Feng‐Ling Yang
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View article: Sepsis Outcomes Worsened by Frailty: Findings from a National Inpatient Sample
Sepsis Outcomes Worsened by Frailty: Findings from a National Inpatient Sample Open
Purpose: While sepsis remains a leading cause of global mortality, the role of frailty in determining patient outcomes has become increasingly recognized. This study investigated the influence of frailty on hospital course and clinical com…
View article: A case of esophageal fibrous polyp treated by suspended laryngoscope in the department of otorhinolaryngology
A case of esophageal fibrous polyp treated by suspended laryngoscope in the department of otorhinolaryngology Open
View article: Prognostic implications of tumor volume reduction during radiotherapy in locally advanced cervical cancer: a risk-stratified analysis
Prognostic implications of tumor volume reduction during radiotherapy in locally advanced cervical cancer: a risk-stratified analysis Open
TVR serves as a pivotal prognostic marker in LACC patients with CYFRA21-1 levels below 7.7 ng/ml undergoing CCRT. Additionally, within the lymph node metastasis subgroup, patients achieving a NVR of ≥ 94% demonstrated a notably improved pr…
View article: Correction: Association between statin usage and mortality outcomes in aging U.S. cancer survivors: a nationwide cohort study
Correction: Association between statin usage and mortality outcomes in aging U.S. cancer survivors: a nationwide cohort study Open
View article: Study on the relationship between NF-kB pathway and skeletal muscle dopamine receptors in muscle-attenuated mice
Study on the relationship between NF-kB pathway and skeletal muscle dopamine receptors in muscle-attenuated mice Open
Background: To investigate the relationship between the NF-kB signaling pathway and muscle-attenuated skeletal muscle dopaminereceptor (DR) in mice. Methodology: 40 specific pathogens free (SPF) C57BL/6 mice aged 6 to 7 months were randoml…
View article: Association between statin usage and mortality outcomes in aging U.S. cancer survivors: a nationwide cohort study
Association between statin usage and mortality outcomes in aging U.S. cancer survivors: a nationwide cohort study Open
View article: <i>Klebsiella pneumoniae</i> K2 capsular polysaccharide degradation by a bacteriophage depolymerase does not require trimer formation
<i>Klebsiella pneumoniae</i> K2 capsular polysaccharide degradation by a bacteriophage depolymerase does not require trimer formation Open
K2-capsular Klebsiella pneumoniae is a hypervirulent pathogen that causes fatal infections. Here, we describe a phage tailspike protein, named K2-2, that specifically depolymerizes the K2 capsular polysaccharide (CPS) of K. pneumoniae into…
View article: Development of a combined model incorporating clinical characteristics and magnetic resonance imaging features to enhance the predictive value of a prognostic model for locally advanced cervical cancer
Development of a combined model incorporating clinical characteristics and magnetic resonance imaging features to enhance the predictive value of a prognostic model for locally advanced cervical cancer Open
Objective This study aimed to develop non-invasive predictive tools based on clinical characteristics and magnetic resonance imaging (MRI) features to predict survival in patients with locally advanced cervical cancer (LACC), thereby facil…
View article: A lectin from <i>Crenomytilus grayanus</i> as a probe for the detection of widespread cancerous and metastatic cells
A lectin from <i>Crenomytilus grayanus</i> as a probe for the detection of widespread cancerous and metastatic cells Open
A novel Gal-binding lectin from mussels (Crenomytilus grayanus, CGL) with 6 binding sites in the dimeric structure has been previously shown to have antifungal, anticancer, and antibacterial activities. In this study, a glycan array was us…
View article: Prognostic value of tumor volume reduction during radiotherapy in patients with locally advanced cervical cancer in different risk groups
Prognostic value of tumor volume reduction during radiotherapy in patients with locally advanced cervical cancer in different risk groups Open
Objective: To evaluate the risk factors of patients with locally advanced cervical cancer (LACC) undergoing radical radiotherapy (with or without concurrent chemotherapy) and to assess the prognostic value of tumor volume regression (TVR) …
View article: An Immunological Polysaccharide from Tremella fuciformis: Essential Role of Acetylation in Immunomodulation
An Immunological Polysaccharide from Tremella fuciformis: Essential Role of Acetylation in Immunomodulation Open
The edible fungus Tremella fuciformis was shown to have a high molecular weight (1.87 × 103 kDa) bioactive polysaccharide, denoted as TFP-F1. Monosaccharide composition and NMR analysis of the polysaccharide and its derivatives indicated i…
View article: Development of Klebsiella pneumoniae Capsule Polysaccharide-Conjugated Vaccine Candidates Using Phage Depolymerases
Development of Klebsiella pneumoniae Capsule Polysaccharide-Conjugated Vaccine Candidates Using Phage Depolymerases Open
Klebsiella pneumoniae is an important pathogen associated with nosocomial infection and has developed increasing resistance to antibiotics such as extended-spectrum β-lactams and carbapenem. In recent years, K. pneumoniae isolates have eme…
View article: Techno-economic assessment of a chemical looping splitting system for H2 and CO Co-generation
Techno-economic assessment of a chemical looping splitting system for H2 and CO Co-generation Open
The natural gas (NG) reforming is currently one of the low-cost methods for hydrogen production. However, the mixture of H2 and CO2 in the produced gas inevitably includes CO2 and necessitates the costly CO2 separation. In this work, a nov…
View article: Structural and biological insights into Klebsiella pneumoniae surface polysaccharide degradation by a bacteriophage K1 lyase: implications for clinical use
Structural and biological insights into Klebsiella pneumoniae surface polysaccharide degradation by a bacteriophage K1 lyase: implications for clinical use Open
View article: A Highly Sensitive and Selective “Off-On” Fluorescent Probe for Cu<sup>2+</sup> Based on Rhodamine B Hydrazone
A Highly Sensitive and Selective “Off-On” Fluorescent Probe for Cu<sup>2+</sup> Based on Rhodamine B Hydrazone Open
作用后颜色从无色变为粉红色, 可以实现 Cu 2＋ 的"裸眼检测".探针 R1 成功用于实际水样中 Cu 2＋ 的检测.
