Fengguang Yang
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View article: Role of mitophagy in spinal cord ischemia-reperfusion injury
Role of mitophagy in spinal cord ischemia-reperfusion injury Open
Spinal cord ischemia-reperfusion injury, a severe form of spinal cord damage, can lead to sensory and motor dysfunction. This injury often occurs after traumatic events, spinal cord surgeries, or thoracoabdominal aortic surgeries. The unpr…
View article: Mechanisms and therapeutic potential of disulphidptosis in cancer
Mechanisms and therapeutic potential of disulphidptosis in cancer Open
SLC7A11 plays a pivotal role in tumour development by facilitating cystine import to enhance glutathione synthesis and counteract oxidative stress. Disulphidptosis, an emerging form of cell death observed in cells with high expression of S…
View article: S100A6 Regulates nucleus pulposus cell apoptosis via Wnt/β-catenin signaling pathway: an in vitro and in vivo study
S100A6 Regulates nucleus pulposus cell apoptosis via Wnt/β-catenin signaling pathway: an in vitro and in vivo study Open
View article: POSTN knockdown suppresses IL‐1β‐induced inflammation and apoptosis of nucleus pulposus cells via inhibiting the NF‐κB pathway and alleviates intervertebral disc degeneration
POSTN knockdown suppresses IL‐1β‐induced inflammation and apoptosis of nucleus pulposus cells via inhibiting the NF‐κB pathway and alleviates intervertebral disc degeneration Open
The aim of this study is to investigate the effects of POSTN on IL‐1β induced inflammation, apoptosis, NF‐κB pathway and intervertebral disc degeneration (IVDD) in Nucleus pulposus (NP) cells (NPCs). NP tissue samples with different Pfirrm…
View article: RETRACTED: Capsaicin attenuates ferroptosis and pyroptosis in nucleus pulposus cells by disrupting the IL-1β/NF-κB-PTGS2 positive feedback loop
RETRACTED: Capsaicin attenuates ferroptosis and pyroptosis in nucleus pulposus cells by disrupting the IL-1β/NF-κB-PTGS2 positive feedback loop Open
The authors have requested that this preprint be removed from Research Square.
View article: Notochordal cells: A potential therapeutic option for intervertebral disc degeneration
Notochordal cells: A potential therapeutic option for intervertebral disc degeneration Open
Intervertebral disc degeneration (IDD) is a prevalent musculoskeletal degenerative disorder worldwide, and ~40% of chronic low back pain cases are associated with IDD. Although the pathogenesis of IDD remains unclear, the reduction in nucl…
View article: S100A6: molecular function and biomarker role
S100A6: molecular function and biomarker role Open
View article: The Role of S100A6 in Human Diseases: Molecular Mechanisms and Therapeutic Potential
The Role of S100A6 in Human Diseases: Molecular Mechanisms and Therapeutic Potential Open
S100A6, also known as calcyclin, is a low-molecular-weight Ca2+-binding protein from the S100 family that contains two EF-hands. S100A6 is expressed in a variety of mammalian cells and tissues. It is also expressed in lung, colorectal, pan…
View article: Treatment of Severe Congenital Scoliosis with Type ІI Respiratory Failure
Treatment of Severe Congenital Scoliosis with Type ІI Respiratory Failure Open
We report a case of a 14-year girl with severe congenital scoliosis (CS) and type ІІ respiratory failure (RF), who underwent preoperative halo-gravity traction in combination with intraoperative orthopaedic surgery on the spine based on th…
View article: Effects of one-stage posterior hemivertebrectomy for hemivertebral imbalance on spinal imbalance and shoulder balance: A retrospective study
Effects of one-stage posterior hemivertebrectomy for hemivertebral imbalance on spinal imbalance and shoulder balance: A retrospective study Open
Background One-stage posterior hemivertebrectomy is widely used for the treatment of hemivertebral-induced scoliosis. However, reports on posterior hemivertebrectomy evaluating hemivertebral-induced spinal imbalance and shoulder balance re…
View article: Role of Advanced Glycation End Products in Intervertebral Disc Degeneration: Mechanism and Therapeutic Potential
Role of Advanced Glycation End Products in Intervertebral Disc Degeneration: Mechanism and Therapeutic Potential Open
The incidence of low back pain caused by lumbar disc degeneration is high, and it can lead to loss of work ability and impose heavy social and economic burdens. The pathogenesis of low back pain is unclear, and there are no effective treat…
View article: Curative Effect of Oblique Lateral Interbody Fusion in the Treatment of Lumbar Tuberculosis
