Explanipedia

Perinatal Arterial Ischemic Stroke in Monochorionic Twins: A Retrospective Observational Single-Center Cohort Study Open

Bregje O van Oldenmark, Mathies Rondagh, P. Adama Van Scheltema, Femke Slaghekke, Lotte E. van der Meeren , et al. · 2025

BACKGROUND: Monochorionic twins, characterized by placental sharing and vascular anastomoses, carry a high risk of brain injury, including perinatal arterial ischemic stroke (PAIS). However, the pathophysiology and timing-related risk fact…

Consensus update on twin‐twin transfusion syndrome staging: An international Delphi study Open

Bettina Paek, Martin Walker, Liesbeth Lewi, Femke Slaghekke, Sarah Običan , et al. · 2025

Introduction Twin‐twin transfusion syndrome (TTTS) affects approximately 15% of monochorionic pregnancies and results in poor outcomes without treatment. The Quintero staging system has been used to characterize the severity of the syndrom…

Diagnostic Accuracy of Estimated Fetal Weight Discordance in Predicting Birthweight Discordance in Monochorionic Twins: A Retrospective Cohort Study Open

Jip A. Spekman, E. J. T. Verweij, Femke Slaghekke, Monique C. Haak, Chiara C.M.M. Lap , et al. · 2025

Objective To evaluate the diagnostic accuracy of sonographic estimated fetal weight discordance (EFWD) ≥ 20% in predicting birthweight discordance (BWD) ≥ 20% (i.e., selective fetal growth restriction [sFGR]) in monochorionic (MC) twin pre…

Doppler ultrasound changes in twin anemia polycythemia sequence treated with fetoscopic laser surgery Open

M J A van de Sande, Femke Slaghekke, Monique C. Haak, E J T Verweij, Chiara C.M.M. Lap , et al. · 2025

Single fetal demise in twin anemia–polycythemia sequence: perinatal outcome of surviving cotwin Open

M J A van de Sande, E. Lopriore, Mariano Lanna, Y. Ville, Liesbeth Lewi , et al. · 2025

Objective To evaluate the perinatal outcome after spontaneous single intrauterine fetal demise (IUFD) in monochorionic twin pregnancies with twin anemia–polycythemia sequence (TAPS). Methods This was a retrospective study of all monochorio…

Characteristics and clinical consequences of bipartite monochorionic twin placentas Open

M J A van de Sande, Enrico Lopriore, Liesbeth Lewi, Jip A. Spekman, Monique C. Haak , et al. · 2025

Although bipartite placentas in MC twin pregnancies are rare, the majority have vascular anastomoses and may therefore develop complications such as TTTS, TAPS or sFGR.

Comparison of intrauterine transfusion techniques in hemolytic disease of the fetus and newborn Open

Renske Marijke van 't Oever, van Duijn, Femke Slaghekke, Monique C. Haak, Derek de Winter , et al. · 2025

Objectives Intrauterine transfusions (IUTs) are the cornerstone in treatment for hemolytic disease of the fetus and newborn (HDFN). It has been suggested that a non‐vascular intraperitoneal blood transfusion used in conjunction with an int…

Proximate cord insertion in monochorionic twins with selective fetal growth restriction Open

Jip A. Spekman, Eva Ros, Liesbeth Lewi, Femke Slaghekke, E.J.T. Joanne Verweij , et al. · 2025

sFGR type III placentas exhibit a high prevalence of PCI, requiring increased awareness due to the presence of larger AA anastomoses and a potentially higher risk of fetal demise.

Increased Risk of Persistent Pulmonary Hypertension of the Newborn in Twin Anaemia Polycythaemia Sequence Donors Open

M J A van de Sande, Femke Slaghekke, Arjan B. te Pas, Ruben S. G. M. Witlox, Enrico Lopriore , et al. · 2024

Introduction: This study aimed to describe the prevalence and risk factors for respiratory complications in monochorionic twins with twin anaemia polycythaemia sequence (TAPS). Methods: All neonates diagnosed with postnatal TAPS at our cen…

Does Catch-Up Growth Come with a Cognitive Cost? Cognitive Outcome and Growth Patterns in Growth Discordant Identical Twins Open

Jeanine M.M. van Klink, Erik W. van Zwet, Enrico Lopriore, Arno A.W. Roest, Monique C. Haak , et al. · 2024

Our results, combining detailed growth measurements and neurodevelopmental follow-up in a discordant identical twin model, demonstrate that FGR itself rather than early postnatal CUG has negative consequences for cognitive development.

