Felix Räsch
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View article: Limited proteolysis-coupled mass spectrometry captures proteome-wide protein structural alterations and biomolecular condensation in living cells
Limited proteolysis-coupled mass spectrometry captures proteome-wide protein structural alterations and biomolecular condensation in living cells Open
The function of a protein is determined by its structure, which may change dynamically in response to post-translational modifications, interaction with other molecules, or environmental factors like temperature. Limited proteolysis-couple…
View article: The role of 4E-T in translational regulation and mRNA decay
The role of 4E-T in translational regulation and mRNA decay Open
The eukaryotic initiation factor 4E (eIF4E) binds the cap structure of an mRNA as the first step of cap dependent translation. Together with the RNA helicase eIF4A and the scaffolding protein eIF4G, eIF4E forms the eIF4F complex, which rec…
View article: 4E-T-bound mRNAs are stored in a silenced and deadenylated form
4E-T-bound mRNAs are stored in a silenced and deadenylated form Open
Human 4E-T is an eIF4E-binding protein (4E-BP) present in processing (P)-bodies that represses translation and regulates decay of mRNAs destabilized by AU-rich elements and microRNAs (miRNAs). However, the underlying regulatory mechanisms …
View article: HELZ directly interacts with CCR4–NOT and causes decay of bound mRNAs
HELZ directly interacts with CCR4–NOT and causes decay of bound mRNAs Open
Eukaryotic superfamily (SF) 1 helicases have been implicated in various aspects of RNA metabolism, including transcription, processing, translation, and degradation. Nevertheless, until now, most human SF1 helicases remain poorly understoo…