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View article: Reshaping the active pocket of an aldo-keto reductase to enhance its detoxification activity towards 3-keto-deoxynivalenol
Reshaping the active pocket of an aldo-keto reductase to enhance its detoxification activity towards 3-keto-deoxynivalenol Open
Deoxynivalenol (DON), the most common mycotoxin in the world, poses serious health hazards to both humans and animals and causes significant economic losses to the food and feed industry. An intriguing method for DON detoxification involve…
View article: Engineering a Lactobacillus Lysine Riboswitch to Dynamically Control Metabolic Pathways for Lysine Production in Corynebacterium glutamicum
Engineering a Lactobacillus Lysine Riboswitch to Dynamically Control Metabolic Pathways for Lysine Production in Corynebacterium glutamicum Open
Knock-out of genes of metabolic pathways is conventionally used in the metabolic engineering of microorganisms, but it is not applicable for genes of essential pathways. In order to avoid undesirable effects caused by gene deletion, it is …
View article: Thermal Stability Enhancement of L-Asparaginase from Corynebacterium glutamicum Based on a Semi-Rational Design and Its Effect on Acrylamide Mitigation Capacity in Biscuits
Thermal Stability Enhancement of L-Asparaginase from Corynebacterium glutamicum Based on a Semi-Rational Design and Its Effect on Acrylamide Mitigation Capacity in Biscuits Open
Acrylamide is present in thermally processed foods, and it possesses toxic and carcinogenic properties. L-asparaginases could effectively regulate the formation of acrylamide at the source. However, current L-asparaginases have drawbacks s…
View article: Improved catalytic performance and molecular insight for lipoxygenase from Enterovibrio norvegicus via directed evolution
Improved catalytic performance and molecular insight for lipoxygenase from Enterovibrio norvegicus via directed evolution Open
Lipoxygenase (LOX) holds significant promise for food and pharmaceutical industries. However, albeit its application has been hampered by low catalytic activity and suboptimal thermostability. To address the drawbacks, a directed evolution…
View article: [mRNA Expression Profile Changes in Angiotensin-Ⅱ-Induced Atrial Myocardial Fibrosis in Rats].
[mRNA Expression Profile Changes in Angiotensin-Ⅱ-Induced Atrial Myocardial Fibrosis in Rats]. Open
Ang Ⅱ can cause myocardial fibrosis in rats. There are significant differences in mRNA expression between fibrotic cardiomyocytes and normal cardiomyocytes. The differentially expressed mRNAs may play an important role in biological proces…
View article: Computational Insights and In Silico Characterization of a Novel Mini-Lipoxygenase from Nostoc Sphaeroides and Its Application in the Quality Improvement of Steamed Bread
Computational Insights and In Silico Characterization of a Novel Mini-Lipoxygenase from Nostoc Sphaeroides and Its Application in the Quality Improvement of Steamed Bread Open
Lipoxygenase (EC1.13.11.12, LOX) has been potentially used in the food industry for food quality improvement. However, the low activity, poor thermal stability, narrow range of pH stability, as well as undesirable isoenzymes and off-flavor…
View article: Additional file 3 of Transcriptomic analysis reveals that Bacillomycin D-C16 induces multiple pathways of disease resistance in cherry tomato
Additional file 3 of Transcriptomic analysis reveals that Bacillomycin D-C16 induces multiple pathways of disease resistance in cherry tomato Open
Additional file 3: Table S3. Table of RNA-seq data after Bacillomycin D-C16 treatment versus control at time 24 h.
View article: Additional file 7 of Transcriptomic analysis reveals that Bacillomycin D-C16 induces multiple pathways of disease resistance in cherry tomato
Additional file 7 of Transcriptomic analysis reveals that Bacillomycin D-C16 induces multiple pathways of disease resistance in cherry tomato Open
Additional file 7: Table S7. Table of KEGG enrichment analysis after Bacillomycin D-C16 treatment versus control at time 24 h.
