Fengling Liu
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View article: OR22-06 JUV-112: A Novel Biologic for Sustaining Weight Loss and Enhancing Metabolism through Energy Expenditure
OR22-06 JUV-112: A Novel Biologic for Sustaining Weight Loss and Enhancing Metabolism through Energy Expenditure Open
Disclosure: R. Datta: None. V. Karuppagounder: None. A. Koranne: None. H. Kim: None. S. Louie: None. A. Yang: None. T. Mai: None. M. Chung: None. R. Jadhav: None. S. Tang: None. F. Liu: None. P. Handa: None. H. Yousef: None. J.D. O'Connell…
View article: Corrigendum to “A multi-functional double cross-linked chitosan hydrogel with tunable mechanical and antibacterial properties for skin wound dressing” [Carbohydrate Polymers 322 (2023) 121344]
Corrigendum to “A multi-functional double cross-linked chitosan hydrogel with tunable mechanical and antibacterial properties for skin wound dressing” [Carbohydrate Polymers 322 (2023) 121344] Open
View article: Postoperative liver and spinal metastasis of primary splenic angiosarcoma: A case report
Postoperative liver and spinal metastasis of primary splenic angiosarcoma: A case report Open
View article: Insight on the Ultrafast Water Treatment over NiFe-Layered Double Hydroxides via Electroactivation of Ferrate(VI): The Role of Spin State Regulation
Insight on the Ultrafast Water Treatment over NiFe-Layered Double Hydroxides via Electroactivation of Ferrate(VI): The Role of Spin State Regulation Open
Ferrate (Fe(VI)), an emerging green oxidant and disinfectant in water treatment, faces challenges due to its limited reaction efficiency stemming from a highly electron-deficient state. To address this, we designed NiFe-Layered Double Hydr…
View article: The Effect of Karst Carbonate Rock Dissolution on Nitrogen Metabolism Microorganisms and Their Functions in Paddy Soils
The Effect of Karst Carbonate Rock Dissolution on Nitrogen Metabolism Microorganisms and Their Functions in Paddy Soils Open
Carbonate rock dissolution (CRD) in karst areas generates abundant ions, which contribute significantly to nitrogen (N) transformation in paddy ecosystems. However, little is known about the microbial mechanisms by which CRD ions (Ca2+, Mg…
View article: Causal associations of ischemic stroke, metabolic factors, and related medications with epilepsy: a Mendelian randomization study
Causal associations of ischemic stroke, metabolic factors, and related medications with epilepsy: a Mendelian randomization study Open
Background Earlier researches have demonstrated that ischemic stroke, metabolic factors, and associated medications may influence the risk of epilepsy. Nevertheless, the causality between these elements and epilepsy remains inconclusive. T…
View article: Transcatheter arterial chemoembolisation combined with lenvatinib and cabozantinib in the treatment of advanced hepatocellular carcinoma
Transcatheter arterial chemoembolisation combined with lenvatinib and cabozantinib in the treatment of advanced hepatocellular carcinoma Open
Transcatheter arterial chemoembolisation combined with lenvatinib and cabozantinib is safe and effective in the treatment of advanced uHCC, with controllable adverse reactions. High NLR and PLR and low BMI values before treatment were inde…
View article: Insight on the Optimized Electronic Structure of Carbon Nitride on Ultrafast Water Treatment Via Photocatalytic Activation of Ferrate
Insight on the Optimized Electronic Structure of Carbon Nitride on Ultrafast Water Treatment Via Photocatalytic Activation of Ferrate Open
View article: Non-linear associations between cardiovascular metabolic indices and metabolic-associated fatty liver disease: A cross-sectional study in the US population (2017–2020)
Non-linear associations between cardiovascular metabolic indices and metabolic-associated fatty liver disease: A cross-sectional study in the US population (2017–2020) Open
The cardiometabolic index (CMI) is an emerging and effective indicator for predicting the presence of metabolic-associated fatty liver disease (MAFLD). This study aims to investigate the relationship between CMI and MAFLD using data from N…
View article: Unveiling the hidden AP-1: revealing the crucial role of AP-1 in ccRCC at single-cell resolution
Unveiling the hidden AP-1: revealing the crucial role of AP-1 in ccRCC at single-cell resolution Open
