Fengqin Xu
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View article: Evaluation and treatment of sleep disorders in adolescents with depression; a scoping review
Evaluation and treatment of sleep disorders in adolescents with depression; a scoping review Open
View article: Trained immunity in myocardial infarction: From mechanisms to translational potential
Trained immunity in myocardial infarction: From mechanisms to translational potential Open
Myocardial infarction (MI) ranks among the leading causes of death globally, with its prognosis closely linked to inflammatory responses. Both excessive early inflammation and persistent residual inflammation lead to adverse cardiac remode…
View article: Panvascular aging and geriatric cardiovascular multimorbidity: current status, prospects, and integrated prevention and treatment strategies of traditional Chinese and Western medicine
Panvascular aging and geriatric cardiovascular multimorbidity: current status, prospects, and integrated prevention and treatment strategies of traditional Chinese and Western medicine Open
View article: Construction and evaluation of a machine learning-based predictive model for enteral nutrition feeding intolerance risk in ICU patients
Construction and evaluation of a machine learning-based predictive model for enteral nutrition feeding intolerance risk in ICU patients Open
Objective We aim to investigate the factors influencing enteral nutrition feeding intolerance (ENFI) in critically ill patients and develop a risk prediction model for ENFI in intensive care unit (ICU) patients, utilizing three machine lea…
View article: Polydatin exerts therapeutic effects on myelodysplastic syndrome by inhibiting the protein expression of oncogenes via hypermethylation in vitro
Polydatin exerts therapeutic effects on myelodysplastic syndrome by inhibiting the protein expression of oncogenes via hypermethylation in vitro Open
DNA methylation plays a critical role in myelodysplastic syndrome (MDS). Here, we aimed to observe the effects of polydatin (PD) on DNA methylation in MDS cells on a genome-wide scale and explore the underlying mechanisms, providing new ev…
View article: The Geriatric Nutritional Risk Index as a Predictor of Outcomes in Urological Cancers: A Systematic Review and Meta-Analysis
The Geriatric Nutritional Risk Index as a Predictor of Outcomes in Urological Cancers: A Systematic Review and Meta-Analysis Open
Introduction: The geriatric nutritional risk index (GNRI) is being used to predict outcomes of several malignancies. However, its utility for urinary tract cancer has not been systematically analyzed. We present the first meta-analysis exa…
View article: Preventive effects of early mobilisation on delirium incidence in critically ill patients: systematic review and meta-analysis
Preventive effects of early mobilisation on delirium incidence in critically ill patients: systematic review and meta-analysis Open
Objective To evaluate whether early mobilisation can reduce the incidence of delirium in critically ill patients and to assess the methodological quality of published studies. Methods Three electronic databases, PubMed, Embase and the Coch…
View article: Role of epicardial adipose tissue in heart failure with preserved ejection fraction: An emerging molecular mechanism and therapeutic potential
Role of epicardial adipose tissue in heart failure with preserved ejection fraction: An emerging molecular mechanism and therapeutic potential Open
Summary With the evolving landscape of diseases, heart failure with preserved ejection fraction (HFpEF) now encompasses more than half of all heart failure patients. This condition is clinically diverse, involving multiple organ systems an…
View article: Global, Regional and National Burden of Cardiovascular Disease in Perimenopausal Women: A Systematic Analysis of Global Burden of Disease Data and Time Trends
Global, Regional and National Burden of Cardiovascular Disease in Perimenopausal Women: A Systematic Analysis of Global Burden of Disease Data and Time Trends Open
View article: Exploring Potential Mechanism of Chuanzhi Qingyu Recipe for Vulnerable Atherosclerosis Plaques Based on Uplc-Q-Tof-Mse, Systems Biology Strategy, and Experimental Validation
Exploring Potential Mechanism of Chuanzhi Qingyu Recipe for Vulnerable Atherosclerosis Plaques Based on Uplc-Q-Tof-Mse, Systems Biology Strategy, and Experimental Validation Open
View article: Construction and validation of a predictive model for allergic rhinitis complicating children with bronchial asthma
Construction and validation of a predictive model for allergic rhinitis complicating children with bronchial asthma Open
This study aimed to investigate the factors influencing the complication of allergic rhinitis in children with bronchial asthma and to construct a nomogram model to predict the occurrence of allergic rhinitis. A total of 190 children with …
View article: Exploring Potential Mechanism of Chuanzhi Qingyu Recipe for Vulnerable Atherosclerosis Plaques Based on Uplc-Q-Tof-Mse, Systems Biology Strategy, and Experimental Validation