Necrotizing enterocolitis in monochorionic twins: Insights from an identical twin model Open

Nour Rebai, Enrico Lopriore, Vincent Bekker, Femke Slaghekke, M.H.D. Schoenaker , et al. · 2024

Necrotizing enterocolitis (NEC) is a major cause of neonatal morbidity and mortality in preterm neonates, yet its pathophysiology remains unclear. The aim of this study is to evaluate risk factors for NEC using an identical twin model. In …

Fetal and neonatal neuroimaging in twin–twin transfusion syndrome Open

Marjolijn S. Spruijt, Jeanine M.M. van Klink, Linda S. de Vries, Femke Slaghekke, Jaap M. Middeldorp , et al. · 2024

Objectives To describe the types of brain injury and subsequent neurodevelopmental outcome in fetuses and neonates from pregnancies with twin–twin transfusion syndrome (TTTS). Additionally, to determine risk factors for brain injury and to…

Necrotizing Enterocolitis in Monochorionic Twins: Insights from an Identical Twin Model Open

Nour Rebai, Enrico Lopriore, Vincent Bekker, Femke Slaghekke, M.H.D. Schoenaker , et al. · 2024

The Current Knowledge of Cerebral Magnetic Resonance Imaging in Monochorionic Twins: A Systematic Review of the Last 20 Years Open

Mathies Rondagh, Enrico Lopriore, Linda S. de Vries, Femke Slaghekke, Lisanne S.A. Tollenaar , et al. · 2023

The distinct placental angioarchitecture in monochorionic (MC) pregnancies increases the risk of complications such as twin–twin transfusion syndrome (TTTS), twin anemia polycythemia sequence (TAPS), and selective fetal growth restriction …

Perinatal outcome after selective fetal reduction in monochorionic twin pregnancies: A comparison of techniques over a 20‐year period Open

Marijke Hoek, Jeanine M.M. van Klink, E. J. T. Verweij, Jaap M. Middeldorp, Monique C. Haak , et al. · 2023

Objective To assess the perinatal outcome after fetal reduction in complicated monochorionic (MC) twin pregnancies by comparing different techniques. Methods A retrospective cohort study at a national referral center comparing data between…

Fetal anemia in monochorionic twins: a review on diagnosis, management, and outcome Open

Lisanne S.A. Tollenaar, Femke Slaghekke, Jaap M. Middeldorp, Enrico Lopriore · 2023

Knowledge on the diagnosis and optimal treatment in TTTS is nowadays widespread, but caregivers often fail to distinguish TAPS from acute peripartum TTTS at birth. A full blood count including reticulocyte count is required, and placental …

Increased Risk of Retinopathy of Prematurity in Donors with Twin-to-Twin Transfusion Syndrome: A Cohort Study Open

Salma El Emrani, Sophie G. Groene, Jip A. Spekman, Femke Slaghekke, Lotte E. van der Meeren , et al. · 2023

Introduction: The purpose of this study was to evaluate the within-pair difference in retinopathy of prematurity (ROP) between donors and recipients with twin-to-twin transfusion syndrome (TTTS) and to identify risk factors for ROP develop…

Intertwin Membrane Perforation and Umbilical Cord Entanglement after Laser Surgery for Twin-Twin Transfusion Syndrome: Prevalence, Risk Factors, and Outcome Open

Patricia J.C. Knijnenburg, Femke Slaghekke, Chinar Rahmattulla, Yuchun Ge, Irene M. Scholl , et al. · 2023

Introduction: Perforation of the intertwin membrane can occur as a complication of fetoscopic laser surgery for twin-twin transfusion syndrome (TTTS). Data on the occurrence and the risk of subsequent cord entanglement are limited. The obj…

Long-term effects of selective fetal growth restriction (LEMON): a cohort study of neurodevelopmental outcome in growth discordant identical twins in the Netherlands Open

Sophie G. Groene, Koen J J Stegmeijer, Ratna N.G.B. Tan, Sylke J. Steggerda, Monique C. Haak , et al. · 2022

Gestational age at birth and outcome in monochorionic twins with different types of selective fetal growth restriction: A systematic literature review Open

Salma El Emrani, Sophie G. Groene, E. J. T. Verweij, Femke Slaghekke, Asma Khalil , et al. · 2022

This systematic review aims to assess the gestational age at birth and perinatal outcome [intrauterine demise (IUD), neonatal mortality and severe cerebral injury] in monochorionic twins with selective fetal growth restriction (sFGR), acco…

