Explanipedia

SPDL1 Promotes Lung Metastasis of Triple-Negative Breast Cancer by Targeting the TGF-β/Smad Pathway to Regulate M2 Macrophage Polarization Open

Xiao Zhang, Dongxiao Shen, Han Cai, Chang Lu, Zean Yang , et al. · 2025

Breast cancer is a malignant tumor originating from breast epithelial tissue. Globally, there are approximately 2.3 million new breast cancer cases annually, accounting for 11.7% of all new cancer cases. Based on molecular subtype classifi…

Ursolic acid suppresses gastric cancer by targeting the miR-27a-3p/Wnt/β-catenin signaling axis Open

Fenfen Xiang, Rongrong Liu, Qing Gu, Mengzhe Zhang, Jiawen Qian , et al. · 2025

Advances in microbial biosynthesis of indirubin Open

Fenfen Xiang, R. C. Long, Dingkun Zhang, Yanan He · 2025

Comparison of respiratory pathogen infections in hospitalized patients before and during the COVID-19 pandemic in Shanghai, China Open

Xiaoxiao Li, Jie Wang, Junhua Dai, Fenfen Xiang, Zixi Chen , et al. · 2025

This study aimed to assess the impact of COVID-19 on the prevalence of respiratory pathogens among hospitalized patients with respiratory tract infections in Shanghai, China. Patients with acute respiratory infections (ARIs) hospitalized a…

Effect of high-pressure steam sterilization on the stability of medicine and food homology oral liquid: from the perspective of chemical composition and physical phase Open

Xiaorong Wei, Jun Tang, Guofeng Xue, Fenfen Xiang, Dingkun Zhang , et al. · 2025

Hunyuan-Large: An Open-Source MoE Model with 52 Billion Activated Parameters by Tencent Open

Xingwu Sun, Yanfeng Chen, Yiqing Huang, Ruobing Xie, Jiaqi Zhu , et al. · 2024

In this paper, we introduce Hunyuan-Large, which is currently the largest open-source Transformer-based mixture of experts model, with a total of 389 billion parameters and 52 billion activation parameters, capable of handling up to 256K t…

Leveraging existing 16S rRNA gene surveys to decipher microbial signatures and dysbiosis in cervical carcinogenesis Open

Xiaoxiao Li, Fenfen Xiang, Tong Liu, Zixi Chen, Mengzhe Zhang , et al. · 2024

Evaluation of the diagnostic performance of colposcopy in the detection of cervical high-grade squamous intraepithelial lesions among women with transformation zone type 3 Open

Xiaoxiao Li, Yunzhi Zhao, Fenfen Xiang, Xinpei Zhang, Zixi Chen , et al. · 2024

Background Inaccurate colposcopy diagnosis may lead to inappropriate management and increase the incidence of cervical cancer. This study aimed to evaluate the diagnostic accuracy of colposcopy in the detection of histologic cervical intra…

Characteristics of lymphocyte subsets and inflammatory factors in patients with COVID-19 Open

Zixi Chen, Jinpeng Li, Jin Zheng, Fenfen Xiang, Xiaoxiao Li , et al. · 2024

Study of miRNA and lymphocyte subsets as potential biomarkers for the diagnosis and prognosis of gastric cancer Open

Jinpeng Li, Zixi Chen, Qian Li, Rongrong Liu, Jin Zheng , et al. · 2024

Objective The aim of this study was to identify the expression of miRNA and lymphocyte subsets in the blood of gastric cancer (GC) patients, elucidate their clinical significance in GC, and establish novel biomarkers for the early diagnosi…

Ursolic acid inhibits the metastasis of colon cancer by downregulating ARL4C expression Open

Mengzhe Zhang, Fenfen Xiang, Yipeng Sun, Rongrong Liu, Qian Li , et al. · 2023

Ursolic acid (UA), a natural pentacyclic triterpenoid, is known to exhibit various biological activities and anticancer effects. However, the underlying anticancer mechanism is not fully understood to date. The present study aimed to inves…

Elevated expression of Toll-like receptor 4 and cytokines in both serum and myometrium at term may serve as promising biomarkers for uterine activation preceding labor Open

Zixi Chen, Jinpeng Li, Xu Wenjuan, Xiaomei Wu, Fenfen Xiang , et al. · 2023

Objective Increased inflammation and cytokine levels are considered risk factors and promoters of preterm birth (PTB). However, the regulatory mechanism of pregnancy-related inflammation remains unclear. Toll-like receptor 4 (TLR4) plays a…

Ursolic Acid Inhibits the Growth of Gastric Cancer by Targeting KLF4/YAP1 Open

Fenfen Xiang, Mengzhe Zhang, Wenbin Hao, Rongrong Liu, Qian Li , et al. · 2023

Krüppel-like factor 4 (KLF4) is a zinc-finger transcription factor which has various mechanisms in different tumors. Ursolic acid (UA), a natural compound that exists in many herbs, is known to prevent tumor progression and has anticancer …

Detection of cervical high-grade squamous intraepithelial lesions and assessing diagnostic performance of colposcopy among women with oncogenic HPV Open

Xiaoxiao Li, Fenfen Xiang, Yunzhi Zhao, Qian Li, Qing Gu , et al. · 2023

Spontaneous intramuscular hemorrhage in cancer-associated dermatomyositis: a case and literature review Open

Rui Xing, Fenfen Xiang, Lingli Dong, Guifen Shen · 2023

Spontaneous intramuscular hemorrhage in cancer-associated dermatomyositis: a case and literature review Open

