bone remodeling by providing an insight to cellular changes. Histomorphometry plays an important role in monitoring changes in bone proper…
View article: Table of Contents
Table of Contents Open
View article: Osteocyte Regulation of Receptor Activator of NF-κB Ligand/Osteoprotegerin in a Sheep Model of Osteoporosis
Osteocyte Regulation of Receptor Activator of NF-κB Ligand/Osteoprotegerin in a Sheep Model of Osteoporosis Open