Lactate acidosis and hypoglycaemia in twin anaemia polycythemia sequence donors Open

M J A van de Sande, Enrico Lopriore, E J T Verweij, C. D. de Bruin, Femke Slaghekke , et al. · 2022

Impact of placental sharing and large bidirectional anastomoses on birthweight discordance in monochorionic twins: a retrospective cohort study in 449 cases Open

Sophie G. Groene, Kristine M. Openshaw, Laura R. Jansén-Storbacka, Femke Slaghekke, Monique C. Haak , et al. · 2022

Birthweight discordance in monochorionic twins was strongly associated with placental share discordance. Large arterioarterial anastomoses can mitigate the effect of unequal placental sharing.

Prediction of fetal death in monochorionic twin pregnancies complicated by Type‐III selective fetal growth restriction Open

Tim Van Mieghem, Liesbeth Lewi, Femke Slaghekke, Enrico Lopriore, Yoav Yinon , et al. · 2022

Objective Monochorionic diamniotic twin pregnancies complicated by Type‐III selective fetal growth restriction (sFGR) are at high risk of fetal death. The aim of this study was to identify predictors of fetal death in these pregnancies. Me…

Neonatal Outcome in Twin-to-Twin Transfusion Syndrome Not Treated with Fetoscopic Laser Surgery Open

E. Lopriore, Femke Slaghekke, E. J. T. Verweij, Monique C. Haak, Annemieke Middeldorp , et al. · 2022

The aim of this study was to describe the neonatal management and outcome in monochorionic twins with twin-to-twin transfusion syndrome (TTTS) not treated with fetoscopic laser surgery. All consecutive live-born neonates with TTTS managed …

Changes in structural brain development after selective fetal growth restriction in monochorionic twins Open

Sophie G. Groene, Linda S. de Vries, Femke Slaghekke, Monique C. Haak, Bastiaan T. Heijmans , et al. · 2021

Objectives Fetal growth restriction (FGR) may alter brain development permanently, resulting in lifelong structural and functional changes. However, in studies addressing this research question, FGR singletons have been compared primarily …

Large Hemoglobin Differences at Birth in Monochorionic Twins with a Placental Chorangioma and Delayed Cord Clamping Open

Sophie G. Groene, Lisanne S.A. Tollenaar, Lotte E. van der Meeren, Femke Slaghekke, E. J. T. Verweij , et al. · 2021

We report a case of a monochorionic diamniotic twin with an uncomplicated pregnancy, but with an unexpected large intertwin hemoglobin (Hb) difference at birth. Twin 1 was delivered vaginally and had an uneventful neonatal course. The umbi…

Neurodevelopmental Trajectories of Preterm Born Survivors of Twin–Twin Transfusion Syndrome: From Birth to 5 Years of Age Open

Patricia J.C. Knijnenburg, Marjolijn S. Spruijt, Lisette Jansen, Monique Rijken, Ratna N.G.B. Tan , et al. · 2021

Growth patterns of monochorionic twin pregnancy complicated by Type‐III selective fetal growth restriction Open

Shiri Shinar, Weijun Xing, Liesbeth Lewi, Femke Slaghekke, Yoav Yinon , et al. · 2021

Objectives Little is known regarding fetal growth patterns in monochorionic twin pregnancy complicated by Type‐III selective fetal growth restriction (sFGR). We aimed to assess fetal growth and umbilical artery Doppler pattern in Type‐III …

Cardiac time intervals and myocardial performance index for prediction of twin–twin transfusion syndrome Open

Manon Gijtenbeek, Sanne J. Eschbach, Jaap M. Middeldorp, Frans J.C.M. Klumper, Femke Slaghekke , et al. · 2021

Objectives To explore whether intertwin discordance in myocardial performance index (MPI) or cardiac time intervals enables the prediction of twin–twin transfusion syndrome (TTTS) in monochorionic diamniotic (MCDA) pregnancies with amnioti…

Fetoscopic myelomeningocoele closure: Is the scientific evidence enough to challenge the gold standard for prenatal surgery? Open

E. J. T. Verweij, Martine C. de Vries, Esther J. Oldekamp, Alex J. Eggink, Dick Oepkes , et al. · 2021

Since the completion of the Management of Myelomeningocoele Study, maternal‐fetal surgery for spina bifida has become a valid option for expecting parents. More recently, multiple groups are exploring a minimally invasive approach and rece…

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