Jing Zhang
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View article: Association Between Prohibitin 3'UTR Gene Polymorphisms and Breast Cancer Susceptibility in the Western Chinese Population
Association Between Prohibitin 3'UTR Gene Polymorphisms and Breast Cancer Susceptibility in the Western Chinese Population Open
Background Breast cancer incidence continues to rise globally, maintaining its position as the second leading cancer. Despite therapeutic advances, enhancing early screening and personalized treatment remains critical. However, population-…
View article: Echocardiographic evaluation of left ventricular function in patients with mitral regurgitation: a meta-analysis
Echocardiographic evaluation of left ventricular function in patients with mitral regurgitation: a meta-analysis Open
Purpose This study aimed to quantitatively assess left ventricular function in patients with mitral regurgitation (MR) using speckle-tracking echocardiography and further clarify its clinical application. Methods PubMed, Embase, Web of Sci…
View article: Integrated multi-omics analysis reveals a glycolytic signature that predicts pan-cancer immune checkpoint inhibitor response and LDHA as a combinatorial target in fumarate hydratase-deficient renal cell carcinoma
Integrated multi-omics analysis reveals a glycolytic signature that predicts pan-cancer immune checkpoint inhibitor response and LDHA as a combinatorial target in fumarate hydratase-deficient renal cell carcinoma Open
Introduction Fumarate hydratase-deficient renal cell carcinoma (FH-deficient RCC) is a rare, aggressive malignancy with limited therapeutic options and poor prognosis. Despite immune checkpoint inhibitors (ICIs) showing efficacy in other c…
View article: Proteogenomic Reassessment Provides Novel Insight into the Life Cycle of Tetrahymena thermophila
Proteogenomic Reassessment Provides Novel Insight into the Life Cycle of Tetrahymena thermophila Open
Tetrahymena thermophila (T. thermophila), a well-established model organism, has been instrumental in advancing our understanding of evolutionarily conserved biological processes. A key biological feature of this unicellular eukaryote is i…
View article: Safety, Tolerability, and Pharmacokinetics of Galcanezumab, an Anti‐CGRP Antibody, in Healthy Chinese Participants
Safety, Tolerability, and Pharmacokinetics of Galcanezumab, an Anti‐CGRP Antibody, in Healthy Chinese Participants Open
Galcanezumab is used in several regions, including the United States, Europe, and China, as a preventive treatment for migraine. This study aimed to evaluate the safety, tolerability, and pharmacokinetics (PK) of galcanezumab in healthy Ch…
View article: Safety and Pharmacokinetics of Long‐Acting Monoclonal Antibodies Tixagevimab and Cilgavimab (AZD7442) in a China Phase 2 Study and Evaluation of Asian Race Effect
Safety and Pharmacokinetics of Long‐Acting Monoclonal Antibodies Tixagevimab and Cilgavimab (AZD7442) in a China Phase 2 Study and Evaluation of Asian Race Effect Open
Safety, pharmacokinetics, and impact of race of pharmacokinetics on monoclonal antibodies tixagevimab and cilgavimab (AZD7442) were assessed in Chinese adult participants in a Phase 2, randomized, double‐blind, placebo‐controlled trial. In…
View article: Harnessing the Immunomodulation of UV‐Exposed Keratinocyte Extracellular Vesicles for Inflammatory Disorder Treatment
Harnessing the Immunomodulation of UV‐Exposed Keratinocyte Extracellular Vesicles for Inflammatory Disorder Treatment Open
Sunbathing excessively heightens the risk of skin carcinogenesis due to ultraviolet (UV)‐mediated immunosuppression. Keratinocytes, the primary cells in epidermis, play a pivotal role in orchestrating the UV‐induced immunosuppressive respo…
View article: Obesity Increases Atherosclerosis Susceptibility via Inter-tissue miR-30e-SLC7A11 Axis
Obesity Increases Atherosclerosis Susceptibility via Inter-tissue miR-30e-SLC7A11 Axis Open
Background With obesity as a risk factor for atherosclerotic disease, recent research suggests that adipose tissue in obese animal models and humans can generate endocrine-like molecules that affect arterial health later on. Previous studi…
View article: Novel Identification of CD74 as a Biomarker for Diagnosing and Prognosing Sepsis Patients
Novel Identification of CD74 as a Biomarker for Diagnosing and Prognosing Sepsis Patients Open
This study presents the first quantitative assessment of human plasma CD74 in sepsis patients. CD74 levels were significantly lower in the sepsis cohort. CD74 warrants further exploration as a potential prognostic and therapeutic target fo…
View article: P024: Updated efficacy and safety of SHR-A1811, an anti-HER2 antibodydrug conjugate, in heavily pretreated advanced solid tumors with HER2-expression or mutations: a global, multicenter, phase 1 study