Curative Effect of Oblique Lateral Interbody Fusion in the Treatment of Lumbar Tuberculosis Open
Objective: This research aimed to investigate the curative effect of oblique lateral interbody fusion (OLIF) in the treatment of lumbar tuberculosis. Methods: A total of 32 patients, including 18 males and 14 females (29-58 years old, with…
View article: Role of microRNAs in intervertebral disc degeneration (Review)
Role of microRNAs in intervertebral disc degeneration (Review) Open
The incidence of lower back pain caused by intervertebral disc degeneration (IDD) is gradually increasing. IDD not only affects the quality of life of the patients, but also poses a major socioeconomic burden. There is currently no optimal…
View article: Trapezoidal Vertebral Body and Spine-Pelvis Sagittal Alignment in Patients with Lumber Spondylolisthesis
Trapezoidal Vertebral Body and Spine-Pelvis Sagittal Alignment in Patients with Lumber Spondylolisthesis Open
BACKGROUND Trapezoidal changes of the vertebral body are more common in patients with lumbar spondylolisthesis than in others. However, we lack an understanding of factors predisposing to the development of a marked trapezoidal deformity. …
View article: Carbon Quantum Dots: In vitro and in vivo Studies on Biocompatibility and Biointeractions for Optical Imaging
Carbon Quantum Dots: In vitro and in vivo Studies on Biocompatibility and Biointeractions for Optical Imaging Open
Xiumei Tian1 ,* Ao Zeng1 ,* Ziying Liu,1 Cunjing Zheng,2 Yuezi Wei,1 Peiheng Yang,1 Minru Zhang,1 Fanwen Yang,1 Fukang Xie1 1School of Basic Medical Sciences, Affiliated Stomatology Hospital, Guangzhou Medical University, Guangzhou 510182,…
View article: Comparison of sagittal spinopelvic parameters in different types of double-level degenerative lumbar spondylolisthesis: a retrospective study
Comparison of sagittal spinopelvic parameters in different types of double-level degenerative lumbar spondylolisthesis: a retrospective study Open
Background Degenerative lumber spondylolisthesis (DLS), a common orthopaedic disease causing low back pain, seriously affects daily life and work. Although sagittal spinopelvic parameters have been studied in single-level DLS patients, inv…
View article: The limited area decompression, intervertebral fusion, and pedicle screw fixation for treating degenerative lumbar spinal stenosis with instability
The limited area decompression, intervertebral fusion, and pedicle screw fixation for treating degenerative lumbar spinal stenosis with instability Open
The aim of the study was to evaluate the clinical effect of the limited area decompression, intervertebral fusion, and pedicle screw fixation for treating degenerative lumbar spinal stenosis (DLSS) with instability. Hemilaminectomy decompr…
View article: Correlation analysis between the pulmonary function test and the radiological parameters of the main right thoracic curve in adolescent idiopathic scoliosis
Correlation analysis between the pulmonary function test and the radiological parameters of the main right thoracic curve in adolescent idiopathic scoliosis Open
Background Scoliosis causes thoracic deformities, and it is necessary to assess these changes in pulmonary function test (PFT). To determine how measurements of spinal and thoracic cage deformities are related to pulmonary function. Method…
View article: Surgical Treatment of Ankylosing Spondylitis with Andersson Lesion
Surgical Treatment of Ankylosing Spondylitis with Andersson Lesion Open
Ankylosing spondylitis (AS) with an Andersson lesion may cause kyphosis. As the disease progresses, kyphosis gradually worsens. When conservative treatment does not improve the symptoms, surgery is often needed to correct the deformity. Th…
View article: Rosmarinic acid exerts a neuroprotective effect on spinal cord injury by suppressing oxidative stress and inflammation via modulating the Nrf2/HO-1 and TLR4/NF-κB pathways
Rosmarinic acid exerts a neuroprotective effect on spinal cord injury by suppressing oxidative stress and inflammation via modulating the Nrf2/HO-1 and TLR4/NF-κB pathways Open
Background: Spinal cord injury (SCI) is a severe central nervous system injury for which few efficacious drugs are available. Rosmarinic acid (RA), a water-soluble polyphenolic phytochemical, has antioxidant, anti-inflammatory, and anti-ap…
View article: Scrotoscopy exploration of testicular rupture
Scrotoscopy exploration of testicular rupture Open
To examine whether scrotoscopy could be used to diagnose testicular rupture (TR) with accuracy. This retrospective study included all patients receiving scrotoscopy followed by immediate open exploration (OE) for suspected TR at two Chines…