Felix Wojcik
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View article: Machine Learning-Guided Discovery of Robust Conditions for Photochemical Nickel-Catalyzed Cysteine Arylation
Machine Learning-Guided Discovery of Robust Conditions for Photochemical Nickel-Catalyzed Cysteine Arylation Open
Late-stage functionalization (LSF) of peptides offers direct access to structurally diverse analogues, but developing general, chemoselective protocols remains challenging due to the complexity of peptide substrates and the vast number of …
View article: Photochemically-enabled, post-translational production of C-terminal amides
Photochemically-enabled, post-translational production of C-terminal amides Open
C-terminal α-amidated peptides are attractive therapeutic targets, but preparative methods to access amidated pharmaceuticals are limited both on lab and manufacturing-scale. Here we report a straightforward and scalable approach to the C-…
View article: Green Solid-Phase Peptide Synthesis: Oxyma-Triggered Spectrophotometric Monitoring of Residual Piperidine
Green Solid-Phase Peptide Synthesis: Oxyma-Triggered Spectrophotometric Monitoring of Residual Piperidine Open
Solid-phase peptide synthesis (SPPS) is an efficient platform technology for synthesizing synthetic peptides but has an environmental downside due to the use of vast amounts of toxic solvents. In recent years, a big effort has been made to…
View article: Oncohistone mutations enhance chromatin remodeling and alter cell fates
Oncohistone mutations enhance chromatin remodeling and alter cell fates Open
View article: Greening the synthesis of peptide therapeutics: an industrial perspective
Greening the synthesis of peptide therapeutics: an industrial perspective Open
This review highlights the efforts made to date to promote greener peptide synthesis, from an industrial perspective.
View article: The Chaperone FACT and Histone H2B Ubiquitination Maintain S. pombe Genome Architecture through Genic and Subtelomeric Functions
The Chaperone FACT and Histone H2B Ubiquitination Maintain S. pombe Genome Architecture through Genic and Subtelomeric Functions Open
View article: JASPer controls interphase histone H3S10 phosphorylation by chromosomal kinase JIL-1 in Drosophila
JASPer controls interphase histone H3S10 phosphorylation by chromosomal kinase JIL-1 in Drosophila Open
View article: JASPer controls interphase histone H3S10 phosphorylation by chromosomal kinase JIL-1 in <i>Drosophila</i>
JASPer controls interphase histone H3S10 phosphorylation by chromosomal kinase JIL-1 in <i>Drosophila</i> Open
In flies, the chromosomal kinase JIL-1 is responsible for most interphase histone H3S10 phosphorylation and has been proposed to protect active chromatin from acquiring heterochromatic marks, like dimethylated histone H3K9 (H3K9me2) and HP…
View article: Functional crosstalk between histone H2B ubiquitylation and H2A modifications and variants
Functional crosstalk between histone H2B ubiquitylation and H2A modifications and variants Open
Ubiquitylation of histone H2B at lysine residue 120 (H2BK120ub) is a prominent histone posttranslational modification (PTM) associated with the actively transcribed genome. Although H2BK120ub triggers several critical downstream histone mo…
View article: ISWI chromatin remodellers sense nucleosome modifications to determine substrate preference
ISWI chromatin remodellers sense nucleosome modifications to determine substrate preference Open
ATP-dependent chromatin remodellers regulate access to genetic information by controlling nucleosome positions in vivo. However, the mechanism by which remodellers discriminate between different nucleosome substrates is poorly understood. …
View article: Long-term hepatitis B infection in a scalable hepatic co-culture system
Long-term hepatitis B infection in a scalable hepatic co-culture system Open
View article: Multivalent display of minimal Clostridium difficile glycan epitopes mimics antigenic properties of larger glycans
Multivalent display of minimal Clostridium difficile glycan epitopes mimics antigenic properties of larger glycans Open