Fei Sun
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View article: The core outer junction protein CFAP77 connects A- and B-tubules within doublet microtubules of cilia and flagella
The core outer junction protein CFAP77 connects A- and B-tubules within doublet microtubules of cilia and flagella Open
The assembly and physiological function of cilia and flagella depend on the stable association of A- and B-tubules, which form axonemal doublet microtubules (DMTs). However, the mechanisms underlying the connection of B-tubules to A-tubule…
View article: ANKRD5: a key component of the axoneme required for sperm motility and male fertility
ANKRD5: a key component of the axoneme required for sperm motility and male fertility Open
Sperm motility is crucial for male reproduction and relies on the structural integrity of the sperm axoneme, which has a “9+2” microtubule configuration. This structure includes nine outer doublet microtubules (DMTs) that house various mac…
View article: MERS-related coronavirus circulating in pangolins exhibits strong fusogenicity in human cells and high sensitivity to fusion inhibitors
MERS-related coronavirus circulating in pangolins exhibits strong fusogenicity in human cells and high sensitivity to fusion inhibitors Open
Unlike preceding MERS-related coronaviruses, the recently identified MjHKU4r-CoV-1 strain can directly infect human cells. Nonetheless, its potential pathogenic attributes and underlying molecular mechanisms remain unclear. We find that Mj…
View article: Identification of a stromal immunosuppressive barrier orchestrated by SPP1+/C1QC+ macrophages and CD8+ exhausted T cells driving gastric cancer immunotherapy resistance
Identification of a stromal immunosuppressive barrier orchestrated by SPP1+/C1QC+ macrophages and CD8+ exhausted T cells driving gastric cancer immunotherapy resistance Open
Purpose The heterogeneity of immune cells is a critical manifestation of gastric cancer (GC) heterogeneity and significantly contributes to immune therapy resistance. Although previous studies have focused on the roles of specific myeloid …
View article: [Effectiveness analysis of arthroscopic outside-in release for gluteal muscle contracture in supine position].
[Effectiveness analysis of arthroscopic outside-in release for gluteal muscle contracture in supine position]. Open
Both surgical positions effectively improve hip function in GMC patients. However, the supine position offers significant advantages over the lateral decubitus position in operation time, anesthesia management, intraoperative blood loss co…
View article: In situ structure of the mouse sperm central apparatus reveals mechanistic insights into asthenozoospermia
In situ structure of the mouse sperm central apparatus reveals mechanistic insights into asthenozoospermia Open
The central apparatus (CA) within the sperm axoneme is vital for sperm motility, yet its molecular architecture and functional mechanisms remain incompletely understood. Combining cryo-electron tomography and AlphaFold2, we resolved the in…
View article: Unraveling the coupling effect of micropore confinement and functional sites of carbon-based adsorbents on flue gas CO2 adsorption: A machine learning study based on multi-scale simulations
Unraveling the coupling effect of micropore confinement and functional sites of carbon-based adsorbents on flue gas CO2 adsorption: A machine learning study based on multi-scale simulations Open
Carbon material is a type of promising adsorbent for flue gas CO2 capture, where micropore and dopants are key functional units and intertwined with each other. Due to the difficulty in detaching micropore and functional sites, their effec…
View article: Phase separation of Polycomb-like (PCL) proteins drive PRC2 complex condensates to regulate gene expression
Phase separation of Polycomb-like (PCL) proteins drive PRC2 complex condensates to regulate gene expression Open
Polycomb group (PcG) proteins function as two major multicomponent protein complexes: Polycomb repressive complex 1 (PRC1) and 2 (PRC2) to repress key developmental genes and maintain epigenetic memory of cell identity during development. …
View article: Structural elucidation of how ARF small GTPases induce membrane tubulation for vesicle fission
Structural elucidation of how ARF small GTPases induce membrane tubulation for vesicle fission Open
ADP-Ribosylation Factor (ARF) small GTPases have been found to act in vesicle fission through a direct ability to tubulate membrane. We have pursued cryoelectron microscopy (EM) to reveal at 3.9 Å resolution how ARF6 assembles into a prote…
View article: Essential role of CFAP77-CCDC105-TEX43 subcomplex in connecting axonemal A and B tubules for mammalian sperm motility
Essential role of CFAP77-CCDC105-TEX43 subcomplex in connecting axonemal A and B tubules for mammalian sperm motility Open
The assembly and physiological function of cilia and flagella depend on the stable association of A and B tubules, which form axonemal microtubule doublets (DMTs). CFAP77 encodes a core outer junction (OJ) protein within DMTs that is conse…
View article: ANKRD5: a key component of the axoneme required for sperm motility and male fertility
ANKRD5: a key component of the axoneme required for sperm motility and male fertility Open
Sperm motility is crucial for male reproduction and relies on the structural integrity of the sperm axoneme, which has a “9+2” microtubule configuration. This structure includes nine outer microtubule doublets that house various macromolec…
View article: ANKEF1 is a key axonemal component essential for murine sperm motility and male fertility
ANKEF1 is a key axonemal component essential for murine sperm motility and male fertility Open
Sperm motility is essential for male fertility and depends on the structural integrity of the sperm axoneme, which features a canonical ‘9 + 2’ microtubule arrangement. This structure comprises nine outer doublet microtubules (DMTs) that a…
View article: Corrigendum to “piR-36249 and DHX36 together inhibit testicular cancer cells progression by upregulating OAS2” [Noncoding RNA Research 2023 8 (2) 174–186]
Corrigendum to “piR-36249 and DHX36 together inhibit testicular cancer cells progression by upregulating OAS2” [Noncoding RNA Research 2023 8 (2) 174–186] Open
[This corrects the article DOI: 10.1016/j.ncrna.2022.12.004.].
