Fengjun Sun
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View article: Risk factors analysis for pathological upgrade after endoscopic submucosal dissection in patients with gastric intraepithelial neoplasia: a single-center retrospective study
Risk factors analysis for pathological upgrade after endoscopic submucosal dissection in patients with gastric intraepithelial neoplasia: a single-center retrospective study Open
Background: Gastric intraepithelial neoplasia (GIN) is a key precancerous lesion of gastric cancer, and discrepancies between preoperative endoscopic forceps biopsy (EFB) pathology and postoperative pathology after endoscopic submucosal di…
View article: The novel pyridine-fused quinolinone PQ-L5 exhibits antibacterial effects and enhances β-lactam activity by targeting PBP2a in methicillin-resistant Staphylococcus aureus
The novel pyridine-fused quinolinone PQ-L5 exhibits antibacterial effects and enhances β-lactam activity by targeting PBP2a in methicillin-resistant Staphylococcus aureus Open
PQ-L5 might be a promising antimicrobial agent against MRSA infections and that the synergistic effect of PQ-L5 combined with β-lactams reduces the required dosages of these drugs and thus minimizes potential toxic side effects.
View article: Energy-Saving Performance and Optimization Study of Adaptive Shading System—A Case Study
Energy-Saving Performance and Optimization Study of Adaptive Shading System—A Case Study Open
In the context of global energy challenges, adaptive shading systems have emerged as pivotal components in building energy efficiency research. This study systematically evaluates critical performance factors influencing energy efficiency …
View article: Polymyxin B combined with amikacin delays the resistance of Klebsiella pneumoniae to polymyxin B by modulating the expression of NlpE
Polymyxin B combined with amikacin delays the resistance of Klebsiella pneumoniae to polymyxin B by modulating the expression of NlpE Open
The combination of PMB and AMK can delay the development of resistance in K. pneumoniae to PMB. The nlpE gene, as a key regulatory factor, can influence PMB resistance by modulating the CpxA/R two-component system and biofilm formation.
View article: Cinnamaldehyde Alleviates Salmonellosis in Chicks by Regulating Gut Health
Cinnamaldehyde Alleviates Salmonellosis in Chicks by Regulating Gut Health Open
Due to the high mortality rate in chicks caused by pullorum disease (PD) and the drawbacks of antibiotic resistance, the poultry industry is increasingly interested in using natural herbal antimicrobial agents as alternatives, with cinnama…
View article: Development and validation of a nomogram to predict linezolid-induced thrombocytopenia in hospitalized adults
Development and validation of a nomogram to predict linezolid-induced thrombocytopenia in hospitalized adults Open
This nomogram provides a practical tool for stratifying LI-TP risk, which provide an important reference for enabling timely clinical interventions to enhance LZD safety.
View article: Cinnamaldehyde nanoemulsion decorated with rhamnolipid for inhibition of methicillin-resistant Staphylococcus aureus biofilm formation: in vitro and in vivo assessment
Cinnamaldehyde nanoemulsion decorated with rhamnolipid for inhibition of methicillin-resistant Staphylococcus aureus biofilm formation: in vitro and in vivo assessment Open
Background Staphylococcus aureus ( S. aureus ) biofilm associated infections are prevalent and persistent, posing a serious threat to human health and causing significant economic losses in animal husbandry. Nanoemulsions demonstrate signi…
View article: A systematic analysis of the global, regional, and national burden of fungal skin diseases from 1990 to 2021
A systematic analysis of the global, regional, and national burden of fungal skin diseases from 1990 to 2021 Open
