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Supplementary Figure S4 from Protein Kinase B (PKB/AKT) Protects IDH-Mutated Glioma from Ferroptosis via Nrf2 Open

Yang Liu, Fu-Ju Chou, Fengchao Lang, Hua Song, Wei Zhang , et al. · 2025

(A) Heatmap of gene expression profile for glioma specimen. The leading edge of the KEGG_MTOR_SIGNALING_PATHWAY geneset was shown. (B) Dose-response curve measured the cell viability in IDH1WT NHA cells in response to TMZ/Ipa combination t…

Supplementary Figure S1 from Protein Kinase B (PKB/AKT) Protects IDH-Mutated Glioma from Ferroptosis via Nrf2 Open

Yang Liu, Fu-Ju Chou, Fengchao Lang, Meili Zhang, Wei Zhang , et al. · 2025

(A) Immunoblotting analysis evaluated the siRNA knockdown efficiency of AKT in U87 cells. (B) Phase contrast imaging showed the cytotoxicity of ipatasertib (Ipa) in IDH1WT and IDH1Mut NHA cells. Bar = 100 mM. (C) Representative flow cytome…

Supplementary Figure S2 from Protein Kinase B (PKB/AKT) Protects IDH-Mutated Glioma from Ferroptosis via Nrf2 Open

Yang Liu, Fu-Ju Chou, Fengchao Lang, Meili Zhang, Wei Zhang , et al. · 2025

(A) Gene expression profiling showed the expression of GPX4 and SLC7A11 in IDH-mutated NHA cells (B) ROS-Glo assay measured the oxidative stress in IDH1WT and IDH1Mut NHA cells in response to ipatasertib (Ipa, 1 mM) treatment. (C) GSH, and…

mtKO: A dedicated guide RNA library for mitochondria research. Open

Karambir Kaur, Javeria Zaheer, Fengchao Lang, Diego Luís Ribeiro, Meili Zhang , et al. · 2025

Mitochondria are multifunctional organelles central to both physiological and pathological processes. In malignant cancer cells, mitochondrial reprogramming establishes the metabolic foundation to meet cellular demands, which is particular…

D-2-hydroxyglutarate impairs DNA repair through epigenetic reprogramming Open

Fengchao Lang, Karambir Kaur, Haiqing Fu, Javeria Zaheer, Diego Luís Ribeiro , et al. · 2025

Cancer-associated mutations in IDH are associated with multiple types of human malignancies, which exhibit distinctive metabolic reprogramming, production of oncometabolite D-2-HG, and shifted epigenetic landscape. IDH mutated malignancies…

Post-Indentation Residual Strain Field Analysis of Carbon Fiber Reinforced Composite Materials with Interface Effects Open

Shiyu Wang, Fengchao Lang, Yongming Xing · 2025

Abrogation of the G2/M checkpoint as a chemosensitization approach for alkylating agents Open

Fengchao Lang, James A. Cornwell, Karambir Kaur, Omar Elmogazy, Wei Zhang , et al. · 2023

Background The cell cycle is tightly regulated by checkpoints, which play a vital role in controlling its progression and timing. Cancer cells exploit the G2/M checkpoint, which serves as a resistance mechanism against genotoxic anticancer…

Supplementary Figure S1 from Protein Kinase B (PKB/AKT) Protects IDH-Mutated Glioma from Ferroptosis via Nrf2 Open

Yang Liu, Fu-Ju Chou, Fengchao Lang, Meili Zhang, Hua Song , et al. · 2023

(A) Immunoblotting analysis evaluated the siRNA knockdown efficiency of AKT in U87 cells. (B) Phase contrast imaging showed the cytotoxicity of ipatasertib (Ipa) in IDH1WT and IDH1Mut NHA cells. Bar = 100 mM. (C) Representative flow cytome…

Data from Protein Kinase B (PKB/AKT) Protects IDH-Mutated Glioma from Ferroptosis via Nrf2 Open

Yang Liu, Fu-Ju Chou, Fengchao Lang, Meili Zhang, Hua Song , et al. · 2023

Purpose:Mutations of the isocitrate dehydrogenase (IDH) gene are common genetic mutations in human malignancies. Increasing evidence indicates that IDH mutations play critical roles in malignant transformation and progression. Howev…

Supplementary Figure S4 from Protein Kinase B (PKB/AKT) Protects IDH-Mutated Glioma from Ferroptosis via Nrf2 Open

Yang Liu, Fu-Ju Chou, Fengchao Lang, Meili Zhang, Hua Song , et al. · 2023

(A) Heatmap of gene expression profile for glioma specimen. The leading edge of the KEGG_MTOR_SIGNALING_PATHWAY geneset was shown. (B) Dose-response curve measured the cell viability in IDH1WT NHA cells in response to TMZ/Ipa combination t…

Supplementary Figure S4 from Protein Kinase B (PKB/AKT) Protects IDH-Mutated Glioma from Ferroptosis via Nrf2 Open