View article: Targeting adenosine enhances immunotherapy in MSS colorectal cancer with EGFRvIII mutation
Targeting adenosine enhances immunotherapy in MSS colorectal cancer with EGFRvIII mutation Open
Background Patients with microsatellite stable (MSS) colorectal cancer (CRC) often display resistance to immunotherapy. Epidermal growth factor receptor (EGFR)-targeted therapies have shown potential in enhancing immunotherapy, yet clinica…
View article: Radiation damage behavior of soft matter in ultrafast cryo-electron microscopy (cryo-UEM)
Radiation damage behavior of soft matter in ultrafast cryo-electron microscopy (cryo-UEM) Open
Whether time-modulated pulsed-electron imaging can mitigate sample radiation damage is still controversial. The effectiveness of such mitigation and relevant potential applications in cryo-EM remain to be explored. Herein, we built an ultr…
View article: SARS-CoV-2 NSP3/4 control formation of replication organelle and recruitment of RNA polymerase NSP12
SARS-CoV-2 NSP3/4 control formation of replication organelle and recruitment of RNA polymerase NSP12 Open
β-coronavirus rearranges the host cellular membranes to form double-membrane vesicles (DMVs) via NSP3/4, which anchor replication–transcription complexes (RTCs), thereby constituting the replication organelles (ROs). However, the impact of…
View article: Mammalian SLC39A13 promotes ER/Golgi iron transport and iron homeostasis in multiple compartments
Mammalian SLC39A13 promotes ER/Golgi iron transport and iron homeostasis in multiple compartments Open
Iron is a potent biochemical, and accurate homeostatic control is orchestrated by a network of interacting players at multiple levels. Although our understanding of organismal iron homeostasis has advanced, intracellular iron homeostasis i…
View article: Radiation damage behavior of soft matter in ultrafast cryo-electron microscopy (cryo-UEM)
Radiation damage behavior of soft matter in ultrafast cryo-electron microscopy (cryo-UEM) Open
Whether time-modulated pulsed-electron imaging in ultrafast electron microscopy (UEM) can mitigate the electron radiation damage that occurs to samples, is still controversial. The effectiveness of such mitigation effect and relevant poten…
View article: ANKRD5: a key component of the axoneme required for sperm motility and male fertility
ANKRD5: a key component of the axoneme required for sperm motility and male fertility Open
Sperm motility is essential for male fertility and depends on the structural integrity of the sperm axoneme, which features a canonical "9+2" microtubule arrangement. This structure comprises nine outer doublet microtubules (DMTs) that are…
View article: De novo identification of protein domains in cryo-electron tomography maps from AlphaFold2 models
De novo identification of protein domains in cryo-electron tomography maps from AlphaFold2 models Open
In situ cryo-electron tomography (cryo-ET) enables visualization of protein complexes within their native cellular environments. However, sub-tomogram averaging (STA) often fails to achieve resolutions sufficient for atomic model building …
View article: Chaperonin TRiC bridges radial spokes for folding proteins locally translated in mammalian sperm flagella
Chaperonin TRiC bridges radial spokes for folding proteins locally translated in mammalian sperm flagella Open
As animals evolved from external to internal fertilization, sperm flagella, which once transiently propelled sperm in water to reach nearby eggs, developed to beat for days or even longer within the female reproductive tract. How flagella …