Yan Lou
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View article: RAB7B as a Potential Therapeutic Target in Liver Cirrhosis: Insights from Protein Expression and Bioinformatics Analyses
RAB7B as a Potential Therapeutic Target in Liver Cirrhosis: Insights from Protein Expression and Bioinformatics Analyses Open
View article: scMOVIR: a single-cell multi-omics database for human viral infections and immune responses
scMOVIR: a single-cell multi-omics database for human viral infections and immune responses Open
Viral infections impose a substantial threat to human health, characterized by a wide range of pathogens, clinical manifestations, and complex immune responses. Single-cell multi-omics technologies have revolutionized the study of antivira…
View article: Metformin attenuates O-GlcNAc modification to improve renal function via AMPK/mTOR signaling in diabetic nephropathy
Metformin attenuates O-GlcNAc modification to improve renal function via AMPK/mTOR signaling in diabetic nephropathy Open
Diabetic nephropathy is a growing global health challenge, significantly increasing the risks of hypertension and cardiovascular complications. Despite existing treatment options, none effectively promote renal repair or halt disease progr…
View article: Association of brain-derived neurotrophic factor levels at different trimesters and new-onset depressive symptom in the third trimester among pregnant women: a longitudinal study
Association of brain-derived neurotrophic factor levels at different trimesters and new-onset depressive symptom in the third trimester among pregnant women: a longitudinal study Open
Background Accumulating evidence e suggests that brain-derived neurotrophic factor (BDNF) may play a role in the development of depression. However, changes in serum BDNF during distinct gestational periods and their association with prena…
View article: Voriconazole-induced liver injury: incidence patterns and risk factors in a retrospective cohort
Voriconazole-induced liver injury: incidence patterns and risk factors in a retrospective cohort Open
Voriconazole, a first-line therapy for invasive aspergillosis, carries hepatotoxicity risks lacking comprehensive epidemiological characterization. Current evidence is limited by heterogeneity in diagnostic criteria (e.g., varying threshol…
View article: Relationship between adolescent gaming addiction and myopia, ocular surface condition, and health status: a questionnaire based cohort study
Relationship between adolescent gaming addiction and myopia, ocular surface condition, and health status: a questionnaire based cohort study Open
This study explores the relationship between gaming addiction among Chinese adolescents and their myopia, ocular surface conditions, and overall health. A cross-sectional questionnaire-based cohort study included 835 participants aged 13-1…
View article: Experimental Study of Random Secret Key Extraction From Atmospheric Optical Channels
Experimental Study of Random Secret Key Extraction From Atmospheric Optical Channels Open
Utilizing reciprocal atmospheric turbulence as a physical entropy source for extracting random secret key is an effective means to achieve physical layer security in wireless channels. To study the impact of turbulence intensity on secret …
View article: Knowledge, attitude, and practice towards occupational burnout among doctors and nurses in intensive care unit
Knowledge, attitude, and practice towards occupational burnout among doctors and nurses in intensive care unit Open
Background Occupational burnout is prevalent among doctors and nurses. This study aimed to investigate the knowledge, attitude, and practice (KAP) of ICU doctors and nurses regarding occupational burnout. Methods A cross-sectional study wa…
View article: Associations of Psychological Anxiety, Depression, and Ocular Surface Status with Internet Gaming Engagement in Chinese Young Population: A Questionnaire-Based Cohort Study
Associations of Psychological Anxiety, Depression, and Ocular Surface Status with Internet Gaming Engagement in Chinese Young Population: A Questionnaire-Based Cohort Study Open
View article: Comparative effectiveness and safety of four traditional Chinese medicine injections with invigorating blood circulation, equivalent effect of anticoagulation or antiplatelet in acute myocardial infarction: a Bayesian network meta-analysis
Comparative effectiveness and safety of four traditional Chinese medicine injections with invigorating blood circulation, equivalent effect of anticoagulation or antiplatelet in acute myocardial infarction: a Bayesian network meta-analysis Open
