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View article: Trends in cognitive outcomes in middle-aged Americans across three birth cohorts
Trends in cognitive outcomes in middle-aged Americans across three birth cohorts Open
Middle age is a key life course period for targeting modifiable risk factors for late-life cognitive decline. Although the prevalence of chronic conditions that are risk factors for cognitive impairment has increased in middle-aged adults …
View article: Prolonged neoadjuvant hormonal therapy enhances IL-17 A/STAT3-mediated inflammation in prostate cancer
Prolonged neoadjuvant hormonal therapy enhances IL-17 A/STAT3-mediated inflammation in prostate cancer Open
Prolonged NHT enhances IL-17 A/IL-17RC-mediated inflammation in prostate cancer, potentially promoting tumor progression through STAT3 activation. Targeting the IL-17 A/STAT3 axis may offer therapeutic potential for advanced prostate cance…
View article: Hematological parameters as predictors of prostate cancer: A study based on multivariable and bidirectional Mendelian randomization
Hematological parameters as predictors of prostate cancer: A study based on multivariable and bidirectional Mendelian randomization Open
This study explores the causal relationship between hematologic parameters and prostate cancer (PCa) risk, offering insights into potential biological pathways and clinical implications. We used genome-wide association studies to perform f…
View article: Learning curve analysis of transurethral thulium fiber laser enucleation of the prostate with preserving urethral Mucosa at the prostatic apex
Learning curve analysis of transurethral thulium fiber laser enucleation of the prostate with preserving urethral Mucosa at the prostatic apex Open
Objective To introduce a unique surgical technique, analyze perioperative data to demonstrate the safety of Thulium Fiber Laser Enucleation of the Prostate (ThuFLEP) with preservation of the urethral mucosa at the prostatic apex, and const…
View article: Characterization of the extrinsic and intrinsic signatures and therapeutic vulnerability of small cell lung cancers
Characterization of the extrinsic and intrinsic signatures and therapeutic vulnerability of small cell lung cancers Open
Small-cell lung cancer (SCLC), an aggressive neuroendocrine tumor strongly associated with exposure to tobacco carcinogens, is characterized by early dissemination and dismal prognosis with a five-year overall survival of less than 7%. Hig…
View article: Prognostic value and predictive model construction for patients undergoing laparoscopic radical prostatectomy based on the preoperative NPL-IRS score and prognostic nutritional index
Prognostic value and predictive model construction for patients undergoing laparoscopic radical prostatectomy based on the preoperative NPL-IRS score and prognostic nutritional index Open
Objective To explore the prognostic value of preoperative hematological indicators for prostate cancer (PCa) patients with laparoscopic radical prostatectomy (LRP) and construct a nomogram prediction model based on hematological indicators…
View article: Estimated glomerular filtration rate, albuminuria, and risk of infection: a collaborative meta-analysis of individual participant data
Estimated glomerular filtration rate, albuminuria, and risk of infection: a collaborative meta-analysis of individual participant data Open
US National Kidney Foundation and the National Institute of Diabetes and Digestive and Kidney Diseases.