Clear cell renal cell carcinoma (ccRCC), as the most common histological subtype of kidney cancer, has been reported to originate primarily from proximal tubule (PT) cells in the kidney. However, the current research on its associated mole…
View article: Unraveling the enigma of B cells in diffuse large B-cell lymphoma: unveiling cancer stem cell-like B cell subpopulation at single-cell resolution
Unraveling the enigma of B cells in diffuse large B-cell lymphoma: unveiling cancer stem cell-like B cell subpopulation at single-cell resolution Open
Background Diffuse large B-cell lymphoma (DLBCL) represents the most prevalent form of aggressive non-Hodgkin lymphoma. Despite receiving standard treatment, a subset of patients undergoes refractory or recurrent cases, wherein the involve…
View article: Discovery of Novel Fedratinib-Based HDAC/JAK/BRD4 Triple Inhibitors with Remarkable Antitumor Activity against Triple Negative Breast Cancer
Discovery of Novel Fedratinib-Based HDAC/JAK/BRD4 Triple Inhibitors with Remarkable Antitumor Activity against Triple Negative Breast Cancer Open
Multitarget HDAC inhibitors capable of simultaneously blocking the BRD4-LIFR-JAK1-STAT3 signaling pathway hold great potential for the treatment of TNBC and other solid tumors. Herein, novel Fedratinib-based multitarget HDAC inhibitors wer…
View article: Discovery of the First Irreversible HDAC6 Isoform Selective Inhibitor with Potent Anti-Multiple Myeloma Activity
Discovery of the First Irreversible HDAC6 Isoform Selective Inhibitor with Potent Anti-Multiple Myeloma Activity Open
In our previous research, a series of phenylsulfonylfuroxan-based hydroxamates were developed, among which compound 1 exhibited remarkable in vitro and in vivo antitumor potency due to its histone deacetylase (HDAC) inhibitory and n…
View article: Synthesis-accessibility-oriented design of c-Jun N-terminal kinase 1 inhibitor
Synthesis-accessibility-oriented design of c-Jun N-terminal kinase 1 inhibitor Open
View article: An adhesive gelatin-coated small intestinal submucosa composite hydrogel dressing aids wound healing
An adhesive gelatin-coated small intestinal submucosa composite hydrogel dressing aids wound healing Open
It is a challenging clinical task to determine how to repair large-area skin defects better. Traditional wound dressings (e.g., cotton and gauze) can only be used as a dressing; consequently, there is an increasing demand for wound dressin…
View article: Spherical CdS Nanoparticles Precipitated from a Cadmium Thiosulfate Complex Using Ultraviolet Light for Photocatalytic Dye Degradation
Spherical CdS Nanoparticles Precipitated from a Cadmium Thiosulfate Complex Using Ultraviolet Light for Photocatalytic Dye Degradation Open
Thiosulfate is an inorganic ligand that forms a soluble light-sensitive cadmium thiosulfate complex, and cadmium sulfide (CdS) with a “size effect” can be produced via ultraviolet (UV) irradiation. This study investigated the activity of C…
View article: Preparation of CdS–Ag <sub>2</sub> S nanocomposites by ultrasound-assisted UV photolysis treatment and its visible light photocatalysis activity
Preparation of CdS–Ag <sub>2</sub> S nanocomposites by ultrasound-assisted UV photolysis treatment and its visible light photocatalysis activity Open
Thiosulfate is a green leaching agent used in the hydrometallurgical process because it is both environmentally benign and can form the required soluble ion complexes. In this article, a novel method for the synthesis of CdS–Ag 2 S nanocom…
View article: Synthesis-Accessibility-Oriented Design of c-Jun N-Terminal Kinase 1 Inhibitor
Synthesis-Accessibility-Oriented Design of c-Jun N-Terminal Kinase 1 Inhibitor Open
View article: Biomimetic Injectable Hydrogel Based on Methacrylate-Modified Silk Fibroin Embedded with Kartogenin for Superficial Cartilage Regeneration
Biomimetic Injectable Hydrogel Based on Methacrylate-Modified Silk Fibroin Embedded with Kartogenin for Superficial Cartilage Regeneration Open
View article: Kinetic and Crystallographic Studies of Drug-Resistant Mutants of HIV-1 Protease: Insights into the Drug Resistance Mechanisms
Kinetic and Crystallographic Studies of Drug-Resistant Mutants of HIV-1 Protease: Insights into the Drug Resistance Mechanisms Open
HIV-1 protease (PR) inhibitors (PIs) are important anti-HIV drugs for the treatment of AIDS and have shown great success in reducing mortality and prolonging the life of HIV-infected individuals. However, the rapid development of drug resi…