Background: Traditional Chinese medicine injections with invigorating blood circulation (TCMI-IBCs), which have been used as antithrombosis therapies, are widely employed by Chinese clinicians as adjuvant therapy for acute myocardial infar…
View article: Elevated RHAMM as a biomarker for predicting diabetic kidney disease in patients with type 2 diabetes
Elevated RHAMM as a biomarker for predicting diabetic kidney disease in patients with type 2 diabetes Open
Background Diabetic kidney disease (DKD) poses a significant challenge globally as a complication of diabetes. Hyaluronan (HA), a critical non-sulfated glycosaminoglycan in the extracellular matrix, plays a pivotal role in the progression …
View article: A Supramolecular Bifunctional Hydrogel with Zero-Order Release Kinetics to Resist Bacterial Infection and Foreign Body Response of Implants
A Supramolecular Bifunctional Hydrogel with Zero-Order Release Kinetics to Resist Bacterial Infection and Foreign Body Response of Implants Open
View article: Engineering Cryptand-like Coordination Sites in Multisite Metal Acyl-Organic Cages for Specific Recognition and Deep Purification of Radioactive Strontium(II)
Engineering Cryptand-like Coordination Sites in Multisite Metal Acyl-Organic Cages for Specific Recognition and Deep Purification of Radioactive Strontium(II) Open
Tailored design of organic linkers or metal nodes can implant desirable binding sites in metal-organic cages (MOCs), expanding the types of guests they can encapsulate. In this work, we propose a feasible method of engineering acyl-type me…
View article: Engineering Multisite Metal-Organic Cages with Metal Acyl Nodes for Specific Recognition and Deep Purification of Radioactive Strontium(II)
Engineering Multisite Metal-Organic Cages with Metal Acyl Nodes for Specific Recognition and Deep Purification of Radioactive Strontium(II) Open
Tailored design of organic linkers or metal nodes can implant desirable binding sites in metal-organic cages (MOCs) and greatly expand the type of guest they can encapsulate. In this work, we propose a feasible method of engineering acyl-t…
View article: Engineering Multisite Metal-Organic Cages with Metal Acyl Nodes for Specific Recognition and Deep Purification of Radioactive Strontium(II)
Engineering Multisite Metal-Organic Cages with Metal Acyl Nodes for Specific Recognition and Deep Purification of Radioactive Strontium(II) Open
Tailored design of organic linkers or metal nodes can implant desirable binding sites in metal-organic cages (MOCs) and greatly expand the type of guest they can encapsulate. In this work, we propose a feasible method of engineering acyl-t…
View article: The RNF214-TEAD-YAP signaling axis promotes hepatocellular carcinoma progression via TEAD ubiquitylation
The RNF214-TEAD-YAP signaling axis promotes hepatocellular carcinoma progression via TEAD ubiquitylation Open
RNF214 is an understudied ubiquitin ligase with little knowledge of its biological functions or protein substrates. Here we show that the TEAD transcription factors in the Hippo pathway are substrates of RNF214. RNF214 induces non-proteoly…
View article: Effect of dietary patterns on mild cognitive impairment and dementia: a machine learning bibliometric and visualization analysis
Effect of dietary patterns on mild cognitive impairment and dementia: a machine learning bibliometric and visualization analysis Open
Objective As a spectrum of neurodegenerative conditions, dementia presents a significant challenge to worldwide health. Mild cognitive impairment (MCI) is recognized as the intermediate stage between normal cognitive functioning and dement…
View article: The Efficacy and Safety of Roxadustat for the Treatment of Posttransplantation Anemia: A Randomized Study
The Efficacy and Safety of Roxadustat for the Treatment of Posttransplantation Anemia: A Randomized Study Open
Roxadustat increased Hb in adult renal transplant recipients who underwent PTA, with an adverse event profile comparable to that of the control group.
View article: Traditional chinese medicine injections with activating blood circulation, equivalent effect of anticoagulation or antiplatelet, for acute myocardial infarction: A systematic review and meta-analysis of randomized clinical trials
Traditional chinese medicine injections with activating blood circulation, equivalent effect of anticoagulation or antiplatelet, for acute myocardial infarction: A systematic review and meta-analysis of randomized clinical trials Open
[INPLASY], identifier [INPLASY202170082].
