Fenella Halstead
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Reducing laboratory delays in blood culture pathogen identification: a quality improvement project Open
Sepsis is a medical emergency caused by bacteria in the bloodstream and a dysregulated immune response. It is important to identify the bacteria rapidly so that the patient receives effective antibiotics. Delays are associated with higher …
I could smell there was something wrong with him: Clinical case of a decade of chronic undiagnosed brucellosis Open
Background: Brucellosis is a zoonotic infection, typically transmitted by ingestion of unpasteurised dairy products or direct contact with infected animals. It is associated with specific occupations, and travel to endemic countries. There…
Loss of microbial diversity and pathogen domination of the gut microbiota in critically ill patients Open
Among long-stay critically ill patients in the adult intensive care unit (ICU), there are often marked changes in the complexity of the gut microbiota. However, it remains unclear whether such patients might benefit from enhanced surveilla…
Violet-Blue Light Arrays at 405 Nanometers Exert Enhanced Antimicrobial Activity for Photodisinfection of Monomicrobial Nosocomial Biofilms Open
This study reports the efficacy of VBL and blue light (BL) and their antimicrobial activity against mature biofilms of a range of important nosocomial pathogens. While this study investigated the antibacterial activity of a range of wavele…
Schistosome Interactions within the <i>Schistosoma haematobium</i> Group, Malawi Open
Molecular analysis of atypical schistosome eggs retrieved from children in Malawi revealed genetic interactions occurring between human (Schistosoma haematobium) and livestock (S. mattheei and S. bovis) schistosome species. Detection of hy…
Loss of microbial diversity and pathogen domination of the gut microbiota in critically ill patients Open
Background For long-stay patients on the adult intensive care unit, the gut microbiota plays a key role in determining the balance between health and disease. However, it remains unclear which ICU patients might benefit from interventions …
Additional file 2: of The potential of visible blue light (405â nm) as a novel decontamination strategy for carbapenemase-producing enterobacteriaceae (CPE) Open
Figure S1: Core phylogeny tree showing the relatedness of the seven Klebsiella pneumoniae isolates that were included in the study. (PDF 278 kb)
Additional file 1: of The potential of visible blue light (405â nm) as a novel decontamination strategy for carbapenemase-producing enterobacteriaceae (CPE) Open
Table S1: Showing the VNTR profiles and MLST types (where available) for the Klebsiella pneumoniae and K. oxytoca isolates used in the study. Table S2: Showing the MLST types (where available) for the Escherichia coli isolates used in the …
The contribution of leucocytes to the antimicrobial activity of platelet-rich plasma preparations: A systematic review Open
The infection of a wound is one of the major contributors to delays in healing and tissue regeneration. As multi-drug resistance to antibiotics is becoming a serious threat, research in this field has focused on finding new agents and stra…
Developing novel topical antimicrobial agents for the treatment of biofilm infections Open
Background \nBacterial wound infections (especially those involving biofilms) represent a major challenge to healthcare, and are responsible for significant morbidity and mortality. Owing to the rise in antimicrobial resistance, there is r…
Antimicrobial peptide coatings for hydroxyapatite: electrostatic and covalent attachment of antimicrobial peptides to surfaces Open
The interface between implanted devices and their host tissue is complex and is often optimized for maximal integration and cell adhesion. However, this also gives a surface suitable for bacterial colonization. We have developed a novel me…
Antibacterial Activity of Blue Light against Nosocomial Wound Pathogens Growing Planktonically and as Mature Biofilms Open
The blue wavelengths within the visible light spectrum are intrinisically antimicrobial and can photodynamically inactivate the cells of a wide spectrum of bacteria (Gram positive and negative) and fungi. Furthermore, blue light is equally…
View article: Demonstration of the Blood-Stage<i>Plasmodium falciparum</i>Controlled Human Malaria Infection Model to Assess Efficacy of the<i>P. falciparum</i>Apical Membrane Antigen 1 Vaccine, FMP2.1/AS01
Demonstration of the Blood-Stage<i>Plasmodium falciparum</i>Controlled Human Malaria Infection Model to Assess Efficacy of the<i>P. falciparum</i>Apical Membrane Antigen 1 Vaccine, FMP2.1/AS01 Open
NCT02044198.