View article: Ergosterol peroxide from marine fungus Phoma sp. induces ROS-dependent apoptosis and autophagy in human lung adenocarcinoma cells
Ergosterol peroxide from marine fungus Phoma sp. induces ROS-dependent apoptosis and autophagy in human lung adenocarcinoma cells Open
View article: <i>Antrodia cinnamomea</i> Galactomannan Elicits Immuno-stimulatory Activity Through Toll-like Receptor 4
<i>Antrodia cinnamomea</i> Galactomannan Elicits Immuno-stimulatory Activity Through Toll-like Receptor 4 Open
Antrodia cinnamomea (A. cinnamomea) is a medicinal fungus used in traditional Chinese medicine to treat different kinds of ailments, including liver diseases, abdominal pain, drug intoxication, diarrhea, itchy skin, hypertens…
View article: Structural basis for fragmenting the exopolysaccharide of Acinetobacter baumannii by bacteriophage ΦAB6 tailspike protein
Structural basis for fragmenting the exopolysaccharide of Acinetobacter baumannii by bacteriophage ΦAB6 tailspike protein Open
View article: Identification of a capsular variant and characterization of capsular acetylation in Klebsiella pneumoniae PLA-associated type K57
Identification of a capsular variant and characterization of capsular acetylation in Klebsiella pneumoniae PLA-associated type K57 Open
Klebsiella pneumoniae can cause community-acquired pyogenic liver abscess (PLA). Capsular polysaccharide (CPS) is important for its virulence. Among 79 capsular (K) types discovered thus far, K57 is often associated with PLA. Here, we repo…
View article: Mycobacterium marinum mmar_2318 and mmar_2319 are Responsible for Lipooligosaccharide Biosynthesis and Virulence Toward Dictyostelium
Mycobacterium marinum mmar_2318 and mmar_2319 are Responsible for Lipooligosaccharide Biosynthesis and Virulence Toward Dictyostelium Open
Resistance to phagocyte killing is an important virulence factor in mycobacteria. Dictyostelium has been used to study the interaction between phagocytes and bacteria, given its similarity to the mammalian macrophage. Here, we investigated…
View article: Total Synthesis of Two Diastereomers of Megastigmane Glycoside Lauroside B
Total Synthesis of Two Diastereomers of Megastigmane Glycoside Lauroside B Open
Lauroside B, a megastigmane sesquiterpene glycoside isolated from L. nobilis leaves, has the potential effect of inducing apoptosis of several highly aggressive malignant melanoma cell lines. To promote the potential development of …
View article: Capsular Polysaccharide Is Involved in NLRP3 Inflammasome Activation by Klebsiella pneumoniae Serotype K1
Capsular Polysaccharide Is Involved in NLRP3 Inflammasome Activation by Klebsiella pneumoniae Serotype K1 Open
Klebsiella pneumoniae (strain 43816, K2 serotype) induces interleukin-1β (IL-1β) secretion, but neither the bacterial factor triggering the activation of these inflammasome-dependent responses nor whether they are mediated by NLRP3 or NLRC…
View article: Protecting-group-free synthesis of the bisindolylmaleimide GF109203X
Protecting-group-free synthesis of the bisindolylmaleimide GF109203X Open
The bisindolylmaleimide GF109203X is a highly selective inhibitor to Protein Kinase C (PKC) and has attracted much attention.However, its reported synthesis required protecting groups.In order to achieve a short and N-protecting-group-free…