View article: Chance-constrained optimal schedule of battery energy storage considering the uncertainties of renewable generation
Chance-constrained optimal schedule of battery energy storage considering the uncertainties of renewable generation Open
Since renewable energy generation has strong uncertainties and pure conventional unit dispatch schemes are limited by the unit-operating capacities, such scheduling is inapplicable for power systems with high proportions of renewable energ…
View article: Novel variant in MYH9 in a child with proteinuria and thrombocytopenia: a case report and literature review
Novel variant in MYH9 in a child with proteinuria and thrombocytopenia: a case report and literature review Open
There is a lack of awareness of the diagnosis and treatment of MYH9 -related disorder ( MYH9 -RD), which is an autosomal dominant disease with heterogeneous clinical manifestations. We summarized the clinical phenotype and reported a novel…
View article: Clinical and prognostic factors guiding diagnosis and treatment of prostate diffuse large B-cell lymphoma
Clinical and prognostic factors guiding diagnosis and treatment of prostate diffuse large B-cell lymphoma Open
View article: Increased Infectious Risk Donor Status and Equity‐Relevant Predictors of Organ Donation Organization Approach and Caregiver Consent for Deceased Organ Donation in a Canadian Province (2015–2021)
Increased Infectious Risk Donor Status and Equity‐Relevant Predictors of Organ Donation Organization Approach and Caregiver Consent for Deceased Organ Donation in a Canadian Province (2015–2021) Open
Background Current donor risk assessments to identify risk of infectious transmission through transplantation have been criticized as unnecessarily discriminatory for sexual and gender minorities. Little is known about how increased infect…
View article: Clonal hematopoiesis of indeterminate potential is associated with reduced risk of cognitive impairment in patients with chronic kidney disease
Clonal hematopoiesis of indeterminate potential is associated with reduced risk of cognitive impairment in patients with chronic kidney disease Open
INTRODUCTION Clonal hematopoiesis of indeterminate potential (CHIP) and dementia disproportionately burden patients with chronic kidney disease (CKD). The association between CHIP and cognitive impairment in CKD patients is unknown. METHOD…
View article: Clonal hematopoiesis of indeterminate potential contributes to accelerated chronic kidney disease progression
Clonal hematopoiesis of indeterminate potential contributes to accelerated chronic kidney disease progression Open
Background Clonal hematopoiesis of indeterminate potential (CHIP) is a common inflammatory condition of aging that causes myriad end-organ damage. We have recently shown associations for CHIP with acute kidney injury and with kidney functi…
View article: Matrix Metalloproteinase-2 and CKD Progression: The Chronic Renal Insufficiency Cohort (CRIC) Study
Matrix Metalloproteinase-2 and CKD Progression: The Chronic Renal Insufficiency Cohort (CRIC) Study Open
View article: Implementation of a geriatric assessment SmartPhrase: A multi‐institutional pilot study
Implementation of a geriatric assessment SmartPhrase: A multi‐institutional pilot study Open
As the population ages, geriatric assessment (GA) is an increasingly important clinical skill. The GA also encompasses many geriatrics competencies recommended for medical students and internal medicine (IM) and family medicine (FM) reside…
View article: Causal Associations between Prostate Cancer and Various Hematological Parameters: Insights from Multivariable and Bidirectional Mendelian Randomization Analyses
Causal Associations between Prostate Cancer and Various Hematological Parameters: Insights from Multivariable and Bidirectional Mendelian Randomization Analyses Open
Purpose This study aims to investigate the causal relationship between hematologic parameters and the risk of developing PCa, employing a rigorous and methodical scientific approach. Methods We applied genome-wide association studies (GWAS…
View article: Depressive Symptoms, Antidepressants, and Clinical Outcomes in Chronic Kidney Disease: Findings from the CRIC Study
Depressive Symptoms, Antidepressants, and Clinical Outcomes in Chronic Kidney Disease: Findings from the CRIC Study Open
View article: The value of preoperative neutrophil‐to‐lymphocyte ratio, platelet‐to‐lymphocyte ratio, and red blood cell distribution width in predicting positive surgical margin after laparoscopic radical prostatectomy
The value of preoperative neutrophil‐to‐lymphocyte ratio, platelet‐to‐lymphocyte ratio, and red blood cell distribution width in predicting positive surgical margin after laparoscopic radical prostatectomy Open