P024: Updated efficacy and safety of SHR-A1811, an anti-HER2 antibodydrug conjugate, in heavily pretreated advanced solid tumors with HER2-expression or mutations: a global, multicenter, phase 1 study Open
View article: Top 100 most-cited articles on apoptosis of non-small cell lung cancer over the past two decades: a bibliometrics analysis
Top 100 most-cited articles on apoptosis of non-small cell lung cancer over the past two decades: a bibliometrics analysis Open
Background Recently there has been an increasing number of studies have explored apoptosis mechanisms in lung cancer (LC). However, no researchers have conducted a bibliometric analysis of the most cited articles in this field. Objective T…
View article: Anti-Tumor Activity and Mechanism of Apoptosis of Cne Cells Induced by Acylhydrazone Based Complexes
Anti-Tumor Activity and Mechanism of Apoptosis of Cne Cells Induced by Acylhydrazone Based Complexes Open
View article: Adoption value of serum hematological inflammatory markers in early diagnosis of necrotising enterocolitis
Adoption value of serum hematological inflammatory markers in early diagnosis of necrotising enterocolitis Open
Background: Early diagnosis and intervention of neonatal necrotising enterocolitis (NEC) are crucial for improving prognosis. It was to assess the diagnostic and staging value of high-sensitivity C-reactive protein (hs-CRP), white blood ce…
View article: The wound healing of deep partial-thickness burn in Bama miniature pigs is accelerated by a higher dose of hUCMSCs
The wound healing of deep partial-thickness burn in Bama miniature pigs is accelerated by a higher dose of hUCMSCs Open
This regenerative cell therapy study using hUCMSCs demonstrates the best efficacy toward a high dose, that is dose of 1 × 10^8 of hUCMSCs was used as a reference therapeutic dose for treating 20 cm2 deep partial-thickness burns …
View article: The Optimal Radiotherapy Strategy for Patients With Small Cell Lung Cancer and Brain Metastasis: A Retrospective Analysis
The Optimal Radiotherapy Strategy for Patients With Small Cell Lung Cancer and Brain Metastasis: A Retrospective Analysis Open
Background Extensive‐stage small cell lung cancer (ES‐SCLC) is a notoriously aggressive malignancy frequently associated with brain metastases (BMs), presenting substantial therapeutic challenges. This study delves into the effectiveness o…
View article: Pirfenidone antagonizes TGF-β1-mediated gabapentin resistance via reversal of desmoplasia and the ‘cold’ microenvironment in pancreatic cancer
Pirfenidone antagonizes TGF-β1-mediated gabapentin resistance via reversal of desmoplasia and the ‘cold’ microenvironment in pancreatic cancer Open
Owing to the desmoplastic stroma constituted by cancer-associated fibroblasts (CAFs), few immune cells infiltrate the pancreatic ductal adenocarcinoma (PDAC). Gabapentin can impede the production of ketoacids by CAFs to support cancer cell…
View article: Reactive Oxygen Species-Scavenging Mesoporous Poly(tannic acid) Nanospheres Alleviate Acute Kidney Injury by Inhibiting Ferroptosis
Reactive Oxygen Species-Scavenging Mesoporous Poly(tannic acid) Nanospheres Alleviate Acute Kidney Injury by Inhibiting Ferroptosis Open
Acute kidney injury (AKI), predominantly associated with the excess production of endogenous ROS, is a serious renal dysfunction syndrome. Ferroptosis characterized by iron-dependent regulated cell death has significant involvement in AKI …
View article: The wound healing of deep partial-thickness burn in Bama miniature pigs is accelerated by a higher dose of hUCMSCs
The wound healing of deep partial-thickness burn in Bama miniature pigs is accelerated by a higher dose of hUCMSCs Open
Background Deep partial-thickness burns have a significant impact on both the physical and mental health of patients. Our previous study demonstrated human Umbilical Cord Mesenchymal stem cells (hUCMSCs) could enhance the healing of severe…
View article: Mesoporous zinc-polyphenol nanozyme for attenuating renal ischemia–reperfusion injury
Mesoporous zinc-polyphenol nanozyme for attenuating renal ischemia–reperfusion injury Open
Aim: To target the reactive oxygen species (ROS) accumulation and renal tubular epithelial cell (rTEC) death in renal ischemia-reperfusion injury (IRI), we constructed a nanoparticle that offers ROS scavenging and rTEC-death inhibit…
View article: Neoadjuvant toripalimab combined with axitinib in patients with locally advanced clear cell renal cell carcinoma: a single-arm, phase II trial
Neoadjuvant toripalimab combined with axitinib in patients with locally advanced clear cell renal cell carcinoma: a single-arm, phase II trial Open
