Fengming Luo
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View article: Enhanced Benefits of Prone Positioning Combined with Lung Recruitment Maneuver in Patients with COVID-19 and Non-COVID-19 ARDS: A Secondary Analysis of a Randomized Clinical Trial
Enhanced Benefits of Prone Positioning Combined with Lung Recruitment Maneuver in Patients with COVID-19 and Non-COVID-19 ARDS: A Secondary Analysis of a Randomized Clinical Trial Open
Background: Early reports highlighted unique features of COVID-19-associated ARDS. The combination of prone position (PP) and positive end-expiratory pressure (PEEP)-induced lung recruitment maneuver (LRM) has demonstrated efficacy in enha…
View article: Body Roundness Index Outperforms Body Mass Index in Predicting Obstructive Sleep Apnea Severity Among Chinese Adults
Body Roundness Index Outperforms Body Mass Index in Predicting Obstructive Sleep Apnea Severity Among Chinese Adults Open
Background: Obesity is a key factor in obstructive sleep apnea (OSA), though Body Mass Index (BMI) may not fully capture this risk as it ignores visceral fat distribution. The Body Roundness Index (BRI), which uses waist circumference and …
View article: CaNO and eCO Might Be Potential Non-Invasive Biomarkers for Disease Severity and Exacerbations in Interstitial Lung Disease
CaNO and eCO Might Be Potential Non-Invasive Biomarkers for Disease Severity and Exacerbations in Interstitial Lung Disease Open
Background: Interstitial lung diseases (ILDs) often progress quickly and are associated with a poor prognosis. New noninvasive biomarkers to assist in the classification and prognostication of ILD are needed. Exhaled nitric oxide (FeNO), C…
View article: Clinical characteristics and prognostic factors of Hermansky-Pudlak syndrome with or without pulmonary fibrosis: a systematic review
Clinical characteristics and prognostic factors of Hermansky-Pudlak syndrome with or without pulmonary fibrosis: a systematic review Open
Background: Hermansky-Pudlak syndrome (HPS) is a rare disease characterized by excessive bleeding, oculocutaneous albinism, and pulmonary fibrosis (PF). However, few studies have systematically summarized the clinical characteristics of HP…
View article: Engineered PW12-polyoxometalate docked Fe sites on CoFe hydroxide anode for durable seawater electrolysis
Engineered PW12-polyoxometalate docked Fe sites on CoFe hydroxide anode for durable seawater electrolysis Open
Seawater electrolysis driven by offshore renewable energy is a promising avenue for large-scale hydrogen production but faces challenges in designing robust anodes that suppress surface chlorine reactions and corrosion at high current dens…
View article: Association Between Allostatic Load and Delirium in ICU Patients: A Retrospective Analysis of the MIMIC-IV Database
Association Between Allostatic Load and Delirium in ICU Patients: A Retrospective Analysis of the MIMIC-IV Database Open
Background: Allostatic load reflects the cumulative physiological effects of chronic and repeated stress on the body and is associated with dysregulation of multiple systems. This study aimed to examine the association between the allostat…
View article: Hexafluorophosphate additive enables durable seawater oxidation at ampere-level current density
Hexafluorophosphate additive enables durable seawater oxidation at ampere-level current density Open
Direct seawater electrolysis at ampere-level current densities, powered by coastal/offshore renewables, is an attractive avenue for sustainable hydrogen production but is undermined by chloride-induced anode degradation. Here we demonstrat…
View article: LAURA Completes the Osimertinib Treatment Jigsaw Puzzle of EGFR+ NSCLC from Stage IB to IV: Adjuvant Osimertinib Significantly Improves PFS and CNS Progression in Unresectable Stage III EGFR-Mutated NSCLC Compared to Placebo (LAURA, NCT03521154)
LAURA Completes the Osimertinib Treatment Jigsaw Puzzle of EGFR+ NSCLC from Stage IB to IV: Adjuvant Osimertinib Significantly Improves PFS and CNS Progression in Unresectable Stage III EGFR-Mutated NSCLC Compared to Placebo (LAURA, NCT03521154) Open
The current standard of care for unresectable stage III non-small cell lung cancer (NSCLC) involves a concurrent platinum-based doublet chemotherapy and chest radiotherapy, followed by consolidative therapy with durvalumab, an anti-program…
View article: Adagrasib in KRYSTAL-12 has Broken the KRASG12C Enigma Code in Non-Small Cell Lung Carcinoma
Adagrasib in KRYSTAL-12 has Broken the KRASG12C Enigma Code in Non-Small Cell Lung Carcinoma Open
Kirsten rat sarcoma viral oncogene homolog (KRAS) G12C-mutant non-small cell lung carcinoma (NSCLC) accounts for approximately 10-13% of advanced nonsquamous NSCLC cases in Western populations, presenting a significant therapeutic challeng…
View article: Clinical characteristics of high-altitude interstitial lung disease: a two-center, retrospective, observational study
Clinical characteristics of high-altitude interstitial lung disease: a two-center, retrospective, observational study Open
Introduction : The impact of high altitude on patients with interstitial lung disease (ILD) remains unclear. This study aimed to describe the clinical characteristics of ILD patients in high-altitude regions. Methods This retrospective obs…
View article: Efficient visual transformer transferring from neural ODE perspective
Efficient visual transformer transferring from neural ODE perspective Open
