Fengfeng Mo
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View article: The Construction and Characterization of an Infectious Clone of the Asian Genotype Chikungunya Virus from Yunnan, China
The Construction and Characterization of an Infectious Clone of the Asian Genotype Chikungunya Virus from Yunnan, China Open
Chikungunya fever (CHIKF), which is caused by the Chikungunya virus (CHIKV), has rapidly spread across the globe in recent years, leading to its listing as a public health concern by the World Health Organization. In 2019, the first local …
View article: Construction and Characterization of an Infectious Clone of the Asian Genotype Chikungunya Virus from Yunnan, China
Construction and Characterization of an Infectious Clone of the Asian Genotype Chikungunya Virus from Yunnan, China Open
Chikungunya fever (CHIKF) is caused by the Chikungunya virus (CHIKV). In recent years, it has rapidly spread globally and has been listed as a public health concern by the World Health Organization. In 2019, the first local outbreak of Asi…
View article: Inactivation of LHA Vglut2 neurons relieves stress-induced intestine inflammation by sympathetic nerve- Intestinal epithelial cell Cxcl1 communication
Inactivation of LHA Vglut2 neurons relieves stress-induced intestine inflammation by sympathetic nerve- Intestinal epithelial cell Cxcl1 communication Open
Purpose: This study aimed to elucidate the role of lateral hypothalamic area (LHA) Vglut2 neurons in stress-induced intestinal inflammation and to investigate the underlying mechanisms involving neuro-immune interactions. Specifically, we …
View article: A Comprehensive Review of Advanced Lactate Biosensor Materials, Methods, and Applications in Modern Healthcare
A Comprehensive Review of Advanced Lactate Biosensor Materials, Methods, and Applications in Modern Healthcare Open
Lactate is a key metabolite in cellular respiration, and elevated levels usually indicate tissue hypoxia or metabolic dysregulation. The real-time detection of lactate levels is particularly important in situations such as exercise, shock,…
View article: Development of Dual Diagnostic-Therapeutic Nanoformulation Effective Against Pancreatic Cancer in Animal Model
Development of Dual Diagnostic-Therapeutic Nanoformulation Effective Against Pancreatic Cancer in Animal Model Open
GFNPs with multiple targeting tumor microenvironments in pancreatic cancer possess diagnostic efficiency and therapeutic potential.
View article: Insulin level regulators may affect cognitive ability caused by motion sickness: an experimental study
Insulin level regulators may affect cognitive ability caused by motion sickness: an experimental study Open
Abnormal acceleration induced motion sickness (MS) and elevated blood glucose levels, showing obviously cognitive impairments. The mechanism of cognitive impairment caused by MS is still unclear. Here, blood metabolite detection, insulin l…
View article: Exploring cerebral structural and functional abnormalities in a mouse model of post-traumatic headache induced by mild traumatic brain injury
Exploring cerebral structural and functional abnormalities in a mouse model of post-traumatic headache induced by mild traumatic brain injury Open
Mild traumatic brain injury (mTBI)-induced post-traumatic headache (PTH) is a pressing public health concern and leading cause of disability worldwide. Although PTH is often accompanied by neurological disorders, the exact underlying mecha…
View article: Graphene Fluorescent Nanoparticles Efficiently Targeting Cancer-Associated Fibroblasts and Pancreatic Cancer Cells
Graphene Fluorescent Nanoparticles Efficiently Targeting Cancer-Associated Fibroblasts and Pancreatic Cancer Cells Open
Background: Pancreatic cancer is a highly aggressive, rapidly progressing fatal digestive tract tumor. Cancer-associated fibroblasts form a barrier to the penetration of drugs or therapeutic immune cells. Therefore, the inhibition of tumor…
View article: Immunotherapy and Prevention of Cancer by Nanovaccines Loaded with Whole‐Cell Components of Tumor Tissues or Cells (Adv. Mater. 43/2021)
Immunotherapy and Prevention of Cancer by Nanovaccines Loaded with Whole‐Cell Components of Tumor Tissues or Cells (Adv. Mater. 43/2021) Open
Cancer Nanovaccines In article number 2104849, Mi Liu and co-workers demonstrate a simple and universal method to prepare therapeutic and preventive cancer nanovaccines based on tumor tissues/cells. Such nanovaccines show both potent preve…
View article: Pyruvate accumulation may contribute to acceleration-induced impairment of physical and cognitive abilities: an experimental study
Pyruvate accumulation may contribute to acceleration-induced impairment of physical and cognitive abilities: an experimental study Open
Background: Fatigue can be induced after acceleration exposure, however its mechanism is still unclear. The aim of the present study was to examine whether metabolites’ changes can decrease cognitive and physical function after acceleratio…
View article: Tumor Targeting: A Highly Efficient Tumor‐Targeting Nanoprobe with a Novel Cell Membrane Permeability Mechanism (Adv. Mater. 12/2019)
Tumor Targeting: A Highly Efficient Tumor‐Targeting Nanoprobe with a Novel Cell Membrane Permeability Mechanism (Adv. Mater. 12/2019) Open
A graphene-based tumor cell nuclear targeting fluorescent nanoprobe (GTTN) can recognize tumor cells at a very early stage by the cell membrane permeability targeting (CMPT) mechanism and track the invasion and metastasis of tumor cells at…
View article: Stress-Induced Mucus Secretion and Its Composition by a Combination of Proteomics and Metabolomics of the Jellyfish Aurelia coerulea
Stress-Induced Mucus Secretion and Its Composition by a Combination of Proteomics and Metabolomics of the Jellyfish Aurelia coerulea Open
Background: Jellyfish respond quickly to external stress that stimulates mucus secretion as a defense. Neither the composition of secreted mucus nor the process of secretion are well understood. Methods: Aurelia coerulea jellyfish were sti…
View article: <em>Portulaca oleracea</em> L. alleviates liver injury in streptozotocin-induced diabetic mice
<em>Portulaca oleracea</em> L. alleviates liver injury in streptozotocin-induced diabetic mice Open
Purslane is a widespread succulent herb that exhibits various pharmacological effects. The purpose of this study was to evaluate the protective effect of Portulaca oleracea L. (purslane) on streptozotocin-induced diabetes in mice. Oral glu…
View article: Physiological stress-induced corticosterone increases heme uptake via KLF4-HCP1 signaling pathway in hippocampus neurons
Physiological stress-induced corticosterone increases heme uptake via KLF4-HCP1 signaling pathway in hippocampus neurons Open
Iron overload has attracted much attention because of its adverse effect in increasing the risk of developing several neurodegenerative disorders. Under various pathologic conditions, a lot of heme are released. The aggregation of heme is …
View article: The hepatocyte-specific HNF4α/miR-122 pathway contributes to iron overload–mediated hepatic inflammation
The hepatocyte-specific HNF4α/miR-122 pathway contributes to iron overload–mediated hepatic inflammation Open
Hepatic iron overload (IO) is a major complication of transfusional therapy. It was generally thought that IO triggers substantial inflammatory responses by producing reactive oxygen species in hepatic macrophages. Recently, a decrease in …
View article: 220. AAV-Mediated miR122 Overexpression Rescues Hepatic Inflammatory Response Induced by Acute Iron-Overload
220. AAV-Mediated miR122 Overexpression Rescues Hepatic Inflammatory Response Induced by Acute Iron-Overload Open
Frequent blood transfusions among patients with thalassaemia and sickle cell disease can lead to acute iron overload (IO), also known as transfusional haemosiderosis. Excessive iron is initially distributed to the liver, the primary organ …