Background A combination of axitinib and immune checkpoint inhibitors (ICIs) demonstrated promising efficacy in the treatment of advanced renal cell carcinoma (RCC). This study aims to prospectively evaluate the safety, efficacy, and bioma…
View article: CYP3A4*18B, CYP3A5*3, and MDR1C3435T gene studies with tacrolimus pharmacokinetics in healthy Chinese subjects
CYP3A4*18B, CYP3A5*3, and MDR1C3435T gene studies with tacrolimus pharmacokinetics in healthy Chinese subjects Open
Aims: To investigate the effects of the CYP3A4*18B, CYP3A5*3, and MDR1C3435T gene polymorphisms on the pharmacokinetics of tacrolimus in healthy Chinese subjects. Methods: Thirty healthy Chinese subjects received single oral doses of 5 mg …
View article: Emerging role of gut microbiota in autoimmune diseases
Emerging role of gut microbiota in autoimmune diseases Open
Accumulating studies have indicated that the gut microbiota plays a pivotal role in the onset of autoimmune diseases by engaging in complex interactions with the host. This review aims to provide a comprehensive overview of the existing li…
View article: Associations between trans fatty acids and systemic immune-inflammation index: a cross-sectional study
Associations between trans fatty acids and systemic immune-inflammation index: a cross-sectional study Open
Background Previous studies have demonstrated that trans fatty acids (TFAs) intake was linked to an increased risk of chronic diseases. As a novel systemic inflammatory biomarker, the clinical value and efficacy of the systemic immune-infl…
View article: Genetically engineered nanomodulators elicit potent immunity against cancer stem cells by checkpoint blockade and hypoxia relief
Genetically engineered nanomodulators elicit potent immunity against cancer stem cells by checkpoint blockade and hypoxia relief Open
View article: Cmtm4 deficiency exacerbates colitis by inducing gut dysbiosis and S100a8/9 expression
Cmtm4 deficiency exacerbates colitis by inducing gut dysbiosis and S100a8/9 expression Open
The dysfunction of innate immunity components is one of the major drivers for ulcerative colitis (UC), and increasing reports indicate that the gut microbiome serves as an intermediate between genetic mutations and UC development. Here, we…
View article: Cost-effectiveness of Automated Medical Systems implementation in hospital setting: A systematic review and meta-analysis
Cost-effectiveness of Automated Medical Systems implementation in hospital setting: A systematic review and meta-analysis Open
Objectives: This systematic review summarized and synthesized the available evidence to examines the cost-effectiveness of the implementation of Automated Medical Systems. Method: PubMed, Embase, Web of Science, The Cochrane Library, China…
View article: Genetic evidence on the causality between gut microbiota and various asthma phenotypes: a two-sample Mendelian randomization study
Genetic evidence on the causality between gut microbiota and various asthma phenotypes: a two-sample Mendelian randomization study Open
Introduction Asthma is a multifarious disease that manifests in various phenotypes. Among the various factors that contribute to the development of asthma, the gut microbiota has recently emerged as a compelling area of investigation. This…
View article: Effect of piperacillin sodium and sulbactam sodium on respiratory function in patients with acute respiratory distress syndrome
Effect of piperacillin sodium and sulbactam sodium on respiratory function in patients with acute respiratory distress syndrome Open
Purpose: To investigate the effect of the combination of piperacillin sodium and sulbactam sodium on respiratory function in patients with acute respiratory distress syndrome (ARDS).
Methods: The clinical data for 151 ARDS patients admitt…
View article: Antirheumatic drug leflunomide attenuates atherosclerosis by regulating lipid metabolism and endothelial dysfunction via DHODH/AMPK signaling pathway
Antirheumatic drug leflunomide attenuates atherosclerosis by regulating lipid metabolism and endothelial dysfunction via DHODH/AMPK signaling pathway Open
The probability of cardiovascular events has been reported lower in rheumatoid arthritis (RA) patients treated with leflunomide. However, the anti-atherosclerotic and cardiovascular protective effects and metabolism of leflunomide are not …
View article: Induction of interleukin-6 by SPZ1-mediated Wnt5a signaling boosts progression of nasopharyngeal carcinoma cells
Induction of interleukin-6 by SPZ1-mediated Wnt5a signaling boosts progression of nasopharyngeal carcinoma cells Open
Nasopharyngeal carcinoma (NPC) is a common malignancy in Southeast Asia, and in the Guangxi and Guangdong provinces of China. The spermatogenic transcription factor zip 1 (SPZ1) is a member of bHLH zip family, and promotes tumorigenesis in…