Rui Xing, Guifen Shen, Fenfen Xiang, Lingli Dong · 2023

Background: Dermatomyositis (DM) is a systemic autoimmune disease with characteristic cutaneous manifestations and muscle weakness of the trunk, symmetrical proximal muscles of the limbs. Spontaneous intramuscular hemorrhage (SIH) is a rar…

Prevalence of cervicovaginal human papillomavirus infection and genotype distribution in Shanghai, China Open

Xiaoxiao Li, Fenfen Xiang, Junhua Dai, Tao Zhang, Zixi Chen , et al. · 2022

Genital Human Papillomavirus Prevalence and Genotyping Among Males in Putuo District of Shanghai, China 2015-2019 Open

Xiaoxiao Li, Fenfen Xiang, Zixi Chen, Tao Zhang, Zhaowei Zhu , et al. · 2021

BACKGROUND Reports of human papillomavirus (HPV) infection and genotype distribution in Chinese men are limited, and HPV vaccination has not yet been recommended for men in China. MATERIAL AND METHODS We retrospectively reviewed the preval…

3,3’-Diindolylmethane Enhances Paclitaxel Sensitivity by Suppressing DNMT1-Mediated KLF4 Methylation in Breast Cancer Open

Fenfen Xiang, Zhaowei Zhu, Mengzhe Zhang, Jie Wang, Zixi Chen , et al. · 2021

Paclitaxel (PTX) is a first-line chemotherapeutic drug for the treatment of breast cancer, but drug resistance seriously limits its clinical use. The aim of the present work was to explore the effect of 3,3’-diindolylmethane (DIM) on PTX s…

Hydrogen Sulfide Contributes to Uterine Quiescence Through Inhibition of NLRP3 Inflammasome Activation by Suppressing the TLR4/NF-κB Signalling Pathway Open

Zhiwei Chen, Ming Zhang, Yang Zhao, Xu W, Fenfen Xiang , et al. · 2021

Zixi Chen,1,* Mengzhe Zhang,1,* Yunzhi Zhao,2 Wenjuan Xu,2 Fenfen Xiang,1 Xiaoxiao Li,1 Tao Zhang,1 Rong Wu,1 Xiangdong Kang1 1Department of Laboratory Medicine, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai…

Hydrogen Sulfide Contributes to Uterine Quiescence Through Inhibition of NLRP3 Inflammasome Activation by Suppressing the TLR4/NF-κB Signalling Pathway Open

Zixi Chen, Mengzhe Zhang, Yunzhi Zhao, Wenjuan Xu, Fenfen Xiang , et al. · 2021

H₂S suppresses CAP expression and the inflammatory response and contributes to uterine quiescence by inhibiting the TLR4/NF-κB signalling pathway and downstream NLRP3 inflammasome activation. Thus, H₂S contributes to …

Ursolic Acid Protects Against Proliferation and Inflammatory Response in LPS-Treated Gastric Tumour Model and Cells by Inhibiting NLRP3 Inﬂammasome Activation Open

Zixi Chen, Qiaoli Liu, Zhaowei Zhu, Fenfen Xiang, Mengzhe Zhang , et al. · 2020

In conclusion, these results demonstrated that ursolic acid could suppress proliferation and the inflammatory response in an LPS-induced mouse gastric tumour model and human BGC-823 cells by inhibiting the activation of the NLRP3 inﬂammaso…

Ursolic Acid Reverses the Chemoresistance of Breast Cancer Cells to Paclitaxel by Targeting MiRNA-149-5p/MyD88 Open

Fenfen Xiang, Yan Fan, Zhenhua Ni, Qiaoli Liu, Zhaowei Zhu , et al. · 2019

Paclitaxel (PTX) is widely used as a front-line chemotherapy for breast cancer treatment. However, its clinical applications are limited by the development of chemoresistance. The objective of this study was to investigate the reversal eff…

Association of 758 G/A polymorphism of 3′untranslated region of prohibitin with risk of gastric cancer Open

Fenfen Xiang, Zhenhua Ni, Yueping Zhan, Jian Xu, Rong Wu , et al. · 2017

Background A polymorphic variant allele (T‐allele) in the 3′‐UTR of prohibitin (C‐to‐T at nucleotide 729) was reported to be associated with an increased risk of breast cancer. However, the association between the 3′‐UTR polymorphism of pr…

Erratum to: Increased expression of MyD88 and association with paclitaxel resistance in breast cancer Open

Fenfen Xiang, Zhenhua Ni, Yueping Zhan, Qianqian Kong, Jian Xu , et al. · 2016

354P Soluble CD160 augments cytokine secretion and cytolytic activity by tumor-specific CD8-T cells in vitro Open

Haibing Xiao, H L Sun, Fenfen Xiang, Qian Xia, X. Liu , et al. · 2015

Ursolic Acid Inhibits the Proliferation of Gastric Cancer Cells by Targeting miR-133a Open

Fenfen Xiang, Chunying Pan, Qianqian Kong, Rong Wu, Jiemin Jiang , et al. · 2015

Ursolic acid (UA), a potential chemotherapeutic agent, has the properties of inhibition of the growth of many human cancer cell lines. Whether UA can inhibit the growth and metastasis of human gastric cancer cells remains unknown. In this …

MiRNA-149 modulates chemosensitivity of ovarian cancer A2780 cells to paclitaxel by targeting MyD88 Open

Yueping Zhan, Fenfen Xiang, Rong Wu, Jian Xu, Zhenhua Ni , et al. · 2015

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