View article: Additional file 4 of Transcriptomic analysis reveals that Bacillomycin D-C16 induces multiple pathways of disease resistance in cherry tomato
Additional file 4 of Transcriptomic analysis reveals that Bacillomycin D-C16 induces multiple pathways of disease resistance in cherry tomato Open
Additional file 4: Table S4. Table of GO enrichment analysis after Bacillomycin D-C16 treatment versus control at time 12 h.
View article: Additional file 6 of Transcriptomic analysis reveals that Bacillomycin D-C16 induces multiple pathways of disease resistance in cherry tomato
Additional file 6 of Transcriptomic analysis reveals that Bacillomycin D-C16 induces multiple pathways of disease resistance in cherry tomato Open
Additional file 6: Table S6. Table of KEGG enrichment analysis after Bacillomycin D-C16 treatment versus control at time 12 h.
View article: Additional file 8 of Transcriptomic analysis reveals that Bacillomycin D-C16 induces multiple pathways of disease resistance in cherry tomato
Additional file 8 of Transcriptomic analysis reveals that Bacillomycin D-C16 induces multiple pathways of disease resistance in cherry tomato Open
Additional file 8: Table S8. Table of transcription factors after Bacillomycin D-C16 treatment versus control at time 12 h.
View article: Additional file 5 of Transcriptomic analysis reveals that Bacillomycin D-C16 induces multiple pathways of disease resistance in cherry tomato
Additional file 5 of Transcriptomic analysis reveals that Bacillomycin D-C16 induces multiple pathways of disease resistance in cherry tomato Open
Additional file 5: Table S5. Table of GO enrichment analysis after Bacillomycin D-C16 treatment versus control at time 24 h.
View article: Effect and Regulation of Pyruvate on Bacillomycin D Synthesis
Effect and Regulation of Pyruvate on Bacillomycin D Synthesis Open
Objective: This paper mainly studied the effects and regulation of exogenous addition of pyruvate, overexpression of pyruvate kinase and acetyl-CoA synthase on the synthesis of Bacillomycin D. Methods: In this study, B. amyloliquefaciens f…
View article: Thermostability Improvement of L-Asparaginase from Acinetobacter soli via Consensus-Designed Cysteine Residue Substitution
Thermostability Improvement of L-Asparaginase from Acinetobacter soli via Consensus-Designed Cysteine Residue Substitution Open
To extend the application range of L-asparaginase in food pre-processing, the thermostability improvement of the enzyme is essential. Herein, two non-conserved cysteine residues with easily oxidized free sulfhydryl groups, Cys8 and Cys283,…
View article: Characterization and Preliminary Application of a Novel Lipoxygenase from Enterovibrio norvegicus
Characterization and Preliminary Application of a Novel Lipoxygenase from Enterovibrio norvegicus Open
Lipoxygenases have proven to be a potential biocatalyst for various industrial applications. However, low catalytic activity, low thermostability, and narrow range of pH stability largely limit its application. Here, a lipoxygenase (LOX) g…
View article: Enhancing the Catalytic Activity of Type II L-Asparaginase from Bacillus licheniformis through Semi-Rational Design
Enhancing the Catalytic Activity of Type II L-Asparaginase from Bacillus licheniformis through Semi-Rational Design Open
Low catalytic activity is a key factor limiting the widespread application of type II L-asparaginase (ASNase) in the food and pharmaceutical industries. In this study, smart libraries were constructed by semi-rational design to improve the…
View article: A Generalized Dynamic Model and Coupling Meshing Force Analysis for Planetary Gear Set Transmissions
A Generalized Dynamic Model and Coupling Meshing Force Analysis for Planetary Gear Set Transmissions Open
The dynamics analysis of a planetary gear set transmissions requires the creation of completely different models for different gears, which is very tedious. In this paper, a generalized dynamics modeling process is proposed for a three pla…
View article: Cis-Element Engineering Promotes the Expression of Bacillus subtilis Type I L-Asparaginase and Its Application in Food