Purpose We aimed to assess the burden of Fungal Skin Diseases (FSD) in 2021 and explore the changing trends from 1990 to 2021 across different age groups and time periods. Methods This study extracted three key indicators of the burden of …
View article: Locally Injectable Chitosan/β-Glycerophosphate Hydrogel Doped with Triptolide–Human Serum Albumin Nanoparticles for Treating Rheumatoid Arthritis
Locally Injectable Chitosan/β-Glycerophosphate Hydrogel Doped with Triptolide–Human Serum Albumin Nanoparticles for Treating Rheumatoid Arthritis Open
Background: Rheumatoid arthritis (RA) tends to occur in symmetrical joints and is always accompanied by synovial hyperplasia and cartilage damage. Triptolide (TP), an extract from Tripterygium, has anti-inflammatory and immunomodulatory pr…
View article: Global, regional, and national burden and trends of migraine among women of childbearing age from 1990 to 2021: insights from the Global Burden of Disease Study 2021
Global, regional, and national burden and trends of migraine among women of childbearing age from 1990 to 2021: insights from the Global Burden of Disease Study 2021 Open
Background Migraine, a neurological disorder with a significant female predilection, is the leading cause of disability-adjusted life years (DALYs) in women of childbearing age (WCBA). There is currently a lack of comprehensive literature …
View article: Jinlida for Diabetes Prevention in Impaired Glucose Tolerance and Multiple Metabolic Abnormalities
Jinlida for Diabetes Prevention in Impaired Glucose Tolerance and Multiple Metabolic Abnormalities Open
Importance Previous studies have shown that Jinlida (JLD) granules, an approved treatment for type 2 diabetes in China, can reduce blood glucose level, reduce glycated hemoglobin (HbA 1c ), and improve insulin resistance in people with typ…
View article: Therapeutic drug monitoring of imipenem/cilastatin and meropenem in critically ill adult patients
Therapeutic drug monitoring of imipenem/cilastatin and meropenem in critically ill adult patients Open
Infection with drug-resistant bacteria is an important factor influencing whether IMI and MEM concentrations reach the target. Furthermore, IMI and MEM concentrations are associated with the clinical outcome, and elevated doses of IMI and …
View article: Brain Tumor Segmentation Based on The Learning Statistical Texture
Brain Tumor Segmentation Based on The Learning Statistical Texture Open
Achieving accurate segmentation of brain tumors in Magnetic Resonance Imaging (MRI) is important for clinical diagnosis and accurate treatment, and the efficient extraction and analysis of MRI multimodal feature information is the key to a…
View article: Docetaxel-loaded pH/ROS dual-responsive nanoparticles with self-supplied ROS for inhibiting metastasis and enhancing immunotherapy of breast cancer
Docetaxel-loaded pH/ROS dual-responsive nanoparticles with self-supplied ROS for inhibiting metastasis and enhancing immunotherapy of breast cancer Open
Background Although stimuli-responsive nanoplatforms were developed to deliver immunogenic cell death (ICD) inducers to enhance cancer immunotherapy, the complete release of ICD inducers into the tumor microenvironment (TME) was limited by…
View article: Cyclic RGD-Functionalized pH/ROS Dual-Responsive Nanoparticle for Targeted Breast Cancer Therapy
Cyclic RGD-Functionalized pH/ROS Dual-Responsive Nanoparticle for Targeted Breast Cancer Therapy Open
Breast cancer is the most common malignant tumor in women and is a big challenge to clinical treatment due to the high morbidity and mortality. The pH/ROS dual-responsive nanoplatforms may be an effective way to significantly improve the t…
View article: Prediction of plasma trough concentration of voriconazole in adult patients using machine learning
Prediction of plasma trough concentration of voriconazole in adult patients using machine learning Open
The ML models can be reliable tools for predicting toxic concentration exposure of VCZ. The SHAP results may provide useful guidelines for dosage adjustment of VCZ.