View article: Application of Conversational Intelligent Reporting System Based on Artificial Intelligence and Large Language Models
Application of Conversational Intelligent Reporting System Based on Artificial Intelligence and Large Language Models Open
As large language models gain traction in the financial sector, they are revolutionizing the workflows of financial professionals. From data analysis and market forecasting to risk assessment and customer management, these models demonstra…
View article: Integration of transcriptomic analysis and multiple machine learning approaches identifies NAFLD progression-specific hub genes to reveal distinct genomic patterns and actionable targets
Integration of transcriptomic analysis and multiple machine learning approaches identifies NAFLD progression-specific hub genes to reveal distinct genomic patterns and actionable targets Open
Background Nonalcoholic fatty liver disease (NAFLD) is a leading public health problem worldwide. Approximately one fourth of patients with nonalcoholic fatty liver (NAFL) progress to nonalcoholic steatohepatitis (NASH), an advanced stage …
View article: Clinical Timing-Sequence Warning Models for Serious Bacterial Infections in Adults Based on Machine Learning: Retrospective Study
Clinical Timing-Sequence Warning Models for Serious Bacterial Infections in Adults Based on Machine Learning: Retrospective Study Open
Background Serious bacterial infections (SBIs) are linked to unplanned hospital admissions and a high mortality rate. The early identification of SBIs is crucial in clinical practice. Objective This study aims to establish and validate cli…
View article: [Retracted] MicroRNA-493 inhibits the proliferation and invasion of osteosarcoma cells through directly targeting specificity protein 1
[Retracted] MicroRNA-493 inhibits the proliferation and invasion of osteosarcoma cells through directly targeting specificity protein 1 Open
[This retracts the article DOI: 10.3892/ol.2018.8268.].
View article: Relationships between attitudes toward mental problems, doctor-patient relationships, and depression/anxiety levels in medical workers: A network analysis.
Relationships between attitudes toward mental problems, doctor-patient relationships, and depression/anxiety levels in medical workers: A network analysis. Open
The "insulting words" may be an intervention target for medical workers' attitudes toward mental problems. The "anhedonia" in depression is the potential symptom that needs to be treated. Intervention targeting these variables may be benef…
View article: Synthesis of Flower-Like Cobalt–Molybdenum Mixed-Oxide Microspheres for Deep Aerobic Oxidative Desulfurization of Fuel
Synthesis of Flower-Like Cobalt–Molybdenum Mixed-Oxide Microspheres for Deep Aerobic Oxidative Desulfurization of Fuel Open
Flower-like cobalt–molybdenum mixed-oxide microspheres (CoMo-FMs) with hierarchical architecture were successfully synthesized via a hydrothermal process and subsequent calcination step. The characterization results show that CoMo-FMs were…
View article: The RNF214-TEAD-YAP signaling axis promotes hepatocellular carcinoma progression via TEAD ubiquitylation
The RNF214-TEAD-YAP signaling axis promotes hepatocellular carcinoma progression via TEAD ubiquitylation Open
RNF214 is an understudied ubiquitin ligase without any knowledge of its biological functions or specific protein substrates. Using an APEX2-mediated proximity labeling method coupled with the mass spectrometry technique, we identified the …
View article: Nursing Students' Self-rated Nurse Professional Competence at the End of an International Collaborative Education Program and Follow-up 1 Year Later
Nursing Students' Self-rated Nurse Professional Competence at the End of an International Collaborative Education Program and Follow-up 1 Year Later Open
Background: International collaborative programs and student active learning are encouraged; yet, little is known about them. Purpose: To compare nursing students' self-rated nurse professional competence (NPC) and general self-efficacy be…
View article: Corrigendum: Platelet abnormalities in autoimmune thyroid diseases: A systematic review and meta-analysis
Corrigendum: Platelet abnormalities in autoimmune thyroid diseases: A systematic review and meta-analysis Open
[This corrects the article DOI: 10.3389/fimmu.2022.1089469.].
View article: Structural and biochemical characteristics of mRNA nanoparticles determine anti–SARS-CoV-2 humoral and cellular immune responses
Structural and biochemical characteristics of mRNA nanoparticles determine anti–SARS-CoV-2 humoral and cellular immune responses Open
The coronavirus disease 2019 (COVID-19) pandemic underlines the urgent need for effective mRNA vaccines. However, current understanding of the immunological outcomes of mRNA vaccines formulated under different nanoplatforms is insufficient…
View article: Experimental study on laser polishing additive manufacturing Ti6Al4V
Experimental study on laser polishing additive manufacturing Ti6Al4V Open
As a new precision processing technology, laser polishing is widely used in metal and non-metal. Laser polishing technology is especially suitable for parts with high hardness and small size. In this paper, a full factor experimental were …