Cis-Element Engineering Promotes the Expression of Bacillus subtilis Type I L-Asparaginase and Its Application in Food Open
Type I L-asparaginase from Bacillus licheniformis Z-1 (BlAase) was efficiently produced and secreted in Bacillus subtilis RIK 1285, but its low yield made it unsuitable for industrial use. Thus, a combined method was used in this study to …
View article: Entrance and Origin of the Extracranial Vertebral Artery: CTA Findings
Entrance and Origin of the Extracranial Vertebral Artery: CTA Findings Open
Objective To investigated morphological variability of VA origin and its entrance level into cervical transverse foramina by CTA. Methods To retrospectively investigated computed tomography angiograms (CTA) of 223 subjects (446 VA courses)…
View article: Epimerization of Deoxynivalenol by the Devosia Strain A6-243 Assisted by Pyrroloquinoline Quinone
Epimerization of Deoxynivalenol by the Devosia Strain A6-243 Assisted by Pyrroloquinoline Quinone Open
Deoxynivalenol (DON) is a secondary metabolite produced by several Fusarium species that is hazardous to humans and animals after entering food chains. In this study, by adding cofactors, the Devosia strain A6-243 is identified as the DON-…
View article: Iturin A Induces Resistance and Improves the Quality and Safety of Harvested Cherry Tomato
Iturin A Induces Resistance and Improves the Quality and Safety of Harvested Cherry Tomato Open
The soft rot disease caused by Rhizopus stolonifer is an important disease in cherry tomato fruit. In this study, the effect of iturin A on soft rot of cherry tomato and its influence on the storage quality of cherry tomato fruit were inve…
View article: Characterization of a Novel L-Asparaginase from Mycobacterium gordonae with Acrylamide Mitigation Potential
Characterization of a Novel L-Asparaginase from Mycobacterium gordonae with Acrylamide Mitigation Potential Open
L-asparaginase (E.C.3.5.1.1) is a well-known agent that prevents the formation of acrylamide both in the food industry and against childhood acute lymphoblastic leukemia in clinical settings. The disadvantages of L-asparaginase, which rest…
View article: Acetate Activates <i>Lactobacillus</i> Bacteriocin Synthesis by Controlling Quorum Sensing
Acetate Activates <i>Lactobacillus</i> Bacteriocin Synthesis by Controlling Quorum Sensing Open
Bacteriocins produced by lactic acid bacteria (LAB) are particularly useful in food preservation and food safety. Bacteriocins might increase bacterial competitive advantage against the indigenous microbiota of the intestines; at the same …
View article: Genome Mining, Heterologous Expression, Antibacterial and Antioxidant Activities of Lipoamides and Amicoumacins from Compost-Associated Bacillus subtilis fmb60
Genome Mining, Heterologous Expression, Antibacterial and Antioxidant Activities of Lipoamides and Amicoumacins from Compost-Associated Bacillus subtilis fmb60 Open
Bacillus subtilis fmb60, which has broad-spectrum antimicrobial activities, was isolated from plant straw compost. A hybrid NRPS/PKS cluster was screened from the genome. Sixteen secondary metabolites produced by the gene cluster were isol…
View article: Acetate and auto‐inducing peptide are independent triggers of quorum sensing in <i>Lactobacillus plantarum</i>
Acetate and auto‐inducing peptide are independent triggers of quorum sensing in <i>Lactobacillus plantarum</i> Open
The synthesis of plantaricin in Lactobacillus plantarum is regulated by quorum sensing. However, the nature of the extra‐cytoplasmic (EC) sensing domain of the histidine kinase (PlnB1) and the ability to recognize the auto‐inducing peptide…
View article: Genome Mining and Heterologous Expression of Lipoamides and Amicoumacins From Compost-Associated <em>Bacillus subtilis</em> fmb60
Genome Mining and Heterologous Expression of Lipoamides and Amicoumacins From Compost-Associated <em>Bacillus subtilis</em> fmb60 Open
Bacillus subtilis fmb60, which has broad-spectrum antimicrobial activities was isolated from plant straw compost. A hybrid NRPS/PKS cluster was screened from the genome. Sixteen secondary metabolites produced by the gene cluster were isola…