View article: Myelin and lymphocyte protein serves as a prognostic biomarker and is closely associated with the tumor microenvironment in the nephroblastoma
Myelin and lymphocyte protein serves as a prognostic biomarker and is closely associated with the tumor microenvironment in the nephroblastoma Open
Nephroblastoma, also known as Wilms' tumor (WT), is the most common renal tumor that occurs in children. Although the efficacy of treatment has been significantly improved by a series of comprehensive treatments, some patients still have p…
View article: A Novel Autophagy-Related Marker for Improved Differential Diagnosis of Rheumatoid Arthritis and Osteoarthritis
A Novel Autophagy-Related Marker for Improved Differential Diagnosis of Rheumatoid Arthritis and Osteoarthritis Open
Rheumatoid arthritis (RA) and osteoarthritis (OA) are two most common rheumatic diseases in the world. Although there are standard methods for the diagnosis of both RA and OA, the differentials in some cases are poor. With deepening resear…
View article: The Prognostic Value of Baseline Distant Metastasis in Icotinib-Treated Patients with EGFR-Mutated Stage IV Non-Small Cell Lung Cancer
The Prognostic Value of Baseline Distant Metastasis in Icotinib-Treated Patients with EGFR-Mutated Stage IV Non-Small Cell Lung Cancer Open
The presence of liver and brain metastasis predicted unfavorable OS, while the presence of lung metastasis predicted favorable OS in first-line icotinib-treated patients with EGFR-mutated stage IV NSCLC.
View article: Development of an immune-related gene pairs index for the prognosis analysis of metastatic melanoma
Development of an immune-related gene pairs index for the prognosis analysis of metastatic melanoma Open
View article: Restore of miR-541 resensitizes pancreatic cancer cells to gemcitabine-induced apoptosis through suppression of HAX-1
Restore of miR-541 resensitizes pancreatic cancer cells to gemcitabine-induced apoptosis through suppression of HAX-1 Open
Background: MiR-541 acts as a tumor suppressor in some cancers. However, the role of miR-541 in regulating the chemosensitivity to cancer cells is still unclear. The aim of this study is to explore the effect of miR-541 on chemoresistance …
View article: Construction of Embedded Heterostructured SrZrO<sub>3</sub>/Flower-like MoS<sub>2</sub> with Enhanced Dye Photodegradation under Solar-Simulated Light Illumination
Construction of Embedded Heterostructured SrZrO<sub>3</sub>/Flower-like MoS<sub>2</sub> with Enhanced Dye Photodegradation under Solar-Simulated Light Illumination Open
SrZrO3/flower-like MoS2 composites with an embedded heterostructure were synthesized via a simple two-step hydrothermal method and their performance was evaluated by photodegradation of methylene blue (MB) under solar…
View article: Derivation of the Shape of an Atomic Orbital from the Angular Nodal Planes and the Symmetries of Their Distribution
Derivation of the Shape of an Atomic Orbital from the Angular Nodal Planes and the Symmetries of Their Distribution Open
The shape of an atomic orbital not only depends on the azimuthal quantum number l, but also associates with the magnetic quantum number m.We discussed about how to derive the shape of an atomic orbital from the numbers and shapes of the an…
View article: Novel loss‑of‑function mutation in BRCA2 gene identified in a Chinese female with a family history of ovarian cancer: A case report
Novel loss‑of‑function mutation in BRCA2 gene identified in a Chinese female with a family history of ovarian cancer: A case report Open
Inherited loss-of-function mutations in the tumor suppressor BRCA2 gene are associated with a high risk of ovarian cancer in the Chinese population. The current case report discusses a novel heterozygous insertion in BRCA2 gene, c.3195_319…
View article: Use of QSPR Modeling to Characterize In Vitro Binding of Drugs to a Gut-Restricted Polymer
Use of QSPR Modeling to Characterize In Vitro Binding of Drugs to a Gut-Restricted Polymer Open
View article: RASSF1A and SIRT6 in non-small cell lung cancer: Relationship with clinical outcome
RASSF1A and SIRT6 in non-small cell lung cancer: Relationship with clinical outcome Open
This study investigated the expression of RASSF1A and SIRT6 in non-small cell lung cancer (NSCLC) and its relationship with clinical prognosis. The expression in 122 cases of NSCLC tissues (NSCLC group) and 122 cases of normal lung tissues…