Exploring Potential Mechanism of Chuanzhi Qingyu Recipe for Vulnerable Atherosclerosis Plaques Based on Uplc-Q-Tof-Mse, Systems Biology Strategy, and Experimental Validation Open
View article: Effect of electronic fibrobronchoscope alveolar lavage combined with local administration of budesonide on the efficacy of Mycoplasma pneumoniae pneumonia in children
Effect of electronic fibrobronchoscope alveolar lavage combined with local administration of budesonide on the efficacy of Mycoplasma pneumoniae pneumonia in children Open
This study investigates the effect of electronic fibrobronchoscope alveolar lavage combined with local administration of budesonide on the efficacy of treating Mycoplasma pneumoniae pneumonia (MPP) in children. A retrospective analysis was…
View article: In Vivo Study of Inoculation Approaches and Pathogenicity in African Swine Fever
In Vivo Study of Inoculation Approaches and Pathogenicity in African Swine Fever Open
African swine fever is an extremely infectious viral disease that can cause nearly 100% mortality in domestic pigs. In this study, we isolated an ASFV strain HB31A and characterized it using hemadsorption assay, immunofluorescence assay, a…
View article: Common ground on immune infiltration landscape and diagnostic biomarkers in diabetes-complicated atherosclerosis: an integrated bioinformatics analysis
Common ground on immune infiltration landscape and diagnostic biomarkers in diabetes-complicated atherosclerosis: an integrated bioinformatics analysis Open
Introduction Type 2 diabetes mellitus (T2DM) is a major cause of atherosclerosis (AS). However, definitive evidence regarding the common molecular mechanisms underlying these two diseases are lacking. This study aimed to investigate the me…
View article: Gut microbiota in combination with blood metabolites reveals characteristics of the disease cluster of coronary artery disease and cognitive impairment: a Mendelian randomization study
Gut microbiota in combination with blood metabolites reveals characteristics of the disease cluster of coronary artery disease and cognitive impairment: a Mendelian randomization study Open
Background The coexistence of coronary artery disease (CAD) and cognitive impairment has become a common clinical phenomenon. However, there is currently limited research on the etiology of this disease cluster, discovery of biomarkers, an…
View article: Effects and mechanisms of Zhizi Chuanxiong herb pair against atherosclerosis: an integration of network pharmacology, molecular docking, and experimental validation
Effects and mechanisms of Zhizi Chuanxiong herb pair against atherosclerosis: an integration of network pharmacology, molecular docking, and experimental validation Open
View article: Global, Regional, and National Burden of Atherosclerotic Cardiovascular Disease Attributed to Metabolic Risks from 1990 to 2021: A Systematic Analysis of Global Burden of Disease Data and Temporal Trends
Global, Regional, and National Burden of Atherosclerotic Cardiovascular Disease Attributed to Metabolic Risks from 1990 to 2021: A Systematic Analysis of Global Burden of Disease Data and Temporal Trends Open
View article: Use of modified nutric score for nutritional risk assessment and prognosis prediction in neurological critically ill patients complicated with omicron infection
Use of modified nutric score for nutritional risk assessment and prognosis prediction in neurological critically ill patients complicated with omicron infection Open
View article: Current status and emerging trends of cardiac metabolism from the past 20 years: A bibliometric study
Current status and emerging trends of cardiac metabolism from the past 20 years: A bibliometric study Open
View article: Effects and mechanisms of Zhizi Chuanxiong herb pair against atherosclerosis: An integration of network pharmacology, molecular docking and experimental validation
Effects and mechanisms of Zhizi Chuanxiong herb pair against atherosclerosis: An integration of network pharmacology, molecular docking and experimental validation Open
Backgrounds Zhizi Chuanxiong herb pair (ZCHP) can delay the pathological progression of atherosclerosis (AS). However, the exact pharmacological mechanism by ZCHP improves AS remain unclear due to the complexity of its components. Therefor…
View article: Mean arterial pressure and mortality in patients with heart failure: a retrospective analysis of Zigong heart failure database
Mean arterial pressure and mortality in patients with heart failure: a retrospective analysis of Zigong heart failure database Open
Background It is commonly observed that a higher target of mean arterial pressure (MAP) is in previous studies. This study assessed the association of MAP with short-term mortality in heart failure (HF) patients. Methods A retrospective co…
View article: Effectiveness of acupoint application of Xiaozhong Zhitong Tie on diarrhea in patients: a retrospective cohort study in China.