View article: First report of coexistence of blaKPC-2-, blaNDM-1- and mcr-9-carrying plasmids in a clinical carbapenem-resistant Enterobacter hormaechei isolate
First report of coexistence of blaKPC-2-, blaNDM-1- and mcr-9-carrying plasmids in a clinical carbapenem-resistant Enterobacter hormaechei isolate Open
Introduction Colistin is regarded as one of the last-resort antibiotics against severe infections caused by carbapenem-resistant Enterobacteriaceae. Strains with cooccurrence of mcr-9 and carbapenemase genes are of particular concern. This…
View article: Simultaneous quantitative analysis and in vitro anti-arthritic effects of five polyphenols from Terminalia chebula
Simultaneous quantitative analysis and in vitro anti-arthritic effects of five polyphenols from Terminalia chebula Open
Background: The fruit of Terminalia chebula has been widely used for a thousand years for treating diarrhea, ulcers, and arthritic diseases in Asian countries. However, the active components of this Traditional Chinese medicine and their m…
View article: Factors influencing plasma concentration of voriconazole and voriconazole- N-oxide in younger adult and elderly patients
Factors influencing plasma concentration of voriconazole and voriconazole- N-oxide in younger adult and elderly patients Open
Background: Voriconazole (VCZ) metabolism is influenced by many factors. Identifying independent influencing factors helps optimize VCZ dosing regimens and maintain its trough concentration (C 0 ) in the therapeutic window. Methods: We con…
View article: Quorum sensing and QsvR tightly control the transcription of vpa0607 encoding an active RNase II-type protein in Vibrio parahaemolyticus
Quorum sensing and QsvR tightly control the transcription of vpa0607 encoding an active RNase II-type protein in Vibrio parahaemolyticus Open
Vibrio parahaemolyticus, a Gram-negative, halophilic bacterium, is a leading cause of acute gastroenteritis in humans. AphA and OpaR are the master quorum sensing (QS) regulators operating at low cell density (LCD) and high cell density (H…
View article: Retraction: Preventive effect of lemon seed flavonoids on carbon tetrachloride-induced liver injury in mice
Retraction: Preventive effect of lemon seed flavonoids on carbon tetrachloride-induced liver injury in mice Open
Retraction of ‘Preventive effect of lemon seed flavonoids on carbon tetrachloride-induced liver injury in mice’ by Ming Yang et al. , RSC Adv. , 2020, 10 , 12800–12809, https://doi.org/10.1039/D0RA01415J.
View article: Clinical and resistance characterization of carbapenem-resistant Klebsiella pneumoniae isolated from intensive care units in China
Clinical and resistance characterization of carbapenem-resistant Klebsiella pneumoniae isolated from intensive care units in China Open
There were a few significant differences in the molecular epidemiology and clinical characteristics, but generally the features of CRKP from the three ICUs aligned fairly well, which might have resulted from dissemination through frequent …
View article: Evaluation of nine formulas for estimating the body surface area of children with hematological malignancies
Evaluation of nine formulas for estimating the body surface area of children with hematological malignancies Open
Objectives Body surface area (BSA) is an important parameter in clinical practice for children. To find out the most accurate BSA formula for Chinese children, nine formulas were compared. Methods This single-center study comprised childre…
View article: The expression and significance of efferocytosis and immune checkpoint related molecules in pancancer samples and the correlation of their expression with anticancer drug sensitivity
The expression and significance of efferocytosis and immune checkpoint related molecules in pancancer samples and the correlation of their expression with anticancer drug sensitivity Open
Background: The efferocytosis-related molecules have been considered to be correlated with the resistance to cancer chemotherapy. The aim of this study was to investigate the expression and significance of efferocytosis-related molecules i…
View article: Effects of Lactobacillus plantarum HFY15 on Lupus Nephritis in Mice by Regulation of the TGF-β1 Signaling Pathway
Effects of Lactobacillus plantarum HFY15 on Lupus Nephritis in Mice by Regulation of the TGF-β1 Signaling Pathway Open
These results indicated that LP-HFY15 plays a significant role in experimental intervention for lupus nephritis. The effect of LP-HFY15 was positively correlated with its concentration, and the effect was similar to that of prednisone at 1…
View article: LncRNA CRLM1 inhibits apoptosis and promotes metastasis through transcriptional regulation cooperated with hnRNPK in colorectal cancer
LncRNA CRLM1 inhibits apoptosis and promotes metastasis through transcriptional regulation cooperated with hnRNPK in colorectal cancer Open
Background Colorectal liver metastases (CRLM) continue to have a low survival rate. The number of CRLM regulators and clinical indicators remains limited. Long non-coding RNAs (lncRNAs) are a new master regulator of cell invasion and metas…