Explanipedia

IL-2/IL-2Rβγ signaling in pruriceptors drives neuroimmune mechanisms of nivolumab- induced persistent itch Open

Lixuan Li, Huijuan Zhao, Jing Guo, Huai Li, Aiping Li , et al. · 2025

Background Immune checkpoint inhibitor (ICI) therapy frequently induces pruritus as a cutaneous immune-related adverse event, affecting 13–25% of patients treated with anti–PD-1 antibodies. Unlike allergy-associated itch, ICI-induced pruri…

A virulence protein activates SERK4 and degrades RNA polymerase IV protein to suppress rice antiviral immunity Open

Yuansheng Wu, Shanshan Zhao, Na Liu, Fengling Wu, Shiting Huang , et al. · 2025

Rice, a major global food staple, is threatened by viral infections that hinder its growth and yield. We have recently shown that the virulence protein P3 of rice grassy stunt virus promotes pathogenesis by inducing proteasome-controlled d…

Global, regional, and national burden of low back pain in working-age population from 1990 to 2021 and projections for 2050 Open

Chichen Zhang, Bing Lv, Yi Qian, Guixing Qiu, Fengling Wu · 2025

Background Low back pain (LBP) is a leading cause of disability worldwide, especially among working-age group. This study evaluates the global, regional, and national burden of LBP among individuals aged 15–64 utilizing data from the Globa…

Exploration of organoids in ovarian cancer: From basic research to clinical translation Open

Siyu Li, Ningjing Lei, Mengyu Chen, Ruixia Guo, Liping Han , et al. · 2024

Ovarian cancer is a highly heterogeneous tumor with a poor prognosis. The lack of reliable and efficient research models that can accurately mimic heterogeneity has impeded in-depth investigations and hindered the clinical translation of r…

Genetic landscape of homologous recombination repair and practical outcomes of PARPi therapy in ovarian cancer management Open

Mengyu Chen, Ningjing Lei, Ruixia Guo, Liping Han, Qinghe Zhao , et al. · 2024

Background: Genetic studies of ovarian cancer (OC) have historically focused on BRCA1/2 mutations, lacking other studies of homologous recombination repair (HRR). Poly (ADP-ribose) polymerase inhibitors (PARPi) exploit synthetic lethality …

Aldolase A promotes cervical cancer cell radioresistance by regulating the glycolysis and DNA damage after irradiation Open

Junying Zhou, Ningjing Lei, Bo Qin, Mengyu Chen, Shuai Gong , et al. · 2023

Radioresistance is the major obstacle that affects the efficacy of radiotherapy which is an important treatment for cervical cancer. By analyzing the databases, we found that aldolase A (ALDOA), which is a key enzyme in metabolic reprogram…

Treatment strategies for intrauterine adhesion: focus on the exosomes and hydrogels Open

Fengling Wu, Ningjing Lei, Shenyu Yang, Junying Zhou, Mengyu Chen , et al. · 2023

Intrauterine adhesion (IUA), also referred to as Asherman Syndrome (AS), results from uterine trauma in both pregnant and nonpregnant women. The IUA damages the endometrial bottom layer, causing partial or complete occlusion of the uterine…

Characterization of fecal microbiota in cervical cancer patients associated with tumor stage and prognosis Open

Lei Chang, Luojie Qiu, Ningjing Lei, Junying Zhou, Ruixia Guo , et al. · 2023

Cervical cancer (CC) is the fourth most frequent malignancy among women worldwide, and its prevention and treatment are evolving rapidly. The gut microbiota has been reported to play a crucial role both in the preservation of homeostasis a…

Recent progress of the tumor microenvironmental metabolism in cervical cancer radioresistance Open

Junying Zhou, Ningjing Lei, Wanjia Tian, Ruixia Guo, Mengyu Chen , et al. · 2022

Radiotherapy is widely used as an indispensable treatment option for cervical cancer patients. However, radioresistance always occurs and has become a big obstacle to treatment efficacy. The reason for radioresistance is mainly attributed …

Proper irrigation amount for eggplant cultivation in a solar greenhouse improved plant growth, fruit quality and yield by influencing the soil microbial community and rhizosphere environment Open

Tuo Ji, Xinyong Guo, Fengling Wu, Min Wei, Jing Li , et al. · 2022

Water scarcity is a worldwide problem, and in order to obtain plenty of production, agricultural irrigation water accounts for a large portion. Many studies have shown that the interaction of root microorganisms and soil can promote crop g…

Genome–Wide Identification and Functional Characterization of Auxin Response Factor (ARF) Genes in Eggplant Open

Jing Chen, Shijie Wang, Fengling Wu, Min Wei, Jing Li , et al. · 2022

Auxin response factors (ARFs) are important plant transcription factors that are differentially expressed in response to auxin and various abiotic stresses. ARFs play important roles in mediating plant growth and stress responses; however,…

Identification and Validation a Major QTL from “Sea Rice 86” Seedlings Conferred Salt Tolerance Open

Fengling Wu, Jun Yang, Diqiu Yu, Peng Xu · 2020

Saline stress severely affects rice (Oryza sativa L.) growth and development and reduces crop yield. Therefore, developing salt-tolerant and high-yielding rice using quantitative trait loci (QTLs) and linkage markers is a priority for mole…

Dual broadband absorber based on graphene metamaterial in the terahertz range Open

Ning Hu, Fengling Wu, Li-an Bian, Hanqing Liu, Peiguo Liu · 2018

In this paper, a dual broadband terahertz (THz) graphene metamaterial absorber (MA) is presented. The absorber consists of patterned graphene, a gating layer, and gold ground separated by a SiO2 substrate. Multiple resonances and broadband…

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