Background Prostate cancer (PCa) is one of the most common malignant tumors in men, and laparoscopic radical prostatectomy (LRP) is commonly used to treat localized and advanced PCa. Positive surgical margin (PSM) is one of the most freque…
View article: Metabolites Associated With Uremic Symptoms in Patients With CKD: Findings From the Chronic Renal Insufficiency Cohort (CRIC) Study
Metabolites Associated With Uremic Symptoms in Patients With CKD: Findings From the Chronic Renal Insufficiency Cohort (CRIC) Study Open
View article: COGNITIVE TRAJECTORIES IN MIDDLE-AGED AMERICANS, 1995–2018
COGNITIVE TRAJECTORIES IN MIDDLE-AGED AMERICANS, 1995–2018 Open
Given evidence that Alzheimer’s disease and related dementias (ADRD) develop over decades, middle age is increasingly recognized as a key life course period to target modifiable risk factors for cognitive decline and ADRD. Epidemiological …
View article: Nuclear respiratory factor 1 drives hepatocellular carcinoma progression by activating LPCAT1-ERK1/2-CREB axis
Nuclear respiratory factor 1 drives hepatocellular carcinoma progression by activating LPCAT1-ERK1/2-CREB axis Open
Background Nuclear respiratory factor 1 (NRF1) is a transcription factor that participates in several kinds of tumor, but its role in hepatocellular carcinoma (HCC) remains elusive. This study aims to explore the role of NRF1 in HCC progre…
View article: Case Report: Analysis of four cases of metastatic bladder masses after radical prostatectomy
Case Report: Analysis of four cases of metastatic bladder masses after radical prostatectomy Open
Objective The aim of this study is to investigate the clinical characteristics and diagnostic and therapeutic methods of bladder metastasis after radical prostatectomy and to improve its diagnosis and treatment. Methods The clinical data o…
View article: Vitamin D Metabolites and Risk of Cardiovascular Disease in Chronic Kidney Disease: The CRIC Study
Vitamin D Metabolites and Risk of Cardiovascular Disease in Chronic Kidney Disease: The CRIC Study Open
Background The ratio of 24,25‐dihydroxyvitamin D 3 /25‐hydroxyvitamin D 3 (vitamin D metabolite ratio [VDMR]) may reflect functional vitamin D activity. We examined associations of the VDMR, 25‐hydroxyvitamin D (25[OH]D), and 1,25‐dihydrox…
View article: Association of urine and plasma ADMA with atherosclerotic risk in DKD cardiovascular disease risk in diabetic kidney disease: findings from the Chronic Renal Insufficiency Cohort (CRIC) study
Association of urine and plasma ADMA with atherosclerotic risk in DKD cardiovascular disease risk in diabetic kidney disease: findings from the Chronic Renal Insufficiency Cohort (CRIC) study Open
Background Chronic kidney disease (CKD) is associated with atherosclerotic cardiovascular disease (ASCVD) risk, especially among those with diabetes. Altered metabolism of solutes that accumulate in CKD [asymmetric dimethylarginine (ADMA),…
View article: Table of Contents
Table of Contents Open
View article: Nuclear Respiratory Factor 1 Drives Hepatocellular Carcinoma Progression by Forming a Positive Feedback Loop with LPCAT1-ERK1/2-CREB Axis
Nuclear Respiratory Factor 1 Drives Hepatocellular Carcinoma Progression by Forming a Positive Feedback Loop with LPCAT1-ERK1/2-CREB Axis Open
View article: Nuclear Respiratory Factor 1 drives hepatocellular carcinoma progression by forming a positive feedback loop with LPCAT1-ERK1/2-CREB axis
Nuclear Respiratory Factor 1 drives hepatocellular carcinoma progression by forming a positive feedback loop with LPCAT1-ERK1/2-CREB axis Open
Background Nuclear respiratory factor 1 (NRF1) is a transcription factor that participates in several kinds of tumor, but its role in hepatocellular carcinoma (HCC) remains elusive. This study aims to explore the role of NRF1 in HCC progre…
View article: Metabolite profiling of CKD progression in the chronic renal insufficiency cohort study
Metabolite profiling of CKD progression in the chronic renal insufficiency cohort study Open
BACKGROUNDMetabolomic profiling in individuals with chronic kidney disease (CKD) has the potential to identify novel biomarkers and provide insight into disease pathogenesis.METHODSWe examined the association between blood metabolites and …
View article: Benzodiazepine and antipsychotic use among hospitalized older adults before versus after restricting visitation: March to May 2020
Benzodiazepine and antipsychotic use among hospitalized older adults before versus after restricting visitation: March to May 2020 Open
Background Hospital visitation restrictions during the COVID‐19 pandemic prompted concerns about unintended consequences for older patients, including an increased incidence of delirium and agitation. While first‐line interventions for the…
View article: Transcriptional regulation and small compound targeting of ACE2 in lung epithelial cells
Transcriptional regulation and small compound targeting of ACE2 in lung epithelial cells Open