Recently, the Visual Image Transformer (ViT) has revolutionized various domains in computer vision. The transfer of pre‐trained ViT models on large‐scale datasets has proven to be a promising method for downstream tasks. However, tradition…
View article: Reversible leukoencephalopathy with seizures: a case of severe high-altitude cerebral edema
Reversible leukoencephalopathy with seizures: a case of severe high-altitude cerebral edema Open
Background Acute high-altitude illness (AHAI) refers to a series of syndromes including acute mountain sickness (AMS), high-altitude pulmonary edema (HAPE) and high-altitude cerebral edema (HACE). Among these, HACE is a severe and potentia…
View article: Sex Hormones and Chronic Obstructive Pulmonary Disease: A Cross-Sectional Study and Mendelian Randomization Analysis
Sex Hormones and Chronic Obstructive Pulmonary Disease: A Cross-Sectional Study and Mendelian Randomization Analysis Open
Although a significant negative association was observed between sex hormones and COPD, the results of MR analysis did not support the causality of this relationship. Our study suggested that sex hormones may indirectly rather than directl…
View article: Prognostic Value of Interstitial Lung Abnormalities in Patients with Liver Cirrhosis: a Retrospective Cohort Study
Prognostic Value of Interstitial Lung Abnormalities in Patients with Liver Cirrhosis: a Retrospective Cohort Study Open
Background: Cirrhosis is the end-stage liver fibrosis and leads to massive death worldwide. Interstitial lung abnormalities (ILAs) have received widespread attention because of their progression to pulmonary fibrosis and mortality. This st…
View article: Association of demographic factors with acute mountain sickness: a retrospective study in Litang
Association of demographic factors with acute mountain sickness: a retrospective study in Litang Open
Objective Acute mountain sickness (AMS) is a common clinical syndrome in high altitude areas, but the role of demographic factors in AMS has not been well-illucidated. This study aims to describe the relationship between demographic factor…
View article: Bibliometric analysis of the pirfenidone and nintedanib in interstitial lung diseases
Bibliometric analysis of the pirfenidone and nintedanib in interstitial lung diseases Open
We summarized and showed developmental alterations of pirfenidone and nintedanib in fibrosing ILD through bibliographic index-based analysis. Our findings showed just dozen years sharp development period of pirfenidone and nintedanib in IL…
View article: Predictive value of NT-proBNP and hs-TnT for outcomes after pediatric congenital cardiac surgery
Predictive value of NT-proBNP and hs-TnT for outcomes after pediatric congenital cardiac surgery Open
Background: The available evidence regarding the predictive value of troponins and natriuretic peptides for early postoperative outcomes in pediatrics is limited, controversial, and based on small sample sizes. The authors aimed to investi…
View article: Lung volume reduction surgery by intra-bullous fibrin sealant application using thoracoscopy, an alternative in the management of vanishing lung syndrome
Lung volume reduction surgery by intra-bullous fibrin sealant application using thoracoscopy, an alternative in the management of vanishing lung syndrome Open
Background: To investigate the efficacy of lung volume reduction surgery (LVRS) through the application of intra-bullous fibrin sealant using thoracoscopy in patients diagnosed with vanishing lung syndrome(VLS). Methods: A retrospective an…
View article: Roles of gender and smoking in the associations between urinary phytoestrogens and asthma/wheeze and lung function: evidence from a cross-sectional study
Roles of gender and smoking in the associations between urinary phytoestrogens and asthma/wheeze and lung function: evidence from a cross-sectional study Open
Background The role of phytoestrogens in asthma/wheeze and lung function remains controversial. Thus, we aimed to examine whether phytoestrogens have beneficial effects on asthma/wheeze, lung function for subgroups and mortality. Methods P…
View article: Gut microbiota and metabolic biomarkers in metabolic dysfunction–associated steatotic liver disease
Gut microbiota and metabolic biomarkers in metabolic dysfunction–associated steatotic liver disease Open
Metabolic dysfunction–associated steatotic liver disease (MASLD), a replacement of the nomenclature employed for NAFLD, is the most prevalent chronic liver disease worldwide. Despite its high global prevalence, NAFLD is often under-recogni…
View article: Segmentation of Lung Lesions through Bilateral Learning Branches to Aggregating Contextual and Local Characteristics
Segmentation of Lung Lesions through Bilateral Learning Branches to Aggregating Contextual and Local Characteristics Open
Detecting and analyzing lung lesion regions using artificial intelligence is of great significance in the medical diagnosis of lung CT images, which can substantially improve the efficiency of doctors. However, segmentation of the inflamma…
View article: Resolving the heterogeneous tumour microenvironment in cardiac myxoma through single‐cell and spatial transcriptomics
Resolving the heterogeneous tumour microenvironment in cardiac myxoma through single‐cell and spatial transcriptomics Open
Background Cardiac myxoma (CM) is the most common (58%–80%) type of primary cardiac tumours. Currently, there is a need to develop medical therapies, especially for patients not physically suitable for surgeries. However, the mechanisms th…