Felix J. Segerer
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View article: 9P Benchmarking instance segmentation architectures for whole-cell segmentation in IHC-stained images: A multi-cancer study
9P Benchmarking instance segmentation architectures for whole-cell segmentation in IHC-stained images: A multi-cancer study Open
View article: Novel Deep Learning Approach to Derive Cytokeratin Expression and Epithelium Segmentation from DAPI
Novel Deep Learning Approach to Derive Cytokeratin Expression and Epithelium Segmentation from DAPI Open
Generative Adversarial Networks (GANs) are state of the art for image synthesis. Here, we present dapi2ck, a novel GAN-based approach to synthesize cytokeratin (CK) staining from immunofluorescent (IF) DAPI staining of nuclei in non-small …
View article: Stain Isolation-based Guidance for Improved Stain Translation
Stain Isolation-based Guidance for Improved Stain Translation Open
Unsupervised and unpaired domain translation using generative adversarial neural networks, and more precisely CycleGAN, is state of the art for the stain translation of histopathology images. It often, however, suffers from the presence of…
View article: Quasi-periodic migration of single cells on short microlanes
Quasi-periodic migration of single cells on short microlanes Open
Cell migration on microlanes represents a suitable and simple platform for the exploration of the molecular mechanisms underlying cell cytoskeleton dynamics. Here, we report on the quasi-periodic movement of cells confined in stripe-shaped…
View article: Quasi-periodic migration of single cells on short microlanes
Quasi-periodic migration of single cells on short microlanes Open
Cell migration on microlanes represents a suitable and simple platform for the exploration of the molecular mechanisms underlying cell cytoskeleton dynamics. Here, we report on the quasi-periodic movement of cells confined in stripe-shaped…
View article: Ring-Shaped Microlanes and Chemical Barriers as a Platform for Probing Single-Cell Migration
Ring-Shaped Microlanes and Chemical Barriers as a Platform for Probing Single-Cell Migration Open
Quantification and discrimination of pharmaceutical and disease-related effects on cell migration requires detailed characterization of single-cell motility. In this context, micropatterned substrates that constrain cells within defined ge…
View article: Versatile method to generate multiple types of micropatterns
Versatile method to generate multiple types of micropatterns Open
Micropatterning techniques have become an important tool for the study of cell behavior in controlled microenvironments. As a consequence, several approaches for the creation of micropatterns have been developed in recent years. However, t…
View article: From single-cell migration to the emergence of collective motion using microstructured surfaces
From single-cell migration to the emergence of collective motion using microstructured surfaces Open
Cell migration is a fundamental process that is essential for the development, maintenance, and functionality of multicellular organisms. A detailed understanding of the underlying mechanisms and phenomenological characteristics of cell mi…
View article: Emergence and Persistence of Collective Cell Migration on Small Circular Micropatterns
Emergence and Persistence of Collective Cell Migration on Small Circular Micropatterns Open
The spontaneous formation of vortices is a hallmark of collective cellular activity. Here, we study the onset and persistence of coherent angular motion as a function of the number of cells N confined in circular micropatterns. We find tha…