Effectiveness of acupoint application of Xiaozhong Zhitong Tie on diarrhea in patients: a retrospective cohort study in China. Open
The efficacy in the treatment group was significantly more improved than that in the control group on the 14th and 28th day.
View article: Epidemiology and control measures of an outbreak of neonatal echovirus 11 infections in Guangdong, China: A retrospective analysis
Epidemiology and control measures of an outbreak of neonatal echovirus 11 infections in Guangdong, China: A retrospective analysis Open
View article: Mendelian randomization study reveals a causal relationship between serum iron status and coronary heart disease and related cardiovascular diseases
Mendelian randomization study reveals a causal relationship between serum iron status and coronary heart disease and related cardiovascular diseases Open
Background Growing observational studies have shown that abnormal systemic iron status is associated with Coronary heart disease (CHD). However, these results from observational studies was not entirely consistent.It remains unclear whethe…
View article: Mapping current status and emerging trends in NETosis: A bibliometric study
Mapping current status and emerging trends in NETosis: A bibliometric study Open
Background: NETosis is a critical innate immune mechanism of neutrophils that contributes to the accelerated progression of autoimmune diseases, thrombosis, cancer, and coronavirus disease 2019 (COVID-19). This study qualitatively and quan…
View article: Mendelian randomization study reveals a causal relationship between coronary artery disease and cognitive impairment
Mendelian randomization study reveals a causal relationship between coronary artery disease and cognitive impairment Open
Background Growing evidence suggests that Coronary artery disease (CAD) is associated with cognitive impairment. However, these results from observational studies was not entirely consistent, with some detecting no such association. And it…
View article: Mitophagy in atherosclerosis: from mechanism to therapy
Mitophagy in atherosclerosis: from mechanism to therapy Open
Mitophagy is a type of autophagy that can selectively eliminate damaged and depolarized mitochondria to maintain mitochondrial activity and cellular homeostasis. Several pathways have been found to participate in different steps of mitopha…
View article: Traditional Chinese Medicine Synonymous Term Conversion
Traditional Chinese Medicine Synonymous Term Conversion Open
Background: The medical records of traditional Chinese medicine (TCM) contain numerous synonymous terms with different descriptions, which is not conducive to computer-aided data mining of TCM. However, there is a lack of models available …
View article: Huazhuotongmai decoction exerts anti-atherosclerotic effects by modulating the expression of ABCA1/SR-B1/PPAR-γ in vivo and in vitro
Huazhuotongmai decoction exerts anti-atherosclerotic effects by modulating the expression of ABCA1/SR-B1/PPAR-γ in vivo and in vitro Open
Background: Previous studies have suggested that treatment with Chinese herbs has a protective effect on atherosclerosis (AS). This study aims to explore the effect mechanism of Huazhuotongmai(HZTM) on AS from the perspective of reverse ch…