Yang Liu, Fu-Ju Chou, Fengchao Lang, Meili Zhang, Hua Song , et al. · 2023

(A) Heatmap of gene expression profile for glioma specimen. The leading edge of the KEGG_MTOR_SIGNALING_PATHWAY geneset was shown. (B) Dose-response curve measured the cell viability in IDH1WT NHA cells in response to TMZ/Ipa combination t…

Supplementary Figure S3 from Protein Kinase B (PKB/AKT) Protects IDH-Mutated Glioma from Ferroptosis via Nrf2 Open

Yang Liu, Fu-Ju Chou, Fengchao Lang, Meili Zhang, Hua Song , et al. · 2023

(A) Phase contrast images showed the cytotoxicity of TMZ (400 mM)/ipatasertib (Ipa, 2 mM) combination treatment in the brain tumor-initiating cells (BTICs). A ferroptosis inhibitor, Ferrstain-1 (Ferr-1, 5 mM), was used to rescue the ferrop…

Supplementary Figure S2 from Protein Kinase B (PKB/AKT) Protects IDH-Mutated Glioma from Ferroptosis via Nrf2 Open

Yang Liu, Fu-Ju Chou, Fengchao Lang, Meili Zhang, Hua Song , et al. · 2023

(A) Gene expression profiling showed the expression of GPX4 and SLC7A11 in IDH-mutated NHA cells (B) ROS-Glo assay measured the oxidative stress in IDH1WT and IDH1Mut NHA cells in response to ipatasertib (Ipa, 1 mM) treatment. (C) GSH, and…

Supplementary Table S1 from Protein Kinase B (PKB/AKT) Protects IDH-Mutated Glioma from Ferroptosis via Nrf2 Open

Yang Liu, Fu-Ju Chou, Fengchao Lang, Meili Zhang, Hua Song , et al. · 2023

Patient sample information

Supplementary Figure S1 from Protein Kinase B (PKB/AKT) Protects IDH-Mutated Glioma from Ferroptosis via Nrf2 Open

Yang Liu, Fu-Ju Chou, Fengchao Lang, Meili Zhang, Hua Song , et al. · 2023

(A) Immunoblotting analysis evaluated the siRNA knockdown efficiency of AKT in U87 cells. (B) Phase contrast imaging showed the cytotoxicity of ipatasertib (Ipa) in IDH1WT and IDH1Mut NHA cells. Bar = 100 mM. (C) Representative flow cytome…

Supplementary Table S1 from Protein Kinase B (PKB/AKT) Protects IDH-Mutated Glioma from Ferroptosis via Nrf2 Open

Yang Liu, Fu-Ju Chou, Fengchao Lang, Meili Zhang, Hua Song , et al. · 2023

Patient sample information

Supplementary Figure S3 from Protein Kinase B (PKB/AKT) Protects IDH-Mutated Glioma from Ferroptosis via Nrf2 Open

Yang Liu, Fu-Ju Chou, Fengchao Lang, Meili Zhang, Hua Song , et al. · 2023

(A) Phase contrast images showed the cytotoxicity of TMZ (400 mM)/ipatasertib (Ipa, 2 mM) combination treatment in the brain tumor-initiating cells (BTICs). A ferroptosis inhibitor, Ferrstain-1 (Ferr-1, 5 mM), was used to rescue the ferrop…

Supplementary Figure S2 from Protein Kinase B (PKB/AKT) Protects IDH-Mutated Glioma from Ferroptosis via Nrf2 Open

Yang Liu, Fu-Ju Chou, Fengchao Lang, Meili Zhang, Hua Song , et al. · 2023

(A) Gene expression profiling showed the expression of GPX4 and SLC7A11 in IDH-mutated NHA cells (B) ROS-Glo assay measured the oxidative stress in IDH1WT and IDH1Mut NHA cells in response to ipatasertib (Ipa, 1 mM) treatment. (C) GSH, and…

Supplementary Figure S1 from Protein Kinase B (PKB/AKT) Protects IDH-Mutated Glioma from Ferroptosis via Nrf2 Open

Yang Liu, Fu-Ju Chou, Fengchao Lang, Meili Zhang, Hua Song , et al. · 2023

(A) Immunoblotting analysis evaluated the siRNA knockdown efficiency of AKT in U87 cells. (B) Phase contrast imaging showed the cytotoxicity of ipatasertib (Ipa) in IDH1WT and IDH1Mut NHA cells. Bar = 100 mM. (C) Representative flow cytome…

Supplementary Figure S4 from Protein Kinase B (PKB/AKT) Protects IDH-Mutated Glioma from Ferroptosis via Nrf2 Open

Yang Liu, Fu-Ju Chou, Fengchao Lang, Meili Zhang, Hua Song , et al. · 2023

(A) Heatmap of gene expression profile for glioma specimen. The leading edge of the KEGG_MTOR_SIGNALING_PATHWAY geneset was shown. (B) Dose-response curve measured the cell viability in IDH1WT NHA cells in response to TMZ/Ipa combination t…

Supplementary Table S1 from Protein Kinase B (PKB/AKT) Protects IDH-Mutated Glioma from Ferroptosis via Nrf2 Open

Yang Liu, Fu-Ju Chou, Fengchao Lang, Meili Zhang, Hua Song , et al. · 2023

Patient sample information

Supplementary Figure S4 from Protein Kinase B (PKB/AKT) Protects IDH-Mutated Glioma from Ferroptosis via Nrf2 Open

Yang Liu, Fu-Ju Chou, Fengchao Lang, Meili Zhang, Hua Song , et al. · 2023

(A) Heatmap of gene expression profile for glioma specimen. The leading edge of the KEGG_MTOR_SIGNALING_PATHWAY geneset was shown. (B) Dose-response curve measured the cell viability in IDH1WT NHA cells in response to TMZ/Ipa combination t…

Supplementary Figure S3 from Protein Kinase B (PKB/AKT) Protects IDH-Mutated Glioma from Ferroptosis via Nrf2 Open

Yang Liu, Fu-Ju Chou, Fengchao Lang, Meili Zhang, Hua Song , et al. · 2023

(A) Phase contrast images showed the cytotoxicity of TMZ (400 mM)/ipatasertib (Ipa, 2 mM) combination treatment in the brain tumor-initiating cells (BTICs). A ferroptosis inhibitor, Ferrstain-1 (Ferr-1, 5 mM), was used to rescue the ferrop…

Supplementary Table S1 from Protein Kinase B (PKB/AKT) Protects IDH-Mutated Glioma from Ferroptosis via Nrf2 Open

Yang Liu, Fu-Ju Chou, Fengchao Lang, Meili Zhang, Hua Song , et al. · 2023

Patient sample information

Supplementary Figure S1 from Protein Kinase B (PKB/AKT) Protects IDH-Mutated Glioma from Ferroptosis via Nrf2 Open

Yang Liu, Fu-Ju Chou, Fengchao Lang, Meili Zhang, Hua Song , et al. · 2023

(A) Immunoblotting analysis evaluated the siRNA knockdown efficiency of AKT in U87 cells. (B) Phase contrast imaging showed the cytotoxicity of ipatasertib (Ipa) in IDH1WT and IDH1Mut NHA cells. Bar = 100 mM. (C) Representative flow cytome…

Supplementary Figure S2 from Protein Kinase B (PKB/AKT) Protects IDH-Mutated Glioma from Ferroptosis via Nrf2 Open

Yang Liu, Fu-Ju Chou, Fengchao Lang, Meili Zhang, Hua Song , et al. · 2023

(A) Gene expression profiling showed the expression of GPX4 and SLC7A11 in IDH-mutated NHA cells (B) ROS-Glo assay measured the oxidative stress in IDH1WT and IDH1Mut NHA cells in response to ipatasertib (Ipa, 1 mM) treatment. (C) GSH, and…

Supplementary Figure S2 from Protein Kinase B (PKB/AKT) Protects IDH-Mutated Glioma from Ferroptosis via Nrf2 Open

Yang Liu, Fu-Ju Chou, Fengchao Lang, Meili Zhang, Hua Song , et al. · 2023

(A) Gene expression profiling showed the expression of GPX4 and SLC7A11 in IDH-mutated NHA cells (B) ROS-Glo assay measured the oxidative stress in IDH1WT and IDH1Mut NHA cells in response to ipatasertib (Ipa, 1 mM) treatment. (C) GSH, and…

Supplementary Figure S3 from Protein Kinase B (PKB/AKT) Protects IDH-Mutated Glioma from Ferroptosis via Nrf2 Open

Yang Liu, Fu-Ju Chou, Fengchao Lang, Meili Zhang, Hua Song , et al. · 2023

(A) Phase contrast images showed the cytotoxicity of TMZ (400 mM)/ipatasertib (Ipa, 2 mM) combination treatment in the brain tumor-initiating cells (BTICs). A ferroptosis inhibitor, Ferrstain-1 (Ferr-1, 5 mM), was used to rescue the ferrop…

Data from Protein Kinase B (PKB/AKT) Protects IDH-Mutated Glioma from Ferroptosis via Nrf2 Open

Yang Liu, Fu-Ju Chou, Fengchao Lang, Meili Zhang, Hua Song , et al. · 2023

Purpose:Mutations of the isocitrate dehydrogenase (IDH) gene are common genetic mutations in human malignancies. Increasing evidence indicates that IDH mutations play critical roles in malignant transformation and progression. Howev…

Data from Protein Kinase B (PKB/AKT) Protects IDH-Mutated Glioma from Ferroptosis via Nrf2 Open

Yang Liu, Fu-Ju Chou, Fengchao Lang, Meili Zhang, Hua Song , et al. · 2023

Purpose:Mutations of the isocitrate dehydrogenase (IDH) gene are common genetic mutations in human malignancies. Increasing evidence indicates that IDH mutations play critical roles in malignant